KEGG   ORTHOLOGY: K06461Help
Entry
K06461                      KO                                     

Name
ITGAM, CD11b
Definition
integrin alpha M
Pathway
ko04015  Rap1 signaling pathway
ko04145  Phagosome
ko04514  Cell adhesion molecules (CAMs)
ko04610  Complement and coagulation cascades
ko04640  Hematopoietic cell lineage
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05146  Amoebiasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06461  ITGAM, CD11b; integrin alpha M
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06461  ITGAM, CD11b; integrin alpha M
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06461  ITGAM, CD11b; integrin alpha M
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06461  ITGAM, CD11b; integrin alpha M
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06461  ITGAM, CD11b; integrin alpha M
   04610 Complement and coagulation cascades
    K06461  ITGAM, CD11b; integrin alpha M
   04670 Leukocyte transendothelial migration
    K06461  ITGAM, CD11b; integrin alpha M
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K06461  ITGAM, CD11b; integrin alpha M
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K06461  ITGAM, CD11b; integrin alpha M
  09171 Infectious disease: bacterial
   05133 Pertussis
    K06461  ITGAM, CD11b; integrin alpha M
   05134 Legionellosis
    K06461  ITGAM, CD11b; integrin alpha M
   05150 Staphylococcus aureus infection
    K06461  ITGAM, CD11b; integrin alpha M
   05152 Tuberculosis
    K06461  ITGAM, CD11b; integrin alpha M
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K06461  ITGAM, CD11b; integrin alpha M
   05140 Leishmaniasis
    K06461  ITGAM, CD11b; integrin alpha M
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06461  ITGAM, CD11b; integrin alpha M
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06461  ITGAM, CD11b; integrin alpha M
   04515 Cell adhesion molecules
    K06461  ITGAM, CD11b; integrin alpha M
   04090 CD molecules
    K06461  ITGAM, CD11b; integrin alpha M
   00536 Glycosaminoglycan binding proteins
    K06461  ITGAM, CD11b; integrin alpha M
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    K06461  ITGAM, CD11b; integrin alpha M
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06461  ITGAM, CD11b; integrin alpha M
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K06461  ITGAM, CD11b; integrin alpha M
CD molecules [BR:ko04090]
 Proteins
  K06461  CD11b, ITGAM; integrin, alpha M
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Haparin
  Adhesion molecules of cell surface
   K06461  ITGAM, CD11b; integrin alpha M
BRITE hierarchy
Genes
HSA: 3684(ITGAM)
PTR: 454069(ITGAM)
PPS: 100992002(ITGAM)
GGO: 101135400(ITGAM)
PON: 100439660(ITGAM)
NLE: 100603969(ITGAM)
MCC: 714832(ITGAM)
MCF: 101866035(ITGAM)
CSAB: 103231383(ITGAM)
RRO: 104661578(ITGAM)
RBB: 108526088 108528119(ITGAM)
CJC: 100389341(ITGAM)
SBQ: 101035688(ITGAM)
MMU: 16409(Itgam)
MCAL: 110298307(Itgam)
MPAH: 110327528(Itgam)
RNO: 25021(Itgam)
MUN: 110564544(Itgam)
CGE: 100758889(Itgam)
NGI: 103726316(Itgam)
HGL: 101719288(Itgam)
CCAN: 109696521
OCU: 100351865(ITGAM)
TUP: 102483623(ITGAM)
CFA: 489928(ITGAM)
VVP: 112929270(ITGAM)
AML: 100475340(ITGAM)
UMR: 103657890(ITGAM)
UAH: 113267723(ITGAM)
ORO: 101374774(ITGAM)
FCA: 101087957
PTG: 102966486(ITGAM)
AJU: 106979120(ITGAM)
BTA: 407124(ITGAM)
BOM: 102270519(ITGAM)
BBUB: 102396526(ITGAM)
PHD: 102328883(ITGAM)
CHX: 102180100(ITGAM)
OAS: 443217(ITGAM)
SSC: 397459(ITGAM)
CFR: 102513083(ITGAM)
CDK: 105089721(ITGAM)
BACU: 103004729(ITGAM)
LVE: 103073578(ITGAM)
OOR: 101287801(ITGAM)
DLE: 111171171 111182295(ITGAM)
ECB: 100064803(ITGAM)
EPZ: 103547251(ITGAM)
EAI: 106831877(ITGAM)
MYB: 102257478(ITGAM)
MYD: 102754125(ITGAM) 102770846
MNA: 107540812(ITGAM)
HAI: 109374167
RSS: 109437821(ITGAM)
DRO: 112304783(ITGAM)
PALE: 102889241(ITGAM)
RAY: 107506837(ITGAM)
TMU: 101357920
MDO: 100016833
PCW: 110220501
OAA: 100085462
PSS: 106731488
ACS: 100556984(itgam) 100564209
PVT: 110078524
XTR: 100495489(itgad) 101731775
NPR: 108801695
TRU: 101074990
NCC: 104955738
PRET: 103481408
SDU: 111220319
SASA: 106564975
OTW: 112223837
LCM: 102360838
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2457584
  Authors
Corbi AL, Kishimoto TK, Miller LJ, Springer TA
  Title
The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.
  Journal
J Biol Chem 263:12403-11 (1988)
  Sequence
[hsa:3684]
Reference
  Authors
Ding C, Ma Y, Chen X, Liu M, Cai Y, Hu X, Xiang D, Nath S, Zhang HG, Ye H, Powell D, Yan J
  Title
Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance.
  Journal
Nat Commun 4:2813 (2013)
DOI:10.1038/ncomms3813
LinkDB All DBs

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