KEGG   ORTHOLOGY: K04527Help
Entry
K04527                      KO                                     

Name
INSR, CD220
Definition
insulin receptor [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04361  Axon regeneration
ko04520  Adherens junction
ko04910  Insulin signaling pathway
ko04913  Ovarian steroidogenesis
ko04923  Regulation of lipolysis in adipocytes
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04960  Aldosterone-regulated sodium reabsorption
Disease
H00719  Leprechaunism
H00942  Rabson-Mendenhall syndrome
H01228  Insulin-resistant diabetes mellitus with acanthosis nigricans
H01267  Familial hyperinsulinemic hypoglycemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04527  INSR, CD220; insulin receptor
   04015 Rap1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04010 MAPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04066 HIF-1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04068 FoxO signaling pathway
    K04527  INSR, CD220; insulin receptor
   04072 Phospholipase D signaling pathway
    K04527  INSR, CD220; insulin receptor
   04022 cGMP-PKG signaling pathway
    K04527  INSR, CD220; insulin receptor
   04151 PI3K-Akt signaling pathway
    K04527  INSR, CD220; insulin receptor
   04152 AMPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04150 mTOR signaling pathway
    K04527  INSR, CD220; insulin receptor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04527  INSR, CD220; insulin receptor
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04527  INSR, CD220; insulin receptor
   04923 Regulation of lipolysis in adipocytes
    K04527  INSR, CD220; insulin receptor
   04913 Ovarian steroidogenesis
    K04527  INSR, CD220; insulin receptor
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04527  INSR, CD220; insulin receptor
  09158 Development and regeneration
   04361 Axon regeneration
    K04527  INSR, CD220; insulin receptor
  09149 Aging
   04211 Longevity regulating pathway
    K04527  INSR, CD220; insulin receptor
   04212 Longevity regulating pathway - worm
    K04527  INSR, CD220; insulin receptor
   04213 Longevity regulating pathway - multiple species
    K04527  INSR, CD220; insulin receptor
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04527  INSR, CD220; insulin receptor
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04527  INSR, CD220; insulin receptor
   04931 Insulin resistance
    K04527  INSR, CD220; insulin receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04527  INSR, CD220; insulin receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04527  INSR, CD220; insulin receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04527  INSR, CD220; insulin receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K04527  INSR, CD220; insulin receptor
CD molecules [BR:ko04090]
 Proteins
  K04527  CD220, INSR; insulin receptor
BRITE hierarchy
Other DBs
GO: 0005009
Genes
HSA: 3643(INSR)
PTR: 455649(INSR)
PPS: 100991905(INSR)
GGO: 101144696(INSR)
PON: 100451422(INSR)
NLE: 100597533(INSR)
MCC: 706009(INSR)
MCF: 102139081(INSR)
CSAB: 103234346(INSR)
RRO: 104679498(INSR)
RBB: 108534554(INSR)
CJC: 100403400(INSR)
SBQ: 101028986(INSR)
MMU: 16337(Insr)
MCAL: 110300622(Insr)
MPAH: 110336317(Insr)
RNO: 24954(Insr)
CGE: 100766818(Insr)
NGI: 103743312(Insr)
HGL: 101722168(Insr)
CCAN: 109694006(Insr)
OCU: 100008911(INSR)
TUP: 102469167(INSR)
CFA: 484990(INSR)
VVP: 112909702(INSR)
AML: 100473956(INSR)
UMR: 103676308(INSR)
UAH: 113242935(INSR)
ORO: 101363371(INSR)
FCA: 100127108(INSR)
PTG: 102967156(INSR)
AJU: 106979040(INSR)
BTA: 408017(INSR)
BOM: 102285317(INSR)
BIU: 109561633(INSR) 109561638
BBUB: 102391024(INSR)
PHD: 102344118(INSR)
CHX: 102168996(INSR)
OAS: 443431(INSR)
SSC: 396755(INSR)
CFR: 102522017(INSR)
CDK: 105087555(INSR)
BACU: 103018249(INSR)
LVE: 103085622(INSR)
OOR: 101283355(INSR)
DLE: 111165931(INSR)
ECB: 100066248(INSR)
EAI: 106844524(INSR)
MYB: 102252005(INSR)
MYD: 102766590(INSR)
MNA: 107540632(INSR)
HAI: 109396062(INSR)
RSS: 109461386(INSR)
DRO: 112296365(INSR)
PALE: 102879346(INSR)
LAV: 100668116(INSR)
MDO: 100027215(INSR)
SHR: 100929204(INSR)
PCW: 110203364(INSR)
OAA: 100079104(INSR)
GGA: 420133(INSR)
MGP: 100550007(INSR)
CJO: 107325585(INSR)
APLA: 101795803(INSR)
ACYG: 106044962(INSR)
TGU: 100228094(INSR)
LSR: 110479633(INSR)
SCAN: 103821923(INSR)
GFR: 102036061(INSR)
FAB: 101813861(INSR)
PHI: 102105828(INSR)
PMAJ: 107215564(INSR)
CCAE: 111940344(INSR)
CCW: 104696982(INSR)
ETL: 114067120 114069501(INSR)
FPG: 101914421(INSR)
FCH: 102056291(INSR)
CLV: 102085804(INSR)
EGZ: 104124372(INSR)
NNI: 104018719(INSR)
AAM: 106495607(INSR)
ASN: 102378715(INSR)
AMJ: 102558884(INSR)
PSS: 102459083(INSR)
CMY: 102935205(INSR)
CPIC: 101947783(INSR)
ACS: 100567954(insr) 103282842
PVT: 110072679(INSR)
PMUR: 107282222(INSR)
GJA: 107111283 107121673(INSR)
XLA: 100158430 398006(insr.L)
XTR: 100492718(insr)
NPR: 108785893(INSR)
DRE: 245699(insra) 245700(insrb)
TRU: 101074083(insr) 101074430
NCC: 104961264(insr) 104965319
XMA: 102227076 102238226(insr)
XCO: 114146472(insr) 114150578
KMR: 108230621 108232893(insr)
LCM: 102345167(INSR) 102358202
CMK: 103181967(insr)
CIN: 778651
SPU: 579152(ir)
APLC: 110990313
SKO: 100329033
AGA: AgaP_AGAP012424(INR)
AME: 411297 725827(InR-2)
NVI: 100122567(INSR)
TCA: 661524(InR) 664271(ilr2)
BMOR: 692560(InR)
PRAP: 111003916
HAW: 110377777
TNL: 113501838
PXY: 105397590
TUT: 107365291
CEL: CELE_Y55D5A.5(daf-2)
CBR: CBG15732(Cbr-daf-2)
BMY: Bm1_19395
TSP: Tsp_06967
PCAN: 112553582
CRG: 105348544
MYI: 110455012
OBI: 106876722
LAK: 106153706
EPA: 110243170
PDAM: 113679838
SPIS: 111344627
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2859121
  Authors
Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Ou JH, Masiarz F, Kan YW, Goldfine ID, et al.
  Title
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
  Journal
Cell 40:747-58 (1985)
DOI:10.1016/0092-8674(85)90334-4
  Sequence
[hsa:3643]
Reference
  Authors
Youngren JF
  Title
Regulation of insulin receptor function.
  Journal
Cell Mol Life Sci 64:873-91 (2007)
DOI:10.1007/s00018-007-6359-9
  Sequence
[rno:24954]
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