KEGG   ORTHOLOGY: K11427Help
Entry
K11427                      KO                                     

Name
DOT1L, DOT1
Definition
histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Pathway
ko00310  Lysine degradation
ko05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific
 09160 Human Diseases
  09161 Cancers
   05202 Transcriptional misregulation in cancers
    K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11427  DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific
BRITE hierarchy
Other DBs
RN: R03875 R03938 R04866 R04867
GO: 0031151
Genes
HSA: 84444(DOT1L)
PTR: 455566(DOT1L)
PPS: 100969530(DOT1L)
GGO: 101134931(DOT1L)
PON: 100450564(DOT1L)
NLE: 100606063(DOT1L)
MCC: 710033(DOT1L)
MCF: 101926502(DOT1L)
CSAB: 103233645(DOT1L)
RRO: 104671393(DOT1L)
RBB: 108531435(DOT1L)
CJC: 100407532(DOT1L)
SBQ: 101038132(DOT1L)
MMU: 208266(Dot1l)
RNO: 362831(Dot1l)
CGE: 100771005(Dot1l)
NGI: 103737299(Dot1l)
HGL: 101712712(Dot1l)
CCAN: 109689927 109689929(Dot1l)
TUP: 102494943(DOT1L)
CFA: 485073(DOT1L)
AML: 100464435(DOT1L)
UMR: 103681799(DOT1L)
ORO: 101366843(DOT1L)
FCA: 101101194(DOT1L)
PTG: 102966497(DOT1L)
AJU: 106983698(DOT1L)
BTA: 510442(DOT1L)
BOM: 102280735(DOT1L)
BIU: 109561797(DOT1L)
PHD: 102319778(DOT1L)
CHX: 102180119(DOT1L)
OAS: 101121261(DOT1L)
SSC: 100738665(DOT1L)
CFR: 102522071(DOT1L) 106729841
CDK: 105103623(DOT1L) 105106057
BACU: 103011331(DOT1L)
LVE: 103083056(DOT1L)
OOR: 101281886(DOT1L)
ECB: 100068506(DOT1L)
EPZ: 103543191 103544492(DOT1L)
EAI: 106834163(DOT1L)
MYB: 102240787(DOT1L)
MYD: 102773641(DOT1L)
HAI: 109390613(DOT1L)
RSS: 109453873(DOT1L)
PALE: 102893368(DOT1L)
LAV: 100661109(DOT1L)
TMU: 101350137
MDO: 100619840(DOT1L)
SHR: 100918350(DOT1L)
OAA: 100088528
GGA: 420078(DOT1L)
MGP: 100546682(DOT1L)
CJO: 107325391(DOT1L)
APLA: 101804645(DOT1L)
ACYG: 106045654(DOT1L)
TGU: 100222310(DOT1L)
GFR: 102036723(DOT1L)
FAB: 101807609(DOT1L)
PHI: 102108358(DOT1L)
PMAJ: 107215544(DOT1L)
CCW: 104696943(DOT1L)
FPG: 101911291(DOT1L)
FCH: 102053275(DOT1L)
CLV: 102097756(DOT1L)
EGZ: 104131107(DOT1L)
ASN: 102368409(DOT1L)
AMJ: 102567829(DOT1L)
PSS: 102455080(DOT1L)
CMY: 102943895(DOT1L)
CPIC: 101947542(DOT1L)
ACS: 103282705(dot1l)
PVT: 110072436(DOT1L) 110072437
PBI: 103061368(DOT1L)
GJA: 107122041(DOT1L)
XLA: 108706873(dot1l.S) 108712856(dot1l.L)
XTR: 100497594(dot1l)
NPR: 108801355
DRE: 559945(dot1l)
IPU: 108270738(dot1l)
AMEX: 103023208(dot1l)
TRU: 101062350(dot1l)
LCO: 104918483(dot1l)
MZE: 101473918(dot1l)
OLA: 101166952(dot1l)
XMA: 102227320(dot1l)
PRET: 103463635(dot1l)
NFU: 107397320(dot1l)
CSEM: 103376710(dot1l)
LCF: 108877359(dot1l)
HCQ: 109532198(dot1l)
BPEC: 110174051(dot1l)
SASA: 106584426 106613781(dot1l)
ELS: 105011570(dot1l)
SFM: 108919875(dot1l)
LCM: 102351844(DOT1L)
CMK: 103181918(dot1l)
CIN: 100178360
SPU: 100891935
APLC: 110985151
SKO: 100366496
DME: Dmel_CG42803(gpp)
DSI: Dsimw501_GD19874(Dsim_GD19874)
MDE: 101896384
AAG: 5579940
AME: 411070
BIM: 100744223
BTER: 100650198
SOC: 105202538
AEC: 105144095
ACEP: 105624533
PBAR: 105433651
HST: 105185248
CFO: 105249170
LHU: 105667327
PGC: 109860719
NVI: 100116648(Dot1l)
TCA: 660658
NVL: 108567082
BMOR: 101736339
PMAC: 106708949
PRAP: 110994938
API: 100168129
DNX: 107162006
ZNE: 110835135
FCD: 110859850
TUT: 107359774
CEL: CELE_F54F7.7(dot-1.2) CELE_F55G7.2(dot-1.4) CELE_W06D11.4(dot-1.3) CELE_Y39G10AR.18(dot-1.1)
BMY: Bm1_56955
TSP: Tsp_05196
CRG: 105340311
MYI: 110440609
LAK: 106164636
SHX: MS3_09541
EPA: 110244289
ADF: 107340719
HMG: 100211036
AQU: 109584002
SCE: YDR440W(DOT1)
ERC: Ecym_4091
KMX: KLMA_40588(DOT1)
NCS: NCAS_0F01220(NCAS0F01220)
NDI: NDAI_0H01750(NDAI0H01750)
TPF: TPHA_0D02550(TPHA0D02550)
TBL: TBLA_0D01440(TBLA0D01440) TBLA_0E03030(TBLA0E03030)
TDL: TDEL_0A04190(TDEL0A04190)
KAF: KAFR_0I00880(KAFR0I00880)
CAL: CAALFM_C306300WA(DOT1)
CAUR: QG37_05752
SLB: AWJ20_173(DOT1)
NCR: NCU06266
NTE: NEUTE1DRAFT146228(NEUTE1DRAFT_146228)
SMP: SMAC_00083(putative dot1)
MGR: MGG_05254
MAW: MAC_04133
MAJ: MAA_08905
CMT: CCM_06781
MBE: MBM_01079
ANI: AN0091.2
ANG: ANI_1_296084(An09g02720)
ABE: ARB_04392
TVE: TRV_03181
PTE: PTT_12191
ZTR: MYCGRDRAFT_23780(DOT2401)
CNE: CNK02230
CNB: CNBK1310
ABP: AGABI1DRAFT32345(AGABI1DRAFT_32345)
ABV: AGABI2DRAFT190074(AGABI2DRAFT_190074)
MGL: MGL_1909
SPAR: SPRG_11639
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Barry ER, Corry GN, Rasmussen TP
  Title
Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development.
  Journal
Expert Opin Ther Targets 14:405-18 (2010)
DOI:10.1517/14728221003623241
Reference
  Authors
San-Segundo PA, Roeder GS
  Title
Role for the silencing protein Dot1 in meiotic checkpoint control.
  Journal
Mol Biol Cell 11:3601-15 (2000)
DOI:10.1091/mbc.11.10.3601
  Sequence
[sce:YDR440W]
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