KEGG   ORTHOLOGY: K06624Help
Entry
K06624                      KO                                     

Name
CDKN1B, P27, KIP1
Definition
cyclin-dependent kinase inhibitor 1B
Pathway
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04151  PI3K-Akt signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04934  Cushing syndrome
ko05162  Measles
ko05165  Human papillomavirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05203  Viral carcinogenesis
ko05206  MicroRNAs in cancer
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05226  Gastric cancer
Disease
H00018  Gastric cancer
H00024  Prostate cancer
H00247  Multiple endocrine neoplasia syndrome
H01102  Pituitary adenomas
H01431  Cushing syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   04066 HIF-1 signaling pathway
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   04068 FoxO signaling pathway
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   04151 PI3K-Akt signaling pathway
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05202 Transcriptional misregulation in cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05206 MicroRNAs in cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05203 Viral carcinogenesis
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
  09162 Cancer: specific types
   05226 Gastric cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05220 Chronic myeloid leukemia
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05215 Prostate cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05222 Small cell lung cancer
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   04934 Cushing syndrome
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
  09172 Infectious disease: viral
   05162 Measles
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05169 Epstein-Barr virus infection
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
   05165 Human papillomavirus infection
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
BRITE hierarchy
Other DBs
GO: 0004861
Genes
HSA: 1027(CDKN1B)
PTR: 466947(CDKN1B)
PPS: 100985362(CDKN1B)
GGO: 101147653(CDKN1B)
PON: 100449905(CDKN1B)
NLE: 100589956(CDKN1B)
MCC: 697188(CDKN1B)
MCF: 102117954(CDKN1B)
CSAB: 103218647(CDKN1B)
RRO: 104668343(CDKN1B)
RBB: 108530341(CDKN1B)
CJC: 100387508(CDKN1B)
SBQ: 101030975(CDKN1B)
MMU: 12576(Cdkn1b)
MCAL: 110296846(Cdkn1b)
MPAH: 110316560(Cdkn1b)
RNO: 83571(Cdkn1b)
MUN: 110551008(Cdkn1b)
CGE: 100689401(Cdkn1b)
NGI: 103737662(Cdkn1b)
HGL: 101698721(Cdkn1b)
CCAN: 109701269(Cdkn1b)
OCU: 100009037(CDKN1B)
TUP: 102501235(CDKN1B)
CFA: 403429(CDKN1B)
VVP: 112917274(CDKN1B)
AML: 100467824(CDKN1B)
UMR: 103677760(CDKN1B)
UAH: 113257870(CDKN1B)
ORO: 101362774(CDKN1B)
FCA: 493958(CDKN1B)
PTG: 102965656(CDKN1B)
AJU: 106965649(CDKN1B)
BTA: 512613(CDKN1B)
BOM: 102276245(CDKN1B)
BIU: 109559641(CDKN1B)
BBUB: 102406138(CDKN1B)
CHX: 102175277(CDKN1B)
OAS: 100127219(CDKN1B)
SSC: 397584(CDKN1B)
CFR: 102518884(CDKN1B)
CDK: 105094245(CDKN1B)
BACU: 103001464(CDKN1B)
LVE: 103070701(CDKN1B)
OOR: 101287264(CDKN1B)
DLE: 111176781(CDKN1B)
PCAD: 102981902(CDKN1B)
ECB: 111773925(CDKN1B)
EPZ: 103552733(CDKN1B)
EAI: 106826745(CDKN1B)
MYB: 102252017(CDKN1B)
MYD: 102767192(CDKN1B)
MNA: 107525363(CDKN1B)
HAI: 109383166(CDKN1B)
RSS: 109454291(CDKN1B)
DRO: 112318485(CDKN1B)
PALE: 102880085(CDKN1B)
RAY: 107516566(CDKN1B)
LAV: 100674125(CDKN1B)
TMU: 101360273
MDO: 100014923(CDKN1B)
SHR: 100928055(CDKN1B)
PCW: 110218707(CDKN1B)
OAA: 100090228(CDKN1B)
GGA: 374106(CDKN1B)
MGP: 100545308(CDKN1B)
CJO: 107317865(CDKN1B)
NMEL: 110390809(CDKN1B)
APLA: 101791694(CDKN1B)
ACYG: 106031051(CDKN1B)
TGU: 100190046(CDKN1B)
LSR: 110472989(CDKN1B)
SCAN: 103819664(CDKN1B)
GFR: 102045566(CDKN1B)
FAB: 101811953(CDKN1B)
PHI: 102099407(CDKN1B)
PMAJ: 107204220(CDKN1B)
CCAE: 111942051(CDKN1B)
FPG: 101922239(CDKN1B)
FCH: 102051672(CDKN1B)
CLV: 102092237(CDKN1B)
EGZ: 104124225(CDKN1B)
NNI: 104012648(CDKN1B)
AAM: 106488961(CDKN1B)
AMJ: 102571564(CDKN1B)
PSS: 102452459(CDKN1B)
CMY: 102935223(CDKN1B)
CPIC: 101954164(CDKN1B)
ACS: 100565024(cdkn1c) 100565071(cdkn1b)
PVT: 110074986
PMUR: 107286956(CDKN1B)
XLA: 108710741 492306(cdkn1b.S)
XTR: 101731332
DRE: 368329(cdkn1bb) 402862(cdkn1ba)
IPU: 100528292(cdkn1b) 108280031
PHYP: 113531770(cdkn1b)
AMEX: 103025923(cdkn1b) 103030485
TRU: 101071664(cdkn1b) 105417782
LCO: 104921009(cdkn1b) 104933552
NCC: 104955518(cdkn1b) 104955766
MZE: 101466273 101468035(cdkn1b)
OLA: 101166473(cdkn1b)
AOCE: 111573186 111577772(cdkn1b)
CSEM: 103380321(cdkn1b) 103382902
POV: 109624669(cdkn1b) 109632735
LCF: 108883075(cdkn1b) 108890602
SDU: 111224759 111229694(cdkn1b)
HCQ: 109523748 109529876(cdkn1b)
BPEC: 110164974 110169421(cdkn1b)
MALB: 109960936 109974134(cdkn1b)
SASA: 106560990(cdkn1b) 106575072(CDN1B) 106584490(CDN1B) 106609100
ELS: 105018460(cdkn1b) 105020266
PKI: 111833308(cdkn1b) 111858596
LCM: 102355060(CDKN1B)
CMK: 103179336(cdkn1b)
CIN: 100176340
APLC: 110991130
NVL: 108558381
PRAP: 110994043
BTAB: 109030635
DPTE: 113798025
ADF: 107339872
PDAM: 113675374
HMG: 100197618
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8033212
  Authors
Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague J
  Title
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
  Journal
Cell 78:59-66 (1994)
DOI:10.1016/0092-8674(94)90572-X
  Sequence
[hsa:1027]
Reference
  Authors
Lee J, Kim SS
  Title
The function of p27 KIP1 during tumor development.
  Journal
Exp Mol Med 41:765-71 (2009)
DOI:10.3858/emm.2009.41.11.102
  Sequence
[hsa:1027]
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