KEGG   ORTHOLOGY: K04696Help
Entry
K04696                      KO                                     

Name
SOCS3, CIS3
Definition
suppressor of cytokine signaling 3
Pathway
ko04120  Ubiquitin mediated proteolysis
ko04380  Osteoclast differentiation
ko04630  JAK-STAT signaling pathway
ko04668  TNF signaling pathway
ko04910  Insulin signaling pathway
ko04917  Prolactin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04935  Growth hormone synthesis, secretion and action
ko05160  Hepatitis C
ko05164  Influenza A
ko05168  Herpes simplex virus 1 infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04668 TNF signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04920 Adipocytokine signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04917 Prolactin signaling pathway
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04935 Growth hormone synthesis, secretion and action
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   04931 Insulin resistance
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
  09172 Infectious disease: viral
   05164 Influenza A
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   05160 Hepatitis C
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
   05168 Herpes simplex virus 1 infection
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   ECS complex
    Target recognizing subunit (SOCS box)
     K04696  SOCS3, CIS3; suppressor of cytokine signaling 3
BRITE hierarchy
Genes
HSA: 9021(SOCS3)
PTR: 454921(SOCS3)
PPS: 100978589(SOCS3)
GGO: 101123839(SOCS3)
PON: 100446544(SOCS3)
NLE: 115838359(SOCS3)
MCC: 715680(SOCS3)
MCF: 102121569(SOCS3)
CSAB: 103243658(SOCS3)
RRO: 104677022(SOCS3)
RBB: 108517203(SOCS3)
CJC: 100398838(SOCS3)
SBQ: 101046533(SOCS3)
MMU: 12702(Socs3)
MCAL: 110304930(Socs3)
MPAH: 110332146(Socs3)
RNO: 89829(Socs3)
MUN: 110550317(Socs3)
CGE: 100769267(Socs3)
NGI: 103747288(Socs3)
HGL: 101704157(Socs3)
CCAN: 109683139(Socs3)
OCU: 103346588(SOCS3)
TUP: 102486692(SOCS3)
CFA: 442949(SOCS3)
VVP: 112920856(SOCS3)
AML: 100475555(SOCS3)
UMR: 103665967(SOCS3)
UAH: 113244564(SOCS3)
ORO: 101364487(SOCS3)
ELK: 111160348
FCA: 101081846(SOCS3)
PPAD: 109276855(SOCS3)
AJU: 113597026(SOCS3)
BTA: 282081(SOCS3)
BOM: 102273017(SOCS3)
BIU: 109574319(SOCS3)
BBUB: 102397559(SOCS3)
CHX: 102187711(SOCS3)
OAS: 100294595(SOCS3)
SSC: 493186(SOCS3)
CFR: 102518913(SOCS3)
CDK: 105092151(SOCS3)
BACU: 103013097(SOCS3)
LVE: 103071774(SOCS3)
OOR: 101284843(SOCS3)
DLE: 111182757(SOCS3)
PCAD: 102978137(SOCS3)
ECB: 100050730(SOCS3)
EPZ: 103554055(SOCS3)
EAI: 106845267(SOCS3)
MYB: 102252296(SOCS3)
MYD: 102763837(SOCS3)
MNA: 107532035(SOCS3)
HAI: 109383617(SOCS3)
DRO: 112298802(SOCS3)
PALE: 102887834(SOCS3)
RAY: 107510063(SOCS3)
MJV: 108407802(SOCS3)
LAV: 100670741(SOCS3)
TMU: 101348420
MDO: 100026656(SOCS3)
SHR: 100934360(SOCS3)
PCW: 110193931(SOCS3)
OAA: 100090302(SOCS3)
GGA: 395299(SOCS3)
MGP: 100547594(SOCS3)
CJO: 107322171(SOCS3)
NMEL: 110407470(SOCS3)
APLA: 101791200(SOCS3)
ACYG: 106046730(SOCS3)
TGU: 100227853(SOCS3)
LSR: 110472448(SOCS3)
SCAN: 103819738(SOCS3)
GFR: 102044994(SOCS3)
FAB: 101810199(SOCS3)
PHI: 102107383(SOCS3)
PMAJ: 107212347(SOCS3)
CCAE: 111937481(SOCS3)
ETL: 114060367(SOCS3)
FPG: 101912299(SOCS3)
FCH: 102058593(SOCS3)
CLV: 102085285(SOCS3)
NNI: 104018614(SOCS3)
PADL: 103917410(SOCS3)
AAM: 106487124(SOCS3)
ASN: 102386715(SOCS3)
AMJ: 102568555(SOCS3) 102570761
PSS: 102446993(SOCS3)
CMY: 102930798(SOCS3)
CPIC: 101947835 101953847(SOCS3)
ACS: 100560082 100564374(socs3)
PVT: 110078594 110090429(SOCS3)
PBI: 103057222 103064119(SOCS3)
TSR: 106538404 106538465(SOCS3)
GJA: 107113150 107115315(SOCS3)
XLA: 100158303 108696746 380467(socs3.S) 414533(socs3.L)
XTR: 394588(socs3) 448204(socs3)
NPR: 108801343 108801441(SOCS3)
DRE: 406596(socs3b)
IPU: 100528984(socs3) 108274104
EEE: 113571447(socs3) 113577679
TRU: 778006(socs3)
MZE: 101468895(socs3) 101479458
ONL: 100702554(socs3) 100704232
OLA: 101170518(socs3) 101170961(socs3)
PRET: 103461355 103481519(socs3)
CVG: 107083123 107089248(socs3)
NFU: 107387732(socs3)
KMR: 108241253 108246316(socs3)
AOCE: 111564669(socs3) 111582347
CSEM: 103381769 103392817(socs3)
POV: 109633948(socs3) 109647155
LCF: 108876107 108902726(socs3)
SLAL: 111657717(socs3) 111673508
HCQ: 109519371(socs3) 109527547
MALB: 109963083 109972264(socs3)
PKI: 111848391(socs3) 111853173
LCM: 102346594(SOCS3) 102360670
CMK: 103175554(socs3)
RTP: 109912889(socs3)
ADF: 107353946
AMIL: 114961722
PDAM: 113666772
SPIS: 111325619
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Dey BR, Furlanetto RW, Nissley P
  Title
Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.
  Journal
Biochem Biophys Res Commun 278:38-43 (2000)
DOI:10.1006/bbrc.2000.3762
  Sequence
[hsa:9021]
Reference
  Authors
Rui L, Yuan M, Frantz D, Shoelson S, White MF.
  Title
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.
  Journal
J Biol Chem 277:42394-8 (2002)
DOI:10.1074/jbc.C200444200
  Sequence
[hsa:9021] [mmu:12702]
Reference
PMID:9266833
  Authors
Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T
  Title
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
  Journal
Biochem Biophys Res Commun 237:79-83 (1997)
DOI:10.1006/bbrc.1997.7080
  Sequence
[hsa:9021]
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