KEGG ORTHOLOGY: K04533

ORTHOLOGY: K04533

Entry

K04533 KO

Name

Definition

huntingtin

Pathway

ko05016

Huntington disease

Disease

H00059

Huntington disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04533  HD; huntingtin
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K04533  HD; huntingtin
   04131 Membrane trafficking
    K04533  HD; huntingtin
   03029 Mitochondrial biogenesis
    K04533  HD; huntingtin
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     K04533  HD; huntingtin
Membrane trafficking [BR:ko04131]
Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K04533  HD; huntingtin
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K04533  HD; huntingtin

Genes

HSA:

3064(HTT)

PTR:	461084(HTT)

PPS:	100978882(HTT)

GGO:	101125657(HTT)

PON:	100442500(HTT)

NLE:	100595586(HTT)

MCC:	700306(HTT)

MCF:	102128821(HTT)

CSAB:

103246449(HTT)

RRO:	104678957(HTT)

RBB:	108522748(HTT)

CJC:	100403524(HTT)

SBQ:	101027463(HTT)

MMU:	15194(Htt)

MCAL:

110295148(Htt)

MPAH:

110330941(Htt)

RNO:	29424(Htt)

MUN:	110552401(Htt)

CGE:	100764729(Htt)

NGI:	103741151(Htt)

HGL:	101697599(Htt)

CCAN:

109687432(Htt)

OCU:	100351801(HTT)

TUP:	102496123(HTT)

CFA:	479074(HTT)

VVP:	112922672(HTT)

AML:	100466808(HTT)

UMR:	103677033(HTT)

UAH:	113245750(HTT)

ORO:	101375437(HTT)

ELK:

111149245

FCA:	101086476(HTT)

PTG:	102961886(HTT)

PPAD:

109269744(HTT)

AJU:	106978831(HTT)

BTA:	615059(HTT)

BOM:	102283586(HTT)

BIU:	109560744(HTT)

BBUB:

102416640(HTT)

CHX:	102183227(HTT)

OAS:	100216476(HTT)

SSC:	397014(HTT)

CFR:	102521890(HTT)

CDK:	105103925(HTT)

BACU:

103013686(HTT)

LVE:	103073863(HTT)

OOR:	101289696(HTT)

DLE:	111164902(HTT)

PCAD:

102987968(HTT)

ECB:	100053721(HTT)

EPZ:	103558676(HTT)

EAI:

106842003

MYB:	102250928(HTT)

MYD:	102768616(HTT)

MNA:	107524070(HTT)

HAI:	109390906(HTT)

DRO:	112316670(HTT)

PALE:

102896722(HTT)

RAY:	107517979(HTT)

MJV:

108395692

LAV:	100670335(HTT)

TMU:

101360779

MDO:	100015315(HTT)

SHR:	100930812(HTT)

PCW:	110212213(HTT)

OAA:	103169301(HTT)

GGA:	422878(HTT)

MGP:

100540532

CJO:	107313923(HTT)

NMEL:

110397762(HTT)

APLA:

101789649(HTT)

ACYG:

106034665(HTT)

TGU:	100219938(HTT)

LSR:	110481892(HTT)

SCAN:

103823923(HTT)

GFR:	102039142(HTT)

FAB:	101807378(HTT)

PHI:	102109876(HTT)

PMAJ:

107202828(HTT)

CCAE:

111928237(HTT)

CCW:	104690918(HTT)

ETL:	114061216(HTT)

FPG:	101912601(HTT)

FCH:	102053260(HTT)

CLV:	102097560(HTT)

EGZ:	104130204(HTT)

NNI:	104018056(HTT)

ACUN:

113479031(HTT)

PADL:

103920991(HTT)

AAM:	106498723(HTT)

ASN:	102381087(HTT)

AMJ:	102572238(HTT)

PSS:	102450502(HTT)

CMY:	102938975(HTT)

CPIC:

101939389(HTT)

ACS:	100565638(htt)

PVT:	110091151(HTT) 110091731

PBI:	103059334(HTT)

PMUR:

107298580(HTT)

PMUA:

114604110(HTT)

GJA:	107118340(HTT)

XLA:

108697843

XTR:	493287(htt)

NPR:	108785827(HTT)

DRE:	30214(htt)

SRX:	107714228 107749891(htt)

SANH:

107674220 107679870

SGH:	107551186 107556526

CCAR:

109098744 109098746

IPU:	108263566(htt)

PHYP:

113538549(htt)

AMEX:

103040957(htt)

EEE:	113571465(htt)

TRU:	101065600(htt)

TNG:	GSTEN00022637G001

LCO:	104921948(htt)

NCC:

104946108

MZE:	101475773(htt)

ONL:	100703195(htt)

OLA:	101174004(htt)

XMA:	102230889(htt)

XCO:	114144472(htt)

PRET:

103464399(htt)

CVG:	107093761(htt)

NFU:	107393230(htt)

KMR:	108236369(htt)

ALIM:

106524348(htt)

AOCE:

111567212(htt)

CSEM:

103384197(htt)

POV:	109627550(htt)

LCF:	108875667(htt)

SDU:	111217939(htt)

SLAL:

111664606(htt)

HCQ:	109527350(htt)

BPEC:

110175726(htt)

MALB:

109957861(htt)

ELS:	105020824(htt)

SFM:	108925735(htt)

PKI:	111853089(htt)

LCM:	102363933(HTT)

CMK:	103186321(htt)

RTP:	109933868(htt)

BFO:	BRAFLDRAFT_101261

CIN:	100145818(htt)

SPU:	373520 591027

APLC:

110973838

SKO:	100329031(Htt)

DME:	Dmel_CG9995(htt)

DER:

6555425

DSI:	Dsimw501_GD21379(Dsim_GD21379)

DYA:	Dyak_GE23798

DSR:

110186345

DPO:	Dpse_GA26800

DPE:

6594769

DMN:

108155943

DWI:

6647961

DGR:	Dgri_GH14159

DMO:	Dmoj_GI22240

DAZ:

DNV:

DHE:

MDE:

LCQ:

AGA:	AgaP_AGAP003681

AAG:

5566195

AALB:

109425439 115263724

CQU:	CpipJ_CPIJ004120

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_209103

PMAC:

PRAP:

HAW:

TNL:

PXY:	105384186 105387789 105391361

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM577330

ZNE:

110832891

FCD:

110858221

DPX:	DAPPUDRAFT_106588

PVM:

TUT:

DPTE:

CSCU:

PTEP:

BMY:

LOA:	LOAG_18001

TSP:

Tsp_02358

HRO:	HELRODRAFT_170769

LGI:	LOTGIDRAFT_160793

PCAN:

CRG:

MYI:

OBI:

LAK:

SMM:	Smp_165420

SHX:

MS3_06168

OVI:	T265_03772

EGL:

EGR_09022

NVE:	NEMVE_v1g196942

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_28161

AQU:

105312249

MBR:	MONBRDRAFT_33791

SRE:	PTSG_00669

DDI:	DDB_G0272344(hd)

DPP:	DICPUDRAFT_95859

DFA:	DFA_08956(hd)

ACAN:

ACA1_131840

» show all

Reference

PMID:8458085

Title

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Journal

Cell 72:971-83 (1993)
DOI:10.1016/0092-8674(93)90585-e

Sequence

[hsa:3064]

Reference

PMID:24407293

Authors

Tourette C, Li B, Bell R, O'Hare S, Kaltenbach LS, Mooney SD, Hughes RE

Title

A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.

Journal

J Biol Chem 289:6709-26 (2014)
DOI:10.1074/jbc.M113.523696

Sequence

[hsa:3064]

LinkDB

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