KEGG   ORTHOLOGY: K05084Help
Entry
K05084                      KO                                     

Name
ERBB3, HER3
Definition
receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04020  Calcium signaling pathway
ko04151  PI3K-Akt signaling pathway
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
Disease
H00408  Type 1 diabetes mellitus
H00865  Lethal congenital contractural syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
   04012 ErbB signaling pathway
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
   04020 Calcium signaling pathway
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
   04151 PI3K-Akt signaling pathway
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
   05205 Proteoglycans in cancer
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
BRITE hierarchy
Genes
HSA: 2065(ERBB3)
PTR: 451980(ERBB3)
PPS: 100974494(ERBB3)
GGO: 109025126
PON: 100174431(ERBB3)
NLE: 100590102(ERBB3)
MCC: 711407(ERBB3)
MCF: 102115998(ERBB3)
CSAB: 103238504(ERBB3)
RRO: 104673694(ERBB3)
RBB: 108515999(ERBB3)
CJC: 100409758(ERBB3)
SBQ: 101030064(ERBB3)
MMU: 13867(Erbb3)
MCAL: 110302668(Erbb3)
MPAH: 110326297(Erbb3)
RNO: 29496(Erbb3)
MUN: 110559383(Erbb3)
CGE: 100767681(Erbb3)
NGI: 103746501(Erbb3)
HGL: 101721671(Erbb3)
CCAN: 109686062(Erbb3)
OCU: 100008807(ERBB3)
TUP: 102468023(ERBB3)
CFA: 481105(ERBB3)
VVP: 112922396(ERBB3)
AML: 100468735(ERBB3)
UMR: 103656927(ERBB3)
UAH: 113256440(ERBB3)
ORO: 101385903(ERBB3)
FCA: 101085388(ERBB3)
PTG: 102948909(ERBB3)
AJU: 106986858(ERBB3)
BTA: 785655(ERBB3)
BOM: 102273820(ERBB3)
BIU: 109559378(ERBB3)
BBUB: 102395621(ERBB3)
PHD: 102342625(ERBB3)
CHX: 102173448(ERBB3)
OAS: 101103889(ERBB3)
SSC: 100525045(ERBB3)
CFR: 102506629(ERBB3)
CDK: 105086379(ERBB3)
BACU: 103015964(ERBB3)
LVE: 103087241(ERBB3)
OOR: 101288152(ERBB3)
DLE: 111173887(ERBB3)
PCAD: 102975550(ERBB3)
ECB: 100059216(ERBB3)
EPZ: 103557568(ERBB3)
EAI: 106832936(ERBB3)
MYB: 102248465(ERBB3)
MYD: 102774755(ERBB3)
MNA: 107546211(ERBB3)
HAI: 109396911(ERBB3)
RSS: 109453016(ERBB3)
DRO: 112319025(ERBB3)
PALE: 102895392(ERBB3)
RAY: 107521255(ERBB3)
LAV: 100668973(ERBB3)
TMU: 101354434
MDO: 100028072 100028103(ERBB3)
SHR: 100924586(ERBB3) 105750765
OAA: 100079793(ERBB3)
GGA: 693245(ERBB3)
CJO: 107325755(ERBB3)
NMEL: 110389140(ERBB3)
ACYG: 106029359
LSR: 110482393(ERBB3)
GFR: 102042709
PHI: 102101993(ERBB3)
ETL: 114070808(ERBB3)
FPG: 101914106(ERBB3)
NNI: 104017527(ERBB3)
AAM: 106482121(ERBB3)
ASN: 102376821(ERBB3)
AMJ: 102577159(ERBB3)
PSS: 102454909(ERBB3)
CPIC: 101942522(ERBB3)
ACS: 100556326(erbb3)
PVT: 110073465(ERBB3)
PBI: 103051488(ERBB3)
PMUR: 107284855(ERBB3)
GJA: 107108277(ERBB3)
XLA: 108708565(erbb3.L) 108709833(erbb3.S)
XTR: 100493384(erbb3)
NPR: 108790515(ERBB3)
DRE: 100149258 386635(erbb3a) 544664(erbb3b)
IPU: 108271615 108276025(erbb3)
PHYP: 113527462(erbb3) 113530351
AMEX: 103028053(erbb3) 103032103
EEE: 113581376 113581542(erbb3)
TRU: 101061551 101069394(erbb3)
LCO: 104932439 104938399(erbb3)
NCC: 104941411(erbb3) 104956941
OLA: 101172402(erbb3) 101172978
XMA: 102225708 102230188(erbb3)
PRET: 103465260(erbb3) 103467364
NFU: 107385695(erbb3) 107390894
KMR: 108235300 108235724(erbb3)
LCF: 108876575 108881471(erbb3)
SDU: 111219064 111221725(erbb3)
BPEC: 110164957 110168364(erbb3)
MALB: 109964444(erbb3) 109971109
PKI: 111854164(erbb3)
LCM: 102353616(ERBB3) 102356830
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2687875
  Authors
Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA
  Title
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.
  Journal
Proc Natl Acad Sci U S A 86:9193-7 (1989)
DOI:10.1073/pnas.86.23.9193
  Sequence
[hsa:2065]
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