ORTHOLOGY: K06476
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Entry
K06476 KO
Name
ITGA2B, CD41
Definition
integrin alpha 2B
Pathway
ko04015
Rap1 signaling pathway
ko04151
PI3K-Akt signaling pathway
ko04510
Focal adhesion
ko04512
ECM-receptor interaction
ko04611
Platelet activation
ko04613
Neutrophil extracellular trap formation
ko04640
Hematopoietic cell lineage
ko04810
Regulation of actin cytoskeleton
ko05165
Human papillomavirus infection
ko05200
Pathways in cancer
ko05222
Small cell lung cancer
ko05410
Hypertrophic cardiomyopathy
ko05412
Arrhythmogenic right ventricular cardiomyopathy
ko05414
Dilated cardiomyopathy
ko05418
Fluid shear stress and atherosclerosis
Disease
H00226
Glanzmann thrombasthenia
H01740
Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
K06476 ITGA2B, CD41; integrin alpha 2B
04151 PI3K-Akt signaling pathway
K06476 ITGA2B, CD41; integrin alpha 2B
09133 Signaling molecules and interaction
04512 ECM-receptor interaction
K06476 ITGA2B, CD41; integrin alpha 2B
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
K06476 ITGA2B, CD41; integrin alpha 2B
09142 Cell motility
04810 Regulation of actin cytoskeleton
K06476 ITGA2B, CD41; integrin alpha 2B
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
K06476 ITGA2B, CD41; integrin alpha 2B
04611 Platelet activation
K06476 ITGA2B, CD41; integrin alpha 2B
04613 Neutrophil extracellular trap formation
K06476 ITGA2B, CD41; integrin alpha 2B
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K06476 ITGA2B, CD41; integrin alpha 2B
09162 Cancer: specific types
05222 Small cell lung cancer
K06476 ITGA2B, CD41; integrin alpha 2B
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
K06476 ITGA2B, CD41; integrin alpha 2B
05410 Hypertrophic cardiomyopathy
K06476 ITGA2B, CD41; integrin alpha 2B
05412 Arrhythmogenic right ventricular cardiomyopathy
K06476 ITGA2B, CD41; integrin alpha 2B
05414 Dilated cardiomyopathy
K06476 ITGA2B, CD41; integrin alpha 2B
09172 Infectious disease: viral
05165 Human papillomavirus infection
K06476 ITGA2B, CD41; integrin alpha 2B
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins
K06476 ITGA2B, CD41; integrin alpha 2B
09183 Protein families: signaling and cellular processes
04147 Exosome
K06476 ITGA2B, CD41; integrin alpha 2B
04515 Cell adhesion molecules
K06476 ITGA2B, CD41; integrin alpha 2B
04090 CD molecules
K06476 ITGA2B, CD41; integrin alpha 2B
Protein phosphatases and associated proteins [BR:
ko01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
K06476 ITGA2B, CD41; integrin alpha 2B
Exosome [BR:
ko04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
K06476 ITGA2B, CD41; integrin alpha 2B
Cell adhesion molecules [BR:
ko04515
]
Integrins
Integrin alpha subunits
K06476 ITGA2B, CD41; integrin alpha 2B
CD molecules [BR:
ko04090
]
Proteins
K06476 CD41, ITGA2B; integrin, alpha 2b
BRITE hierarchy
Genes
HSA:
3674
(ITGA2B)
PTR:
454730
(ITGA2B)
PPS:
100991197
(ITGA2B)
GGO:
101136113
(ITGA2B)
PON:
100452800
(ITGA2B)
NLE:
100601385
(ITGA2B)
MCC:
714955
(ITGA2B)
MCF:
102119413
(ITGA2B)
CSAB:
103243322
(ITGA2B)
RRO:
104654717
(ITGA2B)
RBB:
108532191
(ITGA2B)
CJC:
100408748
(ITGA2B)
SBQ:
101031876
(ITGA2B)
MMU:
16399
(Itga2b)
MCAL:
110304761
(Itga2b)
MPAH:
110331902
(Itga2b)
RNO:
685269
(Itga2b)
MUN:
110551893
(Itga2b)
CGE:
100762814
(Itga2b)
NGI:
103738294
(Itga2b)
HGL:
101714332
(Itga2b)
CCAN:
109686433
(Itga2b)
OCU:
100008734
(ITGA2B)
TUP:
102493954
(ITGA2B)
CFA:
403789
(ITGA2B)
VVP:
112910659
(ITGA2B)
AML:
100484185
(ITGA2B)
UMR:
103665592
(ITGA2B)
UAH:
113265351
(ITGA2B)
ORO:
101369639
(ITGA2B)
ELK:
111158126
FCA:
101100930
(ITGA2B)
PTG:
102951724
(ITGA2B)
PPAD:
109258195
(ITGA2B)
AJU:
106974321
(ITGA2B)
BTA:
515011
(ITGA2B)
BOM:
102275560
(ITGA2B)
BIU:
109573568
(ITGA2B)
BBUB:
102401103
(ITGA2B)
CHX:
102183451
(ITGA2B)
OAS:
101115719
(ITGA2B)
SSC:
397059
(ITGA2B)
CFR:
102521427
(ITGA2B)
CDK:
105094425
(ITGA2B)
BACU:
102999724
(ITGA2B)
LVE:
103075356
(ITGA2B)
OOR:
101276321
(ITGA2B)
DLE:
111170236
(ITGA2B)
PCAD:
102994051
(ITGA2B)
ECB:
100009697
(ITGA2B)
EPZ:
103551206
(ITGA2B)
EAI:
106836459
(ITGA2B)
MYB:
102252761
(ITGA2B)
MYD:
102767172
(ITGA2B)
MNA:
107528854
(ITGA2B)
HAI:
109394948
(ITGA2B)
DRO:
112298771
(ITGA2B)
PALE:
102883900
(ITGA2B)
RAY:
107508144
(ITGA2B)
MJV:
108410024
(ITGA2B)
LAV:
100654429
(ITGA2B)
TMU:
101348507
MDO:
100023354
(ITGA2B)
SHR:
100932021
(ITGA2B)
PCW:
110215866
(ITGA2B)
OAA:
114815046
(ITGA2B)
GGA:
101749783
(ITGA2B)
MGP:
104916711
CJO:
107325000
(ITGA2B)
APLA:
101792319
(ITGA2B)
ACYG:
106046909
(ITGA2B)
TGU:
115490715
(ITGA2B)
LSR:
110475605
(ITGA2B)
SCAN:
103821768
(ITGA2B)
FAB:
101814120
(ITGA2B)
PHI:
102101807
(ITGA2B)
PMAJ:
107215044
(ITGA2B)
ETL:
114071998
(ITGA2B)
FPG:
101913845
(ITGA2B)
FCH:
102046031
CLV:
102098721
(ITGA2B)
EGZ:
104132293
NNI:
104018919
(ITGA2B)
ASN:
102372475
(ITGA2B)
AMJ:
102570562
(ITGA2B)
CPIC:
101947159
(ITGA2B)
ACS:
100557235
(itga2b)
PVT:
110081352
(ITGA2B)
PBI:
103054796
(ITGA2B)
PMUR:
107302354
(ITGA2B)
TSR:
106557240
(ITGA2B)
PMUA:
114608018
(ITGA2B)
XLA:
100191022
(itga2b.1.S)
495051
(itga2b.2.L)
XTR:
100158580
(itga2b.1)
100495138
(itga2b.2)
NPR:
108785975
108785976
DRE:
445380
(itga2b)
SRX:
107725055
SANH:
107684632
SGH:
107590780
IPU:
108258137
(itga2b)
PHYP:
113528575
(itga2b)
AMEX:
103045206
EEE:
113573210
LCO:
104938137
(itga2b)
ONL:
100704409
XMA:
102221313
XCO:
114160244
(itga2b)
PRET:
103469027
CVG:
107082026
(itga2b)
LCF:
108873242
(itga2b)
SDU:
111239798
SLAL:
111657524
MALB:
109972671
(itga2b)
SASA:
106600877
106607455
OTW:
112258495
SALP:
111979899
111980077
ELS:
105023367
SFM:
108941551
PKI:
111855947
NVL:
108563388
BMOR:
101737408
BMAN:
114248875
PVM:
113815644
PCAN:
112565128
» show all
Taxonomy
UniProt
Reference
PMID:
2439501
Authors
Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS
Title
Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.
Journal
J Biol Chem 262:8476-82 (1987)
Sequence
[hsa:
3674
]
Reference
PMID:
24210614
Authors
Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fassler R, Ginsberg MH
Title
The mechanism of kindlin-mediated activation of integrin alphaIIbbeta3.
Journal
Curr Biol 23:2288-95 (2013)
DOI:
10.1016/j.cub.2013.09.050
LinkDB
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DBGET
integrated database retrieval system