KEGG   ORTHOLOGY: K11859Help
Entry
K11859                      KO                                     

Name
TNFAIP3, A20, OTUD7C
Definition
tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12]
Pathway
ko04064  NF-kappa B signaling pathway
ko04217  Necroptosis
ko04621  NOD-like receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko05162  Measles
ko05169  Epstein-Barr virus infection
Disease
H01492  Systemic sclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   04668 TNF signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   04657 IL-17 signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   05169 Epstein-Barr virus infection
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C64
   K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Ubiquitin system [BR:ko04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   OTU
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
BRITE hierarchy
Other DBs
GO: 0004843
Genes
HSA: 7128(TNFAIP3)
PTR: 472136(TNFAIP3)
PPS: 100994797(TNFAIP3)
GGO: 101149274(TNFAIP3)
PON: 100459145(TNFAIP3)
NLE: 100600197(TNFAIP3)
MCC: 704130(TNFAIP3)
MCF: 101867362(TNFAIP3)
CSAB: 103240296(TNFAIP3)
RRO: 104675026(TNFAIP3)
RBB: 108518253(TNFAIP3)
CJC: 100397002(TNFAIP3)
SBQ: 101052980(TNFAIP3)
MMU: 21929(Tnfaip3)
MCAL: 110303143(Tnfaip3)
MPAH: 110338221(Tnfaip3)
RNO: 683206(Tnfaip3)
CGE: 100771931(Tnfaip3)
NGI: 103724893(Tnfaip3)
CCAN: 109697032(Tnfaip3)
OCU: 100350259(TNFAIP3)
TUP: 102477224(TNFAIP3)
CFA: 484006(TNFAIP3)
VVP: 112919472(TNFAIP3)
AML: 100474270(TNFAIP3)
UMR: 103663491(TNFAIP3)
UAH: 113259486(TNFAIP3)
ORO: 101377530(TNFAIP3)
FCA: 101083682(TNFAIP3)
PTG: 102958897(TNFAIP3)
AJU: 106982026(TNFAIP3)
BTA: 508105(TNFAIP3)
BOM: 102266726(TNFAIP3)
BIU: 109563985(TNFAIP3)
BBUB: 102412133(TNFAIP3)
PHD: 102327172(TNFAIP3)
CHX: 102182977(TNFAIP3)
OAS: 101113156(TNFAIP3)
SSC: 100622156(TNFAIP3)
CFR: 102523266(TNFAIP3)
CDK: 105092086(TNFAIP3)
BACU: 103001161(TNFAIP3)
LVE: 103081298(TNFAIP3)
OOR: 101275303(TNFAIP3)
DLE: 111166213(TNFAIP3)
PCAD: 102991611(TNFAIP3)
ECB: 100073197(TNFAIP3)
EPZ: 103549048(TNFAIP3)
EAI: 106846056(TNFAIP3)
MYB: 102258379(TNFAIP3)
MYD: 102761078(TNFAIP3)
MNA: 107530982(TNFAIP3)
HAI: 109385645(TNFAIP3)
RSS: 109447977(TNFAIP3)
DRO: 112297385(TNFAIP3)
PALE: 102887009(TNFAIP3)
RAY: 107505426(TNFAIP3)
LAV: 100670852(TNFAIP3)
TMU: 101345067
MDO: 100025842(TNFAIP3)
SHR: 100919524(TNFAIP3)
PCW: 110199059(TNFAIP3)
OAA: 100075332(TNFAIP3)
GGA: 421684(TNFAIP3)
MGP: 100550484(TNFAIP3)
CJO: 107311676(TNFAIP3)
NMEL: 110396285(TNFAIP3)
APLA: 101796300(TNFAIP3)
ACYG: 106032519(TNFAIP3)
TGU: 100227030(TNFAIP3)
LSR: 110483298(TNFAIP3)
SCAN: 103818470(TNFAIP3)
GFR: 102041044(TNFAIP3)
FAB: 101817397(TNFAIP3)
PHI: 102102986(TNFAIP3)
PMAJ: 107202524(TNFAIP3)
CCAE: 111945140(TNFAIP3)
CCW: 104689521(TNFAIP3)
ETL: 114059512(TNFAIP3)
FPG: 101911730(TNFAIP3)
FCH: 102046472(TNFAIP3)
CLV: 102097352(TNFAIP3)
EGZ: 104131136(TNFAIP3)
NNI: 104008814(TNFAIP3)
ACUN: 113478855(TNFAIP3)
PADL: 103912709(TNFAIP3)
AAM: 106497913(TNFAIP3)
ASN: 102372488(TNFAIP3)
AMJ: 102558492(TNFAIP3)
PSS: 102450291(TNFAIP3)
CMY: 102936943(TNFAIP3)
CPIC: 101945596(TNFAIP3)
ACS: 100564334(tnfaip3)
PVT: 110071261(TNFAIP3)
PBI: 103068002(TNFAIP3)
PMUR: 107294501(TNFAIP3)
GJA: 107122065(TNFAIP3)
XLA: 446998(tnfaip3.S)
NPR: 108795154(TNFAIP3)
DRE: 564497(tnfaip3)
SRX: 107720364 107751155(tnfaip3)
IPU: 108263677(tnfaip3)
PHYP: 113542100(tnfaip3)
AMEX: 103035626(tnfaip3)
EEE: 113585834(tnfaip3)
TRU: 101062530(tnfaip3)
LCO: 104928434(tnfaip3)
NCC: 104955588(tnfaip3)
MZE: 101476138(tnfaip3)
OLA: 101160685(tnfaip3)
XMA: 102237440(tnfaip3)
XCO: 114138247(tnfaip3)
PRET: 103476679(tnfaip3)
NFU: 107375829(tnfaip3)
KMR: 108245439(tnfaip3)
AOCE: 111582004(tnfaip3)
CSEM: 103386958(tnfaip3)
POV: 109634788(tnfaip3)
LCF: 108897419(tnfaip3)
SDU: 111235218(tnfaip3)
HCQ: 109510035(tnfaip3)
BPEC: 110157241(tnfaip3)
MALB: 109959569(tnfaip3)
SASA: 106589680(tnfaip3) 106610821
SALP: 111968025(tnfaip3) 111978266
ELS: 105021223(tnfaip3)
SFM: 108931280 108932919(tnfaip3)
PKI: 111837608(tnfaip3)
LCM: 102362242(TNFAIP3) 106703405
CMK: 103178317(tnfaip3) 103185665
SPU: 590500
APLC: 110974467
SKO: 100369415
PCAN: 112567026
CRG: 105347244
MYI: 110463768
LAK: 106165950
EPA: 110235961
ADF: 107344228
PDAM: 113664510
SPIS: 111325763
AQU: 105316699
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM
  Title
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
  Journal
Nature 430:694-9 (2004)
DOI:10.1038/nature02794
Reference
PMID:2118515
  Authors
Opipari AW Jr, Boguski MS, Dixit VM
  Title
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.
  Journal
J Biol Chem 265:14705-8 (1990)
  Sequence
[hsa:7128]
LinkDB All DBs

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