KEGG   ORTHOLOGY: K05697Help
Entry
K05697                      KO                                     

Name
PTPN6, SHP-1
Definition
tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
Pathway
ko04520  Adherens junction
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko05130  Pathogenic Escherichia coli infection
ko05140  Leishmaniasis
ko05205  Proteoglycans in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
   04660 T cell receptor signaling pathway
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
   04662 B cell receptor signaling pathway
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Protein phosphatases and associated proteins [BR:ko01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
BRITE hierarchy
Other DBs
GO: 0005001
Genes
HSA: 5777(PTPN6)
PTR: 748032(PTPN6)
PPS: 100990286(PTPN6)
GGO: 101137792(PTPN6)
PON: 100448471(PTPN6)
NLE: 100599057(PTPN6)
MCC: 714374(PTPN6)
MCF: 102133910(PTPN6)
CSAB: 103218491(PTPN6)
RRO: 104680085(PTPN6)
RBB: 108542024(PTPN6)
CJC: 100410231(PTPN6)
SBQ: 101032306(PTPN6)
MMU: 15170(Ptpn6)
MCAL: 110295792(Ptpn6)
MPAH: 110314992(Ptpn6)
RNO: 116689(Ptpn6)
MUN: 110548584(Ptpn6)
CGE: 100758996(Ptpn6)
NGI: 103727492(Ptpn6)
HGL: 101725029(Ptpn6)
CCAN: 109682813(Ptpn6)
OCU: 100348648(PTPN6)
TUP: 102488290(PTPN6)
CFA: 486717(PTPN6)
VVP: 112917324(PTPN6)
AML: 100473539(PTPN6)
UMR: 103656221(PTPN6)
UAH: 113257950(PTPN6)
ORO: 101374850(PTPN6)
ELK: 111159680
FCA: 101087073(PTPN6)
PTG: 102951517(PTPN6)
PPAD: 109276095(PTPN6)
AJU: 106965341(PTPN6)
BTA: 512312(PTPN6)
BOM: 102283821(PTPN6)
BIU: 109558908(PTPN6)
BBUB: 102390574(PTPN6)
CHX: 102190308(PTPN6)
OAS: 101108643(PTPN6)
SSC: 100171389(PTPN6)
CFR: 102513195(PTPN6)
CDK: 105098192(PTPN6)
BACU: 103005216(PTPN6)
LVE: 103086882(PTPN6)
OOR: 101289268(PTPN6)
DLE: 111176702(PTPN6)
PCAD: 102989908(PTPN6)
ECB: 100052882(PTPN6)
EPZ: 103547027(PTPN6)
EAI: 106847314(PTPN6)
MYB: 102256821(PTPN6)
MYD: 102755999(PTPN6)
MNA: 107544062(PTPN6)
HAI: 109373664(PTPN6)
DRO: 112321823(PTPN6)
PALE: 102895931(PTPN6)
RAY: 107519829(PTPN6)
MJV: 108384835(PTPN6)
LAV: 100676986(PTPN6)
TMU: 101358096
MDO: 100016514(PTPN6)
SHR: 100916661(PTPN6)
PCW: 110213796(PTPN6)
OAA: 100089663(PTPN6)
GGA: 427947(PTPN6)
MGP: 100541130(PTPN6)
CJO: 107318608(PTPN6)
NMEL: 110398321(PTPN6)
APLA: 101791271(PTPN6)
ACYG: 106047839(PTPN6)
TGU: 100222135(PTPN6)
LSR: 110480841(PTPN6)
SCAN: 103827163(PTPN6)
GFR: 102042677(PTPN6)
FAB: 101809704(PTPN6)
PHI: 102110203(PTPN6)
PMAJ: 107208334(PTPN6)
CCAE: 111938183(PTPN6)
CCW: 104687132(PTPN6)
ETL: 114058137(PTPN6)
FPG: 101914570(PTPN6)
FCH: 102049222(PTPN6)
CLV: 102092597(PTPN6)
EGZ: 104126541(PTPN6)
NNI: 104009493(PTPN6)
ACUN: 113477279(PTPN6)
PADL: 103920898(PTPN6)
AAM: 106497267
ASN: 102374529(PTPN6)
AMJ: 106737112(PTPN6)
PSS: 102450493(PTPN6)
CMY: 102932473(PTPN6)
CPIC: 101943173(PTPN6)
ACS: 100560131 100568003(ptpn6)
PVT: 110084628(PTPN6)
PBI: 103066339(PTPN6)
PMUR: 107285777(PTPN6)
TSR: 106552603(PTPN6)
PMUA: 114587712(PTPN6)
GJA: 107116796(PTPN6)
XLA: 100380954(ptpn6.L) 108696044 108697335(ptpn6.S)
XTR: 100144699(ptpn6) 100486059
NPR: 108784384(PTPN6)
DRE: 335573(ptpn6)
IPU: 108263538(PTPN6)
PHYP: 113525151
AMEX: 103022912(ptpn6) 111196756
EEE: 113574797
TRU: 101073366(ptpn6)
LCO: 104932546(ptpn6)
NCC: 104967151
MZE: 101478586(ptpn6)
ONL: 100707029(ptpn6)
OLA: 101174216(ptpn6)
XMA: 102235723(ptpn6)
XCO: 114142163(ptpn6)
PRET: 103477996(ptpn6)
CVG: 107082167(ptpn6)
NFU: 107379459(ptpn6)
KMR: 108235407(ptpn6)
ALIM: 106529151(ptpn6)
AOCE: 111585704(ptpn6) 111586790
CSEM: 103387950(ptpn6)
POV: 109633267(ptpn6)
LCF: 108880748(ptpn6)
SDU: 111230057(ptpn6)
SLAL: 111669899(ptpn6)
HCQ: 109515280(ptpn6)
BPEC: 110163058(ptpn6)
MALB: 109966237(ptpn6)
SASA: 100195421(ptn6) 106576571(PTN6)
ELS: 105029958(ptpn6)
SFM: 108925851(ptpn6)
PKI: 111835379(ptpn6)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Keilhack H, Muller M, Bohmer SA, Frank C, Weidner KM, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Gunther B, Muller T, Birchmeier C, Bohmer FD
  Title
Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
  Journal
J Cell Biol 152:325-34 (2001)
DOI:10.1083/jcb.152.2.325
  Sequence
[hsa:5777]
Reference
PMID:1732748
  Authors
Yi TL, Cleveland JL, Ihle JN
  Title
Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
  Journal
Mol Cell Biol 12:836-46 (1992)
DOI:10.1128/MCB.12.2.836
  Sequence
[hsa:5777]
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