KEGG   ORTHOLOGY: K09188
Entry
K09188                      KO                                     

Name
MLL3
Definition
[histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]
Pathway
ko00310  Lysine degradation
ko01100  Metabolic pathways
Disease
H00907  Kleefstra syndrome
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
   HMT complexes
    MLL3/MLL4 complex
     K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
Other DBs
RN: R03875 R04866 R04867
GO: 0042800
Genes
HSA: 58508(KMT2C)
PTR: 463875(KMT2C)
PPS: 100992231(KMT2C)
GGO: 101134599(KMT2C)
PON: 100450852(KMT2C)
NLE: 100607151(KMT2C)
MCC: 716753(KMT2C)
MCF: 102128002(KMT2C)
CSAB: 103227268(KMT2C)
RRO: 104678716(KMT2C)
RBB: 108523124(KMT2C)
CJC: 100401397(KMT2C)
SBQ: 101043552(KMT2C)
MMU: 231051(Kmt2c)
MCAL: 110295273(Kmt2c)
MPAH: 110316198(Kmt2c)
RNO: 502710(Kmt2c)
CGE: 100767367(Kmt2c)
NGI: 103745326(Kmt2c)
HGL: 101698170(Kmt2c)
CCAN: 109685268(Kmt2c)
OCU: 100353688(KMT2C)
TUP: 102479012(KMT2C)
CFA: 611094(KMT2C)
VVP: 112916198(KMT2C)
AML: 100465228(KMT2C)
UMR: 103660985(KMT2C)
UAH: 113241427(KMT2C)
ORO: 101365628(KMT2C)
ELK: 111154508
FCA: 101084095(KMT2C)
PTG: 102964154(KMT2C)
PPAD: 109252401(KMT2C)
AJU: 106984461(KMT2C)
BTA: 789336(KMT2C)
BOM: 102267186(KMT2C)
BIU: 109558041(KMT2C)
BBUB: 102396938(KMT2C)
CHX: 102181925(KMT2C)
OAS: 101115617(KMT2C)
SSC: 100514805(KMT2C)
CFR: 102507730(KMT2C)
CDK: 105098689(KMT2C)
BACU: 103004433(KMT2C)
LVE: 103078348(KMT2C)
OOR: 101288516(KMT2C)
DLE: 111176572(KMT2C)
PCAD: 102988929(KMT2C)
ECB: 100064812(KMT2C)
EPZ: 103553137(KMT2C)
EAI: 106823334(KMT2C)
MYB: 102246704(KMT2C)
MYD: 102759674(KMT2C)
MNA: 107524895(KMT2C)
HAI: 109389650(KMT2C)
DRO: 112308262(KMT2C)
PALE: 102897550(KMT2C)
RAY: 107520298(KMT2C)
MJV: 108397889
LAV: 100673765(KMT2C)
TMU: 101349940
MDO: 100019161(KMT2C)
SHR: 100920575(KMT2C)
PCW: 110223876(KMT2C)
OAA: 100074286(KMT2C)
GGA: 420437(KMT2C)
MGP: 100545169(KMT2C)
CJO: 107308762(KMT2C)
NMEL: 110393789(KMT2C)
APLA: 101796266(KMT2C)
ACYG: 106046952(KMT2C) 106047718(KMT2D)
TGU: 100227193(KMT2C)
LSR: 110484559(KMT2C)
SCAN: 103813061(KMT2C)
GFR: 102031396(KMT2C)
FAB: 101806346(KMT2C)
PHI: 102099277(KMT2C)
PMAJ: 107216349(KMT2C)
CCAE: 111925501(KMT2C)
CCW: 104686428(KMT2C)
ETL: 114062389(KMT2C)
FPG: 101917176(KMT2C)
FCH: 102047191(KMT2C)
CLV: 102097963(KMT2C)
EGZ: 104130998(KMT2C)
NNI: 104014894(KMT2C)
ACUN: 113477175(KMT2C)
PADL: 103915639(KMT2C)
AAM: 106485306(KMT2C)
ASN: 102379342(KMT2C)
AMJ: 102567474(KMT2C)
PSS: 102459016(KMT2C)
CMY: 102948345(KMT2C)
CPIC: 101953918(KMT2C)
ACS: 100556055(kmt2c)
PVT: 110071916(KMT2C)
PBI: 103049419
PMUR: 107303312(KMT2C)
TSR: 106556966(KMT2C)
PMUA: 114607001(KMT2C)
GJA: 107123162(KMT2C)
XTR: 100486829(kmt2c)
NPR: 108784343(KMT2C)
DRE: 560793(kmt2ca) 568162(kmt2cb)
IPU: 108267465 108272993(kmt2c)
PHYP: 113540030 113545405(kmt2c)
NCC: 104957667(kmt2c)
XMA: 102216709 102222583(kmt2c)
XCO: 114136765 114145996(kmt2c)
PRET: 103460165(kmt2c) 103479582
CVG: 107083362(kmt2c) 107101949
NFU: 107374212 107383945(kmt2c)
KMR: 108239632(kmt2c) 108251294
AOCE: 111563576 111570146(kmt2c)
CSEM: 103377343(kmt2c) 103396169
POV: 109639815(kmt2c) 109644301
SLAL: 111651182 111670500(kmt2c)
MALB: 109957735 109974986(kmt2c)
SFM: 108931734(kmt2c) 108937588
PKI: 111845839 111851671(kmt2c)
LCM: 102347272(KMT2C)
CMK: 103189435(kmt2c)
CIN: 778537
SPU: 591084
APLC: 110988546
SKO: 100369475
DME: Dmel_CG3848(trr)
DER: 6555719
DSE: 6616046
DSI: Dsimw501_GD16408(Dsim_GD16408)
DSR: 110179623
DPE: 6600700
DMN: 108157568
DWI: 6644769
DAZ: 108618116
DNV: 108655710
DHE: 111596840
MDE: 101890357
LCQ: 111677844
AAG: 5566444
AME: 411466
BIM: 100745609
BTER: 100646364
CCAL: 108626613
OBB: 114872130
SOC: 105197366
MPHA: 105830780
PBAR: 105433546
VEM: 105560415
HST: 105192566
DQU: 106741311
CFO: 105254099
LHU: 105673337
PGC: 109857124
OBO: 105275979
PCF: 106789019
NVI: 100120205
CSOL: 105362352
MDL: 103579560
TCA: 658776
NVL: 108559353
BMOR: 101736107
BMAN: 114242152
PMAC: 106719608
PRAP: 110995177
HAW: 110384023
TNL: 113500809
PXY: 105380357
AGS: 114132664
RMD: 113557307
BTAB: 109034958
CLEC: 106669646
FCD: 110850681
PVM: 113803991
TUT: 107366040
DPTE: 113795465
PTEP: 107452250
CEL: CELE_T12D8.1(set-16)
CBR: CBG18244(Cbr-set-16)
BMY: Bm1_21795
TSP: Tsp_02214
MYI: 110460322
NVE: 5509114
EPA: 110245624
AMIL: 114947053
PDAM: 113672552
SPIS: 111337076
DGT: 114522229
HMG: 100209023
DFA: DFA_05766
SPAR: SPRG_20781
 » show all
Reference
  Authors
Ruault M, Brun ME, Ventura M, Roizes G, De Sario A
  Title
MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.
  Journal
Gene 284:73-81 (2002)
DOI:10.1016/S0378-1119(02)00392-X
  Sequence
[hsa:58508]
Reference
  Authors
Ansari KI, Mandal SS
  Title
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
  Journal
FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x
Reference
  Authors
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K
  Title
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
  Journal
J Biol Chem 282:20395-406 (2007)
DOI:10.1074/jbc.M701574200
  Sequence
[hsa:58508]
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