KEGG   ORTHOLOGY: K08048
Entry
K08048                      KO                                     

Name
ADCY8
Definition
adenylate cyclase 8 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04727  GABAergic synapse
ko04742  Taste transduction
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05032  Morphine addiction
ko05163  Human cytomegalovirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08048  ADCY8; adenylate cyclase 8
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04371 Apelin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04020 Calcium signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04072 Phospholipase D signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04024 cAMP signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04022 cGMP-PKG signaling pathway
    K08048  ADCY8; adenylate cyclase 8
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08048  ADCY8; adenylate cyclase 8
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08048  ADCY8; adenylate cyclase 8
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08048  ADCY8; adenylate cyclase 8
   04062 Chemokine signaling pathway
    K08048  ADCY8; adenylate cyclase 8
  09152 Endocrine system
   04911 Insulin secretion
    K08048  ADCY8; adenylate cyclase 8
   04923 Regulation of lipolysis in adipocytes
    K08048  ADCY8; adenylate cyclase 8
   04912 GnRH signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04913 Ovarian steroidogenesis
    K08048  ADCY8; adenylate cyclase 8
   04915 Estrogen signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04914 Progesterone-mediated oocyte maturation
    K08048  ADCY8; adenylate cyclase 8
   04921 Oxytocin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04926 Relaxin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04935 Growth hormone synthesis, secretion and action
    K08048  ADCY8; adenylate cyclase 8
   04918 Thyroid hormone synthesis
    K08048  ADCY8; adenylate cyclase 8
   04928 Parathyroid hormone synthesis, secretion and action
    K08048  ADCY8; adenylate cyclase 8
   04916 Melanogenesis
    K08048  ADCY8; adenylate cyclase 8
   04925 Aldosterone synthesis and secretion
    K08048  ADCY8; adenylate cyclase 8
   04927 Cortisol synthesis and secretion
    K08048  ADCY8; adenylate cyclase 8
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08048  ADCY8; adenylate cyclase 8
   04270 Vascular smooth muscle contraction
    K08048  ADCY8; adenylate cyclase 8
  09154 Digestive system
   04970 Salivary secretion
    K08048  ADCY8; adenylate cyclase 8
   04971 Gastric acid secretion
    K08048  ADCY8; adenylate cyclase 8
   04972 Pancreatic secretion
    K08048  ADCY8; adenylate cyclase 8
   04976 Bile secretion
    K08048  ADCY8; adenylate cyclase 8
  09156 Nervous system
   04724 Glutamatergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04727 GABAergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04725 Cholinergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04720 Long-term potentiation
    K08048  ADCY8; adenylate cyclase 8
   04723 Retrograde endocannabinoid signaling
    K08048  ADCY8; adenylate cyclase 8
  09157 Sensory system
   04742 Taste transduction
    K08048  ADCY8; adenylate cyclase 8
   04750 Inflammatory mediator regulation of TRP channels
    K08048  ADCY8; adenylate cyclase 8
  09149 Aging
   04211 Longevity regulating pathway
    K08048  ADCY8; adenylate cyclase 8
   04213 Longevity regulating pathway - multiple species
    K08048  ADCY8; adenylate cyclase 8
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08048  ADCY8; adenylate cyclase 8
   04714 Thermogenesis
    K08048  ADCY8; adenylate cyclase 8
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08048  ADCY8; adenylate cyclase 8
  09165 Substance dependence
   05032 Morphine addiction
    K08048  ADCY8; adenylate cyclase 8
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08048  ADCY8; adenylate cyclase 8
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08048  ADCY8; adenylate cyclase 8
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08048  ADCY8; adenylate cyclase 8
   05163 Human cytomegalovirus infection
    K08048  ADCY8; adenylate cyclase 8
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08048  ADCY8; adenylate cyclase 8
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08048  ADCY8; adenylate cyclase 8
Other DBs
RN: R00089 R00434
GO: 0008294
Genes
HSA: 114(ADCY8)
PTR: 464400(ADCY8)
PPS: 100994715(ADCY8)
GGO: 101142672(ADCY8)
PON: 100461383(ADCY8)
NLE: 100592592(ADCY8)
MCC: 695792(ADCY8)
MCF: 102144854(ADCY8)
CSAB: 103237447(ADCY8)
RRO: 104675683(ADCY8)
RBB: 108514094(ADCY8)
CJC: 100404484(ADCY8)
SBQ: 101034552(ADCY8)
MMU: 11514(Adcy8)
MCAL: 110310371(Adcy8)
MPAH: 110334612(Adcy8)
RNO: 29241(Adcy8)
CGE: 113837458
NGI: 103743923(Adcy8)
HGL: 101698293(Adcy8)
CCAN: 109678665(Adcy8)
OCU: 100337882(ADCY8)
TUP: 102472317(ADCY8)
CFA: 482045(ADCY8)
VVP: 112915982(ADCY8)
AML: 100474121(ADCY8)
UMR: 103661704(ADCY8)
UAH: 113252717(ADCY8)
ORO: 101370350(ADCY8)
ELK: 111146667
FCA: 101087555(ADCY8)
PTG: 102948581(ADCY8)
PPAD: 109273118(ADCY8)
AJU: 106976879(ADCY8)
BTA: 535017(ADCY8)
BOM: 102272964(ADCY8)
BIU: 109568647(ADCY8)
BBUB: 102395302(ADCY8)
CHX: 102184919(ADCY8)
OAS: 101121944(ADCY8)
SSC: 100622999(ADCY8)
CFR: 102521259(ADCY8)
CDK: 105096450(ADCY8)
BACU: 103019172(ADCY8)
LVE: 103085845(ADCY8)
OOR: 101273171(ADCY8)
DLE: 111164400(ADCY8)
PCAD: 102975211(ADCY8)
ECB: 100057796(ADCY8)
EPZ: 103565019 103567623(ADCY8)
EAI: 106824833(ADCY8)
MYB: 102249345(ADCY8)
MYD: 102765722(ADCY8)
MNA: 107539500(ADCY8)
HAI: 109372359(ADCY8)
DRO: 112315487(ADCY8)
PALE: 102896789(ADCY8)
RAY: 107497689(ADCY8)
MJV: 108397669(ADCY8)
LAV: 100661616(ADCY8)
TMU: 101350704
MDO: 100026554(ADCY8)
SHR: 100923926(ADCY8)
PCW: 110216073(ADCY8)
OAA: 100077908(ADCY8)
GGA: 420328(ADCY8)
MGP: 100548951(ADCY8)
CJO: 107310566(ADCY8)
NMEL: 110394336(ADCY8)
APLA: 101794043(ADCY8)
ACYG: 106046364(ADCY8)
TGU: 100230277(ADCY8)
LSR: 110476995(ADCY8)
SCAN: 103816719(ADCY8)
GFR: 102037430(ADCY8)
FAB: 101809046(ADCY8)
PHI: 102108193(ADCY8)
PMAJ: 107200813(ADCY8)
CCW: 104692638(ADCY8)
ETL: 114065892(ADCY8)
FPG: 101921528(ADCY8)
FCH: 102056487(ADCY8)
CLV: 102086133(ADCY8)
EGZ: 104134444(ADCY8)
NNI: 104016868(ADCY8)
ACUN: 113476386(ADCY8)
PADL: 103916382(ADCY8)
AAM: 106496221(ADCY8)
ASN: 102369910(ADCY8)
AMJ: 102562540(ADCY8)
PSS: 102448969(ADCY8)
CMY: 102930804(ADCY8)
CPIC: 101947738(ADCY8)
ACS: 100556578(adcy8)
PVT: 110090751(ADCY8)
PBI: 103049018(ADCY8)
PMUR: 107289979(ADCY8)
TSR: 106542281
PMUA: 114600245(ADCY8)
GJA: 107119214(ADCY8)
XLA: 108719413 414729(adcy8.S)
XTR: 549366
NPR: 108788952(ADCY8)
DRE: 100148976(adcy8) 560410(si:ch211-132f19.7) 560719(si:dkey-206f10.1)
IPU: 108257757 108280230(adcy8)
PHYP: 113532110 113543309(adcy8)
EEE: 113584128(adcy8)
LCO: 104922014 104938356(adcy8)
NCC: 104955036(adcy8)
KMR: 108229092(si:ch211-132f19.7) 108246168(adcy8)
ALIM: 106527219(adcy8) 106531266
CSEM: 103380838 103396830(adcy8)
HCQ: 109518125 109518881(adcy8)
BPEC: 110155800 110165875(adcy8)
MALB: 109970259(adcy8) 109971087
SASA: 106568630(adcy8) 106611404
OTW: 112250071(adcy8) 112255820
SALP: 111957123(adcy8) 112076728
ELS: 105023619(adcy8) 105031560
SFM: 108918520 108937764(adcy8)
PKI: 111845896(adcy8)
LCM: 102346737(ADCY8)
CMK: 103183440(adcy8)
RTP: 109914598(adcy8)
BFO: 118405038
CIN: 100181005
SKO: 100370378
DME: Dmel_CG10564(Ac78C)
DER: 6546178
DSE: 6616399
DSI: Dsimw501_GD12142(Dsim_GD12142)
DAN: 6493061
DSR: 110189946
DPE: 6602992
DMN: 108152936
DWI: 6645098
DNV: 108652084
DHE: 111599815
DVI: 6623758
MDE: 101893364
LCQ: 111677112
AAG: 5563558
AALB: 109414810
AME: 726262
BIM: 100741339
BTER: 100650732
CCAL: 108626074
OBB: 114874916
SOC: 105208160
MPHA: 105831878
AEC: 105145442
ACEP: 105621896
PBAR: 105425253
VEM: 105566125
HST: 105185447
DQU: 106740959
CFO: 105247922
LHU: 105672367
PGC: 109856473
OBO: 105279868
PCF: 106787929
NVI: 100679362
CSOL: 105367908
MDL: 103569316
DPA: 109539855
ATD: 109600572
NVL: 108558843
BMOR: 101744252
BMAN: 114249948
PMAC: 106707822
PRAP: 110992313
PXY: 105382561
API: 100161699
DNX: 107163062
AGS: 114123034
RMD: 113561352
BTAB: 109032361
CLEC: 106663679
ZNE: 110834851
FCD: 110854056
PVM: 113803537
TUT: 107365159
DPTE: 113796993
PTEP: 107439048
LAK: 106153878
AQU: 100637659
DFA: DFA_04345(acaA)
SPAR: SPRG_05070
 » show all
Reference
PMID:8076676
  Authors
Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J
  Title
Molecular cloning of the human type VIII adenylyl cyclase.
  Journal
FEBS Lett 351:109-13 (1994)
DOI:10.1016/0014-5793(94)00836-1
  Sequence
[hsa:114]
Reference
  Authors
Roger B, Papin J, Vacher P, Raoux M, Mulot A, Dubois M, Kerr-Conte J, Voy BH, Pattou F, Charpentier G, Jonas JC, Moustaid-Moussa N, Lang J
  Title
Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.
  Journal
Diabetologia 54:390-402 (2011)
DOI:10.1007/s00125-010-1955-x
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