KEGG   ORTHOLOGY: K03875Help
Entry
K03875                      KO                                     

Name
SKP2, FBXL1
Definition
F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04120  Ubiquitin mediated proteolysis
ko04150  mTOR signaling pathway
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
   04150 mTOR signaling pathway
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
   05203 Viral carcinogenesis
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Target recognizing subunit (F-box)
     K03875  SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
BRITE hierarchy
Genes
HSA: 6502(SKP2)
PTR: 471570(SKP2)
PPS: 100978721(SKP2)
GGO: 101134461(SKP2)
PON: 100432371(SKP2)
NLE: 100586655(SKP2)
MCC: 700617(SKP2)
MCF: 102114882(SKP2)
CSAB: 103215131(SKP2)
RRO: 104662024(SKP2)
RBB: 108535053(SKP2)
CJC: 100393248(SKP2) 100396732
SBQ: 101041621
MMU: 27401(Skp2)
MCAL: 110310405(Skp2)
MPAH: 110328844(Skp2)
RNO: 294790(Skp2)
MUN: 110566051(Skp2)
CGE: 100771396(Skp2)
NGI: 103741317(Skp2)
HGL: 101706248(Skp2)
CCAN: 109702695(Skp2)
OCU: 100342452(SKP2)
TUP: 102497164(SKP2)
CFA: 489228(SKP2)
VVP: 112933526(SKP2)
AML: 100480437(SKP2)
UMR: 103664708(SKP2)
UAH: 113260895(SKP2)
ORO: 101383205(SKP2)
FCA: 101099275(SKP2)
PTG: 102964396(SKP2)
AJU: 106979642(SKP2)
BTA: 519018(SKP2)
BOM: 102269700(SKP2) 102277531
BIU: 109574865(SKP2) 109579088
BBUB: 102395935(SKP2)
PHD: 102339171(SKP2)
CHX: 102172762(SKP2)
OAS: 101109483(SKP2)
SSC: 100329128(SKP2)
CFR: 102523584(SKP2)
CDK: 105086996(SKP2)
BACU: 103007736(SKP2)
LVE: 103090160(SKP2)
OOR: 101274005(SKP2)
DLE: 111187525(SKP2)
PCAD: 102991021 114486791(SKP2)
ECB: 100053697(SKP2)
EPZ: 103563536
EAI: 106824722(SKP2)
MYB: 102262715(SKP2)
MYD: 102770564(SKP2)
MNA: 107546230(SKP2)
HAI: 109387065(SKP2)
RSS: 109450197(SKP2)
DRO: 112321074(SKP2)
PALE: 102880695(SKP2)
RAY: 107509711(SKP2)
LAV: 100676976(SKP2)
TMU: 101348198
MDO: 100020421(SKP2)
SHR: 100915218(SKP2)
PCW: 110214774(SKP2)
OAA: 103166602(SKP2)
GGA: 427437(SKP2)
MGP: 100542923(SKP2)
CJO: 107305844(SKP2)
NMEL: 110389514(SKP2)
APLA: 101802477(SKP2)
TGU: 100217547(SKP2)
LSR: 110482530(SKP2)
SCAN: 103821008(SKP2)
GFR: 102037500(SKP2)
FAB: 101810388(SKP2)
PHI: 102109076(SKP2)
PMAJ: 107216438(SKP2)
CCAE: 111940976(SKP2)
CCW: 104686606(SKP2)
ETL: 114055031(SKP2)
FPG: 101911609(SKP2)
FCH: 102053148(SKP2)
CLV: 102084967(SKP2)
EGZ: 104133851(SKP2)
NNI: 104018639(SKP2)
ACUN: 113489833(SKP2)
PADL: 103921478(SKP2)
AAM: 106499538(SKP2)
ASN: 102367894(SKP2)
AMJ: 102558881(SKP2)
PSS: 102445640(SKP2)
CMY: 102932831(SKP2) 102933431
CPIC: 101935689(SKP2)
ACS: 100564206(skp2)
PVT: 110080059(SKP2)
PBI: 103054864(SKP2)
PMUR: 107297968(SKP2)
GJA: 107108086(SKP2)
XLA: 734901(skp2.L)
XTR: 100216169(skp2)
NPR: 108792651(SKP2)
DRE: 563708(skp2)
IPU: 108279378(skp2)
PHYP: 113541502(skp2)
AMEX: 103047278(skp2)
EEE: 113574196(skp2)
TRU: 101066648(skp2)
LCO: 104938172(skp2)
MZE: 101475050(skp2)
OLA: 101156183(skp2)
XMA: 102229286(skp2)
XCO: 114150144(skp2)
PRET: 103474062(skp2)
NFU: 107375004(skp2)
KMR: 108228591(skp2)
AOCE: 111574103(skp2)
POV: 109647460(skp2)
LCF: 108900731
SDU: 111221206(skp2)
HCQ: 109529111(skp2)
BPEC: 110161888(skp2)
MALB: 109960759(skp2)
OTW: 112257530(skp2)
SALP: 111961421 111981396(skp2)
ELS: 105025175(skp2)
SFM: 108933818(skp2)
PKI: 111842164(skp2)
LCM: 102356499(SKP2)
CIN: 100177208
SPU: 574970
APLC: 110977762
SKO: 102801733
DME: Dmel_CG9772(Skp2)
DER: 6552112
DSI: Dsimw501_GD19685(Dsim_GD19685)
DPE: 6594584
DWI: 6647714
DAZ: 108621611
DNV: 108659745
DHE: 111595699
MDE: 101893441
LCQ: 111690972
AAG: 5565946
AME: 412031
BIM: 100741315
BTER: 100650657
SOC: 105205491
MPHA: 105830728
AEC: 105143861
ACEP: 105620077
PBAR: 105432127
VEM: 105567342
HST: 105182661
DQU: 106744145
CFO: 105253116
LHU: 105678405
PGC: 109855325
OBO: 105281121
PCF: 106788562
NVI: 100121294
MDL: 103571238
TCA: 657905
DPA: 109546228
NVL: 108561186
BMOR: 101741790
PMAC: 106711902
PRAP: 110992556
HAW: 110381241
DNX: 107162587
AGS: 114121749
BTAB: 109031308
CLEC: 106671910
ZNE: 110828413
FCD: 110849341
CEL: CELE_F48E8.7(skpt-1)
CBR: CBG05188(Cbr-skpt-1)
PCAN: 112574309
CRG: 105334825
MYI: 110466582
OBI: 106872496
LAK: 106171246
EPA: 110235003
PDAM: 113682927
SPIS: 111323091
HMG: 101236554
ATH: AT1G21410(SKP2A) AT1G77000(SKP2B)
CPAP: 110818172
CIT: 102610462
TCC: 18592471
EGR: 104449651
LJA: Lj0g3v0152909.1(Lj0g3v0152909.1) Lj5g3v0369960.1(Lj5g3v0369960.1) Lj5g3v0369960.2(Lj5g3v0369960.2)
ADU: 107460595
AIP: 107605985
FVE: 101311638
RCN: 112173568
PPER: 18768375
PMUM: 103336511
ZJU: 107423464
CSV: 101220292
CMO: 103485661
MCHA: 111011854
RCU: 8270661
JCU: 105629180
QSU: 112035395
VVI: 100255759
SLY: 101254991
SPEN: 107015571
SOT: 102579014
CANN: 107853333
NSY: 104222373
NTO: 104086244
NAU: 109229641
INI: 109170471
CCAV: 112502665
BVG: 104905903
SOE: 110782035
DOSA: Os01t0881900-01(Os01g0881900) Os05t0425700-01(Os05g0425700)
ATS: 109741353(LOC109741353) 109743063(LOC109743063)
ZMA: 100274332(pco067008) 100274363(FBL2)
DCT: 110116103
PEQ: 110024639
ATR: 18436941
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Nie L, Wu H, Sun XH
  Title
Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP.
  Journal
J Biol Chem 283:684-92 (2008)
DOI:10.1074/jbc.M704981200
  Sequence
[hsa:6502]
Reference
  Authors
Wang W, Nacusi L, Sheaff RJ, Liu X
  Title
Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection.
  Journal
Biochemistry 44:14553-64 (2005)
DOI:10.1021/bi051071j
  Sequence
[hsa:6502]
Reference
  Authors
Li X, Zhao Q, Liao R, Sun P, Wu X
  Title
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation.
  Journal
J Biol Chem 278:30854-8 (2003)
DOI:10.1074/jbc.C300251200
  Sequence
[hsa:6502]
Reference
PMID:7553852
  Authors
Zhang H, Kobayashi R, Galaktionov K, Beach D
  Title
p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.
  Journal
Cell 82:915-25 (1995)
DOI:10.1016/0092-8674(95)90271-6
  Sequence
[hsa:6502]
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