KEGG   ORTHOLOGY: K04189
Entry
K04189                      KO                                     

Name
CXCR4, CD184
Definition
C-X-C chemokine receptor type 4
Pathway
ko04020  Calcium signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04062  Chemokine signaling pathway
ko04144  Endocytosis
ko04360  Axon guidance
ko04670  Leukocyte transendothelial migration
ko04672  Intestinal immune network for IgA production
ko04810  Regulation of actin cytoskeleton
ko05163  Human cytomegalovirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
Disease
H00097  Chemokine receptor defect
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04061 Viral protein interaction with cytokine and cytokine receptor
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04672 Intestinal immune network for IgA production
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04062 Chemokine signaling pathway
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09158 Development and regeneration
   04360 Axon guidance
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   05163 Human cytomegalovirus infection
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04050 Cytokine receptors
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04090 CD molecules
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Chemokine
   CXC Chemokine
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
Cytokine receptors [BR:ko04050]
 Chemokine receptors
  CXC Chemokine
   K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
CD molecules [BR:ko04090]
 Proteins
  K04189  CD184, CXCR4; chemokine (C-X-C motif) receptor 4
Other DBs
GO: 0016494
TC: 9.A.14.13.17
Genes
HSA: 7852(CXCR4)
PTR: 450130(CXCR4)
PPS: 100968161(CXCR4)
GGO: 101137662(CXCR4)
PON: 100451032(CXCR4)
NLE: 100604120(CXCR4)
MCC: 707329(CXCR4)
MCF: 102142487(CXCR4)
CSAB: 103216995(CXCR4)
RRO: 104668781(CXCR4)
RBB: 108539652(CXCR4)
CJC: 100406954(CXCR4)
SBQ: 101042221(CXCR4)
MMU: 12767(Cxcr4)
MCAL: 110299256(Cxcr4)
MPAH: 110321797(Cxcr4)
RNO: 60628(Cxcr4)
MUN: 110555409(Cxcr4)
CGE: 100767733(Cxcr4)
NGI: 103734615(Cxcr4)
HGL: 101699254(Cxcr4)
CCAN: 109695609(Cxcr4)
OCU: 100346189(CXCR4)
TUP: 102472005(CXCR4)
CFA: 483900(CXCR4)
VVP: 112932607(CXCR4)
AML: 100468194(CXCR4)
UMR: 103667676(CXCR4)
UAH: 113263416(CXCR4)
ORO: 101372091(CXCR4)
ELK: 111145588
FCA: 493676(CXCR4)
PTG: 102955333(CXCR4)
PPAD: 109270372(CXCR4)
AJU: 106969444(CXCR4)
BTA: 281736(CXCR4)
BOM: 102280853(CXCR4)
BIU: 109568167(CXCR4)
BBUB: 102394323(CXCR4)
CHX: 102169916(CXCR4)
OAS: 443532(CXCR4)
SSC: 396659(CXCR4)
CFR: 102513077(CXCR4)
CDK: 105092280(CXCR4)
BACU: 103004476(CXCR4)
LVE: 103073013(CXCR4)
OOR: 101270504(CXCR4)
DLE: 111172717(CXCR4)
PCAD: 102989559(CXCR4)
ECB: 100050974(CXCR4)
EPZ: 103548930(CXCR4)
EAI: 106836546(CXCR4)
MYB: 102263583(CXCR4)
MYD: 102753258(CXCR4)
MNA: 107531145(CXCR4)
HAI: 109392711(CXCR4)
DRO: 112313099(CXCR4)
PALE: 102888277(CXCR4)
RAY: 107511206(CXCR4)
MJV: 108401250(CXCR4)
LAV: 100660744(CXCR4)
TMU: 101349103
MDO: 100016627(CXCR4)
SHR: 100934336(CXCR4)
PCW: 110223779(CXCR4)
OAA: 100079713(CXCR4)
GGA: 395324(CXCR4)
MGP: 100541154(CXCR4)
CJO: 107316951(CXCR4)
NMEL: 110400376(CXCR4)
APLA: 101800439(CXCR4)
ACYG: 106039298(CXCR4)
TGU: 100229955(CXCR4)
LSR: 110480593(CXCR4)
SCAN: 103814274(CXCR4)
GFR: 102040756(CXCR4)
FAB: 101817227(CXCR4)
PHI: 102099500(CXCR4)
PMAJ: 107207830(CXCR4)
CCAE: 111931764(CXCR4)
CCW: 104694218(CXCR4)
ETL: 114057696(CXCR4)
FPG: 101917697(CXCR4)
FCH: 102055350(CXCR4)
CLV: 102086794(CXCR4)
EGZ: 104129523(CXCR4)
NNI: 104009787(CXCR4)
ACUN: 113482188(CXCR4)
PADL: 103912661(CXCR4)
AAM: 106498424(CXCR4)
ASN: 102370606(CXCR4)
AMJ: 102568735(CXCR4)
PSS: 102450615(CXCR4)
CMY: 102947229(CXCR4)
CPIC: 101934476(CXCR4)
ACS: 100567304(cxcr4)
PVT: 110071869(CXCR4)
PBI: 103066628(CXCR4)
PMUR: 107284398(CXCR4) 107301724
TSR: 106539054(CXCR4)
PMUA: 114604641(CXCR4)
GJA: 107115414(CXCR4)
XLA: 100192360(cxcr4.L) 380373(cxcr4.S)
XTR: 100038176(cxcr4)
NPR: 108791340(CXCR4)
DRE: 114447(cxcr4b) 140747(cxcr4a)
SRX: 107705531 107706106 107748581 107749897
SANH: 107660136 107663919 107676218 107688919
SGH: 107555414 107556439 107568342 107584845
CCAR: 109054513 109055968 109070166 109096562
IPU: 100335031(cxcr4) 108272900(cxcr4-b)
PHYP: 113526054(cxcr4) 113538220
AMEX: 103038682 103039830(cxcr4)
EEE: 113582600 113585300
TRU: 101066475(cxcr4)
TNG: GSTEN00015094G001 GSTEN00020759G001
LCO: 104926341 104938220
NCC: 104948641 104967493(cxcr4)
MZE: 101476920(cxcr4) 101476935
ONL: 100693032 100703262(cxcr4)
OLA: 100049444 101160103
XMA: 102217040(cxcr4) 102230886
XCO: 114146641 114148729(cxcr4)
PRET: 103460829(cxcr4) 103478845
CVG: 107086826 107101500(cxcr4)
NFU: 107384286 107390218(cxcr4)
KMR: 108238272 108238501(cxcr4b)
ALIM: 106522573 106525767(cxcr4)
AOCE: 111571313 111571831
CSEM: 103392313(cxcr4) 103396234
POV: 109631036(cxcr4) 109647982
LCF: 108883894 108886893
SDU: 111218724(cxcr4) 111228808
SLAL: 111666497 111668384 111668748(cxcr4)
HCQ: 109512797 109523409(cxcr4)
BPEC: 110156151(cxcr4) 110173492
MALB: 109972381(cxcr4) 109974077
SASA: 100306754(cxcr4) 106569491 106581841 106600212
OTW: 112225152(cxcr4) 112226689 112235425 112247434 112260778
SALP: 111974007 111974259 111979451 112079928
ELS: 105021320 105022415(cxcr4)
SFM: 108927921(cxcr4) 108928927
PKI: 111849246 111858385
LCM: 102361208(CXCR4)
CMK: 103180391(cxcr4)
RTP: 109918216(cxcr4)
 » show all
Reference
PMID:8234909
  Authors
Jazin EE, Yoo H, Blomqvist AG, Yee F, Weng G, Walker MW, Salon J, Larhammar D, Wahlestedt C
  Title
A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells.
  Journal
Regul Pept 47:247-58 (1993)
DOI:10.1016/0167-0115(93)90392-L
  Sequence
[hsa:7852]
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