KEGG   ORTHOLOGY: K04374Help
Entry
K04374                      KO                                     

Name
ATF4, CREB2
Definition
cyclic AMP-dependent transcription factor ATF-4
Pathway
ko04010  MAPK signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04137  Mitophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04214  Apoptosis - fly
ko04261  Adrenergic signaling in cardiomyocytes
ko04668  TNF signaling pathway
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04918  Thyroid hormone synthesis
ko04922  Glucagon signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04668 TNF signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04022 cGMP-PKG signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04151 PI3K-Akt signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09143 Cell growth and death
   04210 Apoptosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04214 Apoptosis - fly
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04922 Glucagon signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04912 GnRH signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04915 Estrogen signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04926 Relaxin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04935 Growth hormone synthesis, secretion and action
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04918 Thyroid hormone synthesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04928 Parathyroid hormone synthesis, secretion and action
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04925 Aldosterone synthesis and secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04927 Cortisol synthesis and secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09156 Nervous system
   04725 Cholinergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04728 Dopaminergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04720 Long-term potentiation
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04722 Neurotrophin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09149 Aging
   04211 Longevity regulating pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04212 Longevity regulating pathway - worm
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09162 Cancer: specific types
   05215 Prostate cancer
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09165 Substance dependence
   05030 Cocaine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05031 Amphetamine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05034 Alcoholism
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04934 Cushing syndrome
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05161 Hepatitis B
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05163 Human cytomegalovirus infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
BRITE hierarchy
Other DBs
GO: 0035497
Genes
HSA: 468(ATF4)
PTR: 744513(ATF4)
PPS: 100988487(ATF4)
GGO: 101139584(ATF4)
PON: 100462459(ATF4)
NLE: 100588160(ATF4)
MCC: 703965(ATF4)
MCF: 102117938(ATF4)
CSAB: 103223345(ATF4)
RRO: 104682563(ATF4)
RBB: 108520463(ATF4)
CJC: 100392193(ATF4)
SBQ: 101034435(ATF4)
MMU: 11911(Atf4)
MCAL: 110310868(Atf4)
MPAH: 110334651(Atf4)
RNO: 79255(Atf4)
CGE: 100689386(Atf4)
NGI: 103748563(Atf4)
HGL: 101724287(Atf4)
CCAN: 109693025(Atf4)
OCU: 100339383(ATF4)
TUP: 102478154(ATF4)
CFA: 474503(ATF4)
VVP: 112934037(ATF4)
AML: 100476284(ATF4)
UMR: 103676372(ATF4)
UAH: 113241758(ATF4)
ORO: 101368122(ATF4)
ELK: 111157635
FCA: 101084297(ATF4)
PTG: 102950077(ATF4)
PPAD: 109265586(ATF4)
AJU: 106979942(ATF4)
BTA: 509107(ATF4)
BOM: 102267423(ATF4)
BIU: 109559832(ATF4)
BBUB: 102393344(ATF4)
CHX: 102185072(ATF4)
OAS: 100216465(ATF4)
SSC: 100144302(ATF4)
CFR: 102508076(ATF4)
CDK: 105091928(ATF4)
BACU: 103017770(ATF4)
LVE: 103083306(ATF4)
OOR: 101283438(ATF4)
DLE: 111186212(ATF4)
PCAD: 102984157(ATF4)
ECB: 100070334(ATF4)
EPZ: 103565289(ATF4)
EAI: 106842437(ATF4)
MYB: 102238786(ATF4)
MYD: 102763654(ATF4)
MNA: 107531265(ATF4)
HAI: 109392248(ATF4)
DRO: 112321682(ATF4)
PALE: 102896553(ATF4)
RAY: 107500816(ATF4)
MJV: 108397369(ATF4)
LAV: 100662521(ATF4)
TMU: 101345357
MDO: 100012224(ATF4)
SHR: 100913697(ATF4)
PCW: 110205802(ATF4)
OAA: 100089902(ATF4)
GGA: 395693(ATF4)
MGP: 100550984(ATF4)
CJO: 107312723(ATF4)
NMEL: 110392532(ATF4)
APLA: 101800475(ATF4)
ACYG: 106035925(ATF4)
TGU: 100190733(ATF4)
LSR: 110483790(ATF4)
SCAN: 103813275(ATF4)
GFR: 102036875(ATF4)
FAB: 101814204(ATF4)
PHI: 102100681(ATF4)
PMAJ: 107204914(ATF4)
CCAE: 111934860(ATF4)
CCW: 104696333(ATF4)
ETL: 114055356(ATF4)
FPG: 101921834(ATF4)
FCH: 102049324(ATF4)
CLV: 102093872(ATF4)
EGZ: 104134330(ATF4)
NNI: 104021625(ATF4)
ACUN: 113491317(ATF4)
PADL: 103915003(ATF4)
AAM: 106488703(ATF4)
ASN: 102369745(ATF4)
AMJ: 102564186(ATF4)
PSS: 102449551(ATF4)
CMY: 102941988(ATF4)
CPIC: 101952513(ATF4)
ACS: 100565177(atf4)
PVT: 110088080(ATF4)
PBI: 103055721(ATF4)
PMUR: 107288132(ATF4)
TSR: 106550401(ATF4)
PMUA: 114605162(ATF4)
GJA: 107117129(ATF4)
XLA: 398804(atf4.L) 733336(atf4-iii) 734165(atf4.S)
XTR: 448005(atf4)
DRE: 406514(atf4a) 556410(atf4b)
IPU: 108273192(atf4)
PHYP: 113538304(atf4)
AMEX: 103027942(atf4)
EEE: 113579485(atf4)
TRU: 101070714(atf4) 101075957
NCC: 104958969 104967853(atf4)
MZE: 101464981(atf4) 101475680
ONL: 100706109 100711796(atf4)
OLA: 101168714(atf4-2) 101172388(atf4)
CVG: 107087200(atf4) 107090074
ALIM: 106522498(atf4) 106534845
HCQ: 109511289(atf4) 109520247
ELS: 105008440(atf4) 105029665
SFM: 108928813 108930667(atf4)
LCM: 102365086(ATF4)
RTP: 109919490
CIN: 778545(atf4/5)
SPU: 586579
APLC: 110980911
SKO: 100376413
DME: Dmel_CG8669(crc)
DER: 6548901
DSI: Dsimw501_GD24316(Dsim_GD24316)
DPE: 6596600
DMN: 108163164
DWI: 6646727
DAZ: 108610991
DNV: 108658875
DHE: 111594286
MDE: 101900076
LCQ: 111689832
AAG: 5576642
AME: 410226
BIM: 100743669
BTER: 100651688
CCAL: 108622952
OBB: 114874933
SOC: 105196269
MPHA: 105837964
AEC: 105150924
ACEP: 105624047
PBAR: 105427649
VEM: 105557230
HST: 105183921
DQU: 106740699
CFO: 105254686
LHU: 105676463
PGC: 109855311
OBO: 105286490
PCF: 106789497
NVI: 100122826
CSOL: 105362052
MDL: 103572891
TCA: 658480(ATF4)
DPA: 109541967
NVL: 108565295
BMOR: 692594(Atf)
BMAN: 114249574
PMAC: 106711673
PRAP: 111003028
HAW: 110370227
TNL: 113496582
API: 100161513
DNX: 107161833
AGS: 114122290
RMD: 113551242
BTAB: 109033366
CLEC: 106663140
ZNE: 110834497
FCD: 110848208
PVM: 113817207
DPTE: 113793924
CSCU: 111613017
PTEP: 107437627
CEL: CELE_T04C10.4(atf-5)
CBR: CBG07594(Cbr-atf-5)
BMY: Bm1_39495
PCAN: 112557459
CRG: 105336468
MYI: 110465611
OBI: 106880212
EPA: 110239948
AMIL: 114953195
PDAM: 113670326
SPIS: 111330254
DGT: 114529187
HMG: 100197237
AQU: 100634724
DOSA: Os01t0211800-01(Os01g0211800)
MUS: 103997104
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ameri K, Harris AL
  Title
Activating transcription factor 4.
  Journal
Int J Biochem Cell Biol 40:14-21 (2008)
DOI:10.1016/j.biocel.2007.01.020
Reference
PMID:1534408
  Authors
Karpinski BA, Morle GD, Huggenvik J, Uhler MD, Leiden JM
  Title
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
  Journal
Proc Natl Acad Sci U S A 89:4820-4 (1992)
DOI:10.1073/pnas.89.11.4820
  Sequence
[hsa:468]
Reference
  Authors
Sayer JA, Otto EA, O'Toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, Hildebrandt F
  Title
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.
  Journal
Nat Genet 38:674-81 (2006)
DOI:10.1038/ng1786
  Sequence
[hsa:468]
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