KEGG   ORTHOLOGY: K06854Help
Entry
K06854                      KO                                     

Name
THPO
Definition
thrombopoietin
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04630  JAK-STAT signaling pathway
ko04640  Hematopoietic cell lineage
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K06854  THPO; thrombopoietin
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K06854  THPO; thrombopoietin
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06854  THPO; thrombopoietin
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K06854  THPO; thrombopoietin
Cytokines and growth factors [BR:ko04052]
 Cytokines
  CSF and other factors
   K06854  THPO; thrombopoietin
BRITE hierarchy
Genes
HSA: 7066(THPO)
PTR: 736549(THPO)
PPS: 100980796(THPO)
GGO: 101153569(THPO)
PON: 100452053(THPO)
NLE: 100582097(THPO)
MCC: 100428640(THPO)
MCF: 102144240(THPO)
CSAB: 103221127(THPO)
RRO: 104664621(THPO)
RBB: 108525238(THPO)
CJC: 100399619(THPO) 103795045
SBQ: 101047352(THPO)
MMU: 21832(Thpo)
MCAL: 110311636(Thpo)
MPAH: 110329913(Thpo)
RNO: 108348162(Thpo) 81811(Thpo)
MUN: 110549398(Thpo)
CGE: 100774906(Thpo)
NGI: 103732660(Thpo)
HGL: 101705058(Thpo)
CCAN: 109694098(Thpo)
OCU: 100357079(THPO)
TUP: 102496781(THPO)
CFA: 100855822(THPO)
VVP: 112926269(THPO)
AML: 100469915(THPO)
UMR: 103676077(THPO)
UAH: 113254294(THPO)
ORO: 101363544(THPO)
ELK: 111151805
FCA: 100302539(THPO)
PTG: 102953221(THPO)
PPAD: 109275230(THPO)
AJU: 106983813(THPO)
BTA: 538672(THPO)
BOM: 102275287(THPO)
BIU: 109557333(THPO)
BBUB: 102409271(THPO)
CHX: 102181435(THPO)
OAS: 101119601(THPO)
SSC: 100620258(THPO)
CFR: 102521318(THPO)
CDK: 105085874(THPO)
BACU: 103007149
LVE: 103089418(THPO)
OOR: 101275544(THPO)
DLE: 111173147(THPO)
PCAD: 102978432(THPO)
ECB: 100059159(THPO)
EPZ: 103554738(THPO)
EAI: 106834515(THPO)
MYB: 102245928(THPO)
MYD: 102769651(THPO)
MNA: 107543119(THPO)
HAI: 109371411(THPO)
DRO: 112309408(THPO)
PALE: 102878621(THPO)
RAY: 107504909(THPO)
MJV: 108395274(THPO)
LAV: 100663051(THPO)
TMU: 101356566
MDO: 100026113(THPO)
SHR: 105750562(THPO)
PCW: 110221303(THPO)
OAA: 100090972(THPO)
GGA: 414803(THPO)
MGP: 100543941(THPO)
CJO: 107318257(THPO)
NMEL: 110397883(THPO)
ACYG: 106032161(THPO)
TGU: 100231762(THPO)
LSR: 110478160(THPO)
SCAN: 103815603(THPO)
GFR: 102041268(THPO)
FAB: 101806443(THPO)
PHI: 102103618(THPO)
PMAJ: 107209005(THPO)
CCAE: 111933391(THPO)
CCW: 104687985(THPO)
ETL: 114060825(THPO)
FPG: 101917806(THPO)
FCH: 102051023
CLV: 102089501(THPO)
EGZ: 104122234(THPO)
NNI: 104015698(THPO)
ACUN: 113483431(THPO)
PADL: 103925631(THPO)
AAM: 106494212(THPO)
ASN: 102371526(THPO)
AMJ: 102558692(THPO)
PSS: 102453725(THPO)
CMY: 102937299(THPO)
CPIC: 101950073(THPO)
ACS: 103280792(thpo)
PVT: 110089823(THPO)
PBI: 112542478(THPO)
PMUA: 114598050(THPO)
XLA: 108716349(thpo.L) 108717570(thpo.S)
XTR: 100489048(thpo)
NPR: 108804690(THPO)
DRE: 100189608(thpo)
SGH: 107553247
CCAR: 109086591
IPU: 108280322
ONL: 100689976
OLA: 110016899
NFU: 107383964
AOCE: 111578815(thpo)
CSEM: 103396086
POV: 109640320(thpo)
LCF: 108883465(thpo) 108888164
SDU: 111238992(thpo)
SLAL: 111653527(thpo)
SFM: 108932167(thpo)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kirito K, Watanabe T, Sawada K, Endo H, Ozawa K, Komatsu N
  Title
Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways.
  Journal
J Biol Chem 277:8329-37 (2002)
DOI:10.1074/jbc.M109824200
  Sequence
[hsa:7066]
Reference
  Authors
Chanprasert S, Geddis AE, Barroga C, Fox NE, Kaushansky K
  Title
Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes.
  Journal
Cell Signal 18:1212-8 (2006)
DOI:10.1016/j.cellsig.2005.09.010
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