KEGG ORTHOLOGY: K03176

ORTHOLOGY: K03176

Entry

K03176 KO

Name

NTRK1, TRKA

Definition

neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]

Pathway

ko04010

MAPK signaling pathway

ko04014

Ras signaling pathway

ko04020

Calcium signaling pathway

ko04151

PI3K-Akt signaling pathway

ko04210

Apoptosis

ko04722

Neurotrophin signaling pathway

ko04750

Inflammatory mediator regulation of TRP channels

ko05200

Pathways in cancer

ko05202

Transcriptional misregulation in cancer

ko05216

Thyroid cancer

ko05230

Central carbon metabolism in cancer

Disease

H00032

Thyroid cancer

H00043

Neuroblastoma

H00265

Hereditary sensory and autonomic neuropathy

H01836

Congenital pain insensitivity with anhidrosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04014 Ras signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04020 Calcium signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04151 PI3K-Akt signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05202 Transcriptional misregulation in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05230 Central carbon metabolism in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09162 Cancer: specific types
   05216 Thyroid cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1

Genes

HSA:	4914(NTRK1)

PTR:	457408(NTRK1)

PPS:	100995426(NTRK1)

GGO:	101125993(NTRK1)

PON:	100452269(NTRK1)

NLE:	100585466(NTRK1)

MCC:	719670(NTRK1)

MCF:	102129364(NTRK1)

CSAB:

103223823(NTRK1)

RRO:	104676442(NTRK1)

RBB:	108515538(NTRK1)

CJC:	103789024(NTRK1)

SBQ:	101035626(NTRK1)

MMU:	18211(Ntrk1)

MCAL:

110290875(Ntrk1)

MPAH:

110319787(Ntrk1)

RNO:	59109(Ntrk1)

MUN:	110564977(Ntrk1)

CGE:	100751271(Ntrk1)

NGI:	103750263(Ntrk1)

HGL:	101724441(Ntrk1)

CCAN:

109686202(Ntrk1)

OCU:	100354292(NTRK1)

TUP:	102485200(NTRK1)

CFA:	490404(NTRK1)

VVP:	112918800(NTRK1)

UAH:	113245211(NTRK1)

ORO:	101374117(NTRK1)

ELK:

111138872

FCA:	101081603(NTRK1)

PPAD:

109256209(NTRK1)

AJU:	106988854(NTRK1)

BTA:	353111(NTRK1)

BOM:	102264869(NTRK1)

BIU:	109556725(NTRK1)

BBUB:

102402551(NTRK1)

CHX:	102172584(NTRK1)

OAS:	101109763(NTRK1)

SSC:	100154471(NTRK1)

CFR:	102518397(NTRK1)

CDK:	105105672(NTRK1)

BACU:

103003654(NTRK1)

LVE:	103071756(NTRK1)

OOR:	101273503(NTRK1)

DLE:	111167102(NTRK1)

PCAD:

102990275(NTRK1)

ECB:	100064594(NTRK1)

EPZ:	103548862(NTRK1)

EAI:	106828447(NTRK1)

MYD:	102765751(NTRK1)

MNA:	107543738(NTRK1)

HAI:	109393379(NTRK1)

DRO:	112315668(NTRK1)

PALE:

112472150(NTRK1)

RAY:	107521477(NTRK1)

MJV:	108383338(NTRK1)

LAV:	100668650(NTRK1)

TMU:

101351378

MDO:	100618744(NTRK1)

SHR:	100916388(NTRK1)

PCW:	110212119(NTRK1)

OAA:	103167743(NTRK1)

GGA:	396337(NTRK1)

MGP:	100541244(NTRK1)

CJO:	107324385(NTRK1)

NMEL:

110388022(NTRK1)

TGU:	115498457(NTRK1)

LSR:	110471556(NTRK1)

SCAN:

103824820(NTRK1)

GFR:	102039729(NTRK1)

FAB:	101810326(NTRK1)

PHI:	102113646(NTRK1)

PMAJ:

107214529(NTRK1)

CCAE:

111939539

CCW:	104683563(NTRK1)

ETL:	114071558(NTRK1)

FPG:	101920297(NTRK1)

FCH:	102060232(NTRK1)

CLV:	102086876(NTRK1)

NNI:	104015011(NTRK1)

AAM:	106495087(NTRK1)

ASN:	102381668(NTRK1)

AMJ:	102568424(NTRK1)

PSS:	102456174(NTRK1)

CMY:	102940175(NTRK1)

CPIC:

101934097(NTRK1)

ACS:	100556611(ntrk1)

PVT:	110081467(NTRK1)

PBI:	103064232(NTRK1)

PMUR:

107298512(NTRK1)

TSR:

106540381

PMUA:

114586656(NTRK1)

GJA:	107114884(NTRK1)

XLA:	108699388 108700358

XTR:	100489637(ntrk1)

NPR:	108802180(NTRK1)

DRE:	30546(ntrk1)

SRX:	107726660(ntrk1) 107728446

SANH:

107671431 107688245

SGH:	107592146 107592455

CCAR:

109105038 109106243

IPU:	108256584(ntrk1)

PHYP:

113532627(ntrk1)

AMEX:

103025260(ntrk1)

EEE:	113571898(ntrk1)

TRU:	101074407(ntrk1)

TNG:	GSTEN00019520G001

LCO:	104933369(ntrk1)

NCC:	104949794(ntrk1)

MZE:	101473195(ntrk1)

ONL:	100699013(ntrk1)

OLA:	101164184(ntrk1)

XMA:

102217423

XCO:	114141649(ntrk1)

PRET:

103477579(ntrk1)

CVG:	107101837(ntrk1)

NFU:	107379148(ntrk1)

KMR:	108246005(ntrk1)

ALIM:

106528305(ntrk1)

AOCE:

111579099(ntrk1)

CSEM:

103388944(ntrk1)

POV:	109642014(ntrk1)

LCF:	108899467(ntrk1)

SDU:	111222591(ntrk1)

SLAL:

111655673(ntrk1)

HCQ:	109512189(ntrk1)

BPEC:

110172749

MALB:

109965566(ntrk1)

SASA:

106581868 106605284

OTW:	112222988 112223654

SALP:

111959090 111965133

ELS:	105019278(ntrk1)

SFM:	108926773(ntrk1) 108930374

PKI:	111838441 111853509

LCM:	102354132(NTRK1)

AME:

BIM:

BTER:

CCAL:

SOC:

MPHA:

AEC:

ACEP:

HST:

CFO:

LHU:

CSOL:

AGS:

Reference

PMID:15488758

Authors

Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR

Title

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.

Journal

Cancer Cell 6:347-60 (2004)
DOI:10.1016/j.ccr.2004.09.011

Sequence

[hsa:4914]

LinkDB

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