KEGG   ORTHOLOGY: K05725Help
Entry
K05725                      KO                                     

Name
PTK2, FAK
Definition
focal adhesion kinase 1 [EC:2.7.10.2]
Pathway
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04062  Chemokine signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko04935  Growth hormone synthesis, secretion and action
ko05100  Bacterial invasion of epithelial cells
ko05131  Shigellosis
ko05135  Yersinia infection
ko05146  Amoebiasis
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05222  Small cell lung cancer
ko05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
   04370 VEGF signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
   04151 PI3K-Akt signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05725  PTK2, FAK; focal adhesion kinase 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05725  PTK2, FAK; focal adhesion kinase 1
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K05725  PTK2, FAK; focal adhesion kinase 1
   04062 Chemokine signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05725  PTK2, FAK; focal adhesion kinase 1
  09158 Development and regeneration
   04360 Axon guidance
    K05725  PTK2, FAK; focal adhesion kinase 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
   05202 Transcriptional misregulation in cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
   05205 Proteoglycans in cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K05725  PTK2, FAK; focal adhesion kinase 1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05725  PTK2, FAK; focal adhesion kinase 1
   05135 Yersinia infection
    K05725  PTK2, FAK; focal adhesion kinase 1
   05100 Bacterial invasion of epithelial cells
    K05725  PTK2, FAK; focal adhesion kinase 1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05725  PTK2, FAK; focal adhesion kinase 1
   05163 Human cytomegalovirus infection
    K05725  PTK2, FAK; focal adhesion kinase 1
   05165 Human papillomavirus infection
    K05725  PTK2, FAK; focal adhesion kinase 1
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05725  PTK2, FAK; focal adhesion kinase 1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K05725  PTK2, FAK; focal adhesion kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05725  PTK2, FAK; focal adhesion kinase 1
   01009 Protein phosphatases and associated proteins
    K05725  PTK2, FAK; focal adhesion kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05725  PTK2, FAK; focal adhesion kinase 1
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  FAK family
   K05725  PTK2, FAK; focal adhesion kinase 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K05725  PTK2, FAK; focal adhesion kinase 1
BRITE hierarchy
Other DBs
GO: 0004715
Genes
HSA: 5747(PTK2)
PTR: 464422(PTK2)
PPS: 100989953(PTK2)
GGO: 101128620(PTK2)
PON: 100447959(PTK2)
NLE: 100589794(PTK2)
MCC: 700634(PTK2)
MCF: 101925550(PTK2)
CSAB: 103237724(PTK2)
RRO: 104679749(PTK2)
RBB: 108544148(PTK2)
CJC: 100395283(PTK2)
SBQ: 101052217(PTK2)
MMU: 14083(Ptk2)
MCAL: 110310271(Ptk2)
MPAH: 110334478(Ptk2)
RNO: 25614(Ptk2)
MUN: 110542391(Ptk2)
CGE: 100759464(Ptk2)
NGI: 103748419(Ptk2)
HGL: 101711587(Ptk2)
CCAN: 109681968(Ptk2)
OCU: 100347455(PTK2)
TUP: 102483369(PTK2)
CFA: 475108(PTK2)
VVP: 112909230(PTK2)
AML: 100464496(PTK2)
UMR: 103670589(PTK2)
UAH: 113248466(PTK2)
ORO: 101371010(PTK2)
ELK: 111146744
FCA: 101095952(PTK2)
PTG: 102953254(PTK2)
PPAD: 109273067(PTK2)
AJU: 106984404(PTK2)
BTA: 506270(PTK2)
BOM: 102280095(PTK2)
BIU: 109568429(PTK2)
BBUB: 102389136(PTK2)
CHX: 102177814(PTK2)
OAS: 101120842(PTK2)
SSC: 102167153(PTK2)
CFR: 102516641(PTK2)
CDK: 105095121(PTK2)
BACU: 103013388(PTK2)
LVE: 103082438(PTK2)
OOR: 101275490(PTK2)
DLE: 111165046(PTK2)
PCAD: 102982229(PTK2)
ECB: 100058245(PTK2)
EPZ: 103543504 103561848(PTK2)
EAI: 106846305(PTK2)
MYB: 102245460(PTK2)
MYD: 102754742(PTK2)
MNA: 107533206(PTK2)
HAI: 109390857(PTK2)
DRO: 112315475(PTK2)
PALE: 102898998(PTK2)
RAY: 107504408(PTK2)
LAV: 100668436(PTK2)
TMU: 101351714
MDO: 100027188(PTK2)
SHR: 100933019(PTK2)
PCW: 110194600(PTK2)
OAA: 100076789(PTK2)
GGA: 396416(PTK2)
MGP: 100539811
CJO: 107310587(PTK2)
NMEL: 110393818(PTK2)
APLA: 101796890(PTK2)
ACYG: 106043708(PTK2)
TGU: 100221659(PTK2)
LSR: 110471669(PTK2)
SCAN: 103814761(PTK2)
GFR: 102043366(PTK2)
FAB: 101814936(PTK2)
PHI: 102104319(PTK2)
PMAJ: 107199979(PTK2)
CCAE: 111925177(PTK2)
CCW: 104692616(PTK2)
ETL: 114061597(PTK2)
FPG: 101922646(PTK2)
FCH: 102059158(PTK2)
CLV: 102093049(PTK2)
EGZ: 104135598(PTK2)
NNI: 104020584(PTK2)
ACUN: 113476700(PTK2)
PADL: 103920642(PTK2)
AAM: 106482268 106500023(PTK2)
ASN: 102375664(PTK2)
AMJ: 106736955(PTK2)
PSS: 102453077(PTK2)
CMY: 102945262(PTK2)
CPIC: 101943190(PTK2)
ACS: 100554871(ptk2)
PVT: 110084855(PTK2)
PBI: 103060776(PTK2)
PMUA: 114600216(PTK2)
GJA: 107123467(PTK2) 107124774
XLA: 399286(ptk2.L) 432072(ptk2.S)
XTR: 733890(ptk2)
NPR: 108792768(PTK2)
DRE: 142986(ptk2ab) 386705(ptk2aa)
IPU: 108256909(ptk2) 108267913
PHYP: 113533847 113536245(ptk2)
AMEX: 103033402 103041623(ptk2)
EEE: 113571245 113590645(ptk2)
NCC: 104942825 104967557(ptk2)
MZE: 101465038(ptk2) 101470500
ONL: 100692252 100700494(ptk2)
OLA: 101155713(ptk2) 101162652
PRET: 103472469 103478404(ptk2)
NFU: 107394601 107396176(ptk2)
CSEM: 103388446(ptk2) 103394159
POV: 109632156 109638831(ptk2)
SDU: 111223196 111227757(ptk2)
SLAL: 111657213 111662376(ptk2)
BPEC: 110168868 110171400(ptk2)
SFM: 108922037(ptk2) 108940645
PKI: 111843830(ptk2) 111844688
LCM: 102356941(PTK2)
CMK: 103181063(ptk2)
CIN: 100176095
SPU: 105436929
APLC: 110982757
DME: Dmel_CG10023(Fak)
DER: 6547429
DSI: Dsimw501_GD25321(Dsim_GD25321)
DSR: 110176395
DPO: Dpse_GA10015(Dpse_fak)
DPE: 6590135
DMN: 108160000
DWI: 6640912
DAZ: 108615172
DNV: 115563874
DHE: 111600150
MDE: 101887255
LCQ: 111677048
AAG: 5565233
AALB: 109401644
AME: 724973
BIM: 100742416
BTER: 100651181
CCAL: 108623737
OBB: 114877622
SOC: 105205797
MPHA: 105833444
AEC: 105143988
ACEP: 105625816
PBAR: 105433628
VEM: 105565717
HST: 105186395
DQU: 106745467
CFO: 105253398
LHU: 105669182
PGC: 109858447
OBO: 105283194
PCF: 106784223
NVI: 100118485
CSOL: 105361204
MDL: 103577529
TCA: 664221
DPA: 109534059
ATD: 109608216
BMOR: 101745942
BMAN: 114245095
PMAC: 106718652
PRAP: 110995965
TNL: 113494203
PXY: 105388640
API: 100160998
DNX: 107164318
AGS: 114130920
RMD: 113554034
BTAB: 109040041
CLEC: 106672901
ZNE: 110833268
FCD: 110841658
PVM: 113818212
TUT: 107364395
DPTE: 113798439
CEL: CELE_C30F8.4(kin-32)
CBR: CBG10801(Cbr-kin-32)
BMY: Bm1_48220
PCAN: 112573819
CRG: 105318395
MYI: 110443300
OBI: 106874006
SHX: MS3_07063
EPA: 110246398
ADF: 107333973
AMIL: 114957984
PDAM: 113681524
SPIS: 111326952
DGT: 114525562
HMG: 100192269(fak)
AQU: 100633213
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8422239
  Authors
Andre E, Becker-Andre M
  Title
Expression of an N-terminally truncated form of human focal adhesion kinase in brain.
  Journal
Biochem Biophys Res Commun 190:140-7 (1993)
DOI:10.1006/bbrc.1993.1022
  Sequence
[hsa:5747]
Reference
  Authors
Schaller MD
  Title
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.
  Journal
J Cell Sci 123:1007-13 (2010)
DOI:10.1242/jcs.045112
  Sequence
[hsa:5747]
LinkDB All DBs

DBGET integrated database retrieval system