KEGG ORTHOLOGY: K06476

ORTHOLOGY: K06476

Entry

K06476 KO

Name

ITGA2B, CD41

Definition

integrin alpha 2B

Pathway

ko04015

Rap1 signaling pathway

ko04151

PI3K-Akt signaling pathway

ko04510

Focal adhesion

ko04512

ECM-receptor interaction

ko04611

Platelet activation

ko04640

Hematopoietic cell lineage

ko04810

Regulation of actin cytoskeleton

ko05165

Human papillomavirus infection

ko05200

Pathways in cancer

ko05222

Small cell lung cancer

ko05410

Hypertrophic cardiomyopathy (HCM)

ko05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

ko05414

Dilated cardiomyopathy (DCM)

ko05418

Fluid shear stress and atherosclerosis

Disease

H00226

Glanzmann thrombasthenia

H01740

Macrothrombocytopenia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
   04151 PI3K-Akt signaling pathway
    K06476  ITGA2B, CD41; integrin alpha 2B
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06476  ITGA2B, CD41; integrin alpha 2B
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06476  ITGA2B, CD41; integrin alpha 2B
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06476  ITGA2B, CD41; integrin alpha 2B
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06476  ITGA2B, CD41; integrin alpha 2B
   04611 Platelet activation
    K06476  ITGA2B, CD41; integrin alpha 2B
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K06476  ITGA2B, CD41; integrin alpha 2B
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K06476  ITGA2B, CD41; integrin alpha 2B
   05410 Hypertrophic cardiomyopathy (HCM)
    K06476  ITGA2B, CD41; integrin alpha 2B
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06476  ITGA2B, CD41; integrin alpha 2B
   05414 Dilated cardiomyopathy (DCM)
    K06476  ITGA2B, CD41; integrin alpha 2B
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K06476  ITGA2B, CD41; integrin alpha 2B
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06476  ITGA2B, CD41; integrin alpha 2B
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06476  ITGA2B, CD41; integrin alpha 2B
   04515 Cell adhesion molecules
    K06476  ITGA2B, CD41; integrin alpha 2B
   04090 CD molecules
    K06476  ITGA2B, CD41; integrin alpha 2B
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06476  ITGA2B, CD41; integrin alpha 2B
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06476  ITGA2B, CD41; integrin alpha 2B
Cell adhesion molecules [BR:ko04515]
Integrins
  Integrin alpha subunits
   K06476  ITGA2B, CD41; integrin alpha 2B
CD molecules [BR:ko04090]
Proteins
  K06476  CD41, ITGA2B; integrin, alpha 2b

Genes

HSA:	3674(ITGA2B)

PTR:	454730(ITGA2B)

PPS:	100991197(ITGA2B)

GGO:	101136113(ITGA2B)

PON:	100452800(ITGA2B)

NLE:	100601385(ITGA2B)

MCC:	714955(ITGA2B)

MCF:	102119413(ITGA2B)

CSAB:

103243322(ITGA2B)

RRO:	104654717(ITGA2B)

RBB:	108532191(ITGA2B)

CJC:	100408748(ITGA2B)

SBQ:	101031876(ITGA2B)

MMU:	16399(Itga2b)

MCAL:

110304761(Itga2b)

MPAH:

110331902(Itga2b)

RNO:	685269(Itga2b)

MUN:	110551893(Itga2b)

CGE:	100762814(Itga2b)

NGI:	103738294(Itga2b)

HGL:	101714332(Itga2b)

CCAN:

109686433(Itga2b)

OCU:	100008734(ITGA2B)

TUP:	102493954(ITGA2B)

CFA:	403789(ITGA2B)

VVP:	112910659(ITGA2B)

AML:	100484185(ITGA2B)

UMR:	103665592(ITGA2B)

UAH:	113265351(ITGA2B)

ORO:	101369639(ITGA2B)

FCA:	101100930(ITGA2B)

PTG:	102951724(ITGA2B)

AJU:	106974321(ITGA2B)

BTA:	515011(ITGA2B)

BOM:	102275560(ITGA2B)

BIU:	109573568(ITGA2B)

BBUB:

102401103(ITGA2B)

PHD:	102319110(ITGA2B)

CHX:	102183451(ITGA2B)

OAS:	101115719(ITGA2B)

SSC:	397059(ITGA2B)

CFR:	102521427(ITGA2B)

CDK:	105094425(ITGA2B)

BACU:

102999724(ITGA2B)

LVE:	103075356(ITGA2B)

OOR:	101276321(ITGA2B)

DLE:	111170236(ITGA2B)

PCAD:

102994051(ITGA2B)

ECB:	100009697(ITGA2B)

EPZ:	103551206(ITGA2B)

EAI:	106836459(ITGA2B)

MYB:	102252761(ITGA2B)

MYD:	102767172(ITGA2B)

MNA:	107528854(ITGA2B)

HAI:	109394948(ITGA2B)

RSS:	109458526(ITGA2B)

DRO:	112298771(ITGA2B)

PALE:

102883900(ITGA2B)

RAY:	107508144(ITGA2B)

LAV:	100654429(ITGA2B)

TMU:

101348507

MDO:	100023354(ITGA2B)

SHR:	100932021(ITGA2B)

PCW:	110215866(ITGA2B)

OAA:	114815046(ITGA2B)

GGA:	101749783(ITGA2B)

MGP:

104916711

CJO:	107325000(ITGA2B)

APLA:

101792319(ITGA2B)

ACYG:

106046909(ITGA2B)

LSR:	110475605(ITGA2B)

SCAN:

103821768

GFR:	106632013(ITGA2B)

FAB:	101814120(ITGA2B)

PHI:	102101807(ITGA2B)

PMAJ:

107215044(ITGA2B)

CCAE:

111944597

ETL:	114070734 114071998(ITGA2B)

FPG:	101913845(ITGA2B)

FCH:

102046031

CLV:	102098721(ITGA2B)

EGZ:

104132293

NNI:	104018919(ITGA2B)

ASN:	102372475(ITGA2B)

AMJ:	102570562(ITGA2B)

CMY:	102942431(ITGA2B)

CPIC:

101947159(ITGA2B)

ACS:	100557235(itga2b)

PVT:	110081352(ITGA2B)

PBI:	103054796(ITGA2B)

PMUR:

107302354(ITGA2B)

GJA:

107111368

XLA:	100191022(itga2b.1.S) 495051(itga2b.2.L)

XTR:	100158580(itga2b.1) 100495138(itga2b.2)

NPR:	108785975 108785976

DRE:	445380(itga2b)

SRX:

107725055

SANH:

107684632

SGH:

107590780

IPU:	108258137(itga2b)

PHYP:

113528575(itga2b)

AMEX:

103045206

EEE:

113573210

LCO:	104938137(itga2b)

XMA:

102221313

XCO:	114160244(itga2b)

PRET:

103469027

LCF:	108873242(itga2b)

SDU:

111239798

MALB:

109972671(itga2b)

SASA:

106600877 106607455

OTW:

112258495

SALP:

111979899 111980077 112079852

ELS:

SFM:

PKI:

Reference

PMID:2439501

Authors

Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS

Title

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

Journal

J Biol Chem 262:8476-82 (1987)

Sequence

[hsa:3674]

Reference

PMID:24210614

Authors

Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fassler R, Ginsberg MH

Title

The mechanism of kindlin-mediated activation of integrin alphaIIbbeta3.

Journal

Curr Biol 23:2288-95 (2013)
DOI:10.1016/j.cub.2013.09.050

LinkDB

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