KEGG   ORTHOLOGY: K08735Help
Entry
K08735                      KO                                     

Name
MSH2
Definition
DNA mismatch repair protein MSH2
Pathway
ko01524  Platinum drug resistance
ko03430  Mismatch repair
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Disease
H00020  Colorectal cancer
H00027  Ovarian cancer
H00876  Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    K08735  MSH2; DNA mismatch repair protein MSH2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08735  MSH2; DNA mismatch repair protein MSH2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08735  MSH2; DNA mismatch repair protein MSH2
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08735  MSH2; DNA mismatch repair protein MSH2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K08735  MSH2; DNA mismatch repair protein MSH2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     K08735  MSH2; DNA mismatch repair protein MSH2
BRITE hierarchy
Genes
HSA: 4436(MSH2)
PTR: 107973458(MSH2)
PPS: 100984592(MSH2)
GGO: 101145372(MSH2)
PON: 100431828(MSH2)
NLE: 100580147(MSH2)
MCC: 718017(MSH2)
MCF: 101867487(MSH2)
CSAB: 103220322(MSH2)
RRO: 104663167(MSH2) 115894365
RBB: 108512671(MSH2)
CJC: 100394665(MSH2)
SBQ: 101044013(MSH2)
MMU: 17685(Msh2)
MCAL: 110312708(Msh2)
MPAH: 110335350(Msh2)
RNO: 81709(Msh2)
MUN: 110552895(Msh2)
CGE: 100768127(Msh2)
NGI: 103725741(Msh2)
HGL: 101706924(Msh2)
CCAN: 109675535 109691600(Msh2)
OCU: 103347805(MSH2)
TUP: 102471638(MSH2)
CFA: 494002(MSH2)
VVP: 112915229(MSH2)
AML: 100471735(MSH2)
UMR: 103671767(MSH2)
UAH: 113245944(MSH2)
ORO: 101367758(MSH2)
ELK: 111148098
FCA: 101082051(MSH2)
PTG: 102954275(MSH2)
PPAD: 109247022(MSH2)
AJU: 106977220(MSH2)
BTA: 533115(MSH2)
BOM: 102268614(MSH2)
BIU: 109566059(MSH2)
BBUB: 102409227(MSH2)
CHX: 102172730(MSH2)
OAS: 101107944(MSH2)
SSC: 100337661(MSH2)
CFR: 102512861(MSH2)
CDK: 105092361(MSH2)
BACU: 102999324(MSH2)
LVE: 103088025(MSH2)
OOR: 101272233(MSH2)
DLE: 111174786(MSH2)
PCAD: 102987486(MSH2)
ECB: 100068146(MSH2)
EPZ: 103558101(MSH2)
EAI: 106826002(MSH2)
MYB: 102244813(MSH2)
MYD: 102756016(MSH2)
MNA: 107544316(MSH2)
HAI: 109389912(MSH2)
DRO: 112297937(MSH2)
PALE: 102893728(MSH2)
RAY: 107509554(MSH2)
MJV: 108391861(MSH2)
LAV: 100653677(MSH2)
TMU: 101346702
MDO: 100033358(MSH2)
PCW: 110218513(MSH2)
OAA: 100083981(MSH2)
GGA: 378799(MSH2)
MGP: 100542264(MSH2)
CJO: 107310883(MSH2)
NMEL: 110396247(MSH2)
APLA: 101802532(MSH2)
ACYG: 106043144(MSH2)
TGU: 100226839(MSH2)
LSR: 110475805(MSH2)
SCAN: 103819297(MSH2)
GFR: 102033642(MSH2)
FAB: 101818579(MSH2)
PHI: 102104578(MSH2)
PMAJ: 107202300(MSH2)
CCAE: 111926310(MSH2)
CCW: 104685720(MSH2)
ETL: 114060415(MSH2)
FPG: 101910374(MSH2)
FCH: 102053065(MSH2)
CLV: 102091445(MSH2)
EGZ: 104134601(MSH2)
NNI: 104018118(MSH2)
ACUN: 113478407(MSH2)
PADL: 103925036(MSH2)
AAM: 106490370(MSH2)
ASN: 102372507(MSH2)
AMJ: 102562032(MSH2)
PSS: 102457455(MSH2)
CMY: 102929651(MSH2)
CPIC: 101937123(MSH2)
ACS: 100562005(msh2)
PVT: 110079560(MSH2)
PBI: 103057506(MSH2)
PMUR: 107284056(MSH2)
TSR: 106554294(MSH2)
PMUA: 114594844(MSH2)
GJA: 107124258(MSH2)
XLA: 595045(msh2.L)
XTR: 100380043(msh2)
NPR: 108804519(MSH2)
DRE: 406845(msh2)
IPU: 108274345(msh2)
PHYP: 113527804(msh2)
AMEX: 103047089(msh2)
EEE: 113572822(msh2)
TRU: 101075196(msh2)
LCO: 104923481(msh2)
NCC: 104951045(msh2)
MZE: 101484075(msh2)
ONL: 100697326(msh2)
OLA: 101167993(msh2)
XMA: 102234491(msh2) 106700380
XCO: 114152173(msh2)
PRET: 103481547(msh2)
CVG: 107085521(msh2)
NFU: 107387525(msh2)
KMR: 108248490(msh2)
ALIM: 106516619(msh2)
AOCE: 111577896(msh2)
CSEM: 103381539(msh2)
LCF: 108882675(msh2)
SDU: 111219993(msh2)
SLAL: 111655249(msh2)
HCQ: 109530180(msh2)
BPEC: 110174586(msh2)
MALB: 109962934(msh2)
SASA: 106589405(msh2)
OTW: 112224292(msh2)
SALP: 111967793(msh2)
ELS: 105006146(msh2)
SFM: 108931448(msh2)
PKI: 111848461(msh2)
CMK: 103180793(msh2)
RTP: 109922754 109932239(msh2)
CIN: 100183267
SPU: 589363
APLC: 110984624
SKO: 100370530(MSH2)
DME: Dmel_CG4215(spel1)
DER: 6540643
DSI: Dsimw501_GD23963(Dsim_GD23963)
DSR: 110185631
DPE: 6598122
DMN: 108161674
DWI: 6643724
DAZ: 108611243
DNV: 108649356
DHE: 111600377
MDE: 101891948
LCQ: 111677682
AAG: 5565480
AME: 725348
BIM: 100745953
BTER: 100644548
CCAL: 108630326
OBB: 114873609
SOC: 105202417
MPHA: 105837293
AEC: 105151743
ACEP: 105618910
VEM: 105558517
HST: 105191066
DQU: 106751800
CFO: 105249227
LHU: 105673743
PGC: 109856928
OBO: 105281999
PCF: 106791815
NVI: 100118035(Msh2)
CSOL: 105359470
MDL: 103575164
TCA: 655722
DPA: 109532708
ATD: 109608594
NVL: 108564757
BMOR: 101743378
BMAN: 114245626
PMAC: 106713550
PRAP: 110993151
HAW: 110380087
TNL: 113498334
API: 100160952
DNX: 107161324
AGS: 114128384
RMD: 113553385
BTAB: 109039150
CLEC: 106665222
ZNE: 110838930
FCD: 110845892
PVM: 113820839
TUT: 107369494
DPTE: 113791662
PTEP: 107442808
CEL: CELE_H26D21.2(msh-2)
CBR: CBG12022(Cbr-msh-2)
BMY: Bm1_40840
TSP: Tsp_09659
PCAN: 112566662
CRG: 105335553
MYI: 110460651
OBI: 106868054
LAK: 106156484
SHX: MS3_10731
EPA: 110249970
AMIL: 114961970
PDAM: 113668608
SPIS: 111341692
DGT: 114537619
HMG: 100200908
AQU: 100641505
ATH: AT3G18524(MSH2)
CRB: 17891110
BRP: 103859754
RSZ: 108862549
THJ: 104820406
CIT: 102614656
TCC: 18604054
GRA: 105798704
GAB: 108457313
DZI: 111291050
EGR: 104421462
GMX: 100792272
GSJ: 114393536
VRA: 106769444
VAR: 108323623
VUN: 114177191
CCAJ: 109809762
CAM: 101505823
LJA: Lj4g3v1787050.1(Lj4g3v1787050.1) Lj4g3v1787050.2(Lj4g3v1787050.2)
ADU: 107469314
AIP: 107630408
FVE: 101293489
RCN: 112180984
PPER: 18777066
PMUM: 103342205
PAVI: 110754162
PXB: 103938503
ZJU: 107418858
CSV: 101215589
CMO: 103494106
MCHA: 111007070
CMAX: 111484889
CMOS: 111430121
CPEP: 111780449
RCU: 8286743
JCU: 105650645
HBR: 110651472
MESC: 110624712
POP: 7484706
PEU: 105114805
VVI: 100268052(MSH2)
SLY: 100462655(MSH2)
SPEN: 107021249
SOT: 102598532
CANN: 107855430
NSY: 104244948
NTO: 104117972
NAU: 109227481
INI: 109184200
OEU: 111406449
HAN: 110941615
LSV: 111915654
CCAV: 112513365
DCR: 108192774
SOE: 110789489
NNU: 104603050
OSA: 4338271
DOSA: Os05t0274200-01(Os05g0274200)
OBR: 102704890
BDI: 100842311
ATS: 109751240(LOC109751240)
SBI: 8060623
ZMA: 100279876(mus1)
SITA: 101753902
PDA: 103704345
EGU: 105041044
MUS: 103987730
DCT: 110093633
PEQ: 110023469
AOF: 109822519
ATR: 18433612
PPP: 112275272
APRO: F751_2623
SCE: YOL090W(MSH2)
ERC: Ecym_2796
KMX: KLMA_30578(MSH2)
NCS: NCAS_0A08670(NCAS0A08670)
NDI: NDAI_0G05110(NDAI0G05110)
TPF: TPHA_0A00740(TPHA0A00740)
TBL: TBLA_0B02380(TBLA0B02380)
TDL: TDEL_0D05170(TDEL0D05170)
KAF: KAFR_0C01330(KAFR0C01330)
CAL: CAALFM_C407120CA(MSH2)
SLB: AWJ20_1043(MSH2)
NCR: NCU02230(msh2)
NTE: NEUTE1DRAFT124099(NEUTE1DRAFT_124099)
SMP: SMAC_03669(putative msh2)
MGR: MGG_00879
SSCK: SPSK_00411
MAW: MAC_04666
MAJ: MAA_04555
CMT: CCM_01340
BFU: BCIN_02g08740(Bcmsh2)
MBE: MBM_06832
ANI: AN5006.2
ANG: ANI_1_490144(An16g03520)
ABE: ARB_01205
TVE: TRV_05311
PTE: PTT_15308
SPO: SPBC19G7.01c(msh2)
CNE: CNA07480
CNB: CNBA7300
ABP: AGABI1DRAFT131867(AGABI1DRAFT_131867)
ABV: AGABI2DRAFT187339(AGABI2DRAFT_187339)
MGL: MGL_3578
MRT: MRET_4268
DDI: DDB_G0275809(msh2)
DFA: DFA_02479(msh2)
EHI: EHI_172750(113.t00021)
PYO: PY17X_0807000(PY01096) PY17X_1018600(PY07191)
PCB: PCHAS_080460(PC000592.00.0) PCHAS_101790(PC301346.00.0)
TAN: TA20735
TPV: TP01_0456
BBO: BBOV_I003810(19.m02277)
CPV: cgd8_3950
SMIN: v1.2.002929.t1(symbB.v1.2.002929.t1) v1.2.002929.t2(symbB.v1.2.002929.t2)
FCY: FRACYDRAFT_157228(MSH2_a)
SPAR: SPRG_01049
GTT: GUITHDRAFT_116240(Msh2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8252616
  Authors
Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R
  Title
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
  Journal
Cell 75:1027-38 (1993)
DOI:10.1016/0092-8674(93)90546-3
  Sequence
[hsa:4436]
Reference
  Authors
Seifert M, Scherer SJ, Edelmann W, Bohm M, Meineke V, Lobrich M, Tilgen W, Reichrath J
  Title
The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.
  Journal
J Invest Dermatol 128:203-13 (2008)
DOI:10.1038/sj.jid.5700941
  Sequence
[hsa:4436]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YOL090W]
LinkDB All DBs

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