KEGG   ORTHOLOGY: K04851
Entry
K04851                      KO                                     

Name
CACNA1D, CAV1.3
Definition
voltage-dependent calcium channel L type alpha-1D
Pathway
ko04010  MAPK signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04218  Cellular senescence
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04361  Axon regeneration
ko04530  Tight junction
ko04713  Circadian entrainment
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04921  Oxytocin signaling pathway
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04927  Cortisol synthesis and secretion
ko04929  GnRH secretion
ko04930  Type II diabetes mellitus
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04973  Carbohydrate digestion and absorption
ko05010  Alzheimer disease
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05031  Amphetamine addiction
ko05410  Hypertrophic cardiomyopathy
ko05412  Arrhythmogenic right ventricular cardiomyopathy
ko05414  Dilated cardiomyopathy
Disease
H01603  Primary aldosteronism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04020 Calcium signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04024 cAMP signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04022 cGMP-PKG signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04929 GnRH secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04912 GnRH signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04921 Oxytocin signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04935 Growth hormone synthesis, secretion and action
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04924 Renin secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04925 Aldosterone synthesis and secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04927 Cortisol synthesis and secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04261 Adrenergic signaling in cardiomyocytes
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04270 Vascular smooth muscle contraction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09156 Nervous system
   04724 Glutamatergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04727 GABAergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04725 Cholinergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04728 Dopaminergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04726 Serotonergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04723 Retrograde endocannabinoid signaling
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09158 Development and regeneration
   04361 Axon regeneration
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05020 Prion disease
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05022 Pathways of neurodegeneration - multiple diseases
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09165 Substance dependence
   05031 Amphetamine addiction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05414 Dilated cardiomyopathy
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04934 Cushing syndrome
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
Other DBs
GO: 0005245
TC: 1.A.1.11.1 1.A.1.11.20 1.A.1.11.21
Genes
HSA: 776(CACNA1D)
PTR: 460447(CACNA1D)
PPS: 100975108(CACNA1D)
GGO: 101140987(CACNA1D)
PON: 100453904(CACNA1D)
NLE: 100600997(CACNA1D)
MCC: 693924(CACNA1D)
MCF: 102138213(CACNA1D)
CSAB: 103227762(CACNA1D)
RRO: 104672388(CACNA1D)
RBB: 108515198(CACNA1D)
CJC: 100397940(CACNA1D)
SBQ: 101043152(CACNA1D)
MMU: 12289(Cacna1d)
MCAL: 110309492(Cacna1d)
MPAH: 110325961(Cacna1d)
RNO: 29716(Cacna1d)
MUN: 110547567(Cacna1d)
CGE: 100772497(Cacna1d)
NGI: 103749025(Cacna1d)
HGL: 101714832(Cacna1d)
CCAN: 109674812(Cacna1d)
OCU: 100327259(CACNA1D)
TUP: 102484770(CACNA1D)
CFA: 484724(CACNA1D)
VVP: 112910069(CACNA1D)
AML: 100467700(CACNA1D)
UMR: 103674739(CACNA1D)
UAH: 113256986(CACNA1D)
ORO: 101383514(CACNA1D)
ELK: 111143738
FCA: 101088394(CACNA1D)
PTG: 102958456(CACNA1D)
PPAD: 109247930(CACNA1D)
AJU: 106986998(CACNA1D)
BTA: 408013(CACNA1D)
BOM: 102271623(CACNA1D)
BIU: 109576190(CACNA1D)
BBUB: 102405249(CACNA1D)
CHX: 102174706(CACNA1D)
OAS: 101106371(CACNA1D)
SSC: 100511102(CACNA1D)
CFR: 102504854(CACNA1D)
CDK: 105093176(CACNA1D)
BACU: 103001906(CACNA1D)
LVE: 103074544(CACNA1D)
OOR: 101276749(CACNA1D)
DLE: 111174277(CACNA1D)
PCAD: 102976068(CACNA1D)
ECB: 100051186(CACNA1D)
EPZ: 103560754
EAI: 106822066(CACNA1D)
MYB: 102259218(CACNA1D)
MYD: 102761441(CACNA1D)
MNA: 107534931(CACNA1D)
HAI: 109395944(CACNA1D)
DRO: 112301160(CACNA1D)
PALE: 102888351(CACNA1D)
RAY: 107516535(CACNA1D)
MJV: 108402355(CACNA1D)
LAV: 100659992(CACNA1D)
TMU: 101357085
MDO: 100014450(CACNA1D)
SHR: 100919750(CACNA1D)
PCW: 110197022(CACNA1D)
OAA: 100077296(CACNA1D)
GGA: 395895(CACNA1D)
MGP: 100545748(CACNA1D)
CJO: 107319871(CACNA1D)
NMEL: 110404743(CACNA1D)
APLA: 101803307(CACNA1D)
ACYG: 106048937(CACNA1D)
TGU: 100226925(CACNA1D)
LSR: 110471933(CACNA1D)
SCAN: 103816992(CACNA1D)
GFR: 102035179(CACNA1D)
FAB: 101819434(CACNA1D)
PHI: 102103301(CACNA1D)
PMAJ: 107210294(CACNA1D)
CCAE: 111935128(CACNA1D)
CCW: 104683258(CACNA1D)
ETL: 114058704(CACNA1D)
FPG: 101912795(CACNA1D)
FCH: 102054190(CACNA1D)
CLV: 102091108(CACNA1D)
EGZ: 104126731(CACNA1D)
NNI: 104009116 104010825(CACNA1D)
ACUN: 113484825(CACNA1D)
PADL: 103925489(CACNA1D)
AAM: 106488627(CACNA1D)
ASN: 102373960(CACNA1D)
AMJ: 102576817(CACNA1D)
PSS: 102447276(CACNA1D)
CMY: 102934282(CACNA1D)
CPIC: 101951786(CACNA1D)
ACS: 100554865(cacna1d)
PVT: 110084495(CACNA1D)
PBI: 103056075(CACNA1D)
PMUR: 107287678(CACNA1D)
TSR: 106544410 106555246
PMUA: 114591684(CACNA1D)
GJA: 107116832(CACNA1D)
XLA: 100462912(cacna1d.L) 108704388
NPR: 108786047(CACNA1D)
DRE: 403310(cacna1da) 403311(cacna1db)
SRX: 107711792 107730640 107743249 107751208
SANH: 107659558 107669025 107684460 107685994
SGH: 107549565 107581799 107582429 107594982
CCAR: 109094680 109098788
IPU: 108265454(cacna1d) 108281043
PHYP: 113533266(cacna1d) 113539515
AMEX: 103033357(cacna1d) 103043956
EEE: 113579158 113580442(cacna1d)
TRU: 101066777(cacna1d) 101070235
TNG: GSTEN00022583G001 GSTEN00027380G001
LCO: 104925122 104926938
NCC: 104942817 104946163(cacna1d)
MZE: 101474865(cacna1d) 101485620
ONL: 100693494 100712099(cacna1d)
OLA: 101157531 101171831(cacna1d)
XMA: 102234425(cacna1d)
XCO: 114135515 114148180(cacna1d)
PRET: 103465120 103468016(cacna1d)
CVG: 107086672(cacna1d) 107094760
NFU: 107385116 107390617(cacna1d)
KMR: 108236775(cacna1db) 108247381(cacna1da)
ALIM: 106513069(cacna1d) 106516186
AOCE: 111571955 111584413
CSEM: 103384525 103385821
POV: 109630732 109638586
LCF: 108886531 108891636(cacna1d)
SDU: 111220529 111222823
SLAL: 111660720 111670707
HCQ: 109517788(cacna1d) 109522320
BPEC: 110168588 110174734(cacna1d)
MALB: 109951925 109970859(cacna1d)
SASA: 106565299 106566685 106571974 106583449
OTW: 112215828 112244799 112247175 112255325
SALP: 111962116 111966893 111970724 111976881(cacna1d)
ELS: 105006991 105007355(cacna1d)
SFM: 108925619(cacna1d) 108933838
PKI: 111833375(cacna1d) 111852542
LCM: 102360815(CACNA1D)
CMK: 103185068(cacna1d)
RTP: 109930589(cacna1d)
BFO: 118415799
CIN: 100184376
SPU: 115917871 578128
APLC: 110974142
SKO: 100371433
DME: Dmel_CG4894(Ca-alpha1D)
DER: 6543266
DSE: 6613668
DSI: Dsimw501_GD24041(Dsim_GD24041)
DYA: Dyak_GE21343
DSR: 110186075
DPE: 6598125
DMN: 108161670
DWI: 6643675
DGR: Dgri_GH10399
DAZ: 108611419
DNV: 115564037
DHE: 111594149
MDE: 101899996
LCQ: 111687187
AGA: AgaP_AGAP012433 AgaP_AGAP012434
AAG: 5574639
AALB: 109415132
AME: 100578899
BIM: 100746891
BTER: 100649439
CCAL: 108624459
OBB: 114871919
SOC: 105195131
MPHA: 105827888
AEC: 105144165
ACEP: 105617695 105617706
PBAR: 105427526
VEM: 105568891
HST: 105183370
DQU: 106749620
CFO: 105255351
LHU: 105672748
PGC: 109853346
OBO: 105280692
PCF: 106788672
NVI: 100119154
CSOL: 105365750
MDL: 103575476
TCA: 659557
DPA: 109541068
ATD: 109601172
NVL: 108568734
BMOR: 101735743 101740314
BMAN: 114239650 114251688
DPL: KGM_203769 KGM_214501 KGM_214502
PMAC: 106707301 106711272
PRAP: 110993876 111001158
HAW: 110372633 110372635
TNL: 113497967 113498006
PXY: 105386242
API: 100160955
DNX: 107169074
AGS: 114121007
RMD: 113559335
BTAB: 109041122
CLEC: 106672043
PHU: Phum_PHUM510590
ZNE: 110839478
FCD: 110849059 110850936
DPX: DAPPUDRAFT_310458
PVM: 113811306
ISC: IscW_ISCW008837
TUT: 107359653
DPTE: 113792829
CSCU: 111635672 111641054
PTEP: 107444401 107449579
CEL: CELE_C48A7.1(egl-19)
CBR: CBG05858(Cbr-egl-19)
BMY: Bm1_39550
LOA: LOAG_17197
TSP: Tsp_06861 Tsp_07724
HRO: HELRODRAFT_128998
LGI: LOTGIDRAFT_51275
PCAN: 112571409
CRG: 105345994
MYI: 110461243
OBI: 106872359
LAK: 106176729
SMM: Smp_020270 Smp_159990
SHX: MS3_00024 MS3_00050
OVI: T265_01818 T265_01820 T265_15629
EGL: EGR_02129 EGR_08501
NVE: 5519069 5519367
EPA: 110231991 110242109 110248255
ADF: 107352052 107356574
AMIL: 114953399 114975723
PDAM: 113685515 113686524
SPIS: 111332340 111341163
DGT: 114521657
HMG: 100202002 100215858
CRE: CHLREDRAFT_192415(CAV1)
OLU: OSTLU_13647 OSTLU_32140
OTA: OT_ostta06g02060
SRE: PTSG_09464
PTM: GSPATT00017333001
AAF: AURANDRAFT_67051
PIF: PITG_03693 PITG_08764
SPAR: SPRG_01264 SPRG_10678 SPRG_10680
 » show all
Reference
  Authors
Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nurnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nurnberg P, Striessnig J, Bolz HJ
  Title
Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.
  Journal
Nat Neurosci 14:77-84 (2011)
DOI:10.1038/nn.2694
Reference
PMID:1309948
  Authors
Seino S, Chen L, Seino M, Blondel O, Takeda J, Johnson JH, Bell GI
  Title
Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.
  Journal
Proc Natl Acad Sci U S A 89:584-8 (1992)
DOI:10.1073/pnas.89.2.584
  Sequence
[hsa:776]
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