KEGG   ORTHOLOGY: K06101
Entry
K06101                      KO                                     

Name
ASH1L
Definition
[histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]
Pathway
ko00310  Lysine degradation
ko01100  Metabolic pathways
Disease
H00773  Autosomal dominant mental retardation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
Other DBs
RN: R03875 R04866 R04867
GO: 0042800
Genes
HSA: 55870(ASH1L)
PTR: 107971434(ASH1L)
PPS: 100979709(ASH1L)
GGO: 101134264(ASH1L)
NLE: 100580011(ASH1L)
MCC: 717778(ASH1L)
MCF: 101867084(ASH1L)
CSAB: 103223879(ASH1L)
RRO: 104659604(ASH1L)
RBB: 108526806(ASH1L)
CJC: 100393607(ASH1L)
SBQ: 101046051(ASH1L)
MMU: 192195(Ash1l)
MCAL: 110291461(Ash1l)
MPAH: 110320636(Ash1l)
RNO: 310638(Ash1l)
MUN: 110548961(Ash1l)
CGE: 100754103(Ash1l)
NGI: 103750808(Ash1l)
HGL: 101723836(Ash1l)
CCAN: 109688014(Ash1l)
OCU: 100354541(ASH1L)
TUP: 102469443(ASH1L)
CFA: 480128(ASH1L)
VVP: 112918925(ASH1L)
AML: 100474237(ASH1L)
UMR: 103668369(ASH1L)
UAH: 113245266(ASH1L)
ORO: 101362745(ASH1L)
ELK: 111138933
FCA: 101086114(ASH1L)
PTG: 102969379(ASH1L)
PPAD: 109256230(ASH1L)
AJU: 106981535(ASH1L)
BTA: 540563(ASH1L)
BOM: 102275046(ASH1L)
BIU: 109553548(ASH1L)
BBUB: 102415367(ASH1L)
CHX: 102185413(ASH1L)
OAS: 101119775(ASH1L)
SSC: 100155920(ASH1L)
CFR: 102510601(ASH1L)
CDK: 105088782(ASH1L)
BACU: 103015822(ASH1L)
LVE: 103087473(ASH1L)
OOR: 101288541(ASH1L)
DLE: 111167169(ASH1L)
PCAD: 102993773(ASH1L)
ECB: 100057386(ASH1L)
EAI: 106828486(ASH1L)
MYB: 102256394(ASH1L)
MYD: 102764796(ASH1L)
MNA: 107543779(ASH1L)
HAI: 109393386(ASH1L)
DRO: 112316914(ASH1L)
PALE: 102888124(ASH1L)
RAY: 107521457(ASH1L)
MJV: 108407349(ASH1L)
LAV: 100668468(ASH1L)
TMU: 101348724
MDO: 100017118(ASH1L)
SHR: 100931585(ASH1L)
PCW: 110211945(ASH1L)
OAA: 103168045(ASH1L)
GGA: 425064(ASH1L)
MGP: 100539732(ASH1L)
CJO: 107324503(ASH1L)
NMEL: 110387902(ASH1L)
ACYG: 106048498(ASH1L)
TGU: 100229714(ASH1L)
LSR: 110471483(ASH1L)
SCAN: 103823951(ASH1L)
GFR: 102042927(ASH1L)
FAB: 101819907(ASH1L)
PHI: 102113028(ASH1L)
PMAJ: 107214568(ASH1L)
CCAE: 111939443(ASH1L)
CCW: 104683547(ASH1L)
ETL: 114069574(ASH1L)
FPG: 101913546(ASH1L)
FCH: 102056587(ASH1L)
CLV: 102090928(ASH1L)
EGZ: 104134854(ASH1L)
NNI: 104020487(ASH1L)
ACUN: 113488743(ASH1L)
PADL: 103913294(ASH1L)
AAM: 106494341(ASH1L)
ASN: 102372997(ASH1L)
AMJ: 102571713(ASH1L)
PSS: 102448117(ASH1L)
CMY: 102943662(ASH1L)
CPIC: 101942050(ASH1L)
ACS: 100563888(ash1l)
PVT: 110081037(ASH1L)
PBI: 103060233(ASH1L)
PMUR: 107297020(ASH1L)
TSR: 106538172
PMUA: 114586229(ASH1L)
GJA: 107119617(ASH1L)
XTR: 108645568(ash1l)
NPR: 108794233(ASH1L)
DRE: 563799(ash1l)
CCAR: 109111952
IPU: 108267029(ash1l) 108272684
PHYP: 113535206 113542280(ash1l)
NCC: 104942643 104958848(ash1l)
ONL: 100706567(ash1l) 100707110
OLA: 101156847(ash1l) 101161417
XMA: 102219717 102229525(ash1l)
XCO: 114141764(ash1l) 114156414
PRET: 103472762 103478185(ash1l)
CVG: 107084057 107088414(ash1l)
NFU: 107379592(ash1l) 107394561
KMR: 108240202 108241069(ash1l)
ALIM: 106520872 106531577(ash1l)
AOCE: 111570477
CSEM: 103388251(ash1l) 103394569
LCF: 108885923(ash1l) 108888847
SDU: 111223036 111230135(ash1l)
SLAL: 111652181(ash1l) 111657636
HCQ: 109513128 109521050(ash1l)
BPEC: 110163006(ash1l) 110167402
MALB: 109951508 109964099(ash1l)
SFM: 108925420(ash1l)
PKI: 111840856(ash1l) 111858202
LCM: 102367246(ASH1L)
CMK: 103191129
BFO: 118409424
CIN: 778906
SPU: 579712
APLC: 110987401
SKO: 100373611
DME: Dmel_CG8887(ash1)
DER: 6545341
DSI: Dsimw501_GD12268(Dsim_GD12268)
DSR: 110189866
DPE: 6602353
DMN: 108151207
DWI: 6643058
DAZ: 108612540
DNV: 108651373
DHE: 111605065
MDE: 101901319
LCQ: 111685903
AAG: 5572241
AME: 727238
BIM: 100746434
BTER: 100647786
CCAL: 108627872
OBB: 114875610
SOC: 105193654
MPHA: 105836216
AEC: 105149286
ACEP: 105624295
PBAR: 105427128
VEM: 105562965
HST: 105190078
DQU: 106747370
CFO: 105257554
LHU: 105670382
PGC: 109860146
OBO: 105285768
PCF: 106783908
NVI: 100123305
CSOL: 105365757
MDL: 103568549
TCA: 660094
DPA: 109540203
ATD: 109594925
NVL: 108559411
BMOR: 101737263
BMAN: 114253084
PMAC: 106716351
PRAP: 111004449
HAW: 110370386
TNL: 113503482
PXY: 105391614
API: 100165448
DNX: 107173100
AGS: 114121077
RMD: 113554679
BTAB: 109035586
CLEC: 106674098
ZNE: 110835718
FCD: 110851509
TUT: 107372226
DPTE: 113797853
CSCU: 111619589
PTEP: 107447015
CEL: CELE_T12F5.4(lin-59)
CBR: CBG12017(Cbr-lin-59)
BMY: Bm1_04930
PCAN: 112553748
CRG: 105322748
MYI: 110465579
OBI: 106884485
LAK: 106158443
QSU: 112037971
NCR: NCU01932(set-3)
NTE: NEUTE1DRAFT125465(NEUTE1DRAFT_125465)
MGR: MGG_02937
SSCK: SPSK_05820
NHE: NECHADRAFT_123121(SDG2103)
MAW: MAC_07938
MAJ: MAA_09293
CMT: CCM_06493
MBE: MBM_00593
ANI: AN4764.2
ANG: ANI_1_2518094(An11g09860)
ABE: ARB_07287
TVE: TRV_02019
TASA: A1Q1_02180
 » show all
Reference
  Authors
An S, Yeo KJ, Jeon YH, Song JJ
  Title
Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism.
  Journal
J Biol Chem 286:8369-74 (2011)
DOI:10.1074/jbc.M110.203380
  Sequence
[hsa:55870]
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