KEGG ORTHOLOGY: K04514

ORTHOLOGY: K04514

Entry

K04514                      KO

Symbol

ROCK1

Name

Rho-associated protein kinase 1 [EC:2.7.11.1]

Pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04071

Sphingolipid signaling pathway

map04270

Vascular smooth muscle contraction

map04350

TGF-beta signaling pathway

map04360

Axon guidance

map04510

Focal adhesion

map04520

Adherens junction

map04530

Tight junction

map04611

Platelet activation

map04670

Leukocyte transendothelial migration

map04810

Regulation of actin cytoskeleton

map04921

Oxytocin signaling pathway

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05135

Yersinia infection

map05163

Human cytomegalovirus infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05206

MicroRNAs in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
   04071 Sphingolipid signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
   04024 cAMP signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
   04022 cGMP-PKG signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04514  ROCK1; Rho-associated protein kinase 1
   04520 Adherens junction
    K04514  ROCK1; Rho-associated protein kinase 1
   04530 Tight junction
    K04514  ROCK1; Rho-associated protein kinase 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04514  ROCK1; Rho-associated protein kinase 1
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04514  ROCK1; Rho-associated protein kinase 1
   04670 Leukocyte transendothelial migration
    K04514  ROCK1; Rho-associated protein kinase 1
   04062 Chemokine signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04514  ROCK1; Rho-associated protein kinase 1
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04514  ROCK1; Rho-associated protein kinase 1
  09158 Development and regeneration
   04360 Axon guidance
    K04514  ROCK1; Rho-associated protein kinase 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04514  ROCK1; Rho-associated protein kinase 1
   05206 MicroRNAs in cancer
    K04514  ROCK1; Rho-associated protein kinase 1
   05205 Proteoglycans in cancer
    K04514  ROCK1; Rho-associated protein kinase 1
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04514  ROCK1; Rho-associated protein kinase 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04514  ROCK1; Rho-associated protein kinase 1
   05131 Shigellosis
    K04514  ROCK1; Rho-associated protein kinase 1
   05135 Yersinia infection
    K04514  ROCK1; Rho-associated protein kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04514  ROCK1; Rho-associated protein kinase 1
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K04514  ROCK1; Rho-associated protein kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04514  ROCK1; Rho-associated protein kinase 1
Protein kinases [BR:ko01001]
Serine/threonine kinases: AGC group
  DMPK family [OT]
   K04514  ROCK1; Rho-associated protein kinase 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    K04514  ROCK1; Rho-associated protein kinase 1

Genes

HSA:	6093(ROCK1)

PTR:	455326(ROCK1)

PPS:	100976232(ROCK1)

GGO:	101154194(ROCK1)

PON:	100432582(ROCK1)

NLE:	100586590(ROCK1)

HMH:	116468684(ROCK1)

MCC:	698223(ROCK1)

MCF:	102140851(ROCK1)

MTHB:

126941287

MNI:	105464762(ROCK1)

CSAB:

103222670(ROCK1)

CATY:

105583987(ROCK1)

PANU:

100997671(ROCK1)

TGE:	112611421(ROCK1)

MLEU:

105551188(ROCK1)

RRO:	104655463(ROCK1)

RBB:	108530562(ROCK1)

TFN:	117064083(ROCK1)

PTEH:

111553507(ROCK1)

CANG:

105523045(ROCK1)

CJC:	100394652(ROCK1)

SBQ:	101028677 101051787(ROCK1)

CIMI:

108282896(ROCK1)

CSYR:

103272758(ROCK1)

MMUR:

105860971(ROCK1)

LCAT:

123621906(ROCK1)

PCOQ:

105816606(ROCK1)

OGA:	100964845(ROCK1)

MMU:	19877(Rock1)

MCAL:

110284478(Rock1)

MPAH:

110333549(Rock1)

RNO:	81762(Rock1)

MCOC:

116086826(Rock1)

ANU:	117719597(Rock1)

MUN:	110564211(Rock1)

CGE:	100770074(Rock1)

MAUA:

101843167(Rock1)

PROB:

127234920(Rock1)

PLEU:

114698172(Rock1)

MORG:

121443343 121453250

MFOT:

126505647

AAMP:

119814203(Rock1)

NGI:	103728977(Rock1)

HGL:	101710589(Rock1)

CPOC:

100718968(Rock1)

CCAN:

109689990(Rock1)

DORD:

105984641(Rock1)

DSP:	122104238(Rock1)

PLOP:

125364223(Rock1)

NCAR:

124965296

MMMA:

107139600(Rock1)

OCU:	100009220(ROCK1)

OPI:	101530829(ROCK1)

TUP:	102481136(ROCK1)

GVR:	103592848(ROCK1)

CFA:	480181(ROCK1)

CLUD:

112647981(ROCK1)

VVP:	112925736(ROCK1)

VLG:	121488157(ROCK1)

NPO:	129508826(ROCK1)

AML:	100474469(ROCK1)

UMR:	103662842(ROCK1)

UAH:	113253267(ROCK1)

UAR:	123782085(ROCK1)

ELK:

111142435

LLV:

125081945

MPUF:

101683021(ROCK1)

MNP:	132023518(ROCK1)

MLK:	131811851(ROCK1)

NVS:	122902995(ROCK1)

ORO:	101386230(ROCK1)

EJU:	114200401(ROCK1)

ZCA:	113912439(ROCK1)

MLX:	118004574(ROCK1)

NSU:	110576837(ROCK1)

LWW:	102734862(ROCK1)

FCA:	101092552(ROCK1)

PYU:	121033118(ROCK1)

PCOO:

112868225(ROCK1)

PBG:	122470622(ROCK1)

PVIV:

125148757(ROCK1)

LRUF:

124517572

PTG:	102963520(ROCK1)

PPAD:

109248559(ROCK1)

PUC:

125914402

AJU:

106970030

HHV:	120220661(ROCK1)

BTA:	785911(ROCK1)

BOM:	102284712(ROCK1)

BIU:	109577829(ROCK1)

BBUB:

102398804(ROCK1)

BBIS:

104980280(ROCK1)

CHX:	102171022(ROCK1)

OAS:	101102442(ROCK1)

BTAX:

128067328(ROCK1)

ODA:	120881120(ROCK1)

CCAD:

122425883(ROCK1)

MBEZ:

129549745(ROCK1)

SSC:	397447(ROCK1)

CFR:	102520724(ROCK1)

CBAI:

105071393(ROCK1)

CDK:	105086272(ROCK1)

VPC:	102539343(ROCK1)

BACU:

103002971

BMUS:

118879889(ROCK1)

LVE:

103082455

OOR:	101278979(ROCK1)

DLE:	111181452(ROCK1)

PCAD:

102987332(ROCK1)

PSIU:

116765160(ROCK1)

NASI:

112408295(ROCK1)

ECB:	100034056(ROCK1)

EPZ:	103552805(ROCK1)

EAI:	106843404(ROCK1)

MYB:	102252747(ROCK1)

MYD:	102757900(ROCK1)

MMYO:

118662528(ROCK1)

MLF:	102419225(ROCK1)

PKL:	118707729(ROCK1)

EFUS:

103303158(ROCK1)

MNA:	107535907(ROCK1)

DRO:	112322916(ROCK1)

SHON:

118976915(ROCK1)

AJM:	119058893(ROCK1)

PDIC:

114506701(ROCK1)

PHAS:

123826024(ROCK1)

MMF:	118618764(ROCK1)

PPAM:

129078629(ROCK1)

HAI:	109388840(ROCK1)

RFQ:	117011752(ROCK1)

PALE:

102879861(ROCK1)

PGIG:

120587763(ROCK1)

PVP:	105292284(ROCK1)

RAY:	107520580(ROCK1)

MJV:	108391302(ROCK1)

TOD:	119243152(ROCK1)

SARA:

101540987(ROCK1)

LAV:	100657418(ROCK1)

ETF:	101642345(ROCK1)

DNM:	101439506(ROCK1)

MDO:	100618269(ROCK1)

GAS:	123239370(ROCK1) 123251954 123252087

SHR:	100916611(ROCK1)

AFZ:

127543967

PCW:	110197059(ROCK1)

OAA:	100079648(ROCK1)

GGA:	373970(ROCK1)

PCOC:

116242203(ROCK1)

MGP:	100539446(ROCK1)

CJO:	107310033(ROCK1)

TPAI:

128091426(ROCK1)

LMUT:

125691383(ROCK1)

NMEL:

110393351(ROCK1)

APLA:

101797330(ROCK1)

ACYG:

106037590(ROCK1)

CATA:

118256775(ROCK1)

AFUL:

116486829(ROCK1)

TGU:	100229794(ROCK1)

LSR:	110482370(ROCK1)

SCAN:

103826969(ROCK1)

PMOA:

120500756(ROCK1)

OTC:	121333147(ROCK1)

PRUF:

121359005(ROCK1)

GFR:	102040824(ROCK1)

FAB:	101819345(ROCK1)

OMA:	130250328(ROCK1)

PHI:	102100951(ROCK1)

PMAJ:

107199098(ROCK1)

CCAE:

111924950(ROCK1)

CCW:	104687309(ROCK1)

CBRC:

103618417(ROCK1)

ETL:	114056505(ROCK1)

ZAB:	102065165(ROCK1)

ACHL:

103808662(ROCK1)

SVG:	106850162(ROCK1)

MMEA:

130572902(ROCK1)

HRT:	120750173(ROCK1)

FPG:	101913286(ROCK1)

FCH:	102052286(ROCK1)

CLV:	102097361(ROCK1)

EGZ:	104134126(ROCK1)

NNI:	104018128(ROCK1)

PLET:

104625719(ROCK1)

EHS:	104511921(ROCK1)

PCAO:

104045386(ROCK1)

ACUN:

113476436(ROCK1)

TALA:

104364749(ROCK1)

PADL:

103923171(ROCK1)

AFOR:

103904234(ROCK1)

ACHC:

115340145(ROCK1)

HALD:

104310626

HLE:	104836007(ROCK1)

AGEN:

126050787

GCL:

127013835

CCRI:

104155215(ROCK1)

CSTI:

104554837(ROCK1)

CMAC:

104486585(ROCK1)

MUI:	104544086(ROCK1)

BREG:

104636471(ROCK1)

GSTE:

104260473

LDI:	104349332(ROCK1)

OHA:	104326616(ROCK1)

NNT:

104403821

SHAB:

115618695(ROCK1)

DPUB:

104307755(ROCK1)

PGUU:

104464843(ROCK1)

ACAR:

104531721(ROCK1)

CPEA:

104396934(ROCK1)

AVIT:

104274400(ROCK1)

CVF:	104287891(ROCK1)

RTD:	128904857(ROCK1)

CUCA:

104063001(ROCK1)

TEO:	104379940(ROCK1)

AAM:	106484740(ROCK1)

AROW:

112962444(ROCK1)

NPD:	112944131(ROCK1)

DNE:	112996999(ROCK1)

SCAM:

104142524(ROCK1)

ASN:	102377504(ROCK1)

AMJ:	102558298(ROCK1)

CPOO:

109317893(ROCK1)

GGN:	109303778(ROCK1)

PSS:	102463968(ROCK1)

CMY:	102937514(ROCK1)

CCAY:

125632360(ROCK1)

DCC:	119850482(ROCK1)

CPIC:

101947074(ROCK1)

TST:	117873395(ROCK1)

CABI:

116839290(ROCK1)

MRV:	120396921(ROCK1)

ACS:	100558337(rock1)

ASAO:

132774754(ROCK1)

PVT:	110079445(ROCK1)

SUND:

121917280 121917336

PBI:	103059736(ROCK1)

PMUR:

107285298(ROCK1)

CTIG:

120301395(ROCK1)

TSR:	106549734(ROCK1)

PGUT:

117672689(ROCK1)

APRI:

131196381(ROCK1)

PTEX:

113435487(ROCK1)

NSS:	113413762(ROCK1)

VKO:	123020462(ROCK1)

PMUA:

114600698(ROCK1)

PRAF:

128417568(ROCK1)

ZVI:	118089797(ROCK1)

HCG:	128321969(ROCK1)

GJA:	107120578(ROCK1)

STOW:

125438730(ROCK1)

EMC:	129333079(ROCK1)

XLA:	108695261(rock1.S) 108719215(rock1.L)

XTR:	100496057(rock1)

NPR:	108797185(ROCK1)

RTEM:

120940912(ROCK1)

BBUF:

121000954(ROCK1)

BGAR:

122938923(ROCK1)

MUO:	115476492(ROCK1)

GSH:	117355412(ROCK1)

DRE:	100329779(rock1)

SRX:	107711696(rock1) 107727500

SANH:

107660398 107671690

SGH:	107567877 107593752(rock1)

CCAR:

109104807 109110013

CAUA:

113039947 113046112

CGIB:

127951065 128024786

PTET:

122357918(rock1)

LROH:

127175390(rock1)

OMC:	131525651(rock1)

PPRM:

120468740(rock1)

RKG:	130099530(rock1)

MAMB:

125250859(rock1)

CIDE:

127522588

MASI:

127440936 127441995

TROS:

130554565(rock1)

TDW:	130417455(rock1)

MANU:

129442767(rock1)

IPU:

108267074

IFU:	128610561(rock1)

SMEO:

124387584(rock1)

TFD:	113635005(rock1)

TVC:	132849148(rock1)

CMAO:

118826637(rock1)

EEE:	113588249(rock1)

CHAR:

105900588(rock1)

TRU:	101070472(rock1)

TFS:	130538377(rock1)

TNG:	GSTEN00016121G001

LCO:	104917703(rock1)

TBEN:

117488708(rock1)

CGOB:

115022974(rock1)

PGEO:

117461973(rock1)

GACU:

117558492(rock1)

EMAC:

134866068(rock1)

ELY:	117272237(rock1)

EFO:	125901812(rock1)

PLEP:

121950967(rock1)

SLUC:

116046203(rock1)

ECRA:

117953725(rock1)

ESP:	116698610(rock1)

PFLV:

114565008(rock1)

GAT:	120815903(rock1)

PPUG:

119203938(rock1)

AFB:	129113525(rock1)

MSAM:

119901969(rock1)

SCHU:

122886396(rock1)

CUD:	121519682(rock1)

ALAT:

119011679(rock1)

MZE:	101478273(rock1)

ONL:	100697034(rock1)

OAU:	116316202(rock1)

OLA:	101158388(rock1)

OML:	112147362(rock1)

CSAI:

133452781(rock1)

XMA:	102235948(rock1)

XCO:	114146483(rock1)

XHE:	116721543(rock1)

PRET:

103479725(rock1)

PFOR:

103135735(rock1)

PLAI:

106948715(rock1)

PMEI:

106914242(rock1)

GAF:	122841220(rock1)

PPRL:

129361866(rock1)

CVG:	107081674(rock1)

CTUL:

119794167(rock1)

GMU:	124870088(rock1)

NFU:	107383841(rock1)

KMR:	108241701(rock1)

ALIM:

106533134(rock1)

NWH:	119415171(rock1)

AOCE:

111585713(rock1)

MCEP:

125010798(rock1)

CSEM:

103396393(rock1)

POV:	109642611(rock1)

SSEN:

122766275(rock1)

HHIP:

117777701(rock1)

HSP:	118117622(rock1)

SMAU:

118310370(rock1)

LCF:

108883337

SDU:	111231038(rock1)

SLAL:

111653269(rock1)

XGL:	120798555(rock1)

HCQ:	109521247(rock1)

SSCV:

125985115

SBIA:

133511478(rock1)

PEE:	133411886(rock1)

PTAO:

133488509(rock1)

BPEC:

110166734(rock1)

MALB:

109955368(rock1)

BSPL:

114844307(rock1)

SJO:	128368939(rock1)

SASA:

106569322 106600432

STRU:

115157216 115169563

OTW:	112226775(rock1) 112260654

OMY:	110508561(rock1) 110530503

OGO:	124009341 124041728

ONE:	115102936 115114580

OKI:	109871603 109875460

OKE:	118394827 118401943

SALP:

111956491 111979037

SNH:	120020258 120055988

CCLU:

121535371 121581060

ELS:	105019915(rock1)

SFM:	108937735(rock1)

PKI:	111845883(rock1)

AANG:

118233467(rock1)

LOC:	102698697(rock1)

PSPA:

121313516 121314453(rock1)

ARUT:

117394747(rock1) 117400355

PSEX:

120530313(rock1)

LCM:	102350260(ROCK1)

CMK:	103183447(rock1)

CPLA:

122549054(rock1)

HOC:	132814782(rock1)

LERI:

129696353(rock1)

DME:	Dmel_CG9774(Rok)

DER:

6549996

DSE:

6617961

DSI:	Dsimw501_GD28097(Dsim_GD28097)

DYA:	Dyak_GE15957

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI11100

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ011538

CPII:

CNS:

BCOO:

CGLO:

FAS:

DAM:

AGIF:

CINS:

TCA:

SOY:

AGRG:

CSET:

AGB:

LDC:

APLN:

PPYR:

OTU:

BMOR:

100529202(rock1)

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CFEL:

CCRN:

ACOO:

DVT:

HHAL:

NLU:

HVI:

MQU:

DSV:

RSAN:

RMP:

CEL:	CELE_C10H11.9(let-502)

CBR:	CBG_03960(Cbr-let-502)

CRQ:	GCK72_002973

» show all

Reference

PMID:20230755

Authors

Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggio M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M

Title

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.

Journal

Dev Cell 18:486-95 (2010)
DOI:10.1016/j.devcel.2009.12.020

Reference

PMID:8617235

Authors

Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S

Title

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

Journal

EMBO J 15:1885-93 (1996)
DOI:10.1002/j.1460-2075.1996.tb00539.x

Sequence

[hsa:6093]

LinkDB

DBGET integrated database retrieval system