ORTHOLOGY: K05697
Entry
K05697 KO
Name
PTPN6, SHP-1
Definition
tyrosine-protein phosphatase non-receptor type 6 [EC:
3.1.3.48
]
Pathway
ko04520
Adherens junction
ko04630
JAK-STAT signaling pathway
ko04650
Natural killer cell mediated cytotoxicity
ko04660
T cell receptor signaling pathway
ko04662
B cell receptor signaling pathway
ko05130
Pathogenic Escherichia coli infection
ko05140
Leishmaniasis
ko05205
Proteoglycans in cancer
ko05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 Jak-STAT signaling pathway
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
09140 Cellular Processes
09144 Cellular community - eukaryotes
04520 Adherens junction
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
04660 T cell receptor signaling pathway
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
04662 B cell receptor signaling pathway
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
09174 Infectious disease: parasitic
05140 Leishmaniasis
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Enzymes [BR:
ko01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.48 protein-tyrosine-phosphatase
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Protein phosphatases and associated proteins [BR:
ko01009
]
Protein tyrosine phosphatases (PTPs)
Class I PTPs (Classical)
Non-receptor PTPs
K05697 PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Other DBs
GO:
0005001
Genes
HSA:
5777
(PTPN6)
PTR:
748032
(PTPN6)
PPS:
100990286
(PTPN6)
GGO:
101137792
(PTPN6)
PON:
100448471
(PTPN6)
NLE:
100599057
(PTPN6)
MCC:
714374
(PTPN6)
MCF:
102133910
(PTPN6)
CSAB:
103218491
(PTPN6)
RRO:
104680085
(PTPN6)
RBB:
108542024
(PTPN6)
CJC:
100410231
(PTPN6)
SBQ:
101032306
(PTPN6)
MMU:
15170
(Ptpn6)
MCAL:
110295792
(Ptpn6)
MPAH:
110314992
(Ptpn6)
RNO:
116689
(Ptpn6)
MUN:
110548584
(Ptpn6)
CGE:
100758996
(Ptpn6)
NGI:
103727492
(Ptpn6)
HGL:
101725029
(Ptpn6)
CCAN:
109682813
(Ptpn6)
OCU:
100348648
(PTPN6)
TUP:
102488290
(PTPN6)
CFA:
486717
(PTPN6)
VVP:
112917324
(PTPN6)
AML:
100473539
(PTPN6)
UMR:
103656221
(PTPN6)
UAH:
113257950
(PTPN6)
ORO:
101374850
(PTPN6)
ELK:
111159680
FCA:
101087073
(PTPN6)
PTG:
102951517
(PTPN6)
PPAD:
109276095
(PTPN6)
AJU:
106965341
(PTPN6)
BTA:
512312
(PTPN6)
BOM:
102283821
(PTPN6)
BIU:
109558908
(PTPN6)
BBUB:
102390574
(PTPN6)
CHX:
102190308
(PTPN6)
OAS:
101108643
(PTPN6)
SSC:
100171389
(PTPN6)
CFR:
102513195
(PTPN6)
CDK:
105098192
(PTPN6)
BACU:
103005216
(PTPN6)
LVE:
103086882
(PTPN6)
OOR:
101289268
(PTPN6)
DLE:
111176702
(PTPN6)
PCAD:
102989908
(PTPN6)
ECB:
100052882
(PTPN6)
EPZ:
103547027
(PTPN6)
EAI:
106847314
(PTPN6)
MYB:
102256821
(PTPN6)
MYD:
102755999
(PTPN6)
MNA:
107544062
(PTPN6)
HAI:
109373664
(PTPN6)
DRO:
112321823
(PTPN6)
PALE:
102895931
(PTPN6)
RAY:
107519829
(PTPN6)
MJV:
108384835
(PTPN6)
LAV:
100676986
(PTPN6)
TMU:
101358096
MDO:
100016514
(PTPN6)
SHR:
100916661
(PTPN6)
PCW:
110213796
(PTPN6)
OAA:
100089663
(PTPN6)
GGA:
427947
(PTPN6)
MGP:
100541130
(PTPN6)
CJO:
107318608
(PTPN6)
NMEL:
110398321
(PTPN6)
APLA:
101791271
(PTPN6)
ACYG:
106047839
(PTPN6)
TGU:
100222135
(PTPN6)
LSR:
110480841
(PTPN6)
SCAN:
103827163
(PTPN6)
GFR:
102042677
(PTPN6)
FAB:
101809704
(PTPN6)
PHI:
102110203
(PTPN6)
PMAJ:
107208334
(PTPN6)
CCAE:
111938183
(PTPN6)
CCW:
104687132
(PTPN6)
ETL:
114058137
(PTPN6)
FPG:
101914570
(PTPN6)
FCH:
102049222
(PTPN6)
CLV:
102092597
(PTPN6)
EGZ:
104126541
(PTPN6)
NNI:
104009493
(PTPN6)
ACUN:
113477279
(PTPN6)
PADL:
103920898
(PTPN6)
AAM:
106497267
ASN:
102374529
(PTPN6)
AMJ:
106737112
(PTPN6)
PSS:
102450493
(PTPN6)
CMY:
102932473
(PTPN6)
CPIC:
101943173
(PTPN6)
ACS:
100560131
100568003
(ptpn6)
PVT:
110084628
(PTPN6)
PBI:
103066339
(PTPN6)
PMUR:
107285777
(PTPN6)
TSR:
106552603
(PTPN6)
PMUA:
114587712
(PTPN6)
GJA:
107116796
(PTPN6)
XLA:
100380954
(ptpn6.L)
108696044
108697335
(ptpn6.S)
XTR:
100144699
(ptpn6)
100486059
NPR:
108784384
(PTPN6)
DRE:
335573
(ptpn6)
SRX:
107714609
107724803
SANH:
107671911
107704909
SGH:
107552793
107578506
107587794
(ptpn6)
CCAR:
109104852
109104853
IPU:
108263538
(PTPN6)
PHYP:
113525151
AMEX:
103022912
(ptpn6)
111196756
EEE:
113574797
TRU:
101073366
(ptpn6)
TNG:
GSTEN00015322G001
LCO:
104932546
(ptpn6)
NCC:
104967151
MZE:
101478586
(ptpn6)
ONL:
100707029
(ptpn6)
OLA:
101174216
(ptpn6)
XMA:
102235723
(ptpn6)
XCO:
114142163
(ptpn6)
PRET:
103477996
(ptpn6)
CVG:
107082167
(ptpn6)
NFU:
107379459
(ptpn6)
KMR:
108235407
(ptpn6)
ALIM:
106529151
(ptpn6)
AOCE:
111585704
(ptpn6)
111586790
CSEM:
103387950
(ptpn6)
POV:
109633267
(ptpn6)
LCF:
108880748
(ptpn6)
SDU:
111230057
(ptpn6)
SLAL:
111669899
(ptpn6)
HCQ:
109515280
(ptpn6)
BPEC:
110163058
(ptpn6)
MALB:
109966237
(ptpn6)
SASA:
100195421
(ptn6)
106576571
(PTN6)
OTW:
112226113
112242286
SALP:
112074551
112081040
ELS:
105029958
(ptpn6)
SFM:
108925851
(ptpn6)
PKI:
111835379
(ptpn6)
LCM:
102352106
102354496
» show all
Reference
PMID:
11266449
Authors
Keilhack H, Muller M, Bohmer SA, Frank C, Weidner KM, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Gunther B, Muller T, Birchmeier C, Bohmer FD
Title
Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
Journal
J Cell Biol 152:325-34 (2001)
DOI:
10.1083/jcb.152.2.325
Sequence
[hsa:
5777
]
Reference
PMID:
1732748
Authors
Yi TL, Cleveland JL, Ihle JN
Title
Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
Journal
Mol Cell Biol 12:836-46 (1992)
DOI:
10.1128/MCB.12.2.836
Sequence
[hsa:
5777
]
LinkDB
DBGET
integrated database retrieval system
