KEGG   ORTHOLOGY: K07431
Entry
K07431                      KO                                     

Name
CYP8B1
Definition
sterol 12-alpha-hydroxylase [EC:1.14.14.139]
Pathway
ko00120  Primary bile acid biosynthesis
ko01100  Metabolic pathways
ko03320  PPAR signaling pathway
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K07431  CYP8B1; sterol 12-alpha-hydroxylase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07431  CYP8B1; sterol 12-alpha-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07431  CYP8B1; sterol 12-alpha-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.139  5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
     K07431  CYP8B1; sterol 12-alpha-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP8 family
   K07431  CYP8B1; sterol 12-alpha-hydroxylase
Other DBs
RN: R04826 R07204
GO: 0008397
Genes
HSA: 1582(CYP8B1)
PTR: 736962(CYP8B1)
PPS: 100969929
GGO: 101147556
PON: 100433242
NLE: 100605497
MCC: 717247
MCF: 102132602
CSAB: 103227471(CYP8B1)
RRO: 104670956
RBB: 108532333
CJC: 100402181(CYP8B1)
SBQ: 101037790
MMU: 13124(Cyp8b1)
MCAL: 110302470
MPAH: 110327161
RNO: 81924(Cyp8b1)
MUN: 110554660
CGE: 100770995
NGI: 103747146
CCAN: 109691739
OCU: 100009301(CYP8B1)
TUP: 102479742
CFA: 485619
VVP: 112921604
AML: 100464768
UMR: 103682072
UAH: 113253657
ORO: 101374077
ELK: 111158988
FCA: 101082004
PTG: 102956513
PPAD: 109248827
AJU: 106966675
BTA: 538964(CYP8B1)
BIU: 109576421
BBUB: 102407955
CHX: 102173339
OAS: 101119853
SSC: 403328(CYP8B1)
CFR: 102524173
CDK: 105084606
BACU: 103000983
LVE: 103085360
OOR: 101285967
DLE: 111164311
PCAD: 102990799
ECB: 100054970
EPZ: 103559259
EAI: 106843165
MYB: 102245777
MYD: 102765424
MNA: 107524319
HAI: 109377081
DRO: 112309563
PALE: 102877747
RAY: 107519986
MJV: 108397210
LAV: 100665029
TMU: 101356001
MDO: 100026525 100026549(CYP8B)
SHR: 100918099 100919664 100926550 105749568
PCW: 110217059
OAA: 103166427
GGA: 425055(CYP8B1)
MGP: 100546803
CJO: 107308837
NMEL: 110395135
APLA: 101797490
ACYG: 106036789
TGU: 100217899
LSR: 110474519
SCAN: 103812684
GFR: 102041987
FAB: 101809893
PHI: 102112501
PMAJ: 107201006
CCAE: 111925558
CCW: 104686389
ETL: 114064499
FPG: 101924073
FCH: 102052323
CLV: 102083443
EGZ: 104124585
NNI: 104021734
ACUN: 113476903
PADL: 103924714
ASN: 102374897
AMJ: 102573091(CYP8B1)
PSS: 102444673
CMY: 102934823
CPIC: 101950173
ACS: 100551676 100551876 100562756 100562953 100565509 100565705 100565905 100566106
PVT: 110091568 110091574 110091575
PBI: 103051222 103065731
PMUR: 107284342 107284343 107284344 107284346 107284348 107284362
TSR: 106538485 106538492
PMUA: 114607583 114607705 114607796 114607915
GJA: 107106985 107106986 107110695 107112093 107125164
XLA: 108718630 108718631(cyp8b1.L) 379482(cyp8b1.S)
XTR: 100488015(cyp8b1.2) 100488168(cyp8b1.1)
NPR: 108788787
DRE: 100004274(cyp8b2) 445281(cyp8b1) 447848(cyp8b3)
SRX: 107711691 107727542
SANH: 107661909 107671665
SGH: 107558014 107580338 107593879
CCAR: 109056773 109056779 109056788
IPU: 108261592 108268189 108268197
PHYP: 113524124 113524125
AMEX: 103039627
EEE: 113582944 113590803
TRU: 101070868 101071841 101080232 115248012 115248013
TNG: GSTEN00016125G001 GSTEN00016134G001
LCO: 104917693 104924020
NCC: 104940932 104941058
MZE: 101474730 106675939 106676194
ONL: 100693750 109195682 109195683 109195699
OLA: 101157008
XMA: 102227191
XCO: 114147167
PRET: 103479711
CVG: 107081670
NFU: 107383849
KMR: 108241650 108241654
ALIM: 106533255 106533266
AOCE: 111568649 111568654
CSEM: 103396384
POV: 109625444 109637167 109638123
LCF: 108883349 108893535
SDU: 111231161
SLAL: 111653251
HCQ: 109521313
BPEC: 110154953 110159864
SASA: 106569335 106599887 106599889
OTW: 112226785 112226786 112260644
SALP: 111956862
ELS: 105019795 105019804 106024913
SFM: 108919335 108937621 114910968 114910986
PKI: 111845862 111845867
LCM: 102357417 102361952
CMK: 103188298
RTP: 109923397
 » show all
Reference
  Authors
Gafvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Bjorkhem I, Eggertsen G
  Title
Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns.
  Journal
Genomics 56:184-96 (1999)
DOI:10.1006/geno.1998.5606
  Sequence
[hsa:1582] [mmu:13124]
Reference
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
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