KEGG   ORTHOLOGY: K05126
Entry
K05126                      KO                                     

Name
RET
Definition
proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
Pathway
ko04020  Calcium signaling pathway
ko05200  Pathways in cancer
ko05216  Thyroid cancer
ko05223  Non-small cell lung cancer
ko05230  Central carbon metabolism in cancer
Disease
H00014  Non-small cell lung cancer
H00032  Thyroid cancer
H00247  Multiple endocrine neoplasia syndrome
H00910  Hirschsprung disease
H00916  Congenital central hypoventilation syndrome
H01510  Malignant paraganglioma
H01592  Medullary thyroid cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
   05230 Central carbon metabolism in cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
  09162 Cancer: specific types
   05216 Thyroid cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
   05223 Non-small cell lung cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05126  RET; proto-oncogene tyrosine-protein kinase Ret
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  RET family
   K05126  RET; proto-oncogene tyrosine-protein kinase Ret
Genes
HSA: 5979(RET)
PTR: 100612888(RET)
PPS: 100994039(RET)
GGO: 101141559(RET)
PON: 100442682(RET)
NLE: 100602103(RET)
MCC: 703466(RET)
MCF: 102135879(RET)
CSAB: 103215755(RET)
RRO: 104653928(RET)
RBB: 108513309(RET)
CJC: 100403596(RET)
SBQ: 101053966(RET)
MMU: 19713(Ret)
MCAL: 110295751(Ret)
MPAH: 110315801(Ret)
RNO: 24716(Ret)
MUN: 110558017 110558019
CGE: 100772741(Ret)
NGI: 103733801(Ret)
HGL: 101717565(Ret)
CCAN: 109676742(Ret)
OCU: 100340710(RET)
TUP: 102497228(RET)
CFA: 403494(RET)
VVP: 112913604(RET)
AML: 100467317(RET)
UMR: 103668071
UAH: 113243095(RET)
ORO: 101372117(RET)
ELK: 111145007
FCA: 101101086(RET)
PTG: 102951366(RET)
PPAD: 109264617(RET)
AJU: 106972131(RET)
BTA: 515924(RET)
BOM: 102284923(RET)
BIU: 109553788(RET)
BBUB: 102404389(RET)
CHX: 102172412(RET)
OAS: 101119787(RET)
SSC: 100155053(RET)
CFR: 102514431(RET)
CDK: 105092504(RET)
BACU: 103006627(RET)
LVE: 103069161(RET)
OOR: 101288280(RET)
DLE: 111163990(RET)
PCAD: 102984604(RET)
ECB: 100146791(RET)
EPZ: 103550619(RET)
EAI: 106831339(RET)
MYB: 102238841(RET)
MYD: 102766212(RET)
MNA: 107532547(RET)
HAI: 109395552(RET)
DRO: 112305517(RET)
PALE: 102878133(RET)
RAY: 107517623(RET)
MJV: 108392617(RET)
LAV: 100672176(RET)
TMU: 101357522
MDO: 100016023(RET)
SHR: 100927200(RET)
PCW: 110221483(RET)
OAA: 100076319(RET)
GGA: 396107(RET)
MGP: 100550243(RET)
CJO: 107315612(RET)
NMEL: 110399502(RET)
APLA: 101803164(RET)
ACYG: 106032512(RET)
TGU: 100219340(RET)
LSR: 110468614(RET)
SCAN: 103814210(RET)
GFR: 102042884(RET)
FAB: 101812108(RET)
PHI: 102107711(RET)
PMAJ: 107207043(RET)
CCAE: 111931023(RET)
CCW: 104690242(RET)
ETL: 114062798(RET)
FPG: 101922216(RET)
FCH: 102048122(RET)
CLV: 102083695(RET)
EGZ: 104128999(RET)
NNI: 104015433(RET)
ACUN: 113483380(RET)
PADL: 103924216(RET)
AAM: 106498889(RET)
ASN: 102371199(RET)
AMJ: 102573157(RET)
PSS: 102459127(RET)
CMY: 102940624(RET)
CPIC: 101938031(RET)
ACS: 100563549(ret)
PVT: 110083673(RET)
PBI: 103058664(RET)
PMUR: 107293255(RET)
TSR: 106555050(RET)
PMUA: 114597095(RET)
GJA: 107122192(RET)
XLA: 108696288(ret.L) 373625(ret.S)
XTR: 100495902(ret)
NPR: 108786609(RET)
DRE: 30512(ret)
SRX: 107726966 107743501
SANH: 107655443 107666456
SGH: 107559333(ret) 107601801
CCAR: 109078964 109091940
IPU: 108262651(ret)
PHYP: 113537802(ret)
AMEX: 103028663(ret)
EEE: 113585232(ret)
TRU: 101070188(ret)
TNG: GSTEN00024538G001
LCO: 104921882(ret)
NCC: 104952732(ret)
MZE: 101475370 112434355
ONL: 100702608(ret)
OLA: 101156037(ret)
XMA: 102237488(ret)
XCO: 114137568(ret)
PRET: 103477116(ret)
CVG: 107088598(ret)
NFU: 107375369(ret)
KMR: 108240623(ret)
ALIM: 106525613(ret)
AOCE: 111573084(ret)
CSEM: 103387460(ret)
POV: 109636804(ret)
LCF: 108886252(ret)
SDU: 111220596(ret)
SLAL: 111669539(ret)
HCQ: 109523240(ret)
BPEC: 110162334(ret)
MALB: 109958407(ret)
SASA: 106576823 106604566
OTW: 112252648 112252802
SALP: 111952048 111978543
ELS: 105028647(ret)
SFM: 108932773(ret)
PKI: 111848989(ret)
LCM: 102358285(RET)
CMK: 103182663(ret)
RTP: 109921507(ret)
BFO: 118404917 118405418 118405548 118405570 118405976 118410305 118412287 118413028 118413906 118414791 118415417 118416702 118416911 118420784 118423686 118423702 118427593 118427902 118427903 118427989 118430241 118431998
CIN: 100182804 100186039
SPU: 105437406 105444549 577861 582279 586619
APLC: 110977552 110985025 110987129
SKO: 100369916 102804897
DME: Dmel_CG14396(Ret)
DER: 6548796
DSE: 6618258
DSI: Dsimw501_GD21645(Dsim_GD21645)
DYA: Dyak_GE12994
DSR: 110187405
DPO: Dpse_GA12952
DPE: 6593673
DMN: 108161877
DWI: 6646561
DGR: Dgri_GH10299
DMO: Dmoj_GI17995
DAZ: 108610714
DNV: 115562752
DHE: 111599187
DVI: 6628028
MDE: 101890374
LCQ: 111678362
AGA: AgaP_AGAP008899
AAG: 110680434 5568762
AALB: 109420544 109621254
CQU: CpipJ_CPIJ000502
AME: 412667
BIM: 100741376
BTER: 100652108
CCAL: 108629271
OBB: 114877604
SOC: 105196030
MPHA: 105840080
AEC: 105147214
ACEP: 105619637
PBAR: 105426764
VEM: 105559591
HST: 105181042
DQU: 106748675
CFO: 105250051
LHU: 105668422
PGC: 109856241
OBO: 105284132
PCF: 106791228
NVI: 100120941
CSOL: 105364381
MDL: 103571463
TCA: 657748(ret)
DPA: 109545599
ATD: 109596516
NVL: 108566823
API: 100164983
DNX: 107168806
AGS: 114123818
RMD: 113547799
CLEC: 106662253
PHU: Phum_PHUM495270
ZNE: 110831101
FCD: 110856673
ISC: IscW_ISCW003506
CSCU: 111620592 111621481 111621482 111622754
PTEP: 107447239 107449160
CRG: 105320394 105330510
MYI: 110461040 110466000
OBI: 106879436 106879437 106883560
LAK: 106152770 106154548 106155165 106155174 106155178 106163283 106171307
SMM: Smp_175590
EPA: 110251418
ADF: 107328041 107328278 107341295 107344246 107346416 107355358
AMIL: 114947144 114948672 114956152 114963035 114967418 114969236 114970158 114974412
PDAM: 113670427 113673162 113676074 113676584 113679283 113681729
SPIS: 111325544 111329741 111329799 111332573 111337283 111338500 111338502 111338863 111340958 111340993 111341760 111344722 111346136 111346412 111347582
DGT: 114515600 114526994 114538351 114538355
HMG: 100205623 100209956 101239423
AQU: 100636517 100638869 100639009
 » show all
Reference
  Authors
Santoro M, Melillo RM, Carlomagno F, Vecchio G, Fusco A
  Title
Minireview: RET: normal and abnormal functions.
  Journal
Endocrinology 145:5448-51 (2004)
DOI:10.1210/en.2004-0922
Reference
  Authors
Jhiang SM
  Title
The RET proto-oncogene in human cancers.
  Journal
Oncogene 19:5590-7 (2000)
DOI:10.1038/sj.onc.1203857
LinkDB

DBGET integrated database retrieval system