KEGG   ORTHOLOGY: K04354Help
Entry
K04354                      KO                                     

Name
PPP2R2
Definition
serine/threonine-protein phosphatase 2A regulatory subunit B
Pathway
ko03015  mRNA surveillance pathway
ko04071  Sphingolipid signaling pathway
ko04111  Cell cycle - yeast
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04390  Hippo signaling pathway
ko04391  Hippo signaling pathway - fly
ko04530  Tight junction
ko04728  Dopaminergic synapse
ko05142  Chagas disease (American trypanosomiasis)
ko05160  Hepatitis C
ko05165  Human papillomavirus infection
Disease
H00063  Spinocerebellar ataxia (SCA)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   04391 Hippo signaling pathway - fly
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   04071 Sphingolipid signaling pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   04151 PI3K-Akt signaling pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   04152 AMPK signaling pathway
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
 09140 Cellular Processes
  09143 Cell growth and death
   04111 Cell cycle - yeast
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
  09156 Nervous system
   04728 Dopaminergic synapse
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
   05165 Human papillomavirus infection
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-2 (PP2A)
    Regulatory subunits
     K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Other centromeric chromatin formation proteins
    PP2A (protein phosphatase 2A)
     K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
BRITE hierarchy
Other DBs
GO: 0008601
Genes
HSA: 5520(PPP2R2A) 5521(PPP2R2B) 5522(PPP2R2C) 55844(PPP2R2D)
PTR: 461101(PPP2R2C) 462170(PPP2R2B) 464068(PPP2R2A) 466265(PPP2R2D)
PPS: 100968814(PPP2R2D) 100983884(PPP2R2C) 100990236(PPP2R2B) 100991998(PPP2R2A)
GGO: 101129571(PPP2R2A) 101132841(PPP2R2D) 101135043(PPP2R2B) 101140471(PPP2R2C)
PON: 100174027(PPP2R2B) 100436819(PPP2R2D) 100443527(PPP2R2A) 100462193(PPP2R2C)
NLE: 100583131(PPP2R2C) 100583311(PPP2R2A) 100584267(PPP2R2B) 100585667(PPP2R2D)
MCC: 699520(PPP2R2D) 706988(PPP2R2B) 711023(PPP2R2C) 711920(PPP2R2A)
MCF: 101926197(PPP2R2A) 101926525(PPP2R2C) 102125257(PPP2R2B) 102142696(PPP2R2D)
CSAB: 103215510(PPP2R2A) 103216725(PPP2R2D) 103244749(PPP2R2B) 103246406(PPP2R2C)
RRO: 104659744(PPP2R2D) 104667559(PPP2R2C) 104673955(PPP2R2A) 104678160(PPP2R2B)
RBB: 108516076 108529771(PPP2R2B) 108537733(PPP2R2A) 108538800(PPP2R2C) 108543389(PPP2R2D)
CJC: 100385385(PPP2R2D) 100386371(PPP2R2C) 100407485(PPP2R2A) 100407627(PPP2R2B)
SBQ: 101031700(PPP2R2C) 101038903(PPP2R2D) 101052911(PPP2R2B) 101054317(PPP2R2A)
MMU: 269643(Ppp2r2c) 52432(Ppp2r2d) 71978(Ppp2r2a) 72930(Ppp2r2b)
MCAL: 110284493(Ppp2r2b) 110294530(Ppp2r2c) 110298725(Ppp2r2d) 110309355(Ppp2r2a)
MPAH: 110318923(Ppp2r2d) 110325313(Ppp2r2a) 110330369(Ppp2r2c) 110332843(Ppp2r2b)
RNO: 117104(Ppp2r2a) 117256(Ppp2r2c) 246255(Ppp2r2d) 60660(Ppp2r2b)
MUN: 110544846(Ppp2r2c) 110549018(Ppp2r2d) 110559335(Ppp2r2a) 110564033
CGE: 100750924(Ppp2r2c) 100758873(Ppp2r2a) 100763205(Ppp2r2b) 100774343
NGI: 103724526(Ppp2r2b) 103725821(Ppp2r2d) 103732390(Ppp2r2a) 103750638(Ppp2r2c)
HGL: 101700573(Ppp2r2b) 101708645(Ppp2r2a) 101709789(Ppp2r2d) 101711517(Ppp2r2c)
CCAN: 109684624(Ppp2r2b) 109687460(Ppp2r2c) 109694061(Ppp2r2a) 109698633(Ppp2r2d)
OCU: 100009139(PPP2R2B) 100328616(PPP2R2A) 100328617(PPP2R2C) 100348286
TUP: 102470174(PPP2R2C) 102480799(PPP2R2D) 102485560(PPP2R2B) 102488546(PPP2R2A)
CFA: 477374(PPP2R2A) 478053(PPP2R2B) 491587(PPP2R2D) 610262(PPP2R2C)
VVP: 112920859(PPP2R2C) 112926797(PPP2R2A) 112928797(PPP2R2D) 112934990(PPP2R2B)
AML: 100469264(PPP2R2C) 100478681(PPP2R2B) 100480910(PPP2R2A) 100481821(PPP2R2D)
UMR: 103658340(PPP2R2C) 103658377(PPP2R2D) 103663691(PPP2R2B) 103673291(PPP2R2A)
UAH: 113252071(PPP2R2D) 113255341(PPP2R2B) 113266692(PPP2R2C) 113269966(PPP2R2A)
ORO: 101368625(PPP2R2D) 101378544(PPP2R2C) 101382084(PPP2R2A) 101383262(PPP2R2B)
FCA: 101084083(PPP2R2B) 101086093(PPP2R2D) 101091784(PPP2R2C) 101099546(PPP2R2A)
PTG: 102949872(PPP2R2D) 102951261(PPP2R2B) 102952971(PPP2R2A) 102970289(PPP2R2C)
AJU: 106966536(PPP2R2A) 106982733(PPP2R2C) 106984955(PPP2R2B) 106985785(PPP2R2D)
BTA: 508045(PPP2R2A) 509290(PPP2R2B) 782110(PPP2R2C)
BOM: 102272209(PPP2R2C) 102287363(PPP2R2B) 102287455(PPP2R2A) 102287482(PPP2R2D)
BIU: 109560078(PPP2R2C) 109562172(PPP2R2B) 109563149(PPP2R2A) 109579044(PPP2R2D)
BBUB: 102390645(PPP2R2A) 102392164(PPP2R2C) 102393986(PPP2R2B)
PHD: 102323130(PPP2R2A) 102338279(PPP2R2B) 102338662(PPP2R2C)
CHX: 102170971(PPP2R2B) 102181952(PPP2R2A) 102188298(PPP2R2C)
OAS: 101102148(PPP2R2C) 101110299(PPP2R2A) 101113409(PPP2R2B)
SSC: 100737053(PPP2R2C) 397089(PPP2R2B) 397090(PPP2R2A)
CFR: 102509034(PPP2R2C) 102514622(PPP2R2A) 102517457(PPP2R2B)
CDK: 105085129(PPP2R2C) 105097761(PPP2R2B) 105102343(PPP2R2A)
BACU: 103001451(PPP2R2C) 103003377(PPP2R2B) 103015446(PPP2R2D) 103020854(PPP2R2A)
LVE: 103070944(PPP2R2C) 103075527(PPP2R2B) 103085298(PPP2R2A) 103090378(PPP2R2D)
OOR: 101274682 101279135(PPP2R2A) 101279750(PPP2R2B) 101281621(PPP2R2C) 101287295(PPP2R2D)
DLE: 111172180(PPP2R2D) 111179116(PPP2R2C) 111182926 111183056(PPP2R2B) 111185417(PPP2R2A)
PCAD: 102976080(PPP2R2D) 102982040(PPP2R2B) 102985759(PPP2R2C) 102993492(PPP2R2A)
ECB: 100051737(PPP2R2D) 100059955(PPP2R2A) 100060957(PPP2R2B) 100070133(PPP2R2C)
EPZ: 103546964(PPP2R2B) 103548628(PPP2R2D) 103559125(PPP2R2A) 103561815
EAI: 106834013(PPP2R2A) 106839823(PPP2R2B) 106841056(PPP2R2D) 106843317 106844478
MYB: 102238990(PPP2R2A) 102240425(PPP2R2B) 102243537(PPP2R2C) 102254637(PPP2R2D)
MYD: 102756870(PPP2R2A) 102772844(PPP2R2B) 102773953(PPP2R2D) 102774976(PPP2R2C)
MNA: 107524098(PPP2R2C) 107529477(PPP2R2B) 107529884(PPP2R2A) 107530370(PPP2R2D)
HAI: 109374120(PPP2R2C) 109383556(PPP2R2D) 109391741(PPP2R2A) 109392769
RSS: 109436369(PPP2R2A) 109440279 109440630 109445698(PPP2R2D) 109451141(PPP2R2B) 109456136(PPP2R2C)
DRO: 112300238(PPP2R2D) 112305238(PPP2R2A) 112316681(PPP2R2C) 112319536(PPP2R2B)
PALE: 102882824(PPP2R2A) 102888692(PPP2R2B) 102892945(PPP2R2C)
RAY: 107500870(PPP2R2B) 107515450(PPP2R2A) 107519027(PPP2R2C)
LAV: 100666413(PPP2R2B) 100666680(PPP2R2D) 100668825(PPP2R2A)
MDO: 100014202(PPP2R2C) 100018121(PPP2R2A) 100023749(PPP2R2B) 100023958
SHR: 100922930(PPP2R2C) 100931978(PPP2R2A) 100933266(PPP2R2B) 100935274(PPP2R2D)
PCW: 110192878(PPP2R2B) 110198683(PPP2R2D) 110212192(PPP2R2C) 110222633(PPP2R2A)
OAA: 100082907(PPP2R2D) 100089094(PPP2R2A) 100089164(PPP2R2B) 100682117(PPP2R2C)
GGA: 416350(PPP2R2B) 419523(PPP2R2A) 422858(PPP2R2C) 423970(PPP2R2D)
MGP: 100539113(PPP2R2A) 100547840(PPP2R2D) 100549668(PPP2R2C)
CJO: 107314026(PPP2R2C) 107316269(PPP2R2D) 107320040(PPP2R2B) 107323661(PPP2R2A)
NMEL: 110387073(PPP2R2A) 110397903(PPP2R2C) 110399499(PPP2R2D) 110405154(PPP2R2B)
APLA: 101797307(PPP2R2B) 101798527(PPP2R2D) 101801149(PPP2R2C)
ACYG: 106032725(PPP2R2B) 106035065(PPP2R2C) 106046261 106047324(PPP2R2D)
TGU: 100225233(PPP2R2B) 100225699(PPP2R2C) 100232829(PPP2R2A)
LSR: 110477362(PPP2R2B) 110479193(PPP2R2A) 110481460(PPP2R2D) 110481899(PPP2R2C)
SCAN: 103814089(PPP2R2D) 103817406(PPP2R2B) 103822705(PPP2R2A) 103824110(PPP2R2C)
GFR: 102032631(PPP2R2C) 102036955(PPP2R2D) 102037872(PPP2R2B) 102043663(PPP2R2A)
FAB: 101810844(PPP2R2B) 101812324(PPP2R2A) 101814165(PPP2R2D) 101819160(PPP2R2C)
PHI: 102105305(PPP2R2B) 102105717(PPP2R2C) 102107324(PPP2R2A) 102114376(PPP2R2D)
PMAJ: 107203269(PPP2R2C) 107206593(PPP2R2D) 107210845(PPP2R2B) 107213948(PPP2R2A)
CCAE: 111928208(PPP2R2C) 111931658(PPP2R2D) 111935427(PPP2R2B) 111938800(PPP2R2A)
CCW: 104689468(PPP2R2B) 104690747(PPP2R2C) 104694825(PPP2R2A) 104694957(PPP2R2D)
ETL: 114065675(PPP2R2C) 114066115(PPP2R2D) 114067114(PPP2R2B) 114070639(PPP2R2A)
FPG: 101921274(PPP2R2B) 101921738(PPP2R2D) 101921932(PPP2R2C) 101924330(PPP2R2A)
FCH: 102047212(PPP2R2C) 102050344(PPP2R2A) 102050692(PPP2R2B) 102053115(PPP2R2D)
CLV: 102090341 102091831(PPP2R2B) 102094079(PPP2R2A) 102098008(PPP2R2D)
EGZ: 104123264(PPP2R2C) 104123525(PPP2R2A) 104124969(PPP2R2D) 104133589(PPP2R2B)
NNI: 104012034(PPP2R2B) 104013866(PPP2R2D) 104018039(PPP2R2C) 104019519(PPP2R2A)
ACUN: 113479110(PPP2R2C) 113481728(PPP2R2D) 113485287(PPP2R2B) 113488072(PPP2R2A)
PADL: 103913101(PPP2R2A) 103918516(PPP2R2D) 103920951(PPP2R2C) 103923123(PPP2R2B)
AAM: 106487247(PPP2R2B) 106489262(PPP2R2D) 106494284(PPP2R2A) 106498740(PPP2R2C)
ASN: 102374906(PPP2R2B) 102380229 102380791(PPP2R2C) 102385445(PPP2R2A)
AMJ: 102559987(PPP2R2C) 102572311(PPP2R2A) 102574203(PPP2R2D) 102574435(PPP2R2B)
PSS: 102449014(PPP2R2A) 102449572 102450062 102457546(PPP2R2B) 102461089(PPP2R2C)
CMY: 102930979(PPP2R2D) 102931164(PPP2R2C) 102931325(PPP2R2A) 102938384(PPP2R2B)
CPIC: 101935306(PPP2R2D) 101939506(PPP2R2B) 101951345(PPP2R2C) 101953574(PPP2R2A)
ACS: 100555366(ppp2r2a) 100558872(ppp2r2c) 100563742(ppp2r2b) 100567969(ppp2r2d)
PVT: 110075153(PPP2R2D) 110085954(PPP2R2B) 110088732(PPP2R2C) 110090513(PPP2R2A)
PMUR: 107284338(PPP2R2D) 107291985(PPP2R2B) 107295004(PPP2R2A) 107299171 107301738
GJA: 107108836(PPP2R2D) 107112470(PPP2R2B) 107118342 107121378(PPP2R2C) 107126265(PPP2R2A)
XLA: 108696111 108698023 108706535 108711598 108713256 379305(ppp2r2d.S) 394301(ppp2r2b.L) 399328(ppp2r2a.S)
XTR: 100490097(ppp2r2c) 101732844 448324(ppp2r2d) 496486(ppp2r2a) 549212(ppp2r2b)
NPR: 108784777(PPP2R2D) 108787438 108791048(PPP2R2C) 108795054(PPP2R2A)
DRE: 100002802(ppp2r2ca) 327263(ppp2r2ab) 405816(ppp2r2d) 558752(ppp2r2aa) 558810(ppp2r2bb) 559392(ppp2r2cb)
LCM: 102350099(PPP2R2B) 102355760(PPP2R2C) 102362122(PPP2R2A) 102364042(PPP2R2D)
CMK: 103177292(ppp2r2b) 103180386(ppp2r2d) 103181323(ppp2r2c) 103191459
CIN: 100184014
SPU: 100888421
APLC: 110983067
DME: Dmel_CG6235(tws)
DER: 6551948
DSI: Dsimw501_GD20732(Dsim_GD20732)
DPE: 6588372
DWI: 6646942
DAZ: 108618813
DNV: 108659053
DHE: 111603570
MDE: 101891046
LCQ: 111690390
AAG: 5579206
AME: 410604
BIM: 100746935
BTER: 100645140
SOC: 105206803
MPHA: 105839212
AEC: 105148240
ACEP: 105624552
PBAR: 105431656
VEM: 105560381
HST: 105180873
DQU: 106752197
CFO: 105247975
LHU: 105674470
PGC: 109854645
OBO: 105275712
PCF: 106784790
NVI: 100124058
MDL: 103571851
TCA: 659477
DPA: 109545416
NVL: 108557542
BMOR: 101740520
PMAC: 106715720
PRAP: 111002909
HAW: 110373602
TNL: 113495361
API: 100169090
DNX: 107164255
AGS: 114120168
BTAB: 109036390
CLEC: 106668592
ZNE: 110835315
FCD: 110858036
TUT: 107367230
CEL: CELE_F26E4.1(sur-6)
CBR: CBG03807(Cbr-sur-6)
BMY: Bm1_23460
PCAN: 112563524
CRG: 105320707
MYI: 110462138
OBI: 106874159
LAK: 106153701
ADF: 107342034
PDAM: 113677053
SPIS: 111326265
HMG: 100207863
AQU: 100633074
ATH: AT1G17720(ATB_BETA) AT1G51690(B_ALPHA)
LJA: Lj0g3v0101969.1(Lj0g3v0101969.1) Lj0g3v0101969.2(Lj0g3v0101969.2) Lj3g3v0300670.1(Lj3g3v0300670.1) Lj3g3v0301720.1(Lj3g3v0301720.1) Lj3g3v0301720.2(Lj3g3v0301720.2) Lj3g3v3464480.1(Lj3g3v3464480.1)
DOSA: Os01t0600200-01(Os01g0600200) Os02t0224200-01(Os02g0224200) Os02t0617600-01(Os02g0617600) Os06t0563300-01(Os06g0563300)
ATS: 109746157(LOC109746157) 109753112(LOC109753112) 109772007(LOC109772007)
CRE: CHLREDRAFT_185509(PP2A1)
APRO: F751_3548
SCE: YGL190C(CDC55)
ERC: Ecym_6211
KMX: KLMA_20300(CDC55)
NCS: NCAS_0B04470(NCAS0B04470) NCAS_0B05510(NCAS0B05510)
NDI: NDAI_0B01910(NDAI0B01910) NDAI_0B02680(NDAI0B02680)
TPF: TPHA_0H00350(TPHA0H00350)
TBL: TBLA_0D02160(TBLA0D02160)
TDL: TDEL_0B04610(TDEL0B04610)
KAF: KAFR_0C02950(KAFR0C02950)
PIC: PICST_65430(CDC55)
CAL: CAALFM_C201600CA(CDC55)
SLB: AWJ20_5105(CDC55)
NCR: NCU09377(rgb-1)
NTE: NEUTE1DRAFT142725(NEUTE1DRAFT_142725)
MGR: MGG_05637
SSCK: SPSK_01388
MAW: MAC_09072
MAJ: MAA_00251
CMT: CCM_06685
MBE: MBM_04348
ANI: AN1545.2
ANG: ANI_1_942144(An16g07130)
ABE: ARB_05856
TVE: TRV_06865
PTE: PTT_03504
ZTR: MYCGRDRAFT_67389(MgPP2Aregb1)
SPO: SPAC227.07c(pab1)
CNE: CNF03200
CNB: CNBF1600
ABP: AGABI1DRAFT83170(AGABI1DRAFT_83170)
ABV: AGABI2DRAFT136742(AGABI2DRAFT_136742)
MGL: MGL_1016
DFA: DFA_05083 DFA_09955(phr2AB)
EHI: EHI_148170(1.t00140)
SPAR: SPRG_07315
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1849734
  Authors
Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA
  Title
Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.
  Journal
Biochemistry 30:3589-97 (1991)
DOI:10.1021/bi00229a001
  Sequence
[hsa:5520 5521]
Reference
  Authors
Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S
  Title
Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16.
  Journal
Genomics 67:83-6 (2000)
DOI:10.1006/geno.2000.6219
  Sequence
[hsa:5522]
Reference
  Authors
Chen HF, Lin LN, Chen YX, Wan JX, Luo J, Zhang CZ, Li XJ, Hu YM, Mai JR, Chen W, Lin ZN, Lin YC
  Title
Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bdelta gene.
  Journal
PLoS One 7:e35524 (2012)
DOI:10.1371/journal.pone.0035524
  Sequence
[hsa:55844]
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