KEGG   ORTHOLOGY: K10808Help
Entry
K10808                      KO                                     

Name
RRM2
Definition
ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
Pathway
ko00230  Purine metabolism
ko00240  Pyrimidine metabolism
ko00480  Glutathione metabolism
ko00983  Drug metabolism - other enzymes
ko01100  Metabolic pathways
ko04115  p53 signaling pathway
Module
M00053  Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
Disease
H00469  Mitochondrial DNA depletion syndrome
H01118  Progressive external ophthalmoplegia
H01390  Mitochondrial neurogastrointestinal encephalomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
   00240 Pyrimidine metabolism
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1  ribonucleoside-diphosphate reductase
     K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Other factors with a suspected DNA repair function
   Modulation of nucleotide pools
    K10808  RRM2; ribonucleoside-diphosphate reductase subunit M2
BRITE hierarchy
Other DBs
RN: R02017 R02019 R02024 R08363 R08364 R11893
GO: 0004748
Genes
HSA: 50484(RRM2B) 6241(RRM2)
PTR: 459024(RRM2) 472832(RRM2B)
PPS: 100978164(RRM2B) 100991344(RRM2)
GGO: 101128993(RRM2) 101133309(RRM2B)
PON: 100172878(RRM2B) 100435953(RRM2)
NLE: 100579408(RRM2) 100599865(RRM2B)
MCC: 703138(RRM2) 707062(RRM2B)
MCF: 101865103(RRM2) 101865579(RRM2B)
CSAB: 103220834(RRM2) 103237238(RRM2B)
RRO: 104655148(RRM2B) 104675204(RRM2)
RBB: 108516338(RRM2) 108520195(RRM2B)
CJC: 100406418(RRM2B) 100409431(RRM2)
SBQ: 101041324(RRM2) 101045651(RRM2B) 101053858
MMU: 20135(Rrm2) 382985(Rrm2b)
MCAL: 110306805(Rrm2) 110310656(Rrm2b)
MPAH: 110324512(Rrm2) 110334944(Rrm2b)
RNO: 299976(Rrm2b) 362720(Rrm2)
MUN: 110556931(Rrm2b) 110564262(Rrm2)
CGE: 100752542(Rrm2) 100768429(Rrm2b)
NGI: 103747619(Rrm2) 103751596(Rrm2b)
HGL: 101700655(Rrm2) 101718446(Rrm2b)
CCAN: 109695860(Rrm2b) 109695921(Rrm2)
OCU: 100337711(RRM2B) 100346325(RRM2)
TUP: 102493707(RRM2) 102496069(RRM2B)
CFA: 481988(RRM2B) 482963(RRM2)
VVP: 112916984(RRM2B) 112927720(RRM2)
AML: 100467675(RRM2B) 100484524(RRM2)
UMR: 103660736(RRM2) 103661517(RRM2B)
UAH: 113252861(RRM2B) 113269810(RRM2)
FCA: 101087987(RRM2) 101099777(RRM2B)
PTG: 102950263(RRM2) 102950840(RRM2B)
PPAD: 109268699(RRM2) 109277987(RRM2B)
AJU: 106980049(RRM2B) 106987069(RRM2)
BTA: 508167(RRM2) 528960(RRM2B)
BOM: 102267033(RRM2B) 102280923(RRM2)
BIU: 109566395(RRM2) 109568552(RRM2B)
BBUB: 102389583(RRM2B) 102389951(RRM2)
CHX: 102173102(RRM2B) 102185371(RRM2)
OAS: 101118093(RRM2) 101123639(RRM2B)
SSC: 100157205(RRM2B) 100316853(RRM2)
CFR: 102509951(RRM2) 102517591(RRM2B)
CDK: 105090530(RRM2B) 105091241(RRM2)
BACU: 103001800(RRM2B) 103002730(RRM2)
LVE: 103084791(RRM2) 103085179(RRM2B)
OOR: 101270798(RRM2) 101273644(RRM2B) 105748332
DLE: 111164455(RRM2) 111180369(RRM2B) 115803136
PCAD: 102975539(RRM2) 102991905(RRM2B)
ECB: 100062030(RRM2B) 100072410(RRM2)
EPZ: 103549301(RRM2) 103565153(RRM2B)
EAI: 106823043(RRM2B) 106847469(RRM2)
MYB: 102239344(RRM2B) 102255694(RRM2)
MYD: 102762533(RRM2B) 102768249(RRM2)
MNA: 107526144(RRM2B) 107526638(RRM2)
HAI: 109374753(RRM2B) 109386651(RRM2)
DRO: 112298010(RRM2) 112315437(RRM2B)
PALE: 102895346(RRM2B) 102895581 112469018(RRM2)
RAY: 107507093(RRM2) 107512222(RRM2B)
MJV: 108390113(RRM2B) 108390947(RRM2)
LAV: 100664945(RRM2) 100673076(RRM2B)
MDO: 100030856(RRM2B) 100031990(RRM2)
SHR: 100914438(RRM2B) 100934573(RRM2)
PCW: 110196375(RRM2B) 110212710(RRM2)
OAA: 100073529(RRM2) 100077581(RRM2B)
GGA: 420253(RRM2B) 421936(RRM2)
MGP: 100550027(RRM2B) 100550737(RRM2)
CJO: 107310462(RRM2B) 107312233(RRM2)
NMEL: 110393093(RRM2B) 110396768(RRM2)
APLA: 101794665(RRM2) 101798489(RRM2B)
ACYG: 106030813(RRM2) 106035272(RRM2B)
TGU: 100231721(RRM2) 100231760(RRM2B)
LSR: 110467979(RRM2) 110470079(RRM2B)
SCAN: 103813925(RRM2B) 103820481(RRM2)
GFR: 102033491(RRM2) 102036141(RRM2B)
FAB: 101815464(RRM2) 101819545(RRM2B)
PHI: 102105482(RRM2) 102105901(RRM2B)
PMAJ: 107199938(RRM2B) 107202615(RRM2)
CCAE: 111924489(RRM2B) 111926052(RRM2)
CCW: 104685508(RRM2) 104692711(RRM2B)
ETL: 114057315(RRM2B) 114058978(RRM2)
FPG: 101924453(RRM2) 101924710(RRM2B)
FCH: 102054305(RRM2B) 102056241(RRM2)
CLV: 102089725(RRM2B) 102098900(RRM2)
EGZ: 104125884(RRM2B) 104127145(RRM2)
NNI: 104013008(RRM2) 104016445(RRM2B)
ACUN: 113476693(RRM2B) 113478284(RRM2)
PADL: 103916132(RRM2B) 103924051(RRM2)
AAM: 106483902(RRM2B) 106494774(RRM2)
ASN: 102370540(RRM2) 102379850(RRM2B)
AMJ: 102572985(RRM2) 106737166(RRM2B)
PSS: 102452484(RRM2) 102463887(RRM2B)
CMY: 102929591(RRM2) 102938774(RRM2B)
CPIC: 101930869(RRM2B) 101935883(RRM2)
ACS: 100566226(rrm2b) 100568029(rrm2)
PVT: 110073795(RRM2B) 110080600(RRM2)
PBI: 103049984(RRM2) 103062671
TSR: 106550808(RRM2B)
PMUA: 114593788(RRM2) 114600354(RRM2B)
GJA: 107109636(RRM2) 107124672(RRM2B)
XLA: 108695407 379056(rrm2b.S) 380465(rrm2.2.L) 443815(rrm2.1.L)
XTR: 100144925(rrm2b) 394645(rrm2.1) 493274(rrm2.2)
NPR: 108789065(RRM2B) 108789865(RRM2)
DRE: 100330864 30733(rrm2) 368909(rrm2b)
IPU: 100304963(rrm2) 108256937
PHYP: 113532384(rrm2) 113535868
AMEX: 103024314(rrm2) 103028967
EEE: 113570533(rrm2) 113575046
LCO: 104918649(rrm2b) 104938413
NCC: 104957091
XMA: 102221232(rrm2) 102232339(rrm2b)
XCO: 114155613(rrm2b) 114159077(rrm2)
PRET: 103457161(rrm2) 103472431(rrm2b)
CSEM: 103381368(rrm2) 103394411
POV: 109638772(rrm2b) 109648224
BPEC: 110163838 110167389(rrm2b)
SASA: 100194994(rir2) 106570792 106607664(rrm2)
SALP: 111954357 111972586(rrm2)
ELS: 105017811(rrm2) 105027716(rrm2b)
SFM: 108919262(rrm2b) 108929424(rrm2)
PKI: 111848258(rrm2b) 111851171(rrm2)
LCM: 102361010(RRM2)
CMK: 103180951(rrm2) 103185624
CIN: 100175066
SPU: 577596
DME: Dmel_CG8975(RnrS)
DER: 6546778
DSI: Dsimw501_GD25870(Dsim_GD25870)
DSR: 110178526
DPE: 6602081
DMN: 108158498
DWI: 6643235
DAZ: 108616269
DNV: 108653483
DHE: 111603114
MDE: 101897812
AAG: 5573705
AALB: 109399514
AME: 414008
BIM: 100741599
BTER: 100646244
CCAL: 108630539
OBB: 114877407
MPHA: 105835007
ACEP: 105620921
PBAR: 105430864
VEM: 105567568
HST: 105191222
DQU: 106750581
CFO: 105255837
LHU: 105667883
PCF: 106792164
NVI: 100114323
CSOL: 105367942
MDL: 103579621
TCA: 657724
DPA: 109538900
ATD: 109594163
NVL: 108566059
BMOR: 100873153(RnrS)
BMAN: 114244068
PMAC: 106713913
PRAP: 110994951
HAW: 110381825
TNL: 113496347
DNX: 107167809
RMD: 113548163
BTAB: 109040977
CLEC: 106663235
ZNE: 110833949
FCD: 110852546
CSCU: 111631820
PTEP: 107449543
CEL: CELE_C03C10.3(rnr-2)
CBR: CBG20205(Cbr-rnr-2)
BMY: Bm1_34225
TSP: Tsp_04092
PCAN: 112573879
CRG: 105336299
MYI: 110454415
OBI: 106881801
LAK: 106178433
SHX: MS3_08998
EGL: EGR_02227
ADF: 107335754
AMIL: 114960385
DGT: 114528753
HMG: 100211917
AQU: 100638359
ATH: AT3G23580(RNR2A) AT3G27060(TSO2)
LJA: Lj0g3v0056169.1(Lj0g3v0056169.1) Lj0g3v0328799.1(Lj0g3v0328799.1) Lj1g3v3631770.1(Lj1g3v3631770.1) Lj1g3v3835520.1(Lj1g3v3835520.1) Lj1g3v4361110.1(Lj1g3v4361110.1) Lj4g3v2379450.1(Lj4g3v2379450.1) Lj5g3v0642740.1(Lj5g3v0642740.1)
CSV: 101222416
CMO: 103491720
NTO: 104112191
NAU: 109208108
DOSA: Os06t0127900-01(Os06g0127900) Os06t0257450-01(Os06g0257450)
OBR: 102712731
BDI: 100832889
ATS: 109769404(LOC109769404)
SCE: YGR180C(RNR4) YJL026W(RNR2)
ERC: Ecym_6011
KMX: KLMA_30199(RNR2)
NCS: NCAS_0A06890(NCAS0A06890) NCAS_0D02000(NCAS0D02000)
NDI: NDAI_0C02780(NDAI0C02780) NDAI_0D01950(NDAI0D01950)
TPF: TPHA_0E03210(TPHA0E03210) TPHA_0E03220(TPHA0E03220) TPHA_0N00550(TPHA0N00550) TPHA_0N00560(TPHA0N00560)
TBL: TBLA_0C05960(TBLA0C05960) TBLA_0H02160(TBLA0H02160) TBLA_0H02170(TBLA0H02170)
TDL: TDEL_0E04490(TDEL0E04490)
KAF: KAFR_0D01760(KAFR0D01760) KAFR_0J00620(KAFR0J00620)
PIC: PICST_70259(RNR2)
SLB: AWJ20_3075(RNR2)
NCR: NCU07887
NTE: NEUTE1DRAFT116815(NEUTE1DRAFT_116815)
MGR: MGG_06408
TMN: UCRPA7_77
SSCK: SPSK_02467
MAW: MAC_08322
MAJ: MAA_03602
CMT: CCM_05761
MBE: MBM_01126
ANI: AN0067.2
ANG: ANI_1_944124(An14g06870)
ABE: ARB_03411
TVE: TRV_01368
PTE: PTT_10664
SPO: SPBC25D12.04(suc22)
LBC: LACBIDRAFT_230488(LbRNRbeta)
ABP: AGABI1DRAFT113579(AGABI1DRAFT_113579) AGABI1DRAFT39266(AGABI1DRAFT_39266)
ABV: AGABI2DRAFT116955(AGABI2DRAFT_116955) AGABI2DRAFT191772(AGABI2DRAFT_191772)
MGL: MGL_1758
MRT: MRET_4369
DDI: DDB_G0272616(rnrB-1) DDB_G0274021(rnrB-2) DDB_G0291764
PYO: PY17X_1039000(PY03671) PY17X_1217400(PY07154)
PCB: PCHAS_103740(PC000254.04.0) PCHAS_121490(PC000747.01.0)
TPV: TP01_0725
BBO: BBOV_IV006460(23.m06516) BBOV_IV010610(23.m06273)
CPV: cgd6_690
SMIN: v1.2.003760.t1(symbB.v1.2.003760.t1) v1.2.026582.t1(symbB.v1.2.026582.t1) v1.2.032751.t1(symbB.v1.2.032751.t1)
AAF: AURANDRAFT_60022(RRS2)
VG: 11107163(YKV020c) 1485926(CPXV051_CDS) 16511831(pdul_cds_481) 28340333(PTPV-Aus-006) 29057618(BIZ96_gp040) 29063987(BI079_gp040) 6295440(rr2) 8887768(rr2b) 928921(C10L)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
  Authors
Qiu W, Zhou B, Darwish D, Shao J, Yen Y
  Title
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.
  Journal
Biochem Biophys Res Commun 340:428-34 (2006)
DOI:10.1016/j.bbrc.2005.12.019
  Sequence
[hsa:6241 50484]
Reference
  Authors
Guittet O, Hakansson P, Voevodskaya N, Fridd S, Graslund A, Arakawa H, Nakamura Y, Thelander L
  Title
Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.
  Journal
J Biol Chem 276:40647-51 (2001)
DOI:10.1074/jbc.M106088200
Reference
  Authors
Nguyen HH, Ge J, Perlstein DL, Stubbe J
  Title
Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly.
  Journal
Proc Natl Acad Sci U S A 96:12339-44 (1999)
DOI:10.1073/pnas.96.22.12339
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