KEGG   ORTHOLOGY: K11421
Entry
K11421                      KO                                     

Name
SETDB1
Definition
[histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase [EC:2.1.1.366]
Pathway
ko00310  Lysine degradation
ko01100  Metabolic pathways
ko04550  Signaling pathways regulating pluripotency of stem cells
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.366  [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
     K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K11421  SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
Other DBs
RN: R04867
GO: 0046974
Genes
HSA: 9869(SETDB1)
PTR: 469481(SETDB1)
PPS: 100972839(SETDB1)
GGO: 101146215(SETDB1)
PON: 100431310(SETDB1)
NLE: 100581330(SETDB1)
MCC: 716141(SETDB1)
MCF: 102117410(SETDB1)
CSAB: 103247223(SETDB1)
RRO: 104681064(SETDB1)
RBB: 108533259(SETDB1)
CJC: 100411734(SETDB1)
SBQ: 101042658(SETDB1)
MMU: 84505(Setdb1)
MCAL: 110291522(Setdb1)
MPAH: 110320737(Setdb1)
RNO: 689883(Setdb1)
MUN: 110560774(Setdb1)
CGE: 100765697(Setdb1)
NGI: 103730089(Setdb1)
HGL: 101715248(Setdb1)
CCAN: 109681205(Setdb1)
OCU: 100355877(SETDB1)
TUP: 102502264(SETDB1)
CFA: 483186(SETDB1)
VVP: 112907769(SETDB1)
AML: 100482250(SETDB1)
UMR: 103667532(SETDB1)
UAH: 113246155(SETDB1)
ORO: 101372094(SETDB1)
ELK: 111162065
FCA: 101094118(SETDB1)
PTG: 102970727(SETDB1)
PPAD: 109257028(SETDB1)
AJU: 106979835(SETDB1)
BTA: 100138100(SETDB1)
BOM: 102288279(SETDB1)
BIU: 109555305(SETDB1)
BBUB: 102408652(SETDB1)
CHX: 102180982(SETDB1)
OAS: 101109230(SETDB1)
SSC: 100157920(SETDB1)
CFR: 102512057(SETDB1)
CDK: 105103196(SETDB1)
BACU: 103009894(SETDB1)
LVE: 103076461(SETDB1)
OOR: 101270688(SETDB1)
DLE: 111169744(SETDB1)
ECB: 100059254(SETDB1)
EPZ: 103547642(SETDB1)
EAI: 106846522(SETDB1)
MYB: 102257713(SETDB1)
MYD: 102773684(SETDB1)
MNA: 107539129(SETDB1)
HAI: 109372277(SETDB1)
DRO: 112313537(SETDB1)
RAY: 107499036(SETDB1)
MJV: 108409453(SETDB1)
LAV: 100673374(SETDB1)
TMU: 101349341
MDO: 100618580(SETDB1)
SHR: 100928904(SETDB1)
PCW: 110220597(SETDB1)
OAA: 100091318(SETDB1)
GGA: 100859816(SETDB1)
MGP: 100542346(SETDB1)
CJO: 107324577(SETDB1)
NMEL: 110387900(SETDB1)
APLA: 101794756(SETDB1)
ACYG: 106049268(SETDB1)
TGU: 100231651(SETDB1)
LSR: 110476821(SETDB1)
SCAN: 103824025
GFR: 102034546(SETDB1)
PHI: 102101563(SETDB1)
PMAJ: 107214655(SETDB1)
CCAE: 111939473(SETDB1)
ETL: 114071955(SETDB1)
FPG: 101912073(SETDB1)
FCH: 102055212(SETDB1)
CLV: 102094505(SETDB1)
EGZ: 104129700(SETDB1)
NNI: 104014430(SETDB1)
ACUN: 113488725(SETDB1)
PADL: 103919479(SETDB1)
AAM: 106495416(SETDB1)
ASN: 102382539(SETDB1)
AMJ: 102575637(SETDB1)
CMY: 102937828(SETDB1)
CPIC: 101931963(SETDB1)
ACS: 100565799(setdb1)
PVT: 110081479(SETDB1)
PBI: 103053131(SETDB1)
PMUR: 107292899(SETDB1)
TSR: 106546292(SETDB1)
PMUA: 114586177(SETDB1)
GJA: 107121584(SETDB1)
XLA: 108700333(setdb1.S) 432147(setdb1.L)
XTR: 100490309(setdb1)
NPR: 108789810(SETDB1)
DRE: 553292(setdb1a) 768131(setdb1b)
IPU: 108266106(setdb1) 108272679
PHYP: 113535137 113542451(setdb1)
AMEX: 103027968(setdb1) 103028156
EEE: 113570608(setdb1) 113572599
TRU: 101075200(setdb1)
LCO: 104920543(setdb1)
NCC: 104944919(setdb1)
MZE: 101465322(setdb1)
ONL: 100710331(setdb1)
OLA: 101158302(setdb1)
XMA: 102235762(setdb1)
XCO: 114141956(setdb1)
PRET: 103478723(setdb1)
CVG: 107088829(setdb1)
NFU: 107379696(setdb1)
KMR: 108241152(setdb1)
ALIM: 106515090
AOCE: 111586482(setdb1)
CSEM: 103388279(setdb1)
POV: 109633224
LCF: 108885905(setdb1)
SDU: 111230127(setdb1)
SLAL: 111652197(setdb1)
HCQ: 109522778(setdb1)
BPEC: 110163046(setdb1)
MALB: 109970226
SALP: 111955709 111964582(setdb1)
ELS: 105018987(setdb1) 105030119
SFM: 108923796(setdb1)
PKI: 111853328(setdb1)
LCM: 102356699(SETDB1)
BFO: 118414026
CIN: 101242243
SPU: 764341
APLC: 110986848
SKO: 100372058
DME: Dmel_CG12196(egg)
DER: 6548401
DSE: 6618876
DSI: Dsimw501_GD24920(Dsim_GD24920)
DAN: 6494410
DSR: 110189614
DPE: 6592281
DWI: 6640308
DAZ: 108615991
DNV: 108654234
DHE: 111593833
DVI: 6626333
MDE: 101893339
LCQ: 111689074
AALB: 109429413
AME: 409098
BIM: 100745488
BTER: 100647514
CCAL: 108631329
OBB: 114874120
SOC: 105201335
MPHA: 105833491
AEC: 105144993
ACEP: 105620791
PBAR: 105429250
VEM: 105561499
HST: 105186113
DQU: 106745347
CFO: 105256000
LHU: 105670399
PGC: 109857860
OBO: 105284457
PCF: 106790393
NVI: 100120014
CSOL: 105360527
MDL: 103577834
TCA: 658295
DPA: 109543261
NVL: 108566549
BMOR: 101742950
BMAN: 114244119
PMAC: 106721248
PRAP: 110997400
TNL: 113502290
BTAB: 109030364
ZNE: 110837361
TUT: 107372205
PTEP: 107451716
CEL: CELE_R05D3.11(met-2)
CBR: CBG18157(Cbr-met-2)
BMY: Bm1_19995
PCAN: 112559730
CRG: 105332598
MYI: 110459908
OBI: 106873585
LAK: 106167373
SHX: MS3_06263
EGL: EGR_06122
NVE: 5506681
EPA: 110238173
AMIL: 114974694
PDAM: 113666302
DGT: 114527359
HMG: 100203637
 » show all
Reference
  Authors
Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, Youn MY, Takeyama K, Nakamura T, Mezaki Y, Takezawa S, Yogiashi Y, Kitagawa H, Yamada G, Takada S, Minami Y, Shibuya H, Matsumoto K, Kato S
  Title
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.
  Journal
Nat Cell Biol 9:1273-85 (2007)
DOI:10.1038/ncb1647
  Sequence
[hsa:9869]
Reference
  Authors
Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y
  Title
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.
  Journal
Oncogene 21:148-52 (2002)
DOI:10.1038/sj.onc.1204998
  Sequence
[mmu:84505]
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