KEGG   ORTHOLOGY: K11987Help
Entry
K11987                      KO                                     

Name
PTGS2, COX2
Definition
prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
Pathway
ko00590  Arachidonic acid metabolism
ko01100  Metabolic pathways
ko04064  NF-kappa B signaling pathway
ko04370  VEGF signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04723  Retrograde endocannabinoid signaling
ko04726  Serotonergic synapse
ko04913  Ovarian steroidogenesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko05140  Leishmaniasis
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05204  Chemical carcinogenesis
ko05206  MicroRNAs in cancer
ko05222  Small cell lung cancer
Disease
H00017  Esophageal cancer
H00025  Penile cancer
H00046  Cholangiocarcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04064 NF-kappa B signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04668 TNF signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04657 IL-17 signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04913 Ovarian steroidogenesis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04921 Oxytocin signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09156 Nervous system
   04726 Serotonergic synapse
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04723 Retrograde endocannabinoid signaling
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05206 MicroRNAs in cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05204 Chemical carcinogenesis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05165 Human papillomavirus infection
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
BRITE hierarchy
Other DBs
RN: R00073 R01590
GO: 0004666
Genes
HSA: 5743(PTGS2)
PTR: 469616(PTGS2)
PPS: 100985650(PTGS2)
GGO: 101146681(PTGS2)
PON: 100436566(PTGS2)
NLE: 100591090(PTGS2)
MCC: 716671(PTGS2)
MCF: 102143028(PTGS2)
CSAB: 103230420(PTGS2)
RRO: 104664377(PTGS2)
RBB: 108523178(PTGS2)
CJC: 100407639(PTGS2)
SBQ: 101027603(PTGS2)
MMU: 19225(Ptgs2)
MPAH: 110315297 110321554(Ptgs2)
RNO: 29527(Ptgs2)
MUN: 110553489(Ptgs2)
CGE: 100751220(Ptgs2)
NGI: 103726651(Ptgs2)
HGL: 101704771(Ptgs2)
CCAN: 109685138(Ptgs2)
OCU: 100009248(PTGS2)
TUP: 102478264(PTGS2)
CFA: 442942(PTGS2)
VVP: 112921830(PTGS2)
AML: 100481615(PTGS2)
UMR: 103668648(PTGS2)
UAH: 113262761(PTGS2)
ORO: 101375484(PTGS2)
ELK: 111150791
FCA: 100126581(PTGS2)
PTG: 102948685(PTGS2)
PPAD: 109253602(PTGS2)
AJU: 106967086(PTGS2)
BTA: 282023(PTGS2)
BOM: 102271174(PTGS2)
BIU: 109570734(PTGS2)
BBUB: 102416528(PTGS2)
CHX: 100860905(PTGS2)
OAS: 443460(PTGS2)
SSC: 397590(PTGS2)
CFR: 102509586(PTGS2)
CDK: 105099289(PTGS2)
BACU: 102999195(PTGS2)
LVE: 103088613(PTGS2)
OOR: 101270299(PTGS2)
DLE: 111184673(PTGS2)
PCAD: 102982708(PTGS2)
ECB: 791253(PTGS2)
EPZ: 103547078(PTGS2)
EAI: 106846783(PTGS2)
MYB: 102259598(PTGS2)
MYD: 102774808(PTGS2)
MNA: 107546245(PTGS2)
HAI: 109379092(PTGS2)
DRO: 112296707(PTGS2)
PALE: 102886561(PTGS2)
RAY: 107521616(PTGS2)
MJV: 108406216(PTGS2)
LAV: 100666359(PTGS2)
TMU: 101345018
MDO: 100024802(PTGS2)
SHR: 100926756(PTGS2)
PCW: 110206875(PTGS2)
OAA: 100086096(PTGS2)
GGA: 396451(PTGS2)
MGP: 100550092(PTGS2)
CJO: 107317330(PTGS2)
NMEL: 110402447(PTGS2)
APLA: 101790135(PTGS2)
ACYG: 106034056(PTGS2)
TGU: 100221909(PTGS2)
LSR: 110467832(PTGS2)
SCAN: 103814802(PTGS2)
GFR: 102045242(PTGS2)
FAB: 101816125(PTGS2)
PHI: 102105209(PTGS2)
PMAJ: 107208209(PTGS2)
CCAE: 111932522(PTGS2)
CCW: 104693603(PTGS2)
ETL: 114066906(PTGS2)
FPG: 101918755(PTGS2)
FCH: 102050356(PTGS2)
CLV: 102088650(PTGS2)
EGZ: 104124553(PTGS2)
NNI: 104011302(PTGS2)
ACUN: 113483094(PTGS2)
PADL: 103922182(PTGS2)
ASN: 102369126(PTGS2)
AMJ: 106736995(PTGS2)
PSS: 102459102(PTGS2)
CMY: 102934690(PTGS2)
CPIC: 101941281(PTGS2)
ACS: 100560130(ptgs2)
PVT: 110079773(PTGS2)
PBI: 103063043(PTGS2)
PMUR: 107285158(PTGS2)
TSR: 106542642(PTGS2)
GJA: 107121970(PTGS2)
XLA: 108714508 446781(ptgs2.S)
XTR: 595089(ptgs2)
NPR: 108798706(PTGS2)
DRE: 246227(ptgs2a) 559020(ptgs2b)
CCAR: 109071632(ptgs2) 109081129
TRU: 101064817(ptgs2)
LCO: 104921828(ptgs2)
NCC: 104955130(ptgs2)
MZE: 101472557(ptgs2)
ONL: 100698573(ptgs2)
OLA: 100359365(ptgs2)
XMA: 102228898(ptgs2)
XCO: 114150821(ptgs2)
PRET: 103468244(ptgs2)
CVG: 107085952(ptgs2)
NFU: 107392885(ptgs2)
KMR: 108238364(ptgs2)
ALIM: 106516825(ptgs2)
AOCE: 111585762(ptgs2)
CSEM: 103395284(ptgs2)
POV: 109636696(ptgs2)
LCF: 108896773(ptgs2)
SDU: 111219627(ptgs2)
SLAL: 111645378(ptgs2)
HCQ: 109519080(ptgs2)
BPEC: 110167945(ptgs2)
MALB: 109961724(ptgs2)
ELS: 105028801 105029082(ptgs2)
SFM: 108935147 108935314(ptgs2)
LCM: 102352257(PTGS2)
CMK: 103179983(ptgs2)
RTP: 109933769(ptgs2)
RMD: 113560185
PVM: 113810970
PCAN: 112575294
MYI: 110451344
DGT: 114537549
NCR: NCU05858
NEU: NE1240(Ptgs1)
MET: M446_1624
MNO: Mnod_6498
RDE: RD1_1072
MVA: Mvan_3099
SRO: Sros_8745
GOB: Gobs_1219
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8473346
  Authors
Jones DA, Carlton DP, McIntyre TM, Zimmerman GA, Prescott SM
  Title
Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.
  Journal
J Biol Chem 268:9049-54 (1993)
  Sequence
[hsa:5743]
Reference
  Authors
Kim SF, Huri DA, Snyder SH
  Title
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
  Journal
Science 310:1966-70 (2005)
DOI:10.1126/science.1119407
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