KEGG   ORTHOLOGY: K04849
Entry
K04849                      KO                                     

Name
CACNA1B, CAV2.2
Definition
voltage-dependent calcium channel N type alpha-1B
Pathway
ko04010  MAPK signaling pathway
ko04020  Calcium signaling pathway
ko04721  Synaptic vesicle cycle
ko04723  Retrograde endocannabinoid signaling
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04930  Type II diabetes mellitus
ko05016  Huntington disease
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05032  Morphine addiction
ko05033  Nicotine addiction
Disease
H00831  Primary dystonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04020 Calcium signaling pathway
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04725 Cholinergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04728 Dopaminergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04726 Serotonergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04723 Retrograde endocannabinoid signaling
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04721 Synaptic vesicle cycle
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   05020 Prion disease
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   05022 Pathways of neurodegeneration - multiple diseases
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
  09165 Substance dependence
   05032 Morphine addiction
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   05033 Nicotine addiction
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
Other DBs
GO: 0005245
TC: 1.A.1.11.9
Genes
HSA: 774(CACNA1B)
PTR: 464893(CACNA1B)
PPS: 100979369(CACNA1B)
GGO: 101123776(CACNA1B)
PON: 100450868(CACNA1B)
NLE: 100584807(CACNA1B)
MCC: 721452(CACNA1B)
MCF: 101925455
CSAB: 103239541(CACNA1B)
RRO: 104669605(CACNA1B)
RBB: 108542921(CACNA1B)
CJC: 100390442(CACNA1B)
SBQ: 101049976(CACNA1B)
MMU: 12287(Cacna1b)
MCAL: 110289304(Cacna1b)
MPAH: 110318209(Cacna1b)
RNO: 257648(Cacna1b)
MUN: 110563057 110563058
CGE: 100770495(Cacna1b)
NGI: 103732608(Cacna1b)
HGL: 101697609(Cacna1b)
CCAN: 109693749
OCU: 100008979(CACNA1B)
TUP: 102498317(CACNA1B)
CFA: 480660(CACNA1B)
VVP: 112911427(CACNA1B)
AML: 100466608(CACNA1B)
UMR: 103675324(CACNA1B)
UAH: 113248411 113248451
ORO: 105758129
ELK: 111145672
FCA: 101087362(CACNA1B)
PTG: 102954775(CACNA1B)
PPAD: 109260261(CACNA1B)
AJU: 106986735(CACNA1B)
BTA: 282410(CACNA1B)
BOM: 102266839(CACNA1B)
BBUB: 102395660(CACNA1B)
CHX: 102189138(CACNA1B)
OAS: 101122774(CACNA1B)
SSC: 102164336(CACNA1B)
CFR: 102521766(CACNA1B)
CDK: 105102103(CACNA1B)
BACU: 103004988(CACNA1B)
LVE: 103073411(CACNA1B)
OOR: 101272416(CACNA1B)
DLE: 111176963(CACNA1B)
PCAD: 102983972(CACNA1B)
ECB: 100058760(CACNA1B)
EPZ: 103554173(CACNA1B)
EAI: 106822757(CACNA1B)
MYB: 102245786(CACNA1B)
MYD: 102756826(CACNA1B)
MNA: 107536136(CACNA1B)
HAI: 109382541(CACNA1B)
DRO: 112306604(CACNA1B)
PALE: 102877847(CACNA1B)
RAY: 107505355(CACNA1B)
MJV: 108404638(CACNA1B)
LAV: 100660444(CACNA1B)
TMU: 101351661
MDO: 100023896(CACNA1B)
SHR: 100933192(CACNA1B)
PCW: 110205247(CACNA1B)
OAA: 100681261(CACNA1B)
GGA: 374169(CACNA1B)
MGP: 100539318(CACNA1B)
CJO: 107321666(CACNA1B)
NMEL: 110407048(CACNA1B)
APLA: 101794161
ACYG: 106037093(CACNA1B)
TGU: 100230125(CACNA1B)
LSR: 110476962
SCAN: 103819171(CACNA1B)
GFR: 102043304(CACNA1B)
FAB: 101812454(CACNA1B)
PHI: 102107124(CACNA1B)
PMAJ: 107211935(CACNA1B)
CCAE: 111936929(CACNA1B)
CCW: 104688232(CACNA1B)
ETL: 114071402(CACNA1B)
FPG: 101922058(CACNA1B)
FCH: 102058219(CACNA1B)
CLV: 102086328(CACNA1B)
EGZ: 104124015(CACNA1B)
NNI: 104022209(CACNA1B)
ACUN: 113486402(CACNA1B)
PADL: 103918950(CACNA1B)
AAM: 106497478(CACNA1B)
ASN: 102374664(CACNA1B)
AMJ: 102564626(CACNA1B)
PSS: 102452356(CACNA1B)
CMY: 102935334(CACNA1B)
CPIC: 101941901(CACNA1B)
ACS: 100565533(cacna1b)
PVT: 110089800(CACNA1B)
PBI: 103051885
PMUR: 107297756
PMUA: 114588906(CACNA1B)
GJA: 107118784(CACNA1B)
XLA: 100462926(cacna1b.S) 108699890
XTR: 100489231(cacna1b)
NPR: 108794388(CACNA1B)
DRE: 555941(cacna1ba) 562796(cacna1bb)
SRX: 107709695 107739705 107757972
SANH: 107661415 107681248 107690670 107692312
SGH: 107548771 107560222 107587427 107595700
CCAR: 109062263 109092640
IPU: 108255844 108278949
PHYP: 113535492 113536882
AMEX: 103028778 103037904
EEE: 113573427 113577940
TRU: 101072690
TNG: GSTEN00009266G001
LCO: 104922897 104923804
MZE: 101480715 101486272
ONL: 100700442 100710725
OLA: 101157063 101167885
XMA: 102220117 102232640
XCO: 114149751 114155127
PRET: 103469618 103473951
CVG: 107083739
NFU: 107375116 107397069
KMR: 108245630(cacna1ba) 108251447(cacna1bb)
ALIM: 106527650 106528746
AOCE: 111580308 111588966
CSEM: 103389024 103397386
POV: 109639091 109641798
LCF: 108878412(cacna1b) 108889014
SDU: 111221156 111227530
SLAL: 111647967 111650131
HCQ: 109527074
BPEC: 110154678 110164291
MALB: 109959665 109968661
SASA: 106563134 106567450 106579993 106585428
OTW: 112232795 112234382
SALP: 111961707 111973906 111974985
ELS: 105014228 105014924
SFM: 108922594 108938544
PKI: 111833410 111853984
LCM: 102345610(CACNA1B)
CMK: 103180424(cacna1b)
RTP: 109926711
BFO: 118421257
CIN: 100184382
DSI: Dsimw501_GD15954(Dsim_GD15954)
DSR: 110182064
DPE: 6599410
DMN: 108156392
DWI: 6649112
DGR: Dgri_GH11826
DAZ: 108618327
DNV: 108656582
DHE: 111592349
MDE: 101889994
LCQ: 111681125
AGA: AgaP_AGAP002577 AgaP_AGAP002578
AAG: 110680453 5564339 5564344
AALB: 109399355 109433313 115268722 115268756 115269200
CQU: CpipJ_CPIJ005102
AME: 408764(Cac)
BIM: 100746463
BTER: 100647135
CCAL: 108623463
OBB: 114873253
SOC: 105195981 105196036
MPHA: 105833674
AEC: 105147325 105147386
ACEP: 105620023
PBAR: 105425824
HST: 105185443
DQU: 106745520
CFO: 105258693
OBO: 105285138
PCF: 106791166
NVI: 100121288
CSOL: 105368770
MDL: 103576100
TCA: 661666(Cac)
DPA: 109540220
ATD: 109596221
NVL: 108565398
BMOR: 100306947
BMAN: 114245534
DPL: KGM_213139
PMAC: 106719701
PRAP: 111001832
HAW: 110379158
TNL: 113494500
PXY: 105386568
API: 100164406
DNX: 107174009
AGS: 114121456
RMD: 113550723
BTAB: 109032851
CLEC: 106666338
PHU: Phum_PHUM447690
ZNE: 110836626
FCD: 110842697 110845897
DPX: DAPPUDRAFT_333049
TUT: 107372220
DPTE: 113799879
CSCU: 111625859
PTEP: 107438207 107449199
TSP: Tsp_10911
HRO: HELRODRAFT_119050 HELRODRAFT_128993 HELRODRAFT_68810 HELRODRAFT_73530
PCAN: 112574940
MYI: 110467402
LAK: 106170041
SMM: Smp_004730 Smp_020170
SHX: MS3_00036
OVI: T265_10559
EGL: EGR_00598 EGR_07405
NVE: 5515227
ADF: 107352390
DGT: 114533568
CRE: CHLREDRAFT_189093(CAV5)
TGO: TGME49_205265
 » show all
Reference
PMID:1321501
  Authors
Williams ME, Brust PF, Feldman DH, Patthi S, Simerson S, Maroufi A, McCue AF, Velicelebi G, Ellis SB, Harpold MM
  Title
Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel.
  Journal
Science 257:389-95 (1992)
DOI:10.1126/science.1321501
  Sequence
[hsa:774]
Reference
  Authors
Keum D, Baek C, Kim DI, Kweon HJ, Suh BC
  Title
Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane-localized beta subunit.
  Journal
J Gen Physiol 144:297-309 (2014)
DOI:10.1085/jgp.201411245
  Sequence
[hsa:774]
LinkDB

DBGET integrated database retrieval system