KEGG   ORTHOLOGY: K04674Help
Entry
K04674                      KO                                     

Name
TGFBR1, ALK5
Definition
TGF-beta receptor type-1 [EC:2.7.11.30]
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04380  Osteoclast differentiation
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00018  Gastric cancer
H00800  Loeys-Dietz syndrome
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04350 TGF-beta signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04390 Hippo signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04371 Apelin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04068 FoxO signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09143 Cell growth and death
   04218 Cellular senescence
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05212 Pancreatic cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05225 Hepatocellular carcinoma
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05226 Gastric cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05220 Chronic myeloid leukemia
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05161 Hepatitis B
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR1 family [OT]
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
BRITE hierarchy
Other DBs
GO: 0005025
Genes
HSA: 7046(TGFBR1)
PTR: 472992(TGFBR1)
PPS: 100984463(TGFBR1)
GGO: 101128510(TGFBR1)
PON: 100450864(TGFBR1)
NLE: 100592854(TGFBR1)
MCC: 714952(TGFBR1)
MCF: 102115287(TGFBR1)
CSAB: 103219139(TGFBR1)
RRO: 104657765(TGFBR1)
RBB: 108512466(TGFBR1)
CJC: 100389596(TGFBR1)
SBQ: 101030583(TGFBR1)
MMU: 21812(Tgfbr1)
MCAL: 110292408(Tgfbr1)
MPAH: 110322784(Tgfbr1)
RNO: 29591(Tgfbr1)
MUN: 110551136(Tgfbr1)
CGE: 100772727(Tgfbr1)
NGI: 103744902(Tgfbr1)
HGL: 101718090(Tgfbr1)
CCAN: 109691424(Tgfbr1)
OCU: 100345812(TGFBR1)
TUP: 102476700(TGFBR1)
CFA: 481628(TGFBR1)
VVP: 112930794(TGFBR1)
AML: 100475698(TGFBR1)
UMR: 103678627(TGFBR1)
UAH: 113260405(TGFBR1)
ORO: 101379465(TGFBR1)
ELK: 111146071
FCA: 101094057(TGFBR1)
PTG: 102950020(TGFBR1)
PPAD: 109270084(TGFBR1)
AJU: 106972043(TGFBR1)
BTA: 282382(TGFBR1)
BOM: 102283685(TGFBR1)
BIU: 109563078(TGFBR1)
BBUB: 102396812(TGFBR1)
CHX: 102187767(TGFBR1)
OAS: 554326(TGFBR1)
SSC: 396665(TGFBR1)
CFR: 102522485(TGFBR1)
CDK: 105086891(TGFBR1)
BACU: 102999446(TGFBR1)
LVE: 103071954(TGFBR1)
OOR: 101287555(TGFBR1)
DLE: 111188083(TGFBR1)
PCAD: 102978050(TGFBR1)
ECB: 100034117(TGFBR1)
EPZ: 103555266(TGFBR1)
EAI: 106842924(TGFBR1)
MYB: 102241353(TGFBR1)
MYD: 102765185(TGFBR1)
MNA: 107544970(TGFBR1)
HAI: 109386421(TGFBR1)
DRO: 112304528(TGFBR1)
PALE: 102880759(TGFBR1)
RAY: 107500589(TGFBR1)
MJV: 108394148(TGFBR1)
LAV: 100656286(TGFBR1)
TMU: 101359953
MDO: 100011507(TGFBR1)
SHR: 100913844(TGFBR1)
PCW: 110214564(TGFBR1)
OAA: 100092358(TGFBR1)
GGA: 374094(TGFBR1)
MGP: 100543917(TGFBR1)
CJO: 107309773(TGFBR1)
NMEL: 110394489(TGFBR1)
APLA: 101805328(TGFBR1)
ACYG: 106038346(TGFBR1)
TGU: 100230911(TGFBR1)
LSR: 110483463(TGFBR1)
SCAN: 103819385(TGFBR1)
GFR: 102037879(TGFBR1)
FAB: 101809241(TGFBR1)
PHI: 102113190(TGFBR1)
PMAJ: 107200568(TGFBR1)
CCW: 104688870(TGFBR1)
ETL: 114063815(TGFBR1)
FPG: 101922518(TGFBR1)
FCH: 102055038(TGFBR1)
CLV: 102095465(TGFBR1)
EGZ: 104125437(TGFBR1)
NNI: 104021869(TGFBR1)
ACUN: 113476683(TGFBR1)
PADL: 103917369(TGFBR1)
AAM: 106491015(TGFBR1)
ASN: 102370778(TGFBR1)
AMJ: 102568992(TGFBR1)
CMY: 102942001(TGFBR1)
CPIC: 101944287(TGFBR1)
ACS: 100566944(tgfbr1)
PVT: 110086076(TGFBR1)
TSR: 106538373(TGFBR1)
PMUA: 114608061(TGFBR1)
GJA: 107109116(TGFBR1)
XLA: 108719029 399295(tgfbr1.S)
XTR: 548715(tgfbr1)
NPR: 108799247(TGFBR1)
DRE: 560578(tgfbr1a) 792928(tgfbr1b)
IPU: 108271704(tgfbr1)
PHYP: 113526975(tgfbr1)
AMEX: 103034175
EEE: 113590741(tgfbr1)
TRU: 101062282 101078818(acvr1c)
LCO: 104920074(acvr1c) 104931778
NCC: 104964102
MZE: 101479229
ONL: 100695177
XMA: 102222719
XCO: 114149782
PRET: 103482409
CVG: 107100676
NFU: 107374334
KMR: 108248259
ALIM: 106519000
AOCE: 111569578
CSEM: 103376883
POV: 109638437
LCF: 108898453
SDU: 111220510
SLAL: 111673055
HCQ: 109530275
BPEC: 110165570
MALB: 109965533
LCM: 102350402(TGFBR1)
CMK: 103181552
RTP: 109921531
CIN: 445775(tgfbr-ic)
APLC: 110989541
SKO: 100370253
DME: Dmel_CG8224(babo)
DER: 6540765
DSI: Dsimw501_GD10620(Dsim_GD10620)
DMN: 108159966
DWI: 6646288
DAZ: 108616748
DNV: 108653174
DHE: 111597654
MDE: 101895175
LCQ: 111691242
AAG: 5572069
AALB: 109415848
AME: 550930
BIM: 100740693
BTER: 100643263
CCAL: 108632574
OBB: 114880795
SOC: 105193383
MPHA: 105834262
AEC: 105149442
ACEP: 105627280
PBAR: 105427063
VEM: 105567251
HST: 105191563
DQU: 106742458
CFO: 105256068
LHU: 105676036
PGC: 109857803
OBO: 105287968
PCF: 106793854
NVI: 100114832
CSOL: 105367453
MDL: 103576842
TCA: 659969(babo)
DPA: 109542240
ATD: 109596445
NVL: 108562386
BMOR: 101742113
BMAN: 114250041
PMAC: 106717233
PRAP: 110998149
HAW: 110374498
TNL: 113505189
PXY: 105398137
API: 100164283
DNX: 107173148
AGS: 114125547
RMD: 113550486
BTAB: 109044670
CLEC: 106673837
ZNE: 110839262
FCD: 110842324
DPX: DAPPUDRAFT_347223(BABO)
PVM: 113807067
TUT: 107367555
DPTE: 113797156
BMY: Bm1_44900
PCAN: 112562162
CRG: 105318607
MYI: 110458522
OBI: 106868204
LAK: 106153365
SHX: MS3_01247
EGL: EGR_06011
AMIL: 114966404
PDAM: 113673055
HMG: 100212672
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8242743
  Authors
Franzen P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin CH, Miyazono K
  Title
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
  Journal
Cell 75:681-92 (1993)
DOI:10.1016/0092-8674(93)90489-D
  Sequence
[hsa:7046]
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