KEGG   ORTHOLOGY: K04692Help
Entry
K04692                      KO                                     

Name
STAT3
Definition
signal transducer and activator of transcription 3
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04062  Chemokine signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04217  Necroptosis
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04630  JAK-STAT signaling pathway
ko04659  Th17 cell differentiation
ko04917  Prolactin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04931  Insulin resistance
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05145  Toxoplasmosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05212  Pancreatic cancer
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05321  Inflammatory bowel disease (IBD)
Disease
H00016  Oral cancer
H00107  Other well-defined immunodeficiency syndromes
H01968  Hyper-IgE syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04066 HIF-1 signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04068 FoxO signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04692  STAT3; signal transducer and activator of transcription 3
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04692  STAT3; signal transducer and activator of transcription 3
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04692  STAT3; signal transducer and activator of transcription 3
   04062 Chemokine signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
   04917 Prolactin signaling pathway
    K04692  STAT3; signal transducer and activator of transcription 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05206 MicroRNAs in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05205 Proteoglycans in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05203 Viral carcinogenesis
    K04692  STAT3; signal transducer and activator of transcription 3
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04692  STAT3; signal transducer and activator of transcription 3
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K04692  STAT3; signal transducer and activator of transcription 3
   05221 Acute myeloid leukemia
    K04692  STAT3; signal transducer and activator of transcription 3
   05223 Non-small cell lung cancer
    K04692  STAT3; signal transducer and activator of transcription 3
  09163 Immune disease
   05321 Inflammatory bowel disease (IBD)
    K04692  STAT3; signal transducer and activator of transcription 3
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K04692  STAT3; signal transducer and activator of transcription 3
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04692  STAT3; signal transducer and activator of transcription 3
  09172 Infectious disease: viral
   05162 Measles
    K04692  STAT3; signal transducer and activator of transcription 3
   05161 Hepatitis B
    K04692  STAT3; signal transducer and activator of transcription 3
   05160 Hepatitis C
    K04692  STAT3; signal transducer and activator of transcription 3
   05163 Human cytomegalovirus infection
    K04692  STAT3; signal transducer and activator of transcription 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04692  STAT3; signal transducer and activator of transcription 3
   05169 Epstein-Barr virus infection
    K04692  STAT3; signal transducer and activator of transcription 3
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04692  STAT3; signal transducer and activator of transcription 3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04692  STAT3; signal transducer and activator of transcription 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04692  STAT3; signal transducer and activator of transcription 3
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   STAT
    K04692  STAT3; signal transducer and activator of transcription 3
BRITE hierarchy
Genes
HSA: 6774(STAT3)
PTR: 454682(STAT3)
PPS: 100987766(STAT3)
GGO: 101135038(STAT3)
PON: 100171541(STAT3)
NLE: 100598877(STAT3)
MCC: 574128(STAT3)
MCF: 102118402(STAT3)
CSAB: 103243410(STAT3)
RRO: 104680286(STAT3)
RBB: 108518318(STAT3)
CJC: 100389282(STAT3)
SBQ: 101049662(STAT3)
MMU: 20848(Stat3)
MCAL: 110306201(Stat3)
MPAH: 110332765(Stat3)
RNO: 25125(Stat3)
MUN: 110550916(Stat3)
CGE: 100755865(Stat3)
NGI: 103735896(Stat3)
HGL: 101721899(Stat3)
CCAN: 109687324(Stat3)
OCU: 100348778(STAT3)
TUP: 102492738(STAT3)
CFA: 490967(STAT3)
VVP: 112910741(STAT3)
AML: 100469938(STAT3)
UMR: 103672573(STAT3)
UAH: 113265422(STAT3)
ORO: 101373587(STAT3)
FCA: 101095698(STAT3)
PTG: 102957987(STAT3)
AJU: 106972608(STAT3)
BTA: 508541(STAT3)
BOM: 102282282(STAT3)
BIU: 109573817(STAT3)
BBUB: 102414888(STAT3)
PHD: 102339359(STAT3)
CHX: 102186154(STAT3)
OAS: 100294659(STAT3)
SSC: 733648(STAT3)
CFR: 102520228(STAT3)
CDK: 105090458(STAT3)
BACU: 102997405 103008157(STAT3)
LVE: 103086495(STAT3)
OOR: 101281369(STAT3)
DLE: 111166491(STAT3)
PCAD: 102976764(STAT3) 114486106
ECB: 100034011(STAT3)
EPZ: 103550364(STAT3)
EAI: 106826327(STAT3)
MYB: 102239853(STAT3)
MYD: 102752037(STAT3)
MNA: 107528938(STAT3)
HAI: 109395763(STAT3)
RSS: 109455843(STAT3)
DRO: 112298562(STAT3)
PALE: 102884374(STAT3)
RAY: 107513823(STAT3)
LAV: 100669583(STAT3)
TMU: 101342651
MDO: 100011382(STAT3)
SHR: 100933581(STAT3)
PCW: 110198372(STAT3)
OAA: 100087932(STAT3)
GGA: 420027(STAT3)
MGP: 100547142(STAT3)
CJO: 107325206(STAT3)
NMEL: 110388615(STAT3)
APLA: 101790010(STAT3)
ACYG: 106048026(STAT3)
TGU: 100219856(STAT3)
LSR: 110471842(STAT3)
SCAN: 103821588(STAT3)
GFR: 102036392(STAT3)
FAB: 101809631(STAT3)
PHI: 102101801(STAT3)
PMAJ: 107215123(STAT3)
CCAE: 111939944(STAT3)
CCW: 104697761(STAT3)
ETL: 114063626(STAT3)
FPG: 101917971(STAT3)
FCH: 102053408(STAT3)
CLV: 102090191(STAT3)
EGZ: 104134824(STAT3)
NNI: 104009927(STAT3)
ACUN: 113489073(STAT3)
PADL: 103920524(STAT3)
AAM: 106491102(STAT3)
ASN: 102381312(STAT3)
AMJ: 102575901(STAT3)
PSS: 102460388(STAT3)
CMY: 102932633(STAT3)
CPIC: 101952372(STAT3)
ACS: 100566559(stat3)
PVT: 110074829(STAT3)
PBI: 103059982(STAT3)
PMUR: 107282651(STAT3)
GJA: 107111493(STAT3)
XLA: 108702168 108702458 379264(stat3.2.L) 779100(stat3.1.L)
XTR: 100498278(stat3.1) 100498547(stat3.2)
NPR: 108792989(STAT3)
DRE: 30767(stat3)
SGH: 107560746(stat3) 107567623
IPU: 100304658(stat3) 108272207
PHYP: 113528081(stat3) 113545874
AMEX: 103033344(stat3)
EEE: 113589971(stat3) 113591794
TRU: 101070968(stat3)
LCO: 104925957(stat3)
MZE: 101479682 101480689(stat3)
OLA: 100049477(stat3)
XMA: 102226045(stat3) 102236235
XCO: 114135114 114160261(stat3)
PRET: 103469403(stat3)
NFU: 107378443(stat3)
KMR: 108243798(stat3)
AOCE: 111576401(stat3)
CSEM: 103385958 103393170(stat3)
POV: 109634199(stat3)
LCF: 108901193(stat3)
SDU: 111217480(stat3)
HCQ: 109513792(stat3)
BPEC: 110159498(stat3)
MALB: 109964187(stat3)
ELS: 105013350(stat3)
PKI: 111842512(stat3) 111856019
LCM: 102365345(STAT3)
CMK: 103189176(stat3)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tsai YT, Su YH, Fang SS, Huang TN, Qiu Y, Jou YS, Shih HM, Kung HJ, Chen RH
  Title
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
  Journal
Mol Cell Biol 20:2043-54 (2000)
DOI:10.1128/MCB.20.6.2043-2054.2000
  Sequence
[hsa:6774]
Reference
PMID:7512451
  Authors
Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T
  Title
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
  Journal
Cell 77:63-71 (1994)
DOI:10.1016/0092-8674(94)90235-6
  Sequence
[hsa:6774]
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