KEGG   ORTHOLOGY: K05089Help
Entry
K05089                      KO                                     

Name
PDGFRB, CD140B
Definition
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01574  Familial idiopathic basal ganglia calcification
H01910  Infantile myofibromatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 Jak-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09162 Cancer: specific types
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
BRITE hierarchy
Other DBs
GO: 0004992
Genes
HSA: 5159(PDGFRB)
PTR: 462188(PDGFRB)
PPS: 100975853(PDGFRB)
GGO: 101150577(PDGFRB)
PON: 100460001(PDGFRB)
NLE: 100597894(PDGFRB)
MCC: 711353(PDGFRB)
MCF: 101867161(PDGFRB)
CSAB: 103244790(PDGFRB)
RRO: 104670408(PDGFRB)
RBB: 108532047(PDGFRB)
CJC: 100389852(PDGFRB)
SBQ: 101040158(PDGFRB)
MMU: 18596(Pdgfrb)
MCAL: 110284880(Pdgfrb)
MPAH: 110333065(Pdgfrb)
RNO: 24629(Pdgfrb)
MUN: 110546695(Pdgfrb)
CGE: 100764374(Pdgfrb)
NGI: 103747076(Pdgfrb)
HGL: 101721151(Pdgfrb)
CCAN: 109685664(Pdgfrb) 109685672
OCU: 100342872(PDGFRB)
TUP: 102492413(PDGFRB)
CFA: 442985(PDGFRB)
VVP: 112927357(PDGFRB)
AML: 100472005(PDGFRB)
UMR: 103664600(PDGFRB)
UAH: 113263944(PDGFRB)
ORO: 101374793(PDGFRB)
ELK: 111140848
FCA: 101084600(PDGFRB)
PTG: 102954207(PDGFRB)
PPAD: 109275948(PDGFRB)
AJU: 106985388(PDGFRB)
BTA: 527165(PDGFRB)
BOM: 102270608(PDGFRB)
BIU: 109562197(PDGFRB)
BBUB: 102392216(PDGFRB)
CHX: 102184426(PDGFRB)
OAS: 101122783(PDGFRB)
SSC: 102166564(PDGFRB)
CFR: 102512951(PDGFRB)
CDK: 105098486(PDGFRB)
BACU: 103019883(PDGFRB)
LVE: 103082363(PDGFRB)
OOR: 101272795(PDGFRB)
DLE: 111183086(PDGFRB)
PCAD: 102995915(PDGFRB)
ECB: 100071665(PDGFRB)
EPZ: 103549125(PDGFRB)
EAI: 106838493(PDGFRB)
MYB: 102241145(PDGFRB)
MYD: 102764172(PDGFRB)
MNA: 107535230(PDGFRB)
HAI: 109375002(PDGFRB)
DRO: 112319577(PDGFRB)
PALE: 102887643(PDGFRB)
RAY: 107497163(PDGFRB)
MJV: 108385397(PDGFRB)
LAV: 100671240(PDGFRB)
TMU: 101360003
MDO: 100028943(PDGFRB)
SHR: 100917212(PDGFRB)
PCW: 110192821(PDGFRB)
OAA: 100079459(PDGFRB)
GGA: 770488(PDGFRB)
MGP: 100550611(PDGFRB)
CJO: 107320191(PDGFRB)
NMEL: 110405265(PDGFRB)
APLA: 101799587(PDGFRB)
ACYG: 106032823(PDGFRB)
TGU: 100223375(PDGFRB)
LSR: 110482721(PDGFRB)
SCAN: 103817301(PDGFRB)
GFR: 102045343(PDGFRB)
FAB: 101809926(PDGFRB)
PHI: 102111524(PDGFRB)
PMAJ: 107210844(PDGFRB)
CCAE: 111935543(PDGFRB)
CCW: 104689579(PDGFRB)
ETL: 114063193(PDGFRB)
FPG: 101918438(PDGFRB)
FCH: 102052718(PDGFRB)
CLV: 102096790(PDGFRB)
EGZ: 104123312(PDGFRB)
NNI: 104014196(PDGFRB)
ACUN: 113485173(PDGFRB)
PADL: 103915745(PDGFRB)
AAM: 106493441(PDGFRB)
ASN: 102372962(PDGFRB)
AMJ: 102566175(PDGFRB)
PSS: 102460895(PDGFRB)
CMY: 102944650(PDGFRB)
CPIC: 101940553(PDGFRB)
ACS: 100555784(pdgfrb)
PVT: 110086089(PDGFRB)
PBI: 103051588(PDGFRB)
TSR: 106547766(PDGFRB)
PMUA: 114591343(PDGFRB)
GJA: 107116322(PDGFRB) 107123329
XLA: 108712643(pdgfrb.S)
XTR: 100487523(pdgfrb)
NPR: 108785807(PDGFRB)
DRE: 559529(pdgfrb)
IPU: 108274697(pdgfrb)
PHYP: 113529620(pdgfrb)
AMEX: 103036483
EEE: 113575581(pdgfrb)
TRU: 101061130 101074724(pdgfrb)
NCC: 104965701(pdgfrb)
MZE: 101466822 101484671(pdgfrb)
ONL: 100695603(pdgfrb) 100709470
OLA: 101155039(pdgfrb) 101156428
XMA: 102229755 102233464(pdgfrb)
XCO: 114139478(pdgfrb) 114153115
PRET: 103459902 103471279(pdgfrb)
CVG: 107095000(pdgfrb) 107102292
NFU: 107375657(pdgfrb)
ALIM: 106517359(pdgfrb) 106532997
AOCE: 111569523(pdgfrb) 111575719
CSEM: 103391002(pdgfrb) 103392104
POV: 109626437(pdgfrb) 109647502
LCF: 108873646 108899186(pdgfrb)
SDU: 111226471(pdgfrb) 111239485
HCQ: 109518748(pdgfrb) 109528881
SFM: 108936824(pdgfrb)
PKI: 111855164(pdgfrb)
LCM: 102361386(PDGFRB)
CMK: 103188232(pdgfrb)
RTP: 109924570
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435
  Sequence
[hsa:5159]
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