K09186                      KO                                     

histone-lysine N-methyltransferase MLL1 [EC:]
ko00310  Lysine degradation
ko04934  Cushing syndrome
ko05202  Transcriptional misregulation in cancer
H00001  B-cell acute lymphoblastic leukemia
H00002  T-cell acute lymphoblastic leukemia
H01879  Wiedemann-Steiner syndrome
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
   03036 Chromosome and associated proteins
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases  histone-lysine N-methyltransferase
     K09186  MLL1; histone-lysine N-methyltransferase MLL1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Zinc finger
   Cys4 Trithorax
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09186  MLL1; histone-lysine N-methyltransferase MLL1
   HMT complexes
    MLL-HCF complex
     K09186  MLL1; histone-lysine N-methyltransferase MLL1
BRITE hierarchy
Other DBs
RN: R03875 R03938 R04866 R04867
GO: 0042800
HSA: 4297(KMT2A)
PTR: 451587(KMT2A)
PPS: 100984332(KMT2A)
GGO: 101129366(KMT2A)
PON: 100441102(KMT2A)
NLE: 100604245(KMT2A)
MCC: 705511(KMT2A)
MCF: 101866311(KMT2A)
CSAB: 103248594(KMT2A)
RRO: 104665589(KMT2A)
RBB: 108536375(KMT2A)
CJC: 100391138(KMT2A)
SBQ: 101029847(KMT2A)
MMU: 214162(Kmt2a)
MCAL: 110301786(Kmt2a)
MPAH: 110327485(Kmt2a)
RNO: 315606(Kmt2a)
MUN: 110549115(Kmt2a)
CGE: 100760424(Kmt2a)
NGI: 103748298(Kmt2a)
HGL: 101716671(Kmt2a)
CCAN: 109689973(Kmt2a)
OCU: 100339782 100353733(KMT2A)
TUP: 102473382(KMT2A)
CFA: 479417(KMT2A)
VVP: 112920160(KMT2A)
AML: 100484220(KMT2A)
UMR: 103662507(KMT2A)
UAH: 113259992(KMT2A)
ORO: 101363392 101363669(KMT2A)
FCA: 101090288(KMT2A)
PTG: 102956940(KMT2A)
AJU: 106966460(KMT2A)
BTA: 508330(KMT2A)
BOM: 102280025(KMT2A)
BIU: 109569413(KMT2A)
BBUB: 102401126(KMT2A)
PHD: 102332319(KMT2A)
CHX: 102169033(KMT2A)
OAS: 101101916(KMT2A)
SSC: 100623006(KMT2A)
CFR: 102517824(KMT2A)
CDK: 105090168(KMT2A)
BACU: 103014183(KMT2A)
LVE: 103068531(KMT2A)
OOR: 101278571(KMT2A)
DLE: 111166868(KMT2A)
ECB: 100071238(KMT2A)
EPZ: 103546689(KMT2A)
EAI: 106840333(KMT2A)
MYB: 102246785(KMT2A)
MYD: 102766910(KMT2A) 107182758
HAI: 109385301(KMT2A)
RSS: 109437195(KMT2A)
DRO: 112314381(KMT2A)
PALE: 102893336(KMT2A)
LAV: 100653681(KMT2A)
TMU: 101351964
MDO: 100031440(KMT2A)
SHR: 100924557(KMT2A)
PCW: 110207193(KMT2A)
OAA: 100086068(KMT2A)
GGA: 414897(KMT2A)
MGP: 100540662(KMT2A)
CJO: 107324133(KMT2A)
APLA: 101797321(KMT2A)
ACYG: 106039772(KMT2A)
TGU: 100231049(KMT2A)
LSR: 110470458(KMT2A)
SCAN: 103822784(KMT2A)
GFR: 102036439(KMT2A)
FAB: 101813917(KMT2A)
PHI: 102103515(KMT2A)
PMAJ: 107214385(KMT2A)
CCAE: 111939213(KMT2A)
CCW: 104692048(KMT2A)
ETL: 114056306(KMT2A)
FPG: 101922729(KMT2A)
FCH: 102059401(KMT2A)
CLV: 102084453(KMT2A)
EGZ: 104135361(KMT2A)
NNI: 104016208(KMT2A)
ACUN: 113488577(KMT2A)
AAM: 106485191(KMT2A)
ASN: 102385246(KMT2A)
AMJ: 102572253(KMT2A)
PSS: 102463628(KMT2A)
CMY: 102941272(KMT2A)
CPIC: 101941687(KMT2A)
ACS: 100560745(kmt2a)
PVT: 110079453(KMT2A)
PBI: 103067762(KMT2A)
PMUR: 107284778(KMT2A)
GJA: 107112539(KMT2A)
XTR: 100135006(kmt2a)
NPR: 108794984(KMT2A)
DRE: 557048(kmt2a)
IPU: 108277661(kmt2a)
PHYP: 113533005(kmt2a)
AMEX: 103035686
EEE: 113579441(kmt2a)
TRU: 101079297(kmt2a)
LCO: 104936774(kmt2a)
MZE: 101478918(kmt2a)
OLA: 101171020(kmt2a)
XMA: 102233842(kmt2a)
XCO: 114133379(kmt2a)
PRET: 103474566(kmt2a)
NFU: 107380358(kmt2a)
KMR: 108246035(kmt2a)
CSEM: 103378141(kmt2a)
LCF: 108886384(kmt2a)
SDU: 111228034(kmt2a)
HCQ: 109529394(kmt2a)
BPEC: 110154093(kmt2a)
MALB: 109960262(kmt2a)
SASA: 106612477(kmt2a)
ELS: 105011706(kmt2a)
PKI: 111846253(kmt2a)
LCM: 102357046(KMT2A)
CMK: 103180354(kmt2a)
CIN: 100180972
SPU: 579728
APLC: 110983880
DME: Dmel_CG8651(trx)
DER: 6552649
DPE: 6587342
DSI: Dsimw501_GD20433(Dsim_GD20433)
DWI: 6647544
DAZ: 108621479
DHE: 111593273
DVI: Dvir_GJ22599(Dvir_trx)
MDE: 101896996
AAG: 5573555
AME: 408716
BIM: 100748492
BTER: 100646252
SOC: 105197865
AEC: 105145559
ACEP: 105626604
PBAR: 105422098
HST: 105191719
DQU: 106752351
CFO: 105251303
LHU: 105668075
PGC: 109854362
OBO: 105276941
PCF: 106791610
MDL: 103574171
TCA: 658843(trithorax)
DPA: 109540960
NVL: 108569866
BMOR: 101742231
PMAC: 106715470
PRAP: 110992468
HAW: 110377249
TNL: 113499687
PXY: 105383381
DNX: 107167618
AGS: 114126838
CLEC: 106669164
ZNE: 110832202
CRG: 105347805
MYI: 110462400
OBI: 106883428
SHX: MS3_01195
ADF: 107345259
 » show all
Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF
Structural and biochemical insights into MLL1 core complex assembly.
Structure 19:101-8 (2011)
Ansari KI, Mandal SS
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
FEBS J 277:1790-804 (2010)
Nilson I, Lochner K, Siegler G, Greil J, Beck JD, Fey GH, Marschalek R
Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias.
Br J Haematol 93:966-72 (1996)
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