KEGG   ORTHOLOGY: K07860
Entry
K07860                      KO                                     

Name
RAC2
Definition
Ras-related C3 botulinum toxin substrate 2
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04071  Sphingolipid signaling pathway
ko04310  Wnt signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko04520  Adherens junction
ko04613  Neutrophil extracellular trap formation
ko04650  Natural killer cell mediated cytotoxicity
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05020  Prion disease
ko05135  Yersinia infection
ko05163  Human cytomegalovirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05231  Choline metabolism in cancer
ko05416  Viral myocarditis
ko05418  Fluid shear stress and atherosclerosis
Disease
H00099  Leukocyte adhesion deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04014 Ras signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04015 Rap1 signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04310 Wnt signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04370 VEGF signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04071 Sphingolipid signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04024 cAMP signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04520 Adherens junction
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04650 Natural killer cell mediated cytotoxicity
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04662 B cell receptor signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04664 Fc epsilon RI signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04666 Fc gamma R-mediated phagocytosis
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04670 Leukocyte transendothelial migration
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04062 Chemokine signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09158 Development and regeneration
   04360 Axon guidance
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05231 Choline metabolism in cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05212 Pancreatic cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09164 Neurodegenerative disease
   05020 Prion disease
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05416 Viral myocarditis
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05163 Human cytomegalovirus infection
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
GTP-binding proteins [BR:ko04031]
 Small (monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
Genes
HSA: 5880(RAC2)
PTR: 742575(RAC2)
PPS: 100993959(RAC2)
GGO: 101141534(RAC2)
PON: 100431483(RAC2)
NLE: 100598232(RAC2)
MCC: 696709(RAC2)
MCF: 102137056(RAC2)
CSAB: 103223272(RAC2)
RRO: 104682502(RAC2)
RBB: 108512764(RAC2)
CJC: 100395636(RAC2)
SBQ: 101029481(RAC2)
MMU: 19354(Rac2)
MCAL: 110310226(Rac2)
MPAH: 110334678(Rac2)
RNO: 366957(Rac2)
MUN: 110548466(Rac2)
CGE: 100767225
NGI: 103748617(Rac2)
HGL: 101725000(Rac2)
CCAN: 109698248(Rac2)
OCU: 100356520(RAC2)
TUP: 102495436(RAC2)
CFA: 481271(RAC2)
VVP: 112929159(RAC2)
AML: 100469737(RAC2)
UMR: 103676407(RAC2)
UAH: 113241811(RAC2)
ORO: 101385830(RAC2)
ELK: 111157484
FCA: 101096744(RAC2)
PTG: 102961922(RAC2)
PPAD: 109265228(RAC2)
AJU: 106981077(RAC2)
BTA: 327671(RAC2)
BOM: 102277352(RAC2)
BIU: 109559531(RAC2)
BBUB: 102393591(RAC2)
CHX: 102178149(RAC2)
OAS: 101107592(RAC2)
SSC: 100621675(RAC2)
CFR: 102519112(RAC2)
CDK: 105101582(RAC2)
BACU: 103006132(RAC2)
LVE: 103076541(RAC2)
OOR: 101269741(RAC2)
DLE: 111186216(RAC2)
PCAD: 102990552(RAC2)
ECB: 100054701(RAC2)
EPZ: 103564464(RAC2)
EAI: 106837585(RAC2)
MYB: 102239988(RAC2)
MYD: 102768116(RAC2)
MNA: 107545262(RAC2)
HAI: 109394502(RAC2)
DRO: 112321719(RAC2)
PALE: 102885507(RAC2)
RAY: 107519267(RAC2)
MJV: 108392664(RAC2)
LAV: 100670080(RAC2)
TMU: 101355428
MDO: 100017517(RAC2)
SHR: 100932383(RAC2)
PCW: 110205748(RAC2)
OAA: 100092844(RAC2)
GGA: 418044(RAC2)
MGP: 100547045(RAC2)
CJO: 107313854(RAC2)
NMEL: 110393190(RAC2)
APLA: 101790794(RAC2)
ACYG: 106035903(RAC2)
TGU: 100230090(RAC2)
LSR: 110483874(RAC2)
SCAN: 103813234(RAC2)
GFR: 102031835(RAC2)
FAB: 101808708(RAC2)
PHI: 102106942(RAC2)
PMAJ: 107205038(RAC2)
CCAE: 111944780
CCW: 104696295(RAC2)
ETL: 114055413(RAC2)
FPG: 101915778(RAC2)
FCH: 102059263(RAC2)
CLV: 102092145(RAC2)
EGZ: 104134300(RAC2)
NNI: 104021590(RAC2)
ACUN: 113490117(RAC2)
PADL: 103924148(RAC2)
AAM: 106488354(RAC2)
ASN: 102388854(RAC2)
AMJ: 102567702(RAC2)
PSS: 102457520(RAC2)
CMY: 102936049(RAC2)
CPIC: 101933538(RAC2)
ACS: 100557692(rac2)
PVT: 110075970(RAC2)
PBI: 103057074(RAC2)
PMUR: 107302789(RAC2)
TSR: 106551146
PMUA: 114605675(RAC2)
GJA: 107120055(RAC2)
XLA: 108715797 444184(rac2.L)
XTR: 496738(rac2)
NPR: 108783678(RAC2)
DRE: 415151(rac2)
SRX: 107732889 107733870
SANH: 107680874 107690233
SGH: 107551172 107561353
CCAR: 109057594 109107281
IPU: 108276437
PHYP: 113523793
AMEX: 111193007
EEE: 113572862
TRU: 101071607
TNG: GSTEN00034813G001
LCO: 104925434(rac2)
MZE: 101488012
ONL: 100708296
OLA: 101163549
XMA: 102225118
XCO: 114144415
PRET: 103479675
CVG: 107084283(rac2)
NFU: 107391413
KMR: 108231305(rac2)
ALIM: 106522484
AOCE: 111577589
CSEM: 103383441(rac2)
POV: 109639279
LCF: 108889053(rac2) 108889076
SDU: 111235860
SLAL: 111671871
HCQ: 109511299
BPEC: 110157785
MALB: 109975044
SASA: 106564435(RAC2) 106590297(RAC2) 106601466(RAC2) 106601467(RAC2)
OTW: 112234040 112240485 112258954 112259231
SALP: 111981081
ELS: 105022954(rac2) 105031187(rac2)
SFM: 108925952 108930686
PKI: 111843315 111859727
LCM: 102351732(RAC2)
PTEP: 107457287
EGL: EGR_07105
EIV: EIN_042660 EIN_089020 EIN_124150 EIN_192840
NGR: NAEGRDRAFT_76783 NAEGRDRAFT_78331
 » show all
Reference
PMID:2674130
  Authors
Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R
  Title
rac, a novel ras-related family of proteins that are botulinum toxin substrates.
  Journal
J Biol Chem 264:16378-82 (1989)
  Sequence
[hsa:5880]
Reference
  Authors
Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgeman J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V
  Title
RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia.
  Journal
Blood 118:638-49 (2011)
DOI:10.1182/blood-2010-09-307330
  Sequence
[mmu:19354]
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