KEGG   ORTHOLOGY: K09187Help
Entry
K09187                      KO                                     

Name
MLL2, ALR
Definition
histone-lysine N-methyltransferase MLL2 [EC:2.1.1.43]
Pathway
ko00310  Lysine degradation
ko04934  Cushing syndrome
Disease
H00570  Kabuki syndrome
H01613  Follicular lymphoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2
 09160 Human Diseases
  09167 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2
   03036 Chromosome and associated proteins
    K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Zinc finger
   Cys4 Trithorax
    K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2
   HMT complexes
    MLL-HCF complex
     K09187  MLL2, ALR; histone-lysine N-methyltransferase MLL2
BRITE hierarchy
Other DBs
RN: R03875 R03938 R04866 R04867
GO: 0018024
Genes
HSA: 8085(KMT2D)
PTR: 100610362(KMT2D)
PPS: 100995808(KMT2D)
GGO: 101144774(KMT2D)
PON: 100441715(KMT2D)
NLE: 100586637(KMT2D)
MCC: 710795(KMT2D)
MCF: 102123773(KMT2D)
CSAB: 103238253(KMT2D)
RRO: 104679726(KMT2D)
RBB: 108543918(KMT2D)
CJC: 100408425(KMT2D)
SBQ: 101037539(KMT2D)
MMU: 381022(Kmt2d)
RNO: 100362634(Kmt2d)
CGE: 100765465(Kmt2d)
NGI: 103750570(Kmt2d)
HGL: 101718411(Kmt2d)
CCAN: 109694824(Kmt2d)
OCU: 100357052(KMT2D)
TUP: 102480722(KMT2D)
CFA: 486558(KMT2D)
AML: 100479447(KMT2D)
UMR: 103675622(KMT2D)
ORO: 101369213(KMT2D)
FCA: 101095268(KMT2D)
PTG: 102962859(KMT2D)
AJU: 106969329(KMT2D)
BTA: 506805(KMT2D)
BOM: 102268887(KMT2D)
BIU: 109559148(KMT2D)
PHD: 102336661(KMT2D)
CHX: 102168698(KMT2D)
OAS: 101120741(KMT2D)
SSC: 110260656(KMT2D)
CFR: 102515223(KMT2D)
CDK: 105103813(KMT2D)
BACU: 103004413(KMT2D)
LVE: 103082116(KMT2D)
OOR: 101269640(KMT2D)
ECB: 100058932(KMT2D)
EPZ: 103552202(KMT2D)
EAI: 106836860(KMT2D)
MYB: 102244965(KMT2D)
MYD: 102762410(KMT2D)
HAI: 109393224(KMT2D)
RSS: 109443835(KMT2D)
PALE: 102888593(KMT2D)
LAV: 100670013(KMT2D)
TMU: 101353099
MDO: 103099827(KMT2D)
SHR: 100928575(KMT2D)
OAA: 103170060(KMT2D)
GGA: 425846(KMT2D)
MGP: 104915798
CJO: 107325738(KMT2D)
APLA: 101790769
ACYG: 106047718(KMT2D)
TGU: 100226907(KMT2D)
GFR: 102034037(KMT2D)
FAB: 101818086(KMT2D)
PHI: 102100454(KMT2D)
PMAJ: 107198594(KMT2D)
CCAE: 111940566
FPG: 101916525(KMT2D)
FCH: 102049111(KMT2D)
CLV: 102091442(KMT2D)
EGZ: 104123317
AAM: 106497500(KMT2D)
ASN: 102373099(KMT2D)
AMJ: 102560006(KMT2D) 109281961
PSS: 102450509(KMT2D)
CMY: 102944171
CPIC: 101934288(KMT2D) 101934563
ACS: 100554175(kmt2d)
PVT: 110075080(KMT2D)
PBI: 103051289(KMT2D) 103065683
GJA: 107105838(KMT2D)
XTR: 100494109(kmt2d)
NPR: 108791395(KMT2D)
DRE: 100536523(kmt2d)
SRX: 107708781(kmt2d) 107716211
IPU: 108275851
AMEX: 103042576(kmt2d)
TRU: 101062458(kmt2d)
LCO: 104932523(kmt2d)
NCC: 104956939(kmt2d)
MZE: 101486529(kmt2d)
OLA: 101172242(kmt2d)
XMA: 102237866(kmt2d)
PRET: 103467355(kmt2d)
NFU: 107390885(kmt2d)
KMR: 108235223(kmt2d)
CSEM: 103385102(kmt2d)
LCF: 108876442(kmt2d)
SDU: 111219023(kmt2d)
HCQ: 109531346(kmt2d)
BPEC: 110164958(kmt2d)
MALB: 109968659(kmt2d)
SASA: 106567046(kmt2d) 106572669
OTW: 112221704(kmt2d) 112247360
ELS: 105013562(kmt2d)
LCM: 102354014(KMT2D)
CMK: 103189259(kmt2d)
CRG: 105336526
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Andreu-Vieyra CV, Chen R, Agno JE, Glaser S, Anastassiadis K, Stewart AF, Matzuk MM
  Title
MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.
  Journal
PLoS Biol 8:e1000453 (2010)
DOI:10.1371/journal.pbio.1000453
  Sequence
[hsa:8085] [mmu:381022]
Reference
  Authors
Ansari KI, Mandal SS
  Title
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
  Journal
FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x
Reference
PMID:9247308
  Authors
Prasad R, Zhadanov AB, Sedkov Y, Bullrich F, Druck T, Rallapalli R, Yano T, Alder H, Croce CM, Huebner K, Mazo A, Canaani E
  Title
Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.
  Journal
Oncogene 15:549-60 (1997)
DOI:10.1038/sj.onc.1201211
  Sequence
[hsa:8085]
LinkDB All DBs

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