KEGG   ORTHOLOGY: K04492Help
Entry
K04492                      KO                                     

Name
LEF1
Definition
lymphoid enhancer-binding factor 1
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04916  Melanogenesis
ko04934  Cushing syndrome
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04390 Hippo signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05225 Hepatocellular carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05226 Gastric cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05216 Thyroid cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05221 Acute myeloid leukemia
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05217 Basal cell carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05215 Prostate cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05213 Endometrial cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05224 Breast cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04492  LEF1; lymphoid enhancer-binding factor 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04492  LEF1; lymphoid enhancer-binding factor 1
BRITE hierarchy
Genes
HSA: 51176(LEF1)
PTR: 461425(LEF1)
PPS: 100995847(LEF1)
GGO: 101140253(LEF1)
PON: 100447785(LEF1)
NLE: 100593051(LEF1)
MCC: 695776(LEF1)
MCF: 101925349(LEF1)
CSAB: 103236088(LEF1)
RRO: 104670045(LEF1)
RBB: 108515891(LEF1)
CJC: 100399759(LEF1)
SBQ: 101047688(LEF1)
MMU: 16842(Lef1)
MCAL: 110290892(Lef1)
MPAH: 110319903(Lef1)
RNO: 161452(Lef1)
MUN: 110553391(Lef1)
CGE: 100761200(Lef1)
NGI: 103742515(Lef1)
HGL: 101711023(Lef1)
OCU: 100352691(LEF1)
TUP: 102474621(LEF1)
CFA: 478507(LEF1)
VVP: 112934208(LEF1)
AML: 100465982(LEF1)
UMR: 103661728(LEF1)
UAH: 113255544(LEF1)
ORO: 101372325(LEF1)
ELK: 111154120
FCA: 101088077(LEF1)
PTG: 102970026(LEF1)
PPAD: 109247814(LEF1)
AJU: 106983664(LEF1)
BTA: 535399(LEF1)
BOM: 102266946(LEF1)
BIU: 109560266(LEF1)
BBUB: 102409520(LEF1)
CHX: 100860901(LEF1)
OAS: 780521(LEF1)
SSC: 100170126(LEF1)
CFR: 102510619(LEF1)
CDK: 105105289(LEF1)
BACU: 103020844(LEF1)
LVE: 103068879(LEF1)
OOR: 101287631(LEF1)
DLE: 111171490(LEF1)
PCAD: 102996605(LEF1)
ECB: 100072938(LEF1)
EPZ: 103557035(LEF1)
EAI: 106829814(LEF1)
MYB: 102255910(LEF1)
MYD: 102767379(LEF1)
MNA: 107538292(LEF1)
HAI: 109379461(LEF1)
DRO: 112321441(LEF1)
PALE: 102886933(LEF1)
RAY: 107511497(LEF1)
MJV: 108405595(LEF1)
LAV: 100658960(LEF1)
TMU: 101345125
MDO: 100011783(LEF1)
PCW: 110218610(LEF1)
OAA: 100079818(LEF1)
GGA: 395865(LEF1)
MGP: 100542839(LEF1)
CJO: 107313267(LEF1)
NMEL: 110398346(LEF1)
APLA: 101792052(LEF1)
ACYG: 106038656(LEF1)
TGU: 100228376(LEF1)
LSR: 110468005(LEF1)
SCAN: 103826009(LEF1)
GFR: 102034937(LEF1)
FAB: 101821185(LEF1)
PHI: 102109576(LEF1)
PMAJ: 107203557(LEF1)
CCAE: 111928334(LEF1)
CCW: 104697293(LEF1)
ETL: 114057906(LEF1)
FPG: 101917929(LEF1)
FCH: 102050307(LEF1)
CLV: 102084626(LEF1)
EGZ: 104135527(LEF1)
NNI: 104021166(LEF1)
ACUN: 113479673(LEF1)
PADL: 103919538(LEF1)
AAM: 106491833(LEF1)
ASN: 102385539(LEF1)
AMJ: 102560337(LEF1)
PSS: 102456780(LEF1)
CMY: 102930185(LEF1)
CPIC: 101953582(LEF1)
ACS: 100556215(lef1)
PVT: 110080460(LEF1)
PBI: 103064656(LEF1)
PMUR: 107302616(LEF1)
TSR: 106556004(LEF1)
PMUA: 114603846(LEF1)
GJA: 107123114(LEF1)
XLA: 100337575(lef-1) 398238(lef1.L) 779101(lef1)
XTR: 100493178(lef1)
NPR: 108785415(LEF1)
DRE: 30701(lef1)
SGH: 107583218(lef1) 107594427
IPU: 108262963(lef1)
PHYP: 113538151(lef1)
AMEX: 103033630(lef1)
EEE: 113568617(lef1) 113588325
TRU: 101064872(lef1) 115251054
LCO: 104927262(lef1)
MZE: 101464688(lef1)
ONL: 100704365(lef1)
OLA: 101167344(lef1)
XMA: 102226301(lef1) 111609564
XCO: 114144420(lef1) 114149416
PRET: 103472749(lef1)
CVG: 107094620(lef1)
NFU: 107375038(lef1)
KMR: 108230929(lef1)
ALIM: 106517066(lef1)
AOCE: 111586156(lef1)
POV: 109638362(lef1)
LCF: 108888246(lef1)
SDU: 111236636(lef1)
SLAL: 111671174(lef1)
BPEC: 110165341(lef1)
MALB: 109955531(lef1)
SASA: 106602294 106610340(lef1)
OTW: 112238204
SALP: 112075848
ELS: 105020989(lef1)
PKI: 111837376(lef1) 111852095
LCM: 102354030(LEF1) 106706489
CMK: 103182161
RTP: 109922552
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hovanes K, Li TW, Waterman ML
  Title
The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
  Journal
Nucleic Acids Res 28:1994-2003 (2000)
DOI:10.1093/nar/28.9.1994
  Sequence
[hsa:51176]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
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