KEGG   ORTHOLOGY: K06476
Entry
K06476                      KO                                     

Name
ITGA2B, CD41
Definition
integrin alpha 2B
Pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04611  Platelet activation
ko04613  Neutrophil extracellular trap formation
ko04640  Hematopoietic cell lineage
ko04810  Regulation of actin cytoskeleton
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
ko05410  Hypertrophic cardiomyopathy
ko05412  Arrhythmogenic right ventricular cardiomyopathy
ko05414  Dilated cardiomyopathy
ko05418  Fluid shear stress and atherosclerosis
Disease
H00226  Glanzmann thrombasthenia
H01740  Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
   04151 PI3K-Akt signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06476  ITGA2B, CD41; integrin alpha 2B
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06476  ITGA2B, CD41; integrin alpha 2B
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06476  ITGA2B, CD41; integrin alpha 2B
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06476  ITGA2B, CD41; integrin alpha 2B
   04611 Platelet activation
    K06476  ITGA2B, CD41; integrin alpha 2B
   04613  Neutrophil extracellular trap formation
    K06476  ITGA2B, CD41; integrin alpha 2B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K06476  ITGA2B, CD41; integrin alpha 2B
   05410 Hypertrophic cardiomyopathy
    K06476  ITGA2B, CD41; integrin alpha 2B
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K06476  ITGA2B, CD41; integrin alpha 2B
   05414 Dilated cardiomyopathy
    K06476  ITGA2B, CD41; integrin alpha 2B
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K06476  ITGA2B, CD41; integrin alpha 2B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06476  ITGA2B, CD41; integrin alpha 2B
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06476  ITGA2B, CD41; integrin alpha 2B
   04515 Cell adhesion molecules
    K06476  ITGA2B, CD41; integrin alpha 2B
   04090 CD molecules
    K06476  ITGA2B, CD41; integrin alpha 2B
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06476  ITGA2B, CD41; integrin alpha 2B
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06476  ITGA2B, CD41; integrin alpha 2B
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K06476  ITGA2B, CD41; integrin alpha 2B
CD molecules [BR:ko04090]
 Proteins
  K06476  CD41, ITGA2B; integrin, alpha 2b
Genes
HSA: 3674(ITGA2B)
PTR: 454730(ITGA2B)
PPS: 100991197(ITGA2B)
GGO: 101136113(ITGA2B)
PON: 100452800(ITGA2B)
NLE: 100601385(ITGA2B)
MCC: 714955(ITGA2B)
MCF: 102119413(ITGA2B)
CSAB: 103243322(ITGA2B)
RRO: 104654717(ITGA2B)
RBB: 108532191(ITGA2B)
CJC: 100408748(ITGA2B)
SBQ: 101031876(ITGA2B)
MMU: 16399(Itga2b)
MCAL: 110304761(Itga2b)
MPAH: 110331902(Itga2b)
RNO: 685269(Itga2b)
MUN: 110551893(Itga2b)
CGE: 100762814(Itga2b)
NGI: 103738294(Itga2b)
HGL: 101714332(Itga2b)
CCAN: 109686433(Itga2b)
OCU: 100008734(ITGA2B)
TUP: 102493954(ITGA2B)
CFA: 403789(ITGA2B)
VVP: 112910659(ITGA2B)
AML: 100484185(ITGA2B)
UMR: 103665592(ITGA2B)
UAH: 113265351(ITGA2B)
ORO: 101369639(ITGA2B)
ELK: 111158126
FCA: 101100930(ITGA2B)
PTG: 102951724(ITGA2B)
PPAD: 109258195(ITGA2B)
AJU: 106974321(ITGA2B)
BTA: 515011(ITGA2B)
BOM: 102275560(ITGA2B)
BIU: 109573568(ITGA2B)
BBUB: 102401103(ITGA2B)
CHX: 102183451(ITGA2B)
OAS: 101115719(ITGA2B)
SSC: 397059(ITGA2B)
CFR: 102521427(ITGA2B)
CDK: 105094425(ITGA2B)
BACU: 102999724(ITGA2B)
LVE: 103075356(ITGA2B)
OOR: 101276321(ITGA2B)
DLE: 111170236(ITGA2B)
PCAD: 102994051(ITGA2B)
ECB: 100009697(ITGA2B)
EPZ: 103551206(ITGA2B)
EAI: 106836459(ITGA2B)
MYB: 102252761(ITGA2B)
MYD: 102767172(ITGA2B)
MNA: 107528854(ITGA2B)
HAI: 109394948(ITGA2B)
DRO: 112298771(ITGA2B)
PALE: 102883900(ITGA2B)
RAY: 107508144(ITGA2B)
MJV: 108410024(ITGA2B)
LAV: 100654429(ITGA2B)
TMU: 101348507
MDO: 100023354(ITGA2B)
SHR: 100932021(ITGA2B)
PCW: 110215866(ITGA2B)
OAA: 114815046(ITGA2B)
GGA: 101749783(ITGA2B)
MGP: 104916711
CJO: 107325000(ITGA2B)
APLA: 101792319(ITGA2B)
ACYG: 106046909(ITGA2B)
TGU: 115490715(ITGA2B)
LSR: 110475605(ITGA2B)
SCAN: 103821768(ITGA2B)
FAB: 101814120(ITGA2B)
PHI: 102101807(ITGA2B)
PMAJ: 107215044(ITGA2B)
ETL: 114071998(ITGA2B)
FPG: 101913845(ITGA2B)
FCH: 102046031
CLV: 102098721(ITGA2B)
EGZ: 104132293
NNI: 104018919(ITGA2B)
ASN: 102372475(ITGA2B)
AMJ: 102570562(ITGA2B)
CPIC: 101947159(ITGA2B)
ACS: 100557235(itga2b)
PVT: 110081352(ITGA2B)
PBI: 103054796(ITGA2B)
PMUR: 107302354(ITGA2B)
TSR: 106557240(ITGA2B)
PMUA: 114608018(ITGA2B)
XLA: 100191022(itga2b.1.S) 495051(itga2b.2.L)
XTR: 100158580(itga2b.1) 100495138(itga2b.2)
NPR: 108785975 108785976
DRE: 445380(itga2b)
SRX: 107725055
SANH: 107684632
SGH: 107590780
IPU: 108258137(itga2b)
PHYP: 113528575(itga2b)
AMEX: 103045206
EEE: 113573210
LCO: 104938137(itga2b)
ONL: 100704409
XMA: 102221313
XCO: 114160244(itga2b)
PRET: 103469027
CVG: 107082026(itga2b)
LCF: 108873242(itga2b)
SDU: 111239798
SLAL: 111657524
MALB: 109972671(itga2b)
SASA: 106600877 106607455
OTW: 112258495
SALP: 111979899 111980077
ELS: 105023367
SFM: 108941551
PKI: 111855947
NVL: 108563388
BMOR: 101737408
BMAN: 114248875
PVM: 113815644
PCAN: 112565128
 » show all
Reference
PMID:2439501
  Authors
Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS
  Title
Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.
  Journal
J Biol Chem 262:8476-82 (1987)
  Sequence
[hsa:3674]
Reference
  Authors
Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fassler R, Ginsberg MH
  Title
The mechanism of kindlin-mediated activation of integrin alphaIIbbeta3.
  Journal
Curr Biol 23:2288-95 (2013)
DOI:10.1016/j.cub.2013.09.050
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