KEGG ORTHOLOGY: K09342

ORTHOLOGY: K09342

Entry

K09342 KO

Name

NKX2-1, TITF1

Definition

homeobox protein Nkx-2.1

Disease

H00913

Brain-lung-thyroid syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09342  NKX2-1, TITF1; homeobox protein Nkx-2.1
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Homeo domain ANTP: NKL
    K09342  NKX2-1, TITF1; homeobox protein Nkx-2.1

Genes

HSA:	7080(NKX2-1)

PTR:	452867(NKX2-1)

PPS:	100969731(NKX2-1)

GGO:	101134297(NKX2-1)

PON:	100435695(NKX2-1)

NLE:	100600935(NKX2-1)

MCC:	696771(NKX2-1)

MCF:	102117647(NKX2-1)

CSAB:

103228839(NKX2-1)

RRO:	104663941(NKX2-1)

RBB:	108519664(NKX2-1)

CJC:	100405396(NKX2-1)

SBQ:	101045016(NKX2-1)

MMU:	21869(Nkx2-1)

MCAL:

110307236(Nkx2-1)

MPAH:

110324416(Nkx2-1)

RNO:	25628(Nkx2-1)

MUN:	110561087(Nkx2-1)

CGE:

113836212

NGI:	103732258(Nkx2-1)

HGL:	101703474(Nkx2-1)

CCAN:

109678703(Nkx2-1)

TUP:	102483512(NKX2-1)

VVP:	112935348(NKX2-1)

AML:	100465610(NKX2-1)

UAH:	113266037(NKX2-1)

ORO:	101381834(NKX2-1)

ELK:

111140657

FCA:	101091876(NKX2-1)

PTG:	102965541(NKX2-1)

PPAD:

109253310(NKX2-1)

AJU:	106965524(NKX2-1)

BTA:	613713(NKX2-1)

BOM:	102273984(NKX2-1)

BIU:	109575328(NKX2-1)

BBUB:

102399584(NKX2-1)

CHX:	108638469(NKX2-1)

OAS:	101121204(NKX2-1)

SSC:	100154384(NKX2-1)

CFR:	102504535(NKX2-1)

CDK:	105092147(NKX2-1)

BACU:

103003595

LVE:

103077930

OOR:	101270034(NKX2-1)

DLE:	111173299(NKX2-1)

PCAD:

102982580(NKX2-1)

ECB:	100146136(NKX2-1)

EAI:	106838822(NKX2-1)

MYB:	102258416(NKX2-1)

MYD:	102753802(NKX2-1)

MNA:	107526106(NKX2-1)

HAI:	109383865(NKX2-1)

DRO:	112296567(NKX2-1)

PALE:

102889733(NKX2-1)

RAY:	107514422(NKX2-1)

MJV:	108387551(NKX2-1)

LAV:	100659703(NKX2-1)

TMU:

101345451

MDO:	100011516(NKX2-1)

SHR:	100918766(NKX2-1)

PCW:	110211643(NKX2-1)

OAA:	100080703(NKX2-1)

GGA:	395322(NKX2-1)

MGP:	104911192(NKX2-1)

CJO:	107315058(NKX2-1)

NMEL:

110402062(NKX2-1)

APLA:

101790134(NKX2-1)

ACYG:

106038803(NKX2-1)

TGU:	100227803(NKX2-1)

LSR:	110477286(NKX2-1)

SCAN:

115485451(NKX2-1)

GFR:	102034824(NKX2-1)

FAB:	101817731(NKX2-1)

PHI:	102108499(NKX2-1)

PMAJ:

107206488(NKX2-1)

CCAE:

111922200 111929579(NKX2-1)

CCW:	104684866(NKX2-1)

ETL:	114055968(NKX2-1)

FPG:	101924190(NKX2-1)

FCH:	102058169(NKX2-1)

CLV:	102098222(NKX2-1)

EGZ:	104133299(NKX2-1)

NNI:	104011775(NKX2-1)

PADL:

103913019

AAM:	106483143(NKX2-1)

ASN:	102368907(NKX2-1)

AMJ:	102569395(NKX2-1)

PSS:	102444053 102460094(NKX2-1)

CMY:	102948066(NKX2-1)

CPIC:

101945035(NKX2-1)

ACS:	100557406(nkx2-1) 103279322

PVT:	110083516(NKX2-1)

PBI:	103052648(NKX2-1)

PMUR:

107284891(NKX2-1)

TSR:	106539475(NKX2-1) 106555202

PMUA:

114592352(NKX2-1)

GJA:	107112563(NKX2-1)

XLA:	108698633 373626(nkx2-1.L)

XTR:	100135015(nkx2-1) 100485697

NPR:	108797087(NKX2-1)

DRE:	81883(nkx2.1)

SRX:	107730204 107741875(nkx2-1)

SANH:

107666245 107679765

SGH:	107578306 107582966

CCAR:

109107252 109108631

IPU:	108269557(nkx2-1)

PHYP:

113538887(nkx2-1)

AMEX:

103043023

EEE:	113574141(nkx2-1)

TRU:	101073887(nkx2-1)

LCO:	104929988(nkx2-1)

NCC:	104941582(nkx2-1)

MZE:	101467819(nkx2-1)

ONL:	100702709(nkx2-1)

OLA:	100049404(nkx2-1)

XMA:	102230451(nkx2-1)

XCO:	114133830(nkx2-1)

PRET:

103458384(nkx2-1)

CVG:	107095827(nkx2-1)

NFU:	107392012(nkx2-1)

KMR:	108239045(nkx2.1)

ALIM:

106529798(nkx2-1)

AOCE:

111570006(nkx2-1)

CSEM:

103380542(nkx2-1)

POV:	109636330(nkx2-1)

LCF:	108875095(nkx2-1)

SDU:	111225980(nkx2-1)

SLAL:

111673098(nkx2-1)

HCQ:

109528123

BPEC:

110156339(nkx2-1)

MALB:

109964601(nkx2-1)

SASA:

106603787(nkx2-1) 106611304

OTW:	112235995 112236002 112261540(nkx2-1)

SALP:

111963504 112068048(nkx2-1)

ELS:	105026859(nkx2-1)

SFM:	108921600(nkx2-1) 108924020

PKI:	111852002(nkx2-1) 111858982

LCM:	102346775(NKX2-1)

CMK:	103178539(nkx2-1)

RTP:	109911367(nkx2-1)

BFO:

118423635

CIN:	445676(titf1)

APLC:

110977660

SKO:	100303502(nkx2-1)

DME:	Dmel_CG17594(scro)

DER:

6544440

DSE:

6620502

DYA:	Dyak_GE11056

DAN:

DSR:

DPE:

DMN:

DWI:

DGR:	Dgri_GH18027

DMO:	Dmoj_GI23787

DAZ:

DNV:

DHE:

DVI:

LCQ:

AGA:	AgaP_AGAP013315

AAG:

5578993

AALB:

109429947 109430735 115253994 115257422 115257901

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:	662616(nkx2.1)

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_212817

PMAC:

106708765

PRAP:

110994651

HAW:

110377368

TNL:	113504807 113504860

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM235910

ZNE:

110835543

FCD:

110843469

PVM:

113819901

ISC:	IscW_ISCW020063

TUT:	107369399 107369411

CSCU:

111620083 111631923

PTEP:

107436846

NAI:	NECAME_02262

TSP:

PCAN:

CRG:

MYI:

OBI:	106876811 106881899

LAK:

EGL:

HMG:

Reference

PMID:23763999

Authors

Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T

Title

NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.

Journal

Cancer Cell 23:718-23 (2013)
DOI:10.1016/j.ccr.2013.04.002

Sequence

[hsa:7080]

LinkDB

DBGET integrated database retrieval system