KEGG ORTHOLOGY: K04448

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04448  JUN; transcription factor AP-1
   04013 MAPK signaling pathway - fly
    K04448  JUN; transcription factor AP-1
   04012 ErbB signaling pathway
    K04448  JUN; transcription factor AP-1
   04310 Wnt signaling pathway
    K04448  JUN; transcription factor AP-1
   04668 TNF signaling pathway
    K04448  JUN; transcription factor AP-1
   04024 cAMP signaling pathway
    K04448  JUN; transcription factor AP-1
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04448  JUN; transcription factor AP-1
  09143 Cell growth and death
   04210 Apoptosis
    K04448  JUN; transcription factor AP-1
   04214 Apoptosis - fly
    K04448  JUN; transcription factor AP-1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04448  JUN; transcription factor AP-1
   04530 Tight junction
    K04448  JUN; transcription factor AP-1
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04624 Toll and Imd signaling pathway
    K04448  JUN; transcription factor AP-1
   04621 NOD-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04625 C-type lectin receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04660 T cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04658 Th1 and Th2 cell differentiation
    K04448  JUN; transcription factor AP-1
   04659 Th17 cell differentiation
    K04448  JUN; transcription factor AP-1
   04657 IL-17 signaling pathway
    K04448  JUN; transcription factor AP-1
   04662 B cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04448  JUN; transcription factor AP-1
   04915 Estrogen signaling pathway
    K04448  JUN; transcription factor AP-1
   04921 Oxytocin signaling pathway
    K04448  JUN; transcription factor AP-1
   04926 Relaxin signaling pathway
    K04448  JUN; transcription factor AP-1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04448  JUN; transcription factor AP-1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04448  JUN; transcription factor AP-1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04448  JUN; transcription factor AP-1
   05203 Viral carcinogenesis
    K04448  JUN; transcription factor AP-1
   05231 Choline metabolism in cancer
    K04448  JUN; transcription factor AP-1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04448  JUN; transcription factor AP-1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04448  JUN; transcription factor AP-1
   05211 Renal cell carcinoma
    K04448  JUN; transcription factor AP-1
   05224 Breast cancer
    K04448  JUN; transcription factor AP-1
  09163 Immune disease
   05323 Rheumatoid arthritis
    K04448  JUN; transcription factor AP-1
   05321 Inflammatory bowel disease
    K04448  JUN; transcription factor AP-1
  09165 Substance dependence
   05030 Cocaine addiction
    K04448  JUN; transcription factor AP-1
   05031 Amphetamine addiction
    K04448  JUN; transcription factor AP-1
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04448  JUN; transcription factor AP-1
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04448  JUN; transcription factor AP-1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04448  JUN; transcription factor AP-1
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04448  JUN; transcription factor AP-1
   05130 Pathogenic Escherichia coli infection
    K04448  JUN; transcription factor AP-1
   05132 Salmonella infection
    K04448  JUN; transcription factor AP-1
   05131 Shigellosis
    K04448  JUN; transcription factor AP-1
   05135 Yersinia infection
    K04448  JUN; transcription factor AP-1
   05133 Pertussis
    K04448  JUN; transcription factor AP-1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04448  JUN; transcription factor AP-1
   05170 Human immunodeficiency virus 1 infection
    K04448  JUN; transcription factor AP-1
   05161 Hepatitis B
    K04448  JUN; transcription factor AP-1
   05171 Coronavirus disease - COVID-19
    K04448  JUN; transcription factor AP-1
   05162 Measles
    K04448  JUN; transcription factor AP-1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04448  JUN; transcription factor AP-1
   05169 Epstein-Barr virus infection
    K04448  JUN; transcription factor AP-1
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K04448  JUN; transcription factor AP-1
   05142 Chagas disease
    K04448  JUN; transcription factor AP-1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04448  JUN; transcription factor AP-1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04448  JUN; transcription factor AP-1
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Jun
    K04448  JUN; transcription factor AP-1

Genes

HSA:

3725(JUN)

PTR:	456893(JUN)

PPS:	100980908(JUN)

GGO:	101145729(JUN)

PON:	100450292(JUN)

NLE:	100586501(JUN)

MCC:	716452(JUN)

MCF:	102126446(JUN)

CSAB:

103224726(JUN)

RRO:	104664278(JUN)

RBB:	108532921(JUN)

CJC:	100400411(JUN)

SBQ:	101043809(JUN)

MMU:	16476(Jun)

MCAL:

110292423(Jun)

MPAH:

110323252(Jun)

RNO:	24516(Jun)

MUN:	110559727 110559728

CGE:

113834001

NGI:	103737138(Jun)

HGL:	101722197(Jun)

CCAN:

109700777(Jun)

OCU:	100008856(JUN) 100338341(EIF5A)

TUP:	102496870(JUN)

CFA:	609429(JUN)

VVP:	112926091(JUN)

AML:	100483834(JUN)

UMR:	103670861(JUN)

UAH:	113254611(JUN)

ORO:	101368207(JUN)

ELK:

111143174

FCA:	101097261(JUN)

PTG:	102958666(JUN)

PPAD:

109266785(JUN)

AJU:	106974986(JUN)

BTA:	280831(JUN)

BOM:	102267895(JUN)

BIU:	109556235(JUN)

BBUB:

102405224(JUN)

CHX:	102185423(JUN)

OAS:	443219(JUN)

SSC:	396913(JUN)

CFR:	102516943(JUN)

CDK:	105092850(JUN)

BACU:

103001311 103014668

LVE:	103071861(JUN)

OOR:	101288913(JUN)

DLE:	111175871(JUN)

PCAD:

102975458(JUN)

ECB:	100067469(JUN)

EAI:	106833477(JUN)

MYB:	102260808(JUN)

MYD:	102752693(JUN) 107183844(JUNB)

MNA:	107536966(JUN)

HAI:	109371251(JUN) 109371257

DRO:	112314642(JUN)

PALE:

102896121(JUN)

RAY:	107518352(JUN)

MJV:	108386817(JUN)

LAV:	100670432(JUN)

TMU:

101361653

MDO:	100018774(JUN)

SHR:	116423739(JUN)

PCW:	110212948(JUN)

GGA:	424673(JUN)

MGP:	100548501(JUN)

CJO:	107317693(JUN)

NMEL:

110402812(JUN)

APLA:

101796626(JUN)

ACYG:

106032923(JUN)

TGU:	100229914(JUN)

LSR:	110476957(JUN)

SCAN:

103815057(JUN)

GFR:	102039078(JUN)

FAB:	101816255(JUN)

PHI:	102112236(JUN)

PMAJ:

107208073(JUN)

CCAE:

111932998(JUN)

CCW:	104695158(JUN)

ETL:	114055179(JUN)

FPG:	101918818(JUN)

FCH:	102050406(JUN)

CLV:	102092209(JUN)

EGZ:	104123944(JUN)

NNI:	104009262(JUN)

ACUN:

113482645(JUN)

PADL:

103913320(JUN)

AAM:	106494500(JUN)

ASN:	102374896(JUN)

AMJ:	102566064(JUN)

PSS:	102455008(JUN)

CMY:	102937264(JUN)

CPIC:

101930786(JUN)

ACS:	100567718(jun)

PVT:	110077124(JUN)

PBI:	103057921(JUN)

PMUR:

107302456(JUN)

TSR:	106545185(JUN)

PMUA:

114598927(JUN)

GJA:	107111867(JUN)

XLA:	108700666 379050(jun.S) 399400(jun.L)

XTR:	100493911(jun)

NPR:	108788164(JUN)

DRE:	335916(jun)

SRX:	107712863 107721038 107735627 107739852

SANH:

107669151(jun) 107682222 107684195 107687249

SGH:	107563389 107581481 107597804

CCAR:

109096570 109113360 109113363

IPU:	108258130(jun) 108260086 108267848(JUN)

PHYP:

113531319 113545334 113547281

AMEX:

103021920 103026868(jun)

EEE:	113568701 113582834 113589106

TRU:	101064806(jun) 101077059

TNG:	GSTEN00015028G001 GSTEN00020512G001

LCO:	104926010 104927418(jun) 104937023

NCC:	104962417 104964063(jun) 104967900

MZE:	101463670 101472459 101486839(jun)

ONL:	100703685 100705884 100707786

OLA:	101160956 101173011(jun) 101174822

XMA:	102230050(jun) 102234665

XCO:	114145916(jun) 114151264

PRET:

103463760 103478989(jun)

CVG:	107083648(jun) 107095895

NFU:	107384375(jun) 107396464

KMR:	108230559(jun) 108238338

ALIM:

106521291(jun) 106534447

AOCE:

111577530 111587627(jun)

CSEM:

103376719(jun) 103398819

POV:	109625845 109643961(jun)

LCF:	108879142 108883834(jun)

SDU:	111228982(jun) 111231968

SLAL:

111648134 111666541(jun) 111671973

HCQ:	109521335 109532403

BPEC:

110154702(jun) 110173458

MALB:

109952420 109970646(jun)

SASA:

106568560 106569413 106572830 106584280(JUN) 106600411(jun) 106613963(JUN)

OTW:	112219784 112226753 112248681 112251077 112257314 112260691

SALP:

111956675 111972264 111975849 111979459 112074546 112075772

ELS:	105011734 105020506 105022094(jun)

SFM:	108923530 108935116(jun) 114911311

PKI:	111834818 111842196 111847550

LCM:	102350279(JUN) 102358101

CMK:	103185297(jun)

RTP:	109913093 109923001 109925743(jun)

BFO:

118431712

CIN:	778972(jun)

SPU:	115918562 588294

APLC:

110977802

SKO:

100313553

DME:	Dmel_CG2275(Jra)

DER:

6541513

DSE:

6608460

DSI:	Dsimw501_GD15385(Dsim_GD15385)

DYA:	Dyak_GE19337

DAN:

6494876

DSR:

110178000

DPO:	Dpse_GA30492

DPE:

6592569

DMN:

108160413

DWI:

6640122

DGR:	Dgri_GH21247

DMO:	Dmoj_GI20534

DAZ:

108617394

DNV:

108654006

DHE:	111593729 115483446

DVI:

6626359

MDE:

101896731

LCQ:

111688738

AGA:	AgaP_AGAP006386

AAG:

5578266

AALB:

109408179

CQU:	CpipJ_CPIJ000084

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:	106790673 106790674

NVI:

100123087

CSOL:

105368040

MDL:

103568136

TCA:	663937(Jra)

DPA:

ATD:

NVL:

BMOR:

BMAN:

PMAC:

PRAP:

HAW:

TNL:

PXY:

API:	100160348 100161138

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM379500

ZNE:

110827968

FCD:

110859845

DPX:	DAPPUDRAFT_306002

PVM:

TUT:

DPTE:

CSCU:

PTEP:

BMY:

LOA:	LOAG_16739

TSP:	Tsp_05337 Tsp_05339

HRO:	HELRODRAFT_115827 HELRODRAFT_170243

PCAN:

112574619

CRG:

105341654

MYI:	110463540 110463541

OBI:

106868153

LAK:

106165046

NVE:	5505701 5516132 5518487 5521019

EPA:	110236685 110239358 110248330

ADF:	107336656 107348109

AMIL:

114963836 114971755 114976904

PDAM:

113665429 113681226 113683358

SPIS:

111324065 111328212 111345067

DGT:	114535859 114542465

HMG:	100204820(jun) 105851038

TAD:	TRIADDRAFT_64084

AQU:

100640297

TET:	TTHERM_00703450

» show all

Reference

PMID:26098572

Authors

Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J, Pei D

Title

The oncogene c-Jun impedes somatic cell reprogramming.

Journal

Nat Cell Biol 17:856-67 (2015)
DOI:10.1038/ncb3193

Reference

PMID:3194415

Authors

Hattori K, Angel P, Le Beau MM, Karin M

Title

Structure and chromosomal localization of the functional intronless human JUN protooncogene.

Journal

Proc Natl Acad Sci U S A 85:9148-52 (1988)
DOI:10.1073/pnas.85.23.9148

Sequence

[hsa:3725]

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