KEGG   ORTHOLOGY: K06476Help
Entry
K06476                      KO                                     

Name
ITGA2B, CD41
Definition
integrin alpha 2B
Pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04611  Platelet activation
ko04640  Hematopoietic cell lineage
ko04810  Regulation of actin cytoskeleton
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ko05414  Dilated cardiomyopathy (DCM)
ko05418  Fluid shear stress and atherosclerosis
Disease
H00226  Glanzmann thrombasthenia
H01740  Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
   04151 PI3K-Akt signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06476  ITGA2B, CD41; integrin alpha 2B
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06476  ITGA2B, CD41; integrin alpha 2B
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06476  ITGA2B, CD41; integrin alpha 2B
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06476  ITGA2B, CD41; integrin alpha 2B
   04611 Platelet activation
    K06476  ITGA2B, CD41; integrin alpha 2B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K06476  ITGA2B, CD41; integrin alpha 2B
   05410 Hypertrophic cardiomyopathy (HCM)
    K06476  ITGA2B, CD41; integrin alpha 2B
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06476  ITGA2B, CD41; integrin alpha 2B
   05414 Dilated cardiomyopathy (DCM)
    K06476  ITGA2B, CD41; integrin alpha 2B
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K06476  ITGA2B, CD41; integrin alpha 2B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06476  ITGA2B, CD41; integrin alpha 2B
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06476  ITGA2B, CD41; integrin alpha 2B
   04515 Cell adhesion molecules
    K06476  ITGA2B, CD41; integrin alpha 2B
   04090 CD molecules
    K06476  ITGA2B, CD41; integrin alpha 2B
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06476  ITGA2B, CD41; integrin alpha 2B
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06476  ITGA2B, CD41; integrin alpha 2B
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K06476  ITGA2B, CD41; integrin alpha 2B
CD molecules [BR:ko04090]
 Proteins
  K06476  CD41, ITGA2B; integrin, alpha 2b
BRITE hierarchy
Genes
HSA: 3674(ITGA2B)
PTR: 454730(ITGA2B)
PPS: 100991197(ITGA2B)
GGO: 101136113(ITGA2B)
PON: 100452800(ITGA2B)
NLE: 100601385(ITGA2B)
MCC: 714955(ITGA2B)
MCF: 102119413(ITGA2B)
CSAB: 103243322(ITGA2B)
RRO: 104654717(ITGA2B)
RBB: 108532191(ITGA2B)
CJC: 100408748(ITGA2B)
SBQ: 101031876(ITGA2B)
MMU: 16399(Itga2b)
MCAL: 110304761(Itga2b)
MPAH: 110331902(Itga2b)
RNO: 685269(Itga2b)
MUN: 110551893(Itga2b)
CGE: 100762814(Itga2b)
NGI: 103738294(Itga2b)
HGL: 101714332(Itga2b)
CCAN: 109686433(Itga2b)
OCU: 100008734(ITGA2B)
TUP: 102493954(ITGA2B)
CFA: 403789(ITGA2B)
VVP: 112910659(ITGA2B)
AML: 100484185(ITGA2B)
UMR: 103665592(ITGA2B)
UAH: 113265351(ITGA2B)
ORO: 101369639(ITGA2B)
FCA: 101100930(ITGA2B)
PTG: 102951724(ITGA2B)
AJU: 106974321(ITGA2B)
BTA: 515011(ITGA2B)
BOM: 102275560(ITGA2B)
BIU: 109573568(ITGA2B)
BBUB: 102401103(ITGA2B)
PHD: 102319110(ITGA2B)
CHX: 102183451(ITGA2B)
OAS: 101115719(ITGA2B)
SSC: 397059(ITGA2B)
CFR: 102521427(ITGA2B)
CDK: 105094425(ITGA2B)
BACU: 102999724(ITGA2B)
LVE: 103075356(ITGA2B)
OOR: 101276321(ITGA2B)
DLE: 111170236(ITGA2B)
PCAD: 102994051(ITGA2B)
ECB: 100009697(ITGA2B)
EPZ: 103551206(ITGA2B)
EAI: 106836459(ITGA2B)
MYB: 102252761(ITGA2B)
MYD: 102767172(ITGA2B)
MNA: 107528854(ITGA2B)
HAI: 109394948(ITGA2B)
RSS: 109458526(ITGA2B)
DRO: 112298771(ITGA2B)
PALE: 102883900(ITGA2B)
RAY: 107508144(ITGA2B)
LAV: 100654429(ITGA2B)
TMU: 101348507
MDO: 100023354(ITGA2B)
SHR: 100932021(ITGA2B)
PCW: 110215866(ITGA2B)
OAA: 114815046(ITGA2B)
GGA: 101749783(ITGA2B)
MGP: 104916711
CJO: 107325000(ITGA2B)
APLA: 101792319(ITGA2B)
ACYG: 106046909(ITGA2B)
LSR: 110475605(ITGA2B)
SCAN: 103821768
GFR: 106632013(ITGA2B)
FAB: 101814120(ITGA2B)
PHI: 102101807(ITGA2B)
PMAJ: 107215044(ITGA2B)
CCAE: 111944597
ETL: 114070734 114071998(ITGA2B)
FPG: 101913845(ITGA2B)
FCH: 102046031
CLV: 102098721(ITGA2B)
EGZ: 104132293
NNI: 104018919(ITGA2B)
ASN: 102372475(ITGA2B)
AMJ: 102570562(ITGA2B)
CMY: 102942431(ITGA2B)
CPIC: 101947159(ITGA2B)
ACS: 100557235(itga2b)
PVT: 110081352(ITGA2B)
PBI: 103054796(ITGA2B)
PMUR: 107302354(ITGA2B)
GJA: 107111368
XLA: 100191022(itga2b.1.S) 495051(itga2b.2.L)
XTR: 100158580(itga2b.1) 100495138(itga2b.2)
DRE: 445380(itga2b)
SRX: 107725055
SANH: 107684632
SGH: 107590780
IPU: 108258137(itga2b)
PHYP: 113528575(itga2b)
AMEX: 103045206
EEE: 113573210
LCO: 104938137(itga2b)
XMA: 102221313
XCO: 114160244(itga2b)
PRET: 103469027
LCF: 108873242(itga2b)
SDU: 111239798
MALB: 109972671(itga2b)
OTW: 112258495
ELS: 105023367
SFM: 108941551
PKI: 111855947
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2439501
  Authors
Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS
  Title
Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.
  Journal
J Biol Chem 262:8476-82 (1987)
  Sequence
[hsa:3674]
Reference
  Authors
Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fassler R, Ginsberg MH
  Title
The mechanism of kindlin-mediated activation of integrin alphaIIbbeta3.
  Journal
Curr Biol 23:2288-95 (2013)
DOI:10.1016/j.cub.2013.09.050
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