KEGG ORTHOLOGY: K04409

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04010 MAPK signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04011 MAPK signaling pathway - yeast
    K04409  PAK1; p21-activated kinase 1
   04012 ErbB signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04392 Hippo signaling pathway - multiple species
    K04409  PAK1; p21-activated kinase 1
   04024 cAMP signaling pathway
    K04409  PAK1; p21-activated kinase 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04409  PAK1; p21-activated kinase 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04409  PAK1; p21-activated kinase 1
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04650 Natural killer cell mediated cytotoxicity
    K04409  PAK1; p21-activated kinase 1
   04660 T cell receptor signaling pathway
    K04409  PAK1; p21-activated kinase 1
   04666 Fc gamma R-mediated phagocytosis
    K04409  PAK1; p21-activated kinase 1
   04062 Chemokine signaling pathway
    K04409  PAK1; p21-activated kinase 1
  09158 Development and regeneration
   04360 Axon guidance
    K04409  PAK1; p21-activated kinase 1
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K04409  PAK1; p21-activated kinase 1
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K04409  PAK1; p21-activated kinase 1
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04409  PAK1; p21-activated kinase 1
   05130 Pathogenic Escherichia coli infection
    K04409  PAK1; p21-activated kinase 1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04409  PAK1; p21-activated kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04409  PAK1; p21-activated kinase 1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04409  PAK1; p21-activated kinase 1
   03036 Chromosome and associated proteins
    K04409  PAK1; p21-activated kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04409  PAK1; p21-activated kinase 1
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE20 family
   K04409  PAK1; p21-activated kinase 1
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K04409  PAK1; p21-activated kinase 1
Endocytosis
  Macropinocytosis
   Kinases
    K04409  PAK1; p21-activated kinase 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     K04409  PAK1; p21-activated kinase 1

Other DBs

COG:

COG0515

Genes

HSA:	5058(PAK1)

PTR:	451439(PAK1)

PPS:	100973579(PAK1)

GGO:	101138276(PAK1)

PON:	100449316(PAK1)

NLE:	100588769(PAK1)

MCC:	698585(PAK1)

MCF:	101866132(PAK1)

CSAB:

103248093(PAK1)

RRO:	104664316(PAK1)

RBB:	108543210(PAK1)

CJC:	100392970(PAK1)

SBQ:	101042666(PAK1)

MMU:	18479(Pak1)

MCAL:

110298300(Pak1)

MPAH:

110319929(Pak1)

RNO:	29431(Pak1)

MUN:	110547315(Pak1)

CGE:	100767503(Pak1)

NGI:	103743005(Pak1)

HGL:	101713465(Pak1)

OCU:	100352056(PAK1)

TUP:	102495430(PAK1)

CFA:	607885(PAK1)

VVP:	112928622(PAK1)

AML:	100472811(PAK1)

UMR:	103678069(PAK1)

UAH:	113269353(PAK1)

ORO:	101365642(PAK1)

ELK:

111154419

FCA:	101087171(PAK1)

PTG:	102963927(PAK1)

PPAD:

109267249(PAK1)

AJU:	106976449(PAK1)

BTA:	533729(PAK1)

BOM:	102285596(PAK1)

BIU:	109554525(PAK1)

BBUB:

102406385(PAK1)

CHX:	102180827(PAK1)

OAS:	101111756(PAK1)

SSC:	100525766(PAK1)

CFR:	102514942(PAK1)

CDK:	105097456(PAK1)

BACU:

103010714(PAK1)

LVE:	103072869(PAK1)

OOR:	101288086(PAK1)

DLE:	111184900(PAK1)

PCAD:

102992923(PAK1)

ECB:	100063217(PAK1)

EPZ:	103553799(PAK1)

EAI:	106842897(PAK1)

MYB:	102240321(PAK1) 102257226

MYD:	102755302(PAK1)

MNA:	107524443(PAK1)

HAI:	109376015(PAK1)

DRO:	112316047(PAK1)

PALE:

102880323(PAK1)

RAY:	107519160(PAK1)

MJV:	108384279 108387047(PAK1)

LAV:	100668003 104846721 111747670

TMU:

101343358

MDO:	100018336(PAK1)

SHR:	100928883(PAK1)

PCW:	110210535(PAK1)

OAA:	100086384(PAK1)

GGA:	419083(PAK1)

MGP:

100543242

CJO:	107308538(PAK1)

NMEL:

110391291(PAK1)

APLA:

101795474(PAK1)

ACYG:

106039890(PAK1)

TGU:	100190755(PAK1)

LSR:	110472338(PAK1)

SCAN:

103827218(PAK1)

GFR:	102033628(PAK1) 102033882

FAB:	101820258(PAK1)

PHI:	102109199(PAK1)

PMAJ:

107200206(PAK1) 107215873

CCAE:

111925537(PAK1)

CCW:	104690290(PAK1)

ETL:	114065462(PAK1) 114073078 114073667

FPG:	101923101(PAK1)

FCH:	102053816(PAK1)

CLV:	102084510(PAK1)

EGZ:	104124741(PAK1)

NNI:	104022736(PAK1)

ACUN:

113482214(PAK1)

PADL:

103915162(PAK1)

AAM:	106495371(PAK1)

ASN:	102367767(PAK1)

AMJ:	102576325(PAK1)

PSS:	102457223(PAK1)

CMY:	102936072(PAK1)

CPIC:

101936332(PAK1)

ACS:	100554656 100568195(pak1)

PVT:	110088575(PAK1)

PBI:	103058961 103063547

PMUR:

107300398

TSR:

106540032

PMUA:

114595565(PAK1)

GJA:	107118386(PAK1)

XLA:	398126(pak1.S) 398782

XTR:	100135731(pak1)

NPR:

108794638

DRE:	373103(pak1)

SRX:

107735921

SANH:

107659134 107660698

SGH:	107594372(pak1) 107600821

CCAR:

109110512

IPU:	108264802(pak1)

PHYP:

113526361(pak1)

AMEX:

103037975(pak1)

EEE:	113576959(pak1)

TRU:	101064146(pak1)

TNG:	GSTEN00005875G001 GSTEN00010634G001

NCC:

104949351

MZE:	101483196(pak1)

ONL:	100698864(pak1)

OLA:	101164663(pak1)

XMA:	102217297(pak1)

XCO:	114161941(pak1)

PRET:

103475087(pak1)

CVG:	107091640(pak1)

NFU:	107379762(pak1)

KMR:	108248931(pak1)

ALIM:

106522761(pak1)

AOCE:

111580545 111586271(pak1)

CSEM:

103377945(pak1)

POV:	109641154 109645335

LCF:	108882370(pak1)

SDU:	111216915(pak1)

SLAL:

111652357

HCQ:

109510807

MALB:

109973760(pak1)

SASA:

100380347(pak3) 106612881

OTW:	112234003 112265443

SALP:

111949575 111956852

ELS:	105010576(pak1)

SFM:	108921266 108924646(pak1)

PKI:	111833901(pak1) 111842626

LCM:	102349047(PAK1)

CMK:

RTP:

CIN:

SPU:

APLC:

SKO:

DME:	Dmel_CG10295(Pak) Dmel_CG14895(Pak3)

DER:	6553248 6553358

DSE:	Dsec_GM10890 Dsec_GM15431

DSI:	Dsimw501_GD19869(Dsim_GD19869) Dsimw501_GD20287(Dsim_GD20287)

DYA:	Dyak_GE10214 Dyak_GE26311

DAN:	Dana_GF16514 Dana_GF18356

DSR:	110177282 110191766

DPO:	Dpse_GA10224(Dpse_Pak1) Dpse_GA13332(Dpse_Pak3)

DPE:	6591972 6592024

DMN:	108155098 108156699

DWI:	6647872 6651661

DGR:	Dgri_GH18242 Dgri_GH19531

DMO:	Dmoj_GI10198 Dmoj_GI23008

DAZ:	108608714 108621852

DNV:	108653057 108658221

DHE:	111599588 111604884

DVI:	Dvir_GJ23486 Dvir_GJ24601

MDE:	101887476 101887651 101887822 101887987 101892930 101893105 101895127

LCQ:	111675459 111676756 111689984

AGA:	AgaP_AGAP001790 AgaP_AGAP002986

AAG:

5575304

AALB:

109405050 109622061 115254232

CQU:	CpipJ_CPIJ006042

AME:	551659 724453

BIM:	100741982 100743939

BTER:

100652006 105666875

CCAL:

108622927 108631664

OBB:

114874534

SOC:	105194876 105199039

MPHA:

105831499 105835438

AEC:	105146641 105150080

ACEP:

105621341 105625131

PBAR:

105423102 105428836

VEM:	105561659 105570085

HST:	105181983 105183036

DQU:	106748500 106749922

CFO:	105249671 105254322

LHU:	105671756 105674253

PGC:	109853220 109856175

OBO:	105277671 105277796

PCF:	106791004 106791633

NVI:	100114941 100117689

CSOL:

105364933 105368151

MDL:	103571811 103579235

TCA:	655315 656127

DPA:	109537307 109539805

ATD:	109594393 109603064 109607646

NVL:	108558880 108564801

BMOR:

101743592 101743777

BMAN:

114241623 114248170

DPL:	KGM_203416 KGM_204301

PMAC:

106712289 106717693

PRAP:

110993337 110996433

HAW:	110371021 110376060

TNL:	113492740 113505822

PXY:	105386470 105389073

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM310720 Phum_PHUM373950

ZNE:	110833202 110837544

FCD:	110856164 110860431

DPX:	DAPPUDRAFT_301285

PVM:

113816549

ISC:	IscW_ISCW014013

TUT:	107363199 107364021 107364845 107370844

DPTE:

113790234 113798208

CSCU:

111620156

PTEP:

107437347

CEL:	CELE_C09B8.7(pak-1) CELE_Y38F1A.10(max-2)

CBR:	CBG02802(Cbr-max-2) CBG14818(Cbr-pak-1)

BMY:

Bm1_34325

LOA:	LOAG_17711 LOAG_18674

NAI:	NECAME_02934 NECAME_04858

HRO:	HELRODRAFT_63652 HELRODRAFT_65840 HELRODRAFT_78193 HELRODRAFT_85598 HELRODRAFT_89498

LGI:	LOTGIDRAFT_105396 LOTGIDRAFT_179393

CRG:

105339997

MYI:	110440858 110454131 110460376

OBI:

106875408

LAK:	106153444 106154033 106172042

SMM:	Smp_096670 Smp_175160 Smp_179800

SHX:	MS3_02844 MS3_04303 MS3_04306 MS3_06412

OVI:	T265_02122 T265_10160 T265_12534 T265_12535 T265_12536 T265_14129

EGL:	EGR_03475 EGR_04967 EGR_07442

NVE:	NEMVE_v1g216329

EPA:

110251135

ADF:

107330408

DGT:

114524397

TAD:	TRIADDRAFT_52215

AQU:

100631850

QSU:	111992897 112016810

CCP:	CHC_T00008471001 CHC_T00009341001

SCE:	YHL007C(STE20)

AGO:	AGOS_ABR014W

ERC:

Ecym_2434

KLA:	KLLA0_B13607g

KMX:	KLMA_30058(STE20)

LTH:	KLTH0D06006g

VPO:	Kpol_1055p24

ZRO:	ZYRO0B01166g

CGR:	CAGL0K02673g CAGL0M10153g

NCS:	NCAS_0A05050(NCAS0A05050) NCAS_0A12350(NCAS0A12350)

NDI:	NDAI_0A03870(NDAI0A03870) NDAI_0K02100(NDAI0K02100)

TPF:	TPHA_0G03290(TPHA0G03290)

TBL:	TBLA_0I00280(TBLA0I00280)

TDL:	TDEL_0A02720(TDEL0A02720)

KAF:	KAFR_0A01760(KAFR0A01760) KAFR_0D03390(KAFR0D03390)

PPA:	PAS_c131_0004

DHA:	DEHA2E22220g

PIC:	PICST_84188(CST20)

PGU:	PGUG_02822

SPAA:

SPAPADRAFT_61274

LEL:	LELG_03909

CAL:	CAALFM_C502340CA(CST20)

CTP:	CTRG_05444

COT:	CORT_0B02470

CDU:	CD36_52140(CST20)

CTEN:

CANTEDRAFT_123607

YLI:	YALI0F00572g

CLU:	CLUG_01679

CLUS:

A9F13_13g01243

CAUR:

CJI97_001003

SLB:	AWJ20_1432(STE20)

PKZ:	C5L36_0B04320

NCR:	NCU03894(stk-4)

NTE:	NEUTE1DRAFT88085(NEUTE1DRAFT_88085)

SMP:	SMAC_06321(putative ste20)

PAN:	PODANSg3167

TTT:	THITE_2109765

MTM:	MYCTH_2306416

CTHR:

CTHT_0044110

MGR:

MGG_12821

TMN:	UCRPA7_786

SSCK:

SPSK_04875

FGR:	FGSG_09492

FPU:	FPSE_10477

FVR:	FVEG_04043

FOX:	FOXG_06188

NHE:	NECHADRAFT_33582

TRE:	TRIREDRAFT_104364

TRR:	M419DRAFT_59380

MAW:

MAC_02685

MAJ:

MAA_02118

CMT:

CCM_05107

PLJ:	VFPFJ_03973

VAL:	VDBG_07955

VDA:	VDAG_05525

CFJ:	CFIO01_11451

ELA:	UCREL1_8798

PFY:	PFICI_09818

SSL:	SS1G_02450

BFU:	BCIN_13g03980

MBE:

MBM_08123

PSCO:

LY89DRAFT_207769

GLZ:	GLAREA_01410

ANI:

AN2067.2

AFM:	AFUA_2G04680

AOR:	AO090003000267

ANG:	ANI_1_592094(An11g04320)

AFV:	AFLA_035530

ACT:	ACLA_089970

NFI:	NFIA_081350

PDP:	PDIP_80070

CIM:	CIMG_01236

CPW:	CPC735_051580

PBL:	PAAG_09053

PBN:	PADG_08706

URE:	UREG_01166

ABE:

ARB_05261

TVE:

TRV_02300

AJE:	HCAG_07603 HCAG_07848 HCAG_09016

PNO:	SNOG_12486(SNOG_12485)

PTE:

PTT_13099

BZE:	COCCADRAFT_9683

BSC:	COCSADRAFT_325807

BOR:	COCMIDRAFT_99165

AALT:

CC77DRAFT_1034762

ZTR:	MYCGRDRAFT_85661(MgSte20)

PFJ:	MYCFIDRAFT_48302

BCOM:

BAUCODRAFT_571593

NPA:	UCRNP2_6118

TML:	GSTUM_00006969001

SPO:	SPBC1604.14c(shk1)

CNE:

CNF00140

CNB:

CNBF4570

CGI:	CGB_F6480W

TMS:	TREMEDRAFT_35601

TVS:	TRAVEDRAFT_167674

DSQ:	DICSQDRAFT_80980

PCO:	PHACADRAFT_264512

SHS:	STEHIDRAFT_172673

HIR:	HETIRDRAFT_64508

PSQ:	PUNSTDRAFT_43908

ADL:	AURDEDRAFT_63201

FME:	FOMMEDRAFT_100401

GTR:	GLOTRDRAFT_75230

LBC:	LACBIDRAFT_229673

MRR:	Moror_6988

CCI:	CC1G_00840

SCM:	SCHCODRAFT_108172

ABP:	AGABI1DRAFT118842(AGABI1DRAFT_118842)

ABV:	AGABI2DRAFT205902(AGABI2DRAFT_205902)

CPUT:

CONPUDRAFT_83597

SLA:	SERLADRAFT_473081

WSE:	WALSEDRAFT_13665(Ste20p)

WIC:	J056_003303 J056_004505

UMA:	UMAG_12272

PFP:	PFL1_06042

MGL:

MGL_0010

MRT:

MRET_1293

PGR:	PGTG_14316

MLR:	MELLADRAFT_124624

SRE:	PTSG_01477

DDI:	DDB_G0267450(pakC)

DPP:	DICPUDRAFT_95210 DICPUDRAFT_96263

DFA:	DFA_01526(pakD) DFA_04841(mkcC) DFA_05233(mkcA) DFA_08719(mkcD) DFA_11355

EIV:	EIN_025310 EIN_129230 EIN_371070

ACAN:

ACA1_011260 ACA1_065700 ACA1_089800 ACA1_095220 ACA1_145920 ACA1_302810 ACA1_383610

GTT:	GUITHDRAFT_81068 GUITHDRAFT_83971 GUITHDRAFT_88129

NGR:	NAEGRDRAFT_32381

TVA:	TVAG_116130

GLA:	GL50803_2796

» show all

Reference

PMID:8805275

Authors

Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J

Title

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.

Journal

Curr Biol 6:598-605 (1996)
DOI:10.1016/S0960-9822(02)00546-8

Sequence

[hsa:5058]

Reference

PMID:16246726

Authors

Zhao ZS, Lim JP, Ng YW, Lim L, Manser E

Title

The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

Journal

Mol Cell 20:237-49 (2005)
DOI:10.1016/j.molcel.2005.08.035

Reference

PMID:1464311

Authors

Leberer E, Dignard D, Harcus D, Thomas DY, Whiteway M

Title

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.

Journal

EMBO J 11:4815-24 (1992)

Sequence

[sce:YHL007C]

LinkDB

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