KEGG ORTHOLOGY: K04556

ORTHOLOGY: K04556

Entry

K04556                      KO

Symbol

PARK2

Name

parkin [EC:2.3.2.31]

Pathway

map04120

Ubiquitin mediated proteolysis

map04137

Mitophagy - animal

map04141

Protein processing in endoplasmic reticulum

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00027

Ovarian cancer

H00057

Parkinson disease

H01600

Parkinsonian syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04556  PARK2; parkin
   04120 Ubiquitin mediated proteolysis
    K04556  PARK2; parkin
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04556  PARK2; parkin
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K04556  PARK2; parkin
   05014 Amyotrophic lateral sclerosis
    K04556  PARK2; parkin
   05022 Pathways of neurodegeneration - multiple diseases
    K04556  PARK2; parkin
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04556  PARK2; parkin
   04121 Ubiquitin system
    K04556  PARK2; parkin
   03029 Mitochondrial biogenesis
    K04556  PARK2; parkin
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     K04556  PARK2; parkin
Membrane trafficking [BR:ko04131]
Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    K04556  PARK2; parkin
  Aggrephagy
   Other aggrephagy associated proteins
    K04556  PARK2; parkin
  Xenophagy
   Other xenophagy associated proteins
    K04556  PARK2; parkin
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    K04556  PARK2; parkin
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    K04556  PARK2; parkin

Genes

HSA:	5071(PRKN)

PTR:	741350(PRKN)

PPS:	100978701(PRKN)

GGO:	101154322(PRKN)

PON:	100172433(PRKN)

NLE:	100589757(PRKN)

HMH:	116473652(PRKN)

MCC:	710899(PRKN)

MCF:	102134446(PRKN)

MTHB:

126953705

MNI:	105487519(PRKN)

CSAB:

103240862(PARK2)

CATY:

105594235(PARK2)

PANU:

101013061(PRKN)

TGE:	112623531(PRKN)

MLEU:

105553540(PARK2)

RRO:	104669996(PRKN)

RBB:	108527984(PARK2)

TFN:	117096908(PRKN)

PTEH:

111550282(PRKN)

CANG:

105506721(PARK2)

CJC:	100390242(PRKN)

SBQ:	101029277(PARK2)

CIMI:

108310303(PRKN)

LCAT:

123633441(PRKN)

PCOQ:

105812371(PARK2)

OGA:	100965001(PRKN)

MMU:	50873(Prkn)

MCAL:

110312630(Prkn)

MPAH:

110338080(Prkn)

RNO:	56816(Prkn)

MCOC:

116076805(Prkn)

ANU:	117700262(Prkn)

MUN:	110554861(Prkn)

CGE:	100764359(Prkn)

MAUA:

101825108(Prkn)

PROB:

127237704(Prkn)

PLEU:

114691391(Prkn)

MORG:

121466547(Prkn)

MFOT:

126497719

AAMP:

119820894(Prkn)

NGI:	103729225 103737054(Park2)

HGL:	101700770(Park2)

CPOC:

100724550(Prkn)

CCAN:

109688031

DORD:

105991798(Park2)

DSP:	122116126(Prkn)

PLOP:

125357474(Prkn)

NCAR:

124987958

MMMA:

107153167(Prkn)

OCU:	100358886(PRKN)

OPI:	101518416(PRKN)

TUP:	102469732(PARK2)

CFA:	612316(PRKN)

CLUD:

112644403(PRKN)

VVP:	112932949(PRKN)

VLG:	121485024(PRKN)

NPO:	129501049(PRKN)

AML:	100465415(PRKN)

UMR:	103660821(PRKN)

UAH:	113259330(PRKN)

UAR:	123797535(PRKN)

ELK:

111158711

LLV:

125102349

MPUF:

101689578(PARK2)

MNP:	132018447(PRKN)

MLK:	131833389(PRKN)

NVS:	122902732(PRKN)

ORO:	101385500(PARK2)

EJU:	114209290(PRKN)

ZCA:	113927504(PRKN)

MLX:	118001822 118001946

NSU:	110583162(PRKN)

FCA:	101098228(PRKN)

PYU:	121013069(PRKN)

PCOO:

112862211(PRKN)

PBG:	122490161(PRKN)

PVIV:

125166201(PRKN)

LRUF:

124528391

PTG:	102964689(PARK2)

PPAD:

109245483(PARK2)

PUC:

125938088

AJU:	106985022(PRKN)

BTA:	530858(PRKN)

BOM:	102270304 102284805

BIU:	109564101(PARK2)

BBUB:

102406619(PRKN)

BBIS:

104986252(PARK2)

CHX:	102172812(PARK2)

OAS:	101113503(PRKN)

BTAX:

128053056(PRKN)

ODA:	120862828(PRKN)

CCAD:

122434169(PRKN)

MBEZ:

129561338(PRKN)

SSC:	733673(PRKN)

CFR:	102508809(PRKN)

CBAI:

105077461

CDK:	105086287(PRKN)

VPC:	102541584(PRKN)

BACU:

103006032(PARK2)

BMUS:

118904941(PRKN)

LVE:	103072488(PARK2)

DLE:	111168498(AGPAT4)

PCAD:

102982022(PRKN)

PSIU:

116763621(PRKN)

NASI:

112401646(PRKN)

ECB:	100057832(PRKN)

EAI:	106842050(PRKN)

MYB:	102255484(PARK2)

MYD:	102757960(PARK2)

MMYO:

118660195(PRKN)

MLF:	102439703(PRKN)

PKL:	118708853(PRKN)

EFUS:

103299829(PRKN)

MNA:	107535732(PARK2)

DRO:

112297296

SHON:

118996188(PRKN)

AJM:	119034893(PRKN)

PDIC:

114490084(PRKN)

PHAS:

123822135(PRKN)

MMF:	118621965(PRKN)

PPAM:

129088228(PRKN)

HAI:

109394305

RFQ:	117020770(PRKN)

PALE:

102888747(PRKN)

PGIG:

120617538(PRKN)

PVP:	105301214(PRKN)

RAY:	107501685(PARK2)

SARA:

101557307(PARK2)

SETR:

125996569(PRKN)

LAV:	100665442(PRKN)

TMU:

101340669

ETF:	101639304(PRKN)

DNM:	101440790(PRKN)

MDO:	100032502(PARK2)

GAS:	123246664(PRKN)

SHR:	100928463(PRKN)

AFZ:

127562395

PCW:	110208624(PRKN)

OAA:	114809162(PRKN)

GGA:	421577(PARK2)

PCOC:

116243219(PRKN)

CJO:	107311526(PRKN)

TPAI:

128080954(PRKN)

LMUT:

125690073(PRKN)

NMEL:

110395954(PRKN)

APLA:

101796091(PRKN)

ACYG:

106039539(PRKN)

CATA:

118244030(PRKN)

AFUL:

116487205(PRKN)

TGU:	100221229(PRKN)

LSR:	110477920(PRKN)

SCAN:

103821619(PRKN)

PMOA:

120506840(PRKN)

OTC:	121335883(PRKN)

PRUF:

121358731(PRKN)

GFR:	102043879(PARK2)

FAB:	101810988(PARK2)

OMA:	130251513(PRKN)

PHI:	102105199(PARK2)

PMAJ:

107202287(PRKN)

CCAE:

111926948(PRKN)

CCW:	104684351(PRKN)

CBRC:

103624193(PARK2)

ETL:	114055652(PRKN)

ZAB:	102067017(PRKN)

SVG:	106852963(PARK2)

MMEA:

130576043(PRKN)

HRT:	120751006(PRKN)

FPG:	101918371(PARK2)

FCH:	102048210(PRKN)

CLV:	102084040(PRKN)

EGZ:	104131677 104132542

NNI:	104018425(PARK2)

PCAO:

104045783(PARK2)

ACUN:

113477882(PRKN)

TALA:

116965931(PRKN)

PADL:

103914151(PARK2)

AFOR:

103907876(PARK2)

ACHC:

115344548(PRKN)

HLE:	104842281(PARK2)

AGEN:

126039051

GCL:

127014119

OHA:	104331772(PARK2)

SHAB:

115613649(PRKN)

DPUB:

104307712(PARK2)

ACAR:

104521538

CPEA:

104390821(PARK2)

AVIT:

104277174(PARK2)

CVF:	104287023(PARK2)

RTD:	128907633(PRKN)

CUCA:

104056488(PARK2)

AAM:	106486766(PARK2)

AROW:

112972874(PRKN)

NPD:	112951949(PRKN)

DNE:	112988992(PRKN)

SCAM:

104152834(PARK2)

ASN:	102381887(PRKN)

AMJ:	102573688(PARK2)

CPOO:

109320057(PARK2)

GGN:	109304408(PARK2)

PSS:	102451562(PRKN)

CMY:	102935998(PRKN)

CCAY:

125633981(PRKN)

DCC:	119852618(PRKN)

CPIC:

101941171(PRKN)

TST:	117874779(PRKN)

CABI:

116832464(PRKN)

MRV:	120400709(PRKN)

ACS:	100559435(park2)

ASAO:

132761113(PRKN)

PVT:	110087285(PRKN)

SUND:

121936318(PRKN)

PBI:

103051791

PMUR:

107295102(PRKN)

CTIG:

120312740

TSR:	106550720(PARK2)

PGUT:

117672071(PRKN)

APRI:

131190781(PRKN)

PTEX:

113439291(PRKN)

NSS:	113417048(PRKN)

VKO:	123019079(PRKN)

PMUA:

114594313(PRKN)

PRAF:

128410723(PRKN)

ZVI:	118081953(PRKN)

HCG:	128344625(PRKN)

GJA:	107113335(PARK2) 107118842

STOW:

125428076(PRKN)

EMC:	129324792(PRKN)

DRE:	550328(prkn)

SRX:

107739476

SANH:

107669573 107696378

SGH:	107586494(park2)

CCAR:

109081461(park2)

CAUA:

113057245(prkn)

CGIB:

127969883

PTET:

122356881(prkn)

LROH:

127175445(prkn)

OMC:	131551991(prkn)

PPRM:

120492274(prkn)

RKG:	130084763(prkn)

MAMB:

125277476(prkn)

CIDE:

127525038

MASI:

127412044 127413705

TROS:

130559188(prkn)

TDW:	130431135(prkn)

MANU:

129416543(prkn)

IPU:	108263700(prkn)

IFU:	128605392(prkn)

PHYP:

113545038(prkn)

SMEO:

124402771(prkn)

TFD:	113644945(prkn)

TVC:	132847114(prkn)

AMEX:

103027813(prkn)

CMAO:

118810201(prkn)

EEE:	113572720(prkn)

CHAR:

105912317(prkn)

TRU:	101073892(prkn)

TFS:	130533547(prkn)

TNG:	GSTEN00025039G001

LCO:	104934697(prkn)

TBEN:

117486002(prkn)

CGOB:

115005371 115005373

GACU:

117533533(prkn)

ELY:	117247857(prkn)

EFO:	125903238(prkn)

SLUC:

116034168(prkn)

ECRA:

117940542(prkn)

PFLV:

114572102(prkn)

GAT:	120820523 120820571(prkn)

PPUG:

119214569(prkn)

AFB:	129092676(prkn) 129116199 129116200

CLUM:

117743657 117744402

MSAM:

119911359(prkn)

SCHU:

122884124(prkn)

CUD:	121511048(prkn)

ALAT:

119033279(prkn)

MZE:	101482320(prkn)

ONL:	100708029(prkn)

OAU:	116317395(prkn)

OLA:	101170614(prkn)

OML:	112162103(prkn)

CSAI:

133463368(prkn)

XMA:	102219281(prkn)

XCO:	114137605 114137879

XHE:	116712912(prkn)

PFOR:

103130874(park2)

PLAI:

106936929(park2)

PMEI:

106909354(park2)

GAF:	122842768(prkn)

PPRL:

129356086

CVG:	107101386(park2)

CTUL:

119791950(prkn)

GMU:	124859578(prkn)

NFU:	107396230(park2)

ALIM:

106531494(park2)

NWH:	119419881(prkn)

MCEP:

125018888(prkN)

CSEM:

103387132(park2)

POV:	109644595(park2)

SSEN:

122781835(prkn)

HHIP:

117775686(prkn)

HSP:	118119285(prkn)

LCF:	108874357(prkn) 108891574

SDU:	111223871(prkn)

SLAL:

111656069(prkn)

XGL:	120796450(prkn)

BPEC:

110168027(prkn)

MALB:

109973015(prkn)

BSPL:

114841811(prkn)

SJO:	128373185(prkn)

SASA:

106576740(park2)

STRU:

115193909(prkn)

OTW:	112252884(prkn)

OMY:	110527247(prkn)

OGO:	124041364(prkn)

ONE:	115135230(prkn)

OKI:	109889838(prkn)

OKE:	118369586(prkn)

SALP:

111951983(prkn)

SNH:	120017907(prkn)

CCLU:

121553251(prkn)

ELS:	105025493(prkn)

SFM:	108942718(prkn)

PKI:	111848830(prkn)

AANG:

118218150(prkn)

LOC:	102693248(park2)

PSPA:

121316301(prkn)

ARUT:

117403298(prkn)

PSEX:

120516635(prkn)

CMK:	103176050(prkn)

CPLA:

122552975(prkn)

HOC:	132819480(prkn)

LERI:

129699537(prkn)

BFO:	118421822 118422731

BBEL:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG10523(park)

DER:

6546488

DSE:

6616405

DSI:	Dsimw501_GD12138(Dsim_GD12138)

DYA:	Dyak_GE22356 Dyak_GE28149

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12208

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ014867

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:	124358001 124370560

MQU:	128985404 128986976

PHU:	Phum_PHUM233570

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_221739

DMK:

116921750

DPZ:

124337026

PVM:	113806358 113825825

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

PTEP:

ABRU:

UDV:	129227433 129227651

SDM:

118182692

LPOL:

106467635

PMEO:

129587444

CEL:	CELE_K08E3.7(pdr-1)

CBR:	CBG_18262(Cbr-pdr-1)

CRQ:	GCK72_010359

NAI:	NECAME_11618

LOA:	LOAG_05984

LGI:	LOTGIDRAFT_107352

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111104077 111104494

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

OSN:	115230822 118767830

LAK:

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114541205 114541208 114541209

XEN:

124443162

HMG:

101237967

HSY:

130645526

TAD:	TRIADDRAFT_26044

AQU:	100634532 109582858

» show all

Reference

PMID:12150907

Authors

Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R

Title

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.

Journal

Mol Cell 10:55-67 (2002)
DOI:10.1016/S1097-2765(02)00583-X

Sequence

[hsa:5071]

Reference

PMID:15105460

Authors

Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM

Title

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.

Journal

Science 304:1328-31 (2004)
DOI:10.1126/science.1093891

Sequence

[hsa:5071] [mmu:50873]

Reference

PMID:9560156

Authors

Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N

Title

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.

Journal

Nature 392:605-8 (1998)
DOI:10.1038/33416

Sequence

[hsa:5071]

LinkDB

DBGET integrated database retrieval system