KEGG   ORTHOLOGY: K03982Help
Entry
K03982                      KO                                     

Name
SERPINE1, PAI1
Definition
plasminogen activator inhibitor 1
Pathway
ko04066  HIF-1 signaling pathway
ko04115  p53 signaling pathway
ko04218  Cellular senescence
ko04371  Apelin signaling pathway
ko04390  Hippo signaling pathway
ko04610  Complement and coagulation cascades
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
Disease
H00223  Inherited thrombophilia
H01106  Plasminogen activator inhibitor type 1 deficiency
H01529  Avascular necrosis of femoral head
H01709  Glucocorticoid-induced osteonecrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
   04371 Apelin signaling pathway
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
   04066 HIF-1 signaling pathway
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
   04218 Cellular senescence
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
   00536 Glycosaminoglycan binding proteins
    K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
Peptidases and inhibitors [BR:ko01002]
 Peptidase inhibitors
  Family I4: serpin family
   K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Haparin
  Coagulation and fibrinolysis
   K03982  SERPINE1, PAI1; plasminogen activator inhibitor 1
BRITE hierarchy
Other DBs
GO: 0004867
Genes
HSA: 5054(SERPINE1)
PTR: 472467(SERPINE1)
PPS: 100973457(SERPINE1)
GGO: 101149162(SERPINE1)
PON: 100435876(SERPINE1)
NLE: 100588010(SERPINE1)
MCC: 713883(SERPINE1)
MCF: 102147003(SERPINE1)
CSAB: 103246698(SERPINE1)
RRO: 104681183(SERPINE1)
RBB: 108518939(SERPINE1)
CJC: 100385528(SERPINE1)
SBQ: 101045388(SERPINE1)
MMU: 18787(Serpine1)
MPAH: 110313068(Serpine1)
RNO: 24617(Serpine1)
MUN: 110566254(Serpine1)
CGE: 100759702(Serpine1)
NGI: 103733497(Serpine1)
HGL: 101703903(Serpine1)
CCAN: 109692813(Serpine1)
OCU: 100009588(SERPINE1)
TUP: 102478468(SERPINE1)
CFA: 403476(SERPINE1)
VVP: 112935788(SERPINE1)
AML: 100483472(SERPINE1)
UMR: 103670125(SERPINE1)
UAH: 113267839(SERPINE1)
ORO: 101382421(SERPINE1)
ELK: 111145849
FCA: 100127105(SERPINE1)
PTG: 102972312(SERPINE1)
PPAD: 109250526(SERPINE1)
AJU: 106988114(SERPINE1)
BTA: 281375(SERPINE1)
BOM: 102275884(SERPINE1)
BIU: 109578652(SERPINE1)
BBUB: 102391372(SERPINE1)
CHX: 102169375(SERPINE1)
OAS: 100381267(SERPINE1)
SSC: 396945(SERPINE1)
CFR: 102505188(SERPINE1)
CDK: 105092393(SERPINE1)
BACU: 103019421(SERPINE1)
LVE: 103091622(SERPINE1)
OOR: 101273613(SERPINE1)
DLE: 111182313(SERPINE1)
PCAD: 102996444(SERPINE1)
ECB: 100033931(SERPINE1)
EPZ: 103541183(SERPINE1)
EAI: 106839300(SERPINE1)
MYB: 102262847(SERPINE1)
MYD: 102771956(SERPINE1)
MNA: 107526505(SERPINE1)
HAI: 109385046(SERPINE1)
DRO: 112314968(SERPINE1)
PALE: 102880028(SERPINE1)
RAY: 107511771(SERPINE1)
MJV: 108395779(SERPINE1)
LAV: 100660994(SERPINE1)
TMU: 101348466
MDO: 100017921(SERPINE1)
SHR: 100922915(SERPINE1)
PCW: 110194266(SERPINE1)
OAA: 100090599(SERPINE1)
ASN: 102369661
AMJ: 102563594(SERPINE1)
PSS: 102443480(SERPINE1)
CMY: 102940865(SERPINE1)
CPIC: 101946709 101950595(SERPINE1)
ACS: 100558317(serpine1)
PVT: 110077425(SERPINE1)
PBI: 103062655(SERPINE1)
PMUR: 107285052(SERPINE1)
TSR: 106551758(SERPINE1)
PMUA: 114582468(SERPINE1)
GJA: 107113525(SERPINE1)
XLA: 100049768(serpine1.S) 779433(serpine1.L)
XTR: 100127732(serpine1)
NPR: 108795423(SERPINE1)
DRE: 100136840(serpine1)
SRX: 107750568(serpine1) 107754656
IPU: 108267921(serpine1)
PHYP: 113539927(serpine1)
AMEX: 103042062(serpine1)
EEE: 113580806(serpine1)
TRU: 101069978(serpine1)
LCO: 104938952(serpine1)
NCC: 104941435(serpine1)
MZE: 101481046(serpine1)
ONL: 100703589(serpine1)
OLA: 100529196(serpine1)
XMA: 102226229(serpine1)
XCO: 114158035(serpine1)
PRET: 103480133
CVG: 107100683(serpine1)
NFU: 107374548
KMR: 108242259(serpine1)
ALIM: 106526972(serpine1)
AOCE: 111567630(serpine1)
CSEM: 103385566
POV: 109637625(serpine1)
LCF: 108879720(serpine1)
SDU: 111226956(serpine1)
SLAL: 111654376(serpine1)
HCQ: 109520372(serpine1)
BPEC: 110170785
ELS: 105031309(serpine1)
SFM: 108922853(serpine1)
LCM: 102360184(SERPINE1)
CMK: 103190657(serpine1)
RTP: 109921922
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Vial D, McKeown-Longo PJ
  Title
PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins.
  Journal
J Cell Sci 121:1661-70 (2008)
DOI:10.1242/jcs.020149
Reference
PMID:2430793
  Authors
Pannekoek H, Veerman H, Lambers H, Diergaarde P, Verweij CL, van Zonneveld AJ, van Mourik JA
  Title
Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.
  Journal
EMBO J 5:2539-44 (1986)
  Sequence
[hsa:5054]
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