KEGG   ORTHOLOGY: K09048Help
Entry
K09048                      KO                                     

Name
CREB3
Definition
cyclic AMP-responsive element-binding protein 3
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04668  TNF signaling pathway
ko04714  Thermogenesis
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04922  Glucagon signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04931  Insulin resistance
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04962  Vasopressin-regulated water reabsorption
ko05016  Huntington disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
Disease
H00506  Osteogenesis imperfecta
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04024 cAMP signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04022 cGMP-PKG signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04151 PI3K-Akt signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04152 AMPK signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04922 Glucagon signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04915 Estrogen signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04926 Relaxin signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04935 Growth hormone synthesis, secretion and action
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04918 Thyroid hormone synthesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04928 Parathyroid hormone synthesis, secretion and action
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04916 Melanogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04925 Aldosterone synthesis and secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04927 Cortisol synthesis and secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09156 Nervous system
   04725 Cholinergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04728 Dopaminergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09149 Aging
   04211 Longevity regulating pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09159 Environmental adaptation
   04714 Thermogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09162 Cancer: specific types
   05215 Prostate cancer
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09164 Neurodegenerative disease
   05016 Huntington disease
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09165 Substance dependence
   05030 Cocaine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05031 Amphetamine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05034 Alcoholism
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04934 Cushing syndrome
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05161 Hepatitis B
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05163 Human cytomegalovirus infection
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05165 Human papillomavirus infection
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
BRITE hierarchy
Other DBs
GO: 0008140
Genes
HSA: 10488(CREB3) 148327(CREB3L4) 64764(CREB3L2) 84699(CREB3L3) 90993(CREB3L1)
PTR: 451704(CREB3L1) 457341(CREB3L4) 465081(CREB3) 468672(CREB3L3) 738928(CREB3L2)
PPS: 100977358(CREB3L3) 100977804(CREB3L4) 100981063(CREB3L1) 100986194(CREB3L2) 100989680(CREB3)
GGO: 101128609(CREB3L2) 101144135(CREB3) 101144628(CREB3L1) 101152081(CREB3L4)
PON: 100127093(CREB3L2) 100432292(CREB3L1) 100436186(CREB3L4) 100438869(CREB3) 100441756(CREB3L3)
NLE: 100592170(CREB3L3) 100594080(CREB3L1) 100595943(CREB3L2) 100597876(CREB3) 100603387(CREB3L4)
MCC: 696350(CREB3) 713391(CREB3L1) 714981(CREB3L2) 715951(CREB3L4) 721825(CREB3L3)
MCF: 102134095(CREB3L4) 102136437(CREB3L3) 102139679(CREB3) 102142378(CREB3L1) 102146405(CREB3L2)
CSAB: 103219209(CREB3) 103223942(CREB3L4) 103226974(CREB3L2) 103233716(CREB3L3) 103236571(CREB3L1)
RRO: 104656623(CREB3L2) 104663511(CREB3L4) 104665486(CREB3L3) 104668385(CREB3L1) 104672444(CREB3)
RBB: 108512141(CREB3L3) 108518846(CREB3L4) 108518996(CREB3) 108519245(CREB3L1) 108542557(CREB3L2)
CJC: 100394351(CREB3L3) 100406635(CREB3L1) 100408954(CREB3) 100409637(CREB3L2) 100411140(CREB3L4)
SBQ: 101036473(CREB3L3) 101041199(CREB3L4) 101042795(CREB3L2) 101044974(CREB3L1) 101052885(CREB3)
MMU: 12913(Creb3) 208647(Creb3l2) 208677(Creb3l3) 26427(Creb3l1) 78284(Creb3l4)
MCAL: 110289497(Creb3l1) 110291408(Creb3l4) 110292754(Creb3) 110296066(Creb3l2) 110303337(Creb3l3)
MPAH: 110316152(Creb3l2) 110318364(Creb3l1) 110320678(Creb3l4) 110326077(Creb3l3) 110338975(Creb3)
RNO: 310616(Creb3l4) 314638(Creb3l3) 362165(Creb3l1) 362339(Creb3l2)
MUN: 110549233(Creb3l2) 110549859(Creb3l1) 110554250(Creb3l4) 110555614(Creb3l3) 110561882(Creb3)
CGE: 100762192(Creb3l1) 100766300(Creb3l4) 100771872(Creb3l2) 100772940(Creb3) 100774488(Creb3l3)
NGI: 103726130(Creb3l2) 103737277(Creb3l3) 103741536(Creb3) 103748795(Creb3l1) 103751688(Creb3l4)
HGL: 101698748(Creb3l1) 101706643(Creb3l4) 101715715(Creb3l2) 101716023(Creb3l3) 101718447(Creb3)
CCAN: 109687810(Creb3l3) 109688048(Creb3l4) 109692000(Creb3l1) 109693373(Creb3) 109700597(Creb3l2)
OCU: 100343130(CREB3L2) 100345475(CREB3L1) 100357876(CREB3) 100358175(CREB3L4)
TUP: 102468245 102469074(CREB3) 102471928(CREB3L2) 102484102(CREB3L3) 102491362(CREB3L1) 102494703(CREB3L4)
CFA: 483636(CREB3L1) 485046(CREB3L3) 491369(CREB3L2) 611934(CREB3) 612303(CREB3L4)
VVP: 112908881(CREB3L2) 112918871(CREB3L4) 112924095(CREB3L1) 112930843(CREB3) 112935546(CREB3L3)
AML: 100465448(CREB3L3) 100470867(CREB3L1) 100472104(CREB3) 100483482(CREB3L2) 100484531(CREB3L4)
UMR: 103667087(CREB3) 103668409(CREB3L4) 103669052(CREB3L2) 103672393(CREB3L1) 103681679(CREB3L3)
UAH: 113242823(CREB3L3) 113245324(CREB3L4) 113260470(CREB3) 113264732(CREB3L2) 113264990(CREB3L1)
ORO: 101376293(CREB3L3) 101381943(CREB3L4) 101383806(CREB3) 101385675(CREB3L2) 101385783(CREB3L1)
FCA: 101087097(CREB3L1) 101089838(CREB3L3) 101093555(CREB3) 101100293(CREB3L2) 101100442(CREB3L4)
PTG: 102949496(CREB3L2) 102949885(CREB3L1) 102950730(CREB3) 102954009(CREB3L4) 102956516(CREB3L3)
PPAD: 109245089(CREB3L1) 109255940(CREB3L3) 109256215(CREB3L4) 109269067(CREB3L2) 109270166(CREB3)
AJU: 106970423(CREB3L2) 106975473(CREB3L3) 106978069(CREB3L1) 106981255(CREB3) 106987262(CREB3L4)
BTA: 281715(CREB3) 513010(CREB3L3) 513105(CREB3L1) 529566(CREB3L4) 785086(CREB3L2)
BOM: 102264680(CREB3L2) 102268154(CREB3L1) 102271999(CREB3L3) 102277321(CREB3) 102281505(CREB3L4)
BIU: 109554418(CREB3L4) 109557676(CREB3L2) 109561750(CREB3L3) 109563018(CREB3) 109569868(CREB3L1)
BBUB: 102395032(CREB3) 102398301(CREB3L4) 102400784(CREB3L3) 102406078(CREB3L1) 102416630(CREB3L2)
CHX: 102170199(CREB3L2) 102174829(CREB3L3) 102180221(CREB3) 102183745(CREB3L4) 102183893(CREB3L1)
OAS: 101107485(CREB3L4) 101108743(CREB3L2) 101113586(CREB3L3) 101113882(CREB3L1) 101114243(CREB3)
SSC: 100142688(CREB3L4) 100142689(CREB3) 100516663(CREB3L1) 100520468(CREB3L2) 100522979(CREB3L3)
CFR: 102510171(CREB3L2) 102510394(CREB3) 102511454(CREB3L3) 102516586(CREB3L4) 102516625(CREB3L1)
CDK: 105089327(CREB3L4) 105091622(CREB3L2) 105102288(CREB3) 105105303(CREB3L3) 105106926(CREB3L1)
BACU: 102999898(CREB3L2) 103001736(CREB3) 103003868(CREB3L4) 103007680(CREB3L1) 103018056(CREB3L3)
LVE: 103071696(CREB3L2) 103085711(CREB3L4) 103086171(CREB3) 103087008(CREB3L1) 103091030(CREB3L3)
OOR: 101272184(CREB3) 101283835(CREB3L2) 101284966(CREB3L1) 101286338(CREB3L4) 101287411(CREB3L3)
DLE: 111166195(CREB3L3) 111167181(CREB3L4) 111177962(CREB3L2) 111183987(CREB3L1) 111188007(CREB3)
PCAD: 102975387(CREB3L2) 102986078(CREB3L4) 102987194(CREB3L1) 102994621(CREB3L3)
ECB: 100057002(CREB3L1) 100062307(CREB3L4) 100063153(CREB3L3) 100064828(CREB3L2) 100067794(CREB3)
EPZ: 103545804(CREB3L3) 103555399(CREB3L4) 103560297(CREB3) 103564266(CREB3L2) 103566499(CREB3L1)
EAI: 106829982(CREB3L2) 106832323(CREB3L3) 106843990(CREB3L1) 106846249(CREB3L4) 106846981(CREB3)
MYB: 102241829(CREB3) 102244833(CREB3L1) 102245296(CREB3L2) 102251355(CREB3L3) 102258024(CREB3L4)
MYD: 102762431(CREB3) 102764297(CREB3L3) 102768092(CREB3L1) 102772259(CREB3L4) 102773515(CREB3L2)
MNA: 107525737(CREB3L3) 107530327(CREB3L1) 107543873(CREB3L4) 107544136(CREB3L2) 107544933(CREB3)
HAI: 109373471(CREB3L4) 109388532(CREB3L2) 109388636(CREB3L3) 109390233(CREB3L1) 109393756(CREB3)
DRO: 112299769(CREB3L2) 112303463(CREB3L1) 112304550(CREB3) 112312688(CREB3L3) 112316383(CREB3L4)
PALE: 102878515(CREB3L4) 102879289(CREB3L3) 102882888(CREB3L2) 102886510(CREB3) 102894633(CREB3L1)
RAY: 107499057(CREB3L2) 107502779(CREB3) 107509179(CREB3L4) 107510647(CREB3L3) 107511864(CREB3L1)
MJV: 108385045(CREB3L3) 108389264 108389410 108401935(CREB3L2) 108406808(CREB3L1) 108407563(CREB3) 108408210(CREB3L4)
LAV: 100653565(CREB3L1) 100666211(CREB3L2) 100670574(CREB3L3) 100673694(CREB3L4) 100677344(CREB3)
MDO: 100015046(CREB3L1) 100017208(CREB3L2) 100020067(CREB3L4) 100022547(CREB3L3) 103104366(CREB3)
SHR: 100913890(CREB3L1) 100916355(CREB3) 100917654(CREB3L3) 100923082(CREB3L4) 100926416(CREB3L2)
PCW: 110197489(CREB3L3) 110201451(CREB3) 110211994(CREB3L4) 110216252(CREB3L2) 110224036(CREB3L1)
OAA: 100076562(CREB3L1) 100078176(CREB3L3) 100092528(CREB3L2) 103165821(CREB3)
GGA: 100859610(CREB3L1) 418123(CREB3L2) 427417(CREB3) 428333(CREB3L3)
MGP: 100539552(CREB3L1) 100551035(CREB3L2) 100551184(CREB3L3) 104914805(CREB3)
CJO: 107305791(CREB3) 107314830(CREB3L1) 107315837(CREB3L2) 107325596(CREB3L3)
NMEL: 110388853(CREB3L3) 110389944(CREB3) 110394585(CREB3L2) 110400949(CREB3L1)
APLA: 101792907(CREB3L2) 101795642(CREB3L1) 101798346 113840230(CREB3)
ACYG: 106030991(CREB3L2) 106036307(CREB3) 106043464(CREB3L1) 106044950(CREB3L3)
TGU: 100219636(CREB3L2) 100220102(CREB3L1) 100222350(CREB3) 115490820(CREB3L3)
LSR: 110472078(CREB3L1) 110478465(CREB3L3) 110482629(CREB3L2) 110484175(CREB3)
SCAN: 103819702(CREB3L2) 103822893(CREB3) 103824532(CREB3L3) 103825377 103826679(CREB3L1) 115484624(CREB3L4)
GFR: 102032931(CREB3L1) 102037565(CREB3L2) 102040985(CREB3L3) 102041988(CREB3)
FAB: 101807577(CREB3L1) 101807611(CREB3) 101810924(CREB3L2) 101814634(CREB3L3)
PHI: 102100666(CREB3L1) 102102105(CREB3L3) 102104228(CREB3L2) 102110548(CREB3L4) 102110913(CREB3)
PMAJ: 107204840(CREB3L2) 107206327(CREB3L1) 107214697(CREB3L4) 107215468(CREB3L3) 107216394(CREB3)
CCAE: 111930186(CREB3L1) 111936759(CREB3L2) 111940201(CREB3L3) 111941176(CREB3)
CCW: 104686582(CREB3) 104696487(CREB3L2) 104697409(CREB3L3) 104698184(CREB3L1)
ETL: 114056194(CREB3L2) 114059138(CREB3L1) 114068838(CREB3L3) 114069771(CREB3)
FPG: 101915392(CREB3L1) 101915893(CREB3) 101922621(CREB3L2) 101924469(CREB3L3)
FCH: 102049519(CREB3L3) 102052762(CREB3) 102055433(CREB3L2) 102060195(CREB3L1) 106630837(CREB3L4)
CLV: 102083943(CREB3L2) 102089621(CREB3L1) 102093765(CREB3L3) 102095967(CREB3)
EGZ: 104124398(CREB3L3) 104126149(CREB3L2) 104133839(CREB3) 104134083(CREB3L1)
NNI: 104012401(CREB3L2) 104015313 104018284(CREB3L4) 104018462 104018808(CREB3L3) 104020372(CREB3L1)
ACUN: 113480521(CREB3L1) 113489424(CREB3L3) 113489898(CREB3) 113490242(CREB3L2)
PADL: 103921718(CREB3L1) 103924510(CREB3L2) 103926010
AAM: 106488699(CREB3L2) 106492194(CREB3L3) 106498354(CREB3L1) 106499571(CREB3)
ASN: 102371679(CREB3L2) 102375258(CREB3L3) 102378465(CREB3L1) 102380509(CREB3L4)
AMJ: 102558288(CREB3L1) 102562994(CREB3L3) 102565945(CREB3) 102571170(CREB3L4) 102574172(CREB3L2)
PSS: 102446107(CREB3L1) 102446716(CREB3L2) 102457323(CREB3L3)
CMY: 102939907(CREB3L2) 102940413(CREB3L1) 102941831(CREB3L3) 102946430(CREB3L4) 102948242(CREB3)
CPIC: 101931889(CREB3L1) 101933099(CREB3L3) 101933490(CREB3) 101941397(CREB3L2) 101949087(CREB3L4)
ACS: 100557424(creb3l2) 100565677(creb3l1) 103281351(creb3)
PVT: 110072462(CREB3L3) 110078269(CREB3L2) 110081714(CREB3L1) 110082837(CREB3) 110088478(CREB3L4)
PBI: 103048883(CREB3L1) 103049180 103049609 103057599(CREB3L2) 103066719 107326149(CREB3L4)
PMUR: 107290408(CREB3L1) 107294181(CREB3L2) 107295319(CREB3L3) 107300011
TSR: 106546013(CREB3L1) 106552868(CREB3L4) 106554690(CREB3)
PMUA: 114588541(CREB3L3) 114596052(CREB3L1) 114605296(CREB3L2) 114606604(CREB3)
GJA: 107107817(CREB3L1) 107110879(CREB3L4) 107118239(CREB3L3) 107120250 107121734(CREB3L2)
XLA: 100037168(creb3l2.L) 108699636(creb3l4.L) 108700416(creb3l4.S) 108712546(creb3l2.S) 108713769(creb3l1.L) 108715242 735076(creb3.S)
XTR: 100127204(creb3) 100145418(creb3l2) 100496679(creb3l1) 101733496(creb3l3) 780164(creb3l4)
NPR: 108785446(CREB3L1) 108788718(CREB3L2) 108798798(CREB3L4) 108801809
DRE: 100333318(creb3l4) 338317(creb3l1) 406853(creb3l3l) 553700(creb3l3a) 791169(creb3l2)
IPU: 108259676(creb3l1) 108263495(CREB3L4) 108264943 108271409 108280078(creb3l2) 108280217(creb3l3)
AMEX: 103023873(creb3l2) 103037168 103039026 103040796(creb3l3) 103042370(creb3l1)
TRU: 101063133(creb3l4) 101065014 101067583 101070432(creb3l1) 101078259(creb3l2) 115247989
LCO: 104917983(creb3l1) 104920685(creb3l3) 104921083 104929667 104935986(creb3l2) 104938216
MZE: 101466226(creb3l4) 101469085(creb3l1) 101480575(creb3l2) 101483965 101486384 101487513
ONL: 100702359 100703380(creb3l1) 100705423(creb3l2) 100708760 100709801 100710280(creb3l4)
OLA: 101164317 101164631(creb3l4) 101165931(creb3l2) 101167274(creb3l1) 101171479 105356229
XMA: 102216562 102218843 102222043(creb3l4) 102226512(creb3l2) 102233894 102237210(creb3l1)
PRET: 103459160(creb3l2) 103463663(creb3l3) 103470136 103475175(creb3l1) 103477467
NFU: 107379008 107380915(creb3l1) 107384140(creb3l3) 107387370(creb3l2) 107394107 107395105
ALIM: 106513612 106515012(creb3l3) 106524439(creb3l2) 106526404 106529646(creb3l1) 106532492
POV: 109625400 109639345 109640074(creb3l1) 109641651(creb3l3) 109642995(creb3l2) 109643269
LCF: 108877321 108882528 108883606 108884667(creb3l4) 108892924(creb3l1) 108895942(creb3l2)
HCQ: 109507313 109512147(creb3l4) 109517508 109520937(creb3l1) 109530066(creb3l2) 109531892
MALB: 109953821 109956522 109960567(creb3l1) 109964980(creb3l2) 109965712 109970108(creb3l4)
LCM: 102350106(CREB3L3) 102352986(CREB3L4) 102353080(CREB3L2) 102357132(CREB3L1) 102361726
CMK: 103180995(creb3) 103181867(creb3l2) 103183529(creb3l3) 103186023(creb3l1)
RTP: 109911765(creb3l3) 109915849(creb3l2) 109916114 109918439(creb3l1) 109925779
CIN: 778569(creb/atf-a) 778570(creb/atf-b)
NVI: 100120780
CSOL: 105365458
FCD: 110842466
TUT: 107366869
DPTE: 113798030
CSCU: 111625880
BMY: Bm1_36045
TSP: Tsp_05619
SHX: MS3_02458
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Jang SW, Kim YS, Kim YR, Sung HJ, Ko J
  Title
Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1.
  Journal
J Biol Chem 282:11092-100 (2007)
DOI:10.1074/jbc.M607962200
  Sequence
[hsa:10488]
Reference
PMID:9271389
  Authors
Lu R, Yang P, O'Hare P, Misra V
  Title
Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor.
  Journal
Mol Cell Biol 17:5117-26 (1997)
DOI:10.1128/MCB.17.9.5117
  Sequence
[hsa:10488]
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