KEGG   ORTHOLOGY: K11411Help
Entry
K11411                      KO                                     

Name
SIRT1, SIR2L1
Definition
NAD+-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
Pathway
ko00760  Nicotinate and nicotinamide metabolism
ko01100  Metabolic pathways
ko04068  FoxO signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04922  Glucagon signaling pathway
ko05031  Amphetamine addiction
ko05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
   04152 AMPK signaling pathway
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
  09149 Aging
   04211 Longevity regulating pathway
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
   04212 Longevity regulating pathway - worm
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
   04213 Longevity regulating pathway - multiple species
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
  09165 Substance dependence
   05031 Amphetamine addiction
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
   03029 Mitochondrial biogenesis
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K11411  SIRT1, SIR2L1; NAD+-dependent protein deacetylase sirtuin 1
BRITE hierarchy
Other DBs
RN: R10633 R10634
Genes
HSA: 23411(SIRT1)
PTR: 107966703(SIRT1)
PPS: 100984983(SIRT1)
GGO: 101147879(SIRT1)
PON: 100443901(SIRT1)
NLE: 100605499(SIRT1)
MCC: 695682(SIRT1)
MCF: 102134009(SIRT1)
CSAB: 103216104(SIRT1)
RRO: 104671788(SIRT1)
RBB: 108514897(SIRT1)
CJC: 100395149(SIRT1)
SBQ: 101029573(SIRT1)
MMU: 93759(Sirt1)
MCAL: 110303892(Sirt1)
MPAH: 110326468(Sirt1)
RNO: 309757(Sirt1)
MUN: 110554873(Sirt1)
CGE: 100763298(Sirt1)
NGI: 103733767(Sirt1)
HGL: 101720282(Sirt1)
CCAN: 109681555(Sirt1)
OCU: 100349271(SIRT1)
TUP: 102484296(SIRT1)
CFA: 489012(SIRT1)
VVP: 112927672(SIRT1)
AML: 100484328(SIRT1)
UMR: 103667762(SIRT1)
UAH: 113259105(SIRT1)
ORO: 101382490(SIRT1)
ELK: 111145159
FCA: 101087610(SIRT1)
PTG: 102963908(SIRT1)
PPAD: 109264323(SIRT1)
AJU: 106967135(SIRT1)
BTA: 613629(SIRT1)
BOM: 102276604(SIRT1)
BIU: 109553808(SIRT1)
BBUB: 102409911(SIRT1)
CHX: 102180824(SIRT1)
OAS: 101102956(SIRT1)
SSC: 751859(SIRT1)
CFR: 102515768(SIRT1)
CDK: 105093901(SIRT1)
BACU: 103011001(SIRT1)
LVE: 103080304(SIRT1)
OOR: 101279007(SIRT1)
DLE: 111183434(SIRT1)
PCAD: 102993364(SIRT1)
ECB: 100072571(SIRT1)
EPZ: 103562180(SIRT1)
EAI: 106844401 106844414(SIRT1)
MYB: 102240165(SIRT1)
MYD: 102756748(SIRT1)
MNA: 107526052(SIRT1)
HAI: 109371987(SIRT1)
DRO: 112305485(SIRT1)
PALE: 102880351(SIRT1)
RAY: 107501303(SIRT1)
MJV: 108407546(SIRT1)
LAV: 100667672(SIRT1)
TMU: 101342951
MDO: 100015574(SIRT1)
SHR: 100920847(SIRT1)
PCW: 110216385(SIRT1)
OAA: 100077037(SIRT1)
GGA: 423646(SIRT1)
MGP: 100540948(SIRT1)
CJO: 107315730(SIRT1)
NMEL: 110399426(SIRT1)
APLA: 101799275(SIRT1)
ACYG: 106031113(SIRT1)
TGU: 100229233(SIRT1)
LSR: 110469870(SIRT1)
SCAN: 103821200(SIRT1)
GFR: 102038978(SIRT1)
FAB: 101810475(SIRT1)
PHI: 102101980(SIRT1)
PMAJ: 107206664(SIRT1)
CCAE: 111931513(SIRT1)
CCW: 104690233(SIRT1)
ETL: 114064018(SIRT1)
FPG: 101912911(SIRT1)
FCH: 102058467(SIRT1)
CLV: 102091510(SIRT1)
EGZ: 104124613(SIRT1)
NNI: 104013536(SIRT1)
ACUN: 113481816(SIRT1)
PADL: 103918614(SIRT1)
AAM: 106486965(SIRT1)
ASN: 102369643(SIRT1)
AMJ: 102561292(SIRT1)
PSS: 102446525(SIRT1)
CMY: 102930541(SIRT1)
CPIC: 101935658(SIRT1)
ACS: 100564010(sirt1)
PVT: 110087595(SIRT1)
PBI: 103054603(SIRT1)
PMUR: 107288080(SIRT1)
TSR: 106539436(SIRT1)
PMUA: 114597181(SIRT1)
GJA: 107120476(SIRT1)
XLA: 100036963(sirt1.L) 108697451(sirt1.S)
XTR: 100145679(sirt1)
NPR: 108801625(SIRT1)
DRE: 797132(sirt1)
IPU: 108261052(sirt1)
PHYP: 113542038(sirt1)
AMEX: 103031674(sirt1)
EEE: 113567518(sirt1)
TRU: 101061405(sirt1)
LCO: 104921892(sirt1)
NCC: 104964612(sirt1)
MZE: 101480414(sirt1)
ONL: 100700447(sirt1)
OLA: 101175344(sirt1)
XMA: 102222322(sirt1)
XCO: 114138276(sirt1)
PRET: 103477104(sirt1)
CVG: 107088648(sirt1)
NFU: 107375374(sirt1)
KMR: 108240687(sirt1)
ALIM: 106525621(sirt1)
AOCE: 111573092(sirt1)
CSEM: 103391355(sirt1)
POV: 109634091(sirt1)
LCF: 108886237(sirt1)
SDU: 111220735(sirt1)
SLAL: 111669537(sirt1)
BPEC: 110162160(sirt1)
MALB: 109961229(sirt1)
SASA: 106576833(sirt1) 106604510
ELS: 105028637(sirt1)
SFM: 108932694(sirt1)
PKI: 111855069(sirt1)
LCM: 102348704(SIRT1)
CMK: 103181092(sirt1)
RTP: 109912079(sirt1)
CIN: 101242972
SPU: 591711
APLC: 110973619
SKO: 100368502
DME: Dmel_CG5216(Sirt1)
DER: 6541429
DSI: Dsimw501_GD23867(Dsim_GD23867)
DSR: 110182601
DPE: 6602244
DMN: 108163184
DWI: 6642746
DAZ: 108611624
DNV: 115563957
DHE: 111605492
MDE: 101899580
LCQ: 111679526
AME: 411917
BIM: 100750085
BTER: 100650920
CCAL: 108628131
OBB: 114876075
SOC: 105206368
MPHA: 105839964
AEC: 105148879
ACEP: 105625845
PBAR: 105431398
VEM: 105560518
HST: 105192145
DQU: 106741183
CFO: 105247797
LHU: 105677681
PGC: 109853605
OBO: 105281423
PCF: 106785875
NVI: 100122518
CSOL: 105364125
MDL: 103575980
TCA: 655430
DPA: 109534501
ATD: 109596596
NVL: 108559984
API: 100167327
DNX: 107171649
AGS: 114128361
RMD: 113556630
BTAB: 109033143
CLEC: 106668020
ZNE: 110838057
FCD: 110842942
DPX: DAPPUDRAFT_290541(SIR2)
PVM: 113810777
TUT: 107366214
DPTE: 113799177
CSCU: 111633155
PTEP: 107438690
CEL: CELE_R11A8.4(sir-2.1)
CBR: CBG23756(Cbr-sir-2.1)
BMY: Bm1_38355
TSP: Tsp_07421
PCAN: 112561600
CRG: 105339186
MYI: 110460060
OBI: 106881695
LAK: 106174398
SHX: MS3_07997
EGL: EGR_03567
EPA: 110232026
ADF: 107357308
AMIL: 114976584
PDAM: 113677824
SPIS: 111336637
DGT: 114530937
HMG: 100210841
AQU: 100639948
DDI: DDB_G0289967(sir2D)
DFA: DFA_08068(sir2D)
SPAR: SPRG_10369
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA
  Title
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
  Journal
Cell 107:149-59 (2001)
DOI:10.1016/S0092-8674(01)00527-X
  Sequence
[hsa:23411]
Reference
  Authors
Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L
  Title
SIRT1 deacetylates and positively regulates the nuclear receptor LXR.
  Journal
Mol Cell 28:91-106 (2007)
DOI:10.1016/j.molcel.2007.07.032
  Sequence
[hsa:23411] [mmu:93759]
Reference
  Authors
Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T
  Title
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
  Journal
Proc Natl Acad Sci U S A 105:3374-9 (2008)
DOI:10.1073/pnas.0712145105
  Sequence
[hsa:23411] [mmu:93759]
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