KEGG   ORTHOLOGY: K04433Help
Entry
K04433                      KO                                     

Name
MAP2K6, MKK6
Definition
mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
Pathway
ko04010  MAPK signaling pathway
ko04015  Rap1 signaling pathway
ko04212  Longevity regulating pathway - worm
ko04218  Cellular senescence
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko04912  GnRH signaling pathway
ko04935  Growth hormone synthesis, secretion and action
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05135  Yersinia infection
ko05145  Toxoplasmosis
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04010 MAPK signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04668 TNF signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04664 Fc epsilon RI signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04935 Growth hormone synthesis, secretion and action
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09149 Aging
   04212 Longevity regulating pathway - worm
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis (ALS)
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05161 Hepatitis B
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05163 Human cytomegalovirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05169 Epstein-Barr virus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
BRITE hierarchy
Other DBs
GO: 0004708
Genes
HSA: 5608(MAP2K6)
PTR: 468310(MAP2K6)
PPS: 100972424(MAP2K6)
GGO: 101142374(MAP2K6)
PON: 100448382(MAP2K6)
NLE: 100591256(MAP2K6)
MCC: 693914(MAP2K6)
MCF: 101925060(MAP2K6)
CSAB: 103243132(MAP2K6)
RRO: 104654038(MAP2K6)
RBB: 108523215(MAP2K6)
CJC: 100397389(MAP2K6)
SBQ: 101030219(MAP2K6)
MMU: 26399(Map2k6)
MCAL: 110304684(Map2k6)
MPAH: 110331335(Map2k6)
RNO: 114495(Map2k6)
CGE: 100771767(Map2k6)
NGI: 103742218(Map2k6)
HGL: 101703028(Map2k6)
CCAN: 109698990(Map2k6)
OCU: 100355230(MAP2K6)
TUP: 102482054(MAP2K6)
CFA: 480454(MAP2K6)
VVP: 112920749(MAP2K6)
AML: 100469111(MAP2K6)
UMR: 103665687(MAP2K6)
UAH: 113265227(MAP2K6)
ORO: 101382167(MAP2K6)
ELK: 111158041
FCA: 101089813(MAP2K6)
PTG: 102966485(MAP2K6)
PPAD: 109277026(MAP2K6)
AJU: 106988444(MAP2K6)
BTA: 286883(MAP2K6)
BOM: 102272962(MAP2K6)
BIU: 109573853(MAP2K6)
BBUB: 102403288(MAP2K6)
CHX: 102169516(MAP2K6)
OAS: 101115047(MAP2K6)
SSC: 100625946(MAP2K6)
CFR: 102519784(MAP2K6)
CDK: 105085694(MAP2K6)
BACU: 103012537(MAP2K6)
LVE: 103081641
OOR: 101280413(MAP2K6)
DLE: 111182897(MAP2K6)
PCAD: 102982175(MAP2K6)
ECB: 100053056(MAP2K6)
EPZ: 103564566(MAP2K6)
EAI: 106830236(MAP2K6)
MYB: 102246913(MAP2K6)
MYD: 102759247(MAP2K6)
MNA: 107528394(MAP2K6)
HAI: 109371344(MAP2K6)
DRO: 112316519(MAP2K6)
PALE: 102888822(MAP2K6)
RAY: 107510279(MAP2K6)
MJV: 108405137(MAP2K6)
LAV: 100662511(MAP2K6)
TMU: 101344286
MDO: 100029049(MAP2K6)
PCW: 110219359(MAP2K6)
OAA: 100078394(MAP2K6)
GGA: 417445(MAP2K6)
MGP: 100545287(MAP2K6)
CJO: 107322198(MAP2K6)
NMEL: 110407251(MAP2K6)
ACYG: 106034753(MAP2K6)
TGU: 100226231(MAP2K6)
LSR: 110473926(MAP2K6)
SCAN: 103819965(MAP2K6)
GFR: 102039445(MAP2K6)
FAB: 101819388(MAP2K6)
PHI: 102105268(MAP2K6)
PMAJ: 107212284(MAP2K6)
CCAE: 111937452(MAP2K6)
CCW: 104696025(MAP2K6)
ETL: 114060693(MAP2K6)
FPG: 101913671(MAP2K6)
FCH: 102053088(MAP2K6)
CLV: 102086996(MAP2K6)
EGZ: 104132828(MAP2K6)
NNI: 104014353(MAP2K6)
ACUN: 113486793(MAP2K6)
PADL: 103916640(MAP2K6)
AAM: 106490233(MAP2K6)
ASN: 102373782(MAP2K6)
AMJ: 106736984(MAP2K6)
PSS: 102461243(MAP2K6)
CMY: 102942953(MAP2K6)
CPIC: 101935028(MAP2K6)
ACS: 100567963(map2k6)
PVT: 110077815(MAP2K6)
PBI: 103058491
PMUR: 107282569(MAP2K6)
TSR: 106543486
PMUA: 114588447(MAP2K6)
GJA: 107122462(MAP2K6)
XLA: 379638(map2k6.L) 399150(map2k3)
XTR: 448132(map2k6)
DRE: 65239(map2k6)
SANH: 107684112
IPU: 108274084(map2k6)
PHYP: 113527237
AMEX: 111191499
EEE: 113585643
SFM: 108922496 108924851(map2k6)
PKI: 111848425(map2k6) 111859759
LCM: 102362389(MAP2K6)
CMK: 103175734(map2k6)
RTP: 109935499
CIN: 778902(mapkk3/6)
SPU: 585817
APLC: 110980301
SKO: 102800622
CEL: CELE_R03G5.2(sek-1)
CBR: CBG16802(Cbr-sek-1)
BMY: Bm1_39990
MYI: 110465116
SHX: MS3_07915
EPA: 110248902
AMIL: 114959468
PDAM: 113671527
SPIS: 111324764
DGT: 114529031
HMG: 100209591
AQU: 100633628
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8622669
  Authors
Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ
  Title
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
  Journal
Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247
  Sequence
[hsa:5608]
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