KEGG ORTHOLOGY: K04650

ORTHOLOGY: K04650

Entry

K04650                      KO

Symbol

NCOR1, N-CoR

Name

nuclear receptor co-repressor 1

Pathway

map01522

Endocrine resistance

map04350

TGF-beta signaling pathway

map04919

Thyroid hormone signaling pathway

map05202

Transcriptional misregulation in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HDAC complexes
    SMART complex
     K04650  NCOR1, N-CoR; nuclear receptor co-repressor 1

Genes

HSA:	9611(NCOR1)

PTR:	468370(NCOR1)

PPS:	100986655(NCOR1)

GGO:	101148051(NCOR1)

PON:	100449226(NCOR1)

NLE:	100598888(NCOR1)

HMH:	116459333(NCOR1)

MCC:	696351(NCOR1)

MCF:	101925549(NCOR1)

MTHB:

126938786

MNI:	105491091(NCOR1)

CSAB:

103242451(NCOR1)

CATY:

105571941(NCOR1)

PANU:

101004642(NCOR1)

TGE:	112609887(NCOR1)

MLEU:

105536022(NCOR1)

RRO:	104681440(NCOR1)

RBB:	108522162(NCOR1)

TFN:	117066416(NCOR1)

PTEH:

111526448(NCOR1)

CANG:

105523186(NCOR1)

CJC:	100414861(NCOR1)

SBQ:	101045587(NCOR1)

CIMI:

108281319(NCOR1)

CSYR:

103264905(NCOR1)

MMUR:

105856305(NCOR1)

LCAT:

123650565(NCOR1)

PCOQ:

105816094(NCOR1)

OGA:	100945051(NCOR1)

MMU:	20185(Ncor1)

MCAL:

110305303(Ncor1)

MPAH:

110331333(Ncor1)

RNO:	54299(Ncor1)

MCOC:

116078675(Ncor1)

ANU:	117712009(Ncor1)

MUN:	110549803(Ncor1)

CGE:	100760832(Ncor1)

MAUA:

101826693(Ncor1)

PROB:

127219150(Ncor1)

PLEU:

114682964(Ncor1)

MORG:

121456049(Ncor1)

MFOT:

126514638

AAMP:

119811147(Ncor1)

NGI:	103726371(Ncor1)

HGL:	101715929(Ncor1)

CPOC:

100722145(Ncor1)

CCAN:

109699495(Ncor1)

DORD:

105985720(Ncor1)

DSP:	122101531(Ncor1)

PLOP:

125366192(Ncor1)

NCAR:

124980870

MMMA:

107160165(Ncor1)

OCU:

100354310

OPI:	101517215(NCOR1)

TUP:	102486196(NCOR1)

GVR:	103588966(NCOR1)

CFA:	479515(NCOR1)

CLUD:

112647292(NCOR1)

VVP:	112924930(NCOR1)

VLG:	121499503(NCOR1)

NPO:	129496983(NCOR1)

AML:	100482935(NCOR1)

UMR:	103658515(NCOR1)

UAH:	113271257(NCOR1)

UAR:	123779776(NCOR1)

ELK:

111139473

LLV:

125088135

MPUF:

101677398(NCOR1)

MNP:	132004324(NCOR1)

MLK:	131816856(NCOR1)

NVS:	122906796(NCOR1)

ORO:	101372646(NCOR1)

EJU:	114198174(NCOR1)

ZCA:	113939419(NCOR1)

MLX:	118000110(NCOR1)

NSU:	110584532(NCOR1)

LWW:	102730957(NCOR1)

FCA:	101095293(NCOR1)

PYU:	121015844(NCOR1)

PCOO:

112857128(NCOR1)

PBG:	122485002(NCOR1)

PVIV:

125151670(NCOR1)

LRUF:

124519628

PTG:	102951947(NCOR1)

PPAD:

109245811(NCOR1)

PUC:

125927560

AJU:

106981419

HHV:	120228749(NCOR1)

BTA:	507663(NCOR1)

BOM:	102267545(NCOR1)

BIU:	109573398(NCOR1)

BBUB:

102399672(NCOR1)

BBIS:

104990686(NCOR1)

CHX:	102188080(NCOR1)

OAS:	101117774(NCOR1)

BTAX:

128065518(NCOR1)

ODA:	120867419(NCOR1)

CCAD:

122444633(NCOR1)

MBEZ:

129544181(NCOR1)

SSC:	100628075(NCOR1)

CFR:	102518187(NCOR1)

CBAI:

105084036

CDK:	105085104(NCOR1)

VPC:	102544280(NCOR1)

BACU:

102997482(NCOR1)

BMUS:

118886152(NCOR1)

LVE:	103077563(NCOR1)

OOR:	101286859(NCOR1)

DLE:	111167742(NCOR1)

PCAD:

102986914(NCOR1)

PSIU:

116745439(NCOR1)

NASI:

112405125(NCOR1)

ECB:	100063285(NCOR1)

EPZ:	103560478(NCOR1)

EAI:	106838856(NCOR1)

MYB:	102249238(NCOR1)

MYD:	102765108(NCOR1)

MMYO:

118649372(NCOR1)

MLF:	102433303(NCOR1)

PKL:	118704686(NCOR1)

EFUS:

103299374(NCOR1)

MNA:	107524503(NCOR1)

DRO:	112308471(NCOR1)

SHON:

119002794(NCOR1)

AJM:	119064403(NCOR1)

PDIC:

114514979(NCOR1)

PHAS:

123809294(NCOR1)

MMF:	118641237(NCOR1)

PPAM:

129068777(NCOR1)

HAI:

109382177

RFQ:	117013482(NCOR1)

PALE:

102894128(NCOR1)

PGIG:

120589812(NCOR1)

PVP:	105291301(NCOR1)

RAY:	107511056(NCOR1)

MJV:	108403991(NCOR1)

TOD:	119232474(NCOR1)

SARA:

101544545(NCOR1)

SETR:

126013630(NCOR1)

LAV:	100669709(NCOR1)

TMU:

101359018

ETF:	101650558(NCOR1)

DNM:	101440444(NCOR1)

MDO:	100014037(NCOR1)

GAS:	123244498(NCOR1)

SHR:	100914315(NCOR1)

AFZ:

127558772

PCW:	110222197(NCOR1)

OAA:	100076684(NCOR1)

GGA:	417598(NCOR1)

PCOC:

116228014(NCOR1)

CJO:	107322409(NCOR1)

TPAI:

128083585(NCOR1)

LMUT:

125703130(NCOR1)

NMEL:

110407628(NCOR1)

APLA:

101799868(NCOR1)

ACYG:

106045767(NCOR1)

CATA:

118255060(NCOR1)

AFUL:

116497161(NCOR1)

TGU:	100230035(NCOR1)

LSR:	110467691(NCOR1)

SCAN:

103820146(NCOR1)

PMOA:

120507608(NCOR1)

OTC:	121345882(NCOR1)

PRUF:

121361828(NCOR1)

GFR:	102041117(NCOR1)

FAB:	101806968(NCOR1)

OMA:	130261098(NCOR1)

PHI:	102107181(NCOR1)

PMAJ:

107212775(NCOR1)

CCAE:

111937795(NCOR1)

CCW:	104691036(NCOR1)

CBRC:

103613351(NCOR1)

ETL:	114061257(NCOR1)

ZAB:	102070856(NCOR1)

ACHL:

103810667(NCOR1)

SVG:	106853304(NCOR1)

MMEA:

130576948(NCOR1)

HRT:	120761378(NCOR1)

FPG:	101912637(NCOR1)

FCH:	102047526(NCOR1)

CLV:	102095752(NCOR1)

EGZ:	104121909(NCOR1)

NNI:	104012186(NCOR1)

PCRI:

104038847(NCOR1)

PLET:

104624517(NCOR1)

EHS:	104503188(NCOR1)

PCAO:

104041571(NCOR1)

ACUN:

113487111(NCOR1)

TALA:

104366679(NCOR1)

PADL:

103920797(NCOR1)

AFOR:

103897993(NCOR1)

ACHC:

115346860(NCOR1)

HALD:

104313502(NCOR1)

HLE:	104835615(NCOR1)

AGEN:

126039974

GCL:

127024558

CCRI:

104157148 104168474(NCOR1)

CSTI:

104553770(NCOR1)

CMAC:

104477702(NCOR1)

MUI:	104548286(NCOR1)

BREG:

104633505(NCOR1)

FGA:	104080822(NCOR1)

GSTE:

104262055

LDI:	104350368(NCOR1)

MNB:	103772761(NCOR1)

OHA:	104339609(NCOR1)

NNT:	104413354(NCOR1)

SHAB:

115601986(NCOR1)

DPUB:

104302737(NCOR1)

PGUU:

104458302(NCOR1)

ACAR:

104531039(NCOR1)

CPEA:

104398928(NCOR1)

AVIT:

104277519(NCOR1)

CVF:	104284385(NCOR1)

RTD:	128912791(NCOR1)

CUCA:

104057146(NCOR1)

TEO:	104372685(NCOR1)

BRHI:

104493976

AAM:	106493755(NCOR1)

AROW:

112960662(NCOR1)

NPD:	112945402(NCOR1)

TGT:	104572414(NCOR1)

DNE:	112983933(NCOR1)

SCAM:

104142802(NCOR1)

ASN:	102368392(NCOR1)

AMJ:	102560876(NCOR1)

CPOO:

109317217(NCOR1)

GGN:	109293346(NCOR1)

PSS:	102448548(NCOR1)

CMY:	102936803(NCOR1)

CCAY:

125623766(NCOR1)

DCC:	119844863(NCOR1)

CPIC:

101947868(NCOR1)

TST:	117867368(NCOR1)

CABI:

116827065(NCOR1)

MRV:	120387230(NCOR1)

ASAO:

132763407(NCOR1)

PVT:	110087388(NCOR1)

SUND:

121916935

PBI:	103050724(NCOR1)

CTIG:

120298012

APRI:

131188618(NCOR1)

VKO:	123023577(NCOR1)

PMUA:

114585390(NCOR1)

PRAF:

128403037(NCOR1)

ZVI:	118097120(NCOR1)

HCG:	128335929 128335990(NCOR1)

GJA:	107119554(NCOR1)

STOW:

125445572(NCOR1)

EMC:	129344712(NCOR1)

XLA:	108707936(ncor1.L) 398304(ncor1.S)

XTR:	613105(ncor1)

RTEM:

120927735(NCOR1)

BBUF:

120994647(NCOR1)

BGAR:

122930392(NCOR1)

MUO:

115482561

GSH:	117349079(NCOR1)

DRE:	393246(ncor1)

SRX:	107718342 107746860

SANH:

107676644 107680951

SGH:	107552540 107553567

CCAR:

109072913

CAUA:

113049164 113078317

CGIB:

127957976 128001428

PTET:

122345890(ncor1)

LROH:

127165355(ncor1)

OMC:	131540221(ncor1)

PPRM:

120461860(ncor1)

RKG:	130103744(ncor1)

MAMB:

125267039(ncor1)

CIDE:

127513640

MASI:

127427329 127440151

TROS:

130568302(ncor1)

TDW:	130419452(ncor1)

MANU:

129440582(ncor1)

IPU:

108259869

IFU:	128603467(ncor1)

PHYP:

113531303

SMEO:

124379082(ncor1)

TFD:	113634166(ncor1)

TVC:	132840833(ncor1)

AMEX:

103035566(ncor1)

CMAO:

118814788(ncor1)

EEE:	113589990(ncor1)

CHAR:

105909628(ncor1)

TRU:	101063896(ncor1)

TFS:	130537122(ncor1)

TNG:	GSTEN00016242G001

LCO:	104923453(ncor1)

TBEN:

117470084(ncor1)

CGOB:

115018735(ncor1)

PGEO:

117459004(ncor1)

GACU:

117557262(ncor1)

EMAC:

134872549(ncor1)

ELY:	117264003(ncor1)

EFO:	125897938(ncor1)

SLUC:

116058133(ncor1)

ECRA:

117955530(ncor1)

ESP:	116700543(ncor1)

PFLV:

114567299(ncor1)

GAT:	120821509(ncor1)

PPUG:

119215038(ncor1)

AFB:	129113981(ncor1)

CLUM:

117742402(ncor1)

PSWI:

130210189(ncor1)

MSAM:

119895296(ncor1)

SCHU:

122888109(ncor1)

CUD:	121518578(ncor1)

ALAT:

119031690(ncor1)

MZE:	101469949(ncor1)

ONL:	100702761(ncor1)

OAU:	116331907(ncor1)

OLA:	105355657(ncor1)

OML:	112141765(ncor1)

CSAI:

133459794(ncor1)

XMA:	102229406(ncor1)

XCO:	114152811(ncor1)

XHE:	116728177(ncor1)

PRET:

103476039(ncor1)

PFOR:

103133864(ncor1)

PLAI:

106936213(ncor1) 106949390

PMEI:

106919386 106933197(ncor1)

GAF:	122845197(ncor1)

PPRL:

129368495(ncor1)

CVG:	107091737(ncor1)

CTUL:

119791478(ncor1)

GMU:	124876501(ncor1)

NFU:	107386639(ncor1)

KMR:	108233829(ncor1)

ALIM:

106525394(ncor1)

NWH:	119420621(ncor1)

AOCE:

111575203(ncor1)

MCEP:

125020932(ncor1)

CSEM:

103394907(ncor1)

POV:	109628545(ncor1)

SSEN:

122779631(ncor1)

HHIP:

117774017(ncor1)

HSP:	118122220(ncor1)

SMAU:

118301164(ncor1)

LCF:

108893218

SDU:	111222173(ncor1)

SLAL:

111663916(ncor1)

XGL:	120802100(ncor1)

HCQ:	109531079(ncor1)

SSCV:

125982627

SBIA:

133491480(ncor1)

PEE:	133416511(ncor1)

PTAO:

133467544(ncor1)

BPEC:

110165109(ncor1)

MALB:

109960446(ncor1)

BSPL:

114870063(ncor1)

SJO:	128370848(ncor1)

SASA:

106567980(ncor1)

STRU:

115148853 115154316

OTW:	112257859(ncor1)

OMY:	110533631 110537494(ncor1)

OGO:	123998600(ncor1) 124010745

ONE:	115105527 115135922

OKI:	109872630 109892751

OKE:	118390072 118391154(ncor1)

SALP:

111980519

SNH:	120030268(ncor1) 120057057

CCLU:

121574537 121579440

ELS:	105027552(ncor1)

SFM:	108936158(ncor1)

PKI:	111854760(ncor1)

AANG:

118210117 118235368(ncor1)

LOC:	107079901(ncor1)

PSPA:

121308430(ncor1)

ARUT:

117429646(ncor1) 117430661

PSEX:

120531551(ncor1)

LCM:	102367610(NCOR1)

CPLA:

122561486(ncor1)

HOC:	132830454(ncor1)

LERI:

129710503(ncor1)

PMRN:

116950239

LRJ:	133348764(NCOR1)

BFO:

BBEL:

CIN:

SCLV:

DME:	Dmel_CG4013(Smr)

DER:

6551120

DSE:

6618589

DSI:	Dsimw501_GD15920(Dsim_GD15920)

DYA:	Dyak_GE16202

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI14696

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:

MDE:	101893260 109612913

SCAC:

LCQ:

LSQ:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ002505 CpipJ_CPIJ002507

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114876882 114877066

OLG:

MGEN:

NMEA:

CGIG:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

SOY:

CSET:

AGB:

LDC:

APLN:

PPYR:

OTU:

HHAL:

NLU:

FOC:

TPAL:

CSEC:

DMK:

DPZ:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

PPOI:

DSV:

RSAN:

RMP:

SDM:

GAE:

HRF:

HRJ:

CRG:

PMAX:

MMER:

OSN:

SMM:	Smp_163290

HMG:

101236675

TAD:	TRIADDRAFT_61318

» show all

Reference

PMID:9724795

Authors

Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM

Title

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.

Journal

Proc Natl Acad Sci U S A 95:10860-5 (1998)
DOI:10.1073/pnas.95.18.10860

Sequence

[hsa:9611]

Reference

PMID:21049000

Authors

Hayakawa T, Nakayama J

Title

Physiological roles of class I HDAC complex and histone demethylase.

Journal

J Biomed Biotechnol 2011:129383 (2011)
DOI:10.1155/2011/129383

LinkDB

DBGET integrated database retrieval system