KEGG ORTHOLOGY: K04364

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04013 MAPK signaling pathway - fly
    K04364  GRB2; growth factor receptor-bound protein 2
   04012 ErbB signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04014 Ras signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04630 JAK-STAT signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04068 FoxO signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04072 Phospholipase D signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04151 PI3K-Akt signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04150 mTOR signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04364  GRB2; growth factor receptor-bound protein 2
   04540 Gap junction
    K04364  GRB2; growth factor receptor-bound protein 2
   04550 Signaling pathways regulating pluripotency of stem cells
    K04364  GRB2; growth factor receptor-bound protein 2
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04364  GRB2; growth factor receptor-bound protein 2
   04660 T cell receptor signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04662 B cell receptor signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04664 Fc epsilon RI signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04062 Chemokine signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04912 GnRH signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04915 Estrogen signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04917 Prolactin signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04926 Relaxin signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04935 Growth hormone synthesis, secretion and action
    K04364  GRB2; growth factor receptor-bound protein 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04364  GRB2; growth factor receptor-bound protein 2
   04380 Osteoclast differentiation
    K04364  GRB2; growth factor receptor-bound protein 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K04364  GRB2; growth factor receptor-bound protein 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05206 MicroRNAs in cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05205 Proteoglycans in cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05203 Viral carcinogenesis
    K04364  GRB2; growth factor receptor-bound protein 2
   05231 Choline metabolism in cancer
    K04364  GRB2; growth factor receptor-bound protein 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05225 Hepatocellular carcinoma
    K04364  GRB2; growth factor receptor-bound protein 2
   05226 Gastric cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05214 Glioma
    K04364  GRB2; growth factor receptor-bound protein 2
   05221 Acute myeloid leukemia
    K04364  GRB2; growth factor receptor-bound protein 2
   05220 Chronic myeloid leukemia
    K04364  GRB2; growth factor receptor-bound protein 2
   05211 Renal cell carcinoma
    K04364  GRB2; growth factor receptor-bound protein 2
   05215 Prostate cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05213 Endometrial cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05224 Breast cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05223 Non-small cell lung cancer
    K04364  GRB2; growth factor receptor-bound protein 2
  09165 Substance dependence
   05034 Alcoholism
    K04364  GRB2; growth factor receptor-bound protein 2
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04364  GRB2; growth factor receptor-bound protein 2
   05160 Hepatitis C
    K04364  GRB2; growth factor receptor-bound protein 2
   05163 Human cytomegalovirus infection
    K04364  GRB2; growth factor receptor-bound protein 2
   05165 Human papillomavirus infection
    K04364  GRB2; growth factor receptor-bound protein 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04364  GRB2; growth factor receptor-bound protein 2
   01522 Endocrine resistance
    K04364  GRB2; growth factor receptor-bound protein 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04364  GRB2; growth factor receptor-bound protein 2
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K04364  GRB2; growth factor receptor-bound protein 2
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    K04364  GRB2; growth factor receptor-bound protein 2
Domain-containing proteins not elsewhere classified [BR:ko04990]
Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   K04364  GRB2; growth factor receptor-bound protein 2

Other DBs

GO:	0005070 0005154

Genes

HSA:	2885(GRB2)

PTR:	737245(GRB2)

PPS:	100993451(GRB2)

GGO:	101133976(GRB2)

PON:	100173972(GRB2)

NLE:	100588468(GRB2)

MCC:	702041(GRB2)

MCF:	102118276(GRB2)

CSAB:

103243048(GRB2)

RRO:	104681311(GRB2)

RBB:	108537414(GRB2)

CJC:	100395682(GRB2)

SBQ:	101038666(GRB2)

MMU:	14784(Grb2)

MCAL:

110304772(Grb2)

MPAH:

110331195(Grb2)

RNO:	81504(Grb2)

MUN:	110547825(Grb2)

CGE:	100769627(Grb2)

NGI:	103732729(Grb2)

HGL:	101717035(Grb2)

CCAN:

109681589(Grb2)

OCU:	100342500(GRB2)

TUP:	102493080(GRB2)

CFA:	483312(GRB2)

VVP:	112920790(GRB2)

AML:	100468916(GRB2)

UMR:	103665736(GRB2)

UAH:	113244637(GRB2)

ORO:	101362094(GRB2)

ELK:

111160411

FCA:	101099916(GRB2)

PTG:	102970459(GRB2)

PPAD:

109276940(GRB2)

AJU:	106987795(GRB2)

BTA:	535298(GRB2)

BOM:	102286241(GRB2)

BIU:	109574040(GRB2)

BBUB:

102394713(GRB2)

CHX:	102170356(GRB2)

OAS:	101109893(GRB2) 114110058

SSC:	100192436(GRB2)

CFR:	102515306(GRB2)

CDK:	105104642(GRB2)

BACU:

103010512(GRB2)

LVE:	103079766(GRB2)

OOR:	101271441(GRB2)

DLE:	111182833(GRB2)

PCAD:

114483947(GRB2)

ECB:	100051866(GRB2)

EPZ:	103546580(GRB2)

EAI:	106830292(GRB2)

MYB:	102241832(GRB2)

MYD:	102754991(GRB2)

MNA:	107536618(GRB2)

HAI:	109383688(GRB2)

DRO:	112298645(GRB2)

PALE:

102878822(GRB2)

RAY:	107503781(GRB2)

MJV:	108388820 108400653(GRB2) 108409005

LAV:	100655474(GRB2)

TMU:

101359012

MDO:	100022894(GRB2)

SHR:	100928380(GRB2)

PCW:	110219266(GRB2)

OAA:	100075806(GRB2)

GGA:	386572(GRB2)

MGP:	100541322(GRB2)

CJO:	107322339(GRB2)

NMEL:

110407421(GRB2)

APLA:

101797458(GRB2)

ACYG:

106034739(GRB2)

TGU:	100190285(GRB2)

LSR:	110484064(GRB2)

SCAN:

103819847(GRB2)

GFR:	102038068(GRB2)

FAB:	101812321(GRB2)

PHI:	102101539(GRB2)

PMAJ:

107212507(GRB2)

CCAE:

111937316(GRB2)

CCW:	104694312(GRB2)

ETL:	114063378(GRB2)

FPG:	101913969(GRB2)

FCH:	102057209(GRB2)

CLV:	102098952(GRB2)

EGZ:	104125396(GRB2)

NNI:	104020665(GRB2)

ACUN:

113486738(GRB2)

PADL:

103916707(GRB2)

AAM:	106485676(GRB2)

ASN:	102376596(GRB2)

AMJ:	102564907(GRB2)

PSS:	102463609(GRB2)

CMY:	102945306(GRB2)

CPIC:

101937357(GRB2)

ACS:	100564375(grb2)

PVT:	110085805(GRB2)

PBI:	103062398(GRB2)

PMUR:

107292723(GRB2)

TSR:	106553913(GRB2)

PMUA:

114590607

GJA:	107110018(GRB2)

XLA:	399458(grb2.L) 444095(grb2.S)

XTR:	493492(grb2)

NPR:	108791159(GRB2)

DRE:	406308(grb2b) 493609(grb2a)

SRX:	107719324 107723603 107728184 107733915

SANH:

107659857 107672145 107672691 107704009

SGH:	107561023 107573530 107583254 107602286

CCAR:

109049415 109049422 109088127 109094968 109096902 109106994

IPU:	100528114(grb2) 108256494

PHYP:

113524560 113528201(grb2)

AMEX:

103046713 111188768 111191028

EEE:	113575233 113584789

TRU:	101061204 101070656(grb2)

TNG:	GSTEN00006471G001

LCO:	104929435(grb2)

MZE:	101467818(grb2) 101477192

ONL:	100707796 100711914(grb2)

OLA:	101160816(grb2)

XMA:	102231736(grb2)

XCO:	114160045(grb2)

PRET:

103468398(grb2)

CVG:	107093104(grb2)

NFU:	107376249(grb2)

KMR:	108236256(grb2b)

ALIM:

106523871

AOCE:

111567912(grb2)

CSEM:

103393705(grb2)

POV:	109641399(grb2)

LCF:	108898666(grb2)

SDU:	111238087(grb2)

SLAL:

111673746(grb2)

HCQ:	109508473(grb2)

BPEC:

110155075(grb2)

MALB:

109973503(grb2)

SASA:

100306767(grb2) 106564671 106587111 106607067

OTW:	112230281 112234492 112234604 112264096

SALP:

111980424 111980548 112067730 112067754

ELS:	105012273 105013161

SFM:	108937443(grb2) 108939904

PKI:	111833563 111834215(grb2)

LCM:	102353904(GRB2)

CMK:	103175438(grb2)

RTP:	109933522(grb2)

BFO:

118428890

CIN:	100177206 100182493 100183719

SPU:	580900 583430 756009

APLC:

110973669 110973690 110988110

SKO:	100370255 100371410

DME:	Dmel_CG6033(drk)

DER:

6549549

DSI:	Dsimw501_GD25755(Dsim_drk)

DYA:	Dyak_GE13357

DSR:

110184783

DPO:	Dpse_GA19310

DPE:

6592753

DMN:	108160505 117191151

DWI:

6637889

DGR:	Dgri_GH22624

DMO:	Dmoj_GI21333

DAZ:

DNV:

DHE:

MDE:

LCQ:

AGA:	AgaP_AGAP011768

AAG:

5564363

AALB:

109408765 109432682

CQU:	CpipJ_CPIJ000806

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

100862763(DRK)

BMAN:

114253365

DPL:	KGM_205344

PMAC:

PRAP:

HAW:

TNL:

PXY:

API:

DNX:

AGS:	114130652 114130740

RMD:

113551873

BTAB:

109031773

CLEC:

106663478

PHU:	Phum_PHUM423150

ZNE:

110836794

FCD:

110852988

PVM:

113817579

ISC:	IscW_ISCW016244

TUT:

DPTE:

CSCU:

PTEP:

CEL:	CELE_C14F5.5(sem-5)

CBR:	CBG16856(Cbr-sem-5) CBG23363

BMY:

Bm1_39900

LOA:	LOAG_05951

NAI:	NECAME_09671

TSP:

Tsp_07994

HRO:	HELRODRAFT_73566

LGI:	LOTGIDRAFT_196407

PCAN:

112558784 112564189

CRG:

105329475

MYI:	110454140 110454146 110454153

OBI:	106878698 106879692

LAK:	106164896 106164897 106167277 106172168

SMM:	Smp_062950

SHX:

MS3_05983

NVE:	116616585 5500531 5509670

EPA:	110238105 110240084 110248663

ADF:	107329489 107332660 107332671

AMIL:

114956695 114956704

PDAM:

113680425 113680426

SPIS:

111321583 111321592

DGT:	114536200 114536201

HMG:

100199343

AQU:	100633328 105313222

SRE:	PTSG_04141

» show all

Reference

PMID:7689150

Authors

Suen KL, Bustelo XR, Pawson T, Barbacid M

Title

Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.

Journal

Mol Cell Biol 13:5500-12 (1993)
DOI:10.1128/MCB.13.9.5500

Sequence

[mmu:14784]

LinkDB

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