KEGG   ORTHOLOGY: K12077Help
Entry
K12077                      KO                                     

Name
PDK1
Definition
pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]
Pathway
ko04066  HIF-1 signaling pathway
ko04360  Axon guidance
ko05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.2  [pyruvate dehydrogenase (acetyl-transferring)] kinase
     K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PDHK family [OT]
   K12077  PDK1; pyruvate dehydrogenase kinase isoform 1
BRITE hierarchy
Other DBs
GO: 0004740
Genes
HSA: 5163(PDK1)
PTR: 459743(PDK1)
PPS: 100968174(PDK1)
GGO: 101150048(PDK1)
PON: 100442853(PDK1)
NLE: 100601990(PDK1)
MCC: 697772(PDK1)
MCF: 102132161(PDK1)
CSAB: 103217325(PDK1)
RRO: 104673517(PDK1)
RBB: 108522274(PDK1)
CJC: 100402844(PDK1)
SBQ: 101037963(PDK1)
MMU: 228026(Pdk1)
MCAL: 110312693(Pdk1)
MPAH: 110318417(Pdk1)
RNO: 116551(Pdk1)
MUN: 110565621(Pdk1)
CGE: 100774056(Pdk1)
NGI: 103728651 103751806(Pdk1)
HGL: 101705587(Pdk1)
CCAN: 109699522(Pdk1)
OCU: 100351323(PDK1)
TUP: 102499515(PDK1)
CFA: 476828(PDK1)
VVP: 112916403(PDK1)
AML: 100483652(PDK1)
UMR: 103659566(PDK1)
UAH: 113250772(PDK1)
ORO: 101383119(PDK1)
ELK: 111144206
FCA: 101092705(PDK1)
PTG: 102960301(PDK1)
PPAD: 109273020(PDK1)
AJU: 106987925(PDK1)
BTA: 528655(PDK1)
BOM: 102265648(PDK1)
BIU: 109566453(PDK1)
BBUB: 102416388(PDK1)
CHX: 102186251(PDK1)
OAS: 101113205(PDK1)
SSC: 100286871(PDK1)
CFR: 102518782(PDK1)
CDK: 105091095(PDK1)
BACU: 103016999(PDK1)
LVE: 103078387(PDK1)
OOR: 101271748(PDK1)
DLE: 111172870(PDK1)
PCAD: 102993902(PDK1)
ECB: 100064091(PDK1)
EPZ: 103553122(PDK1)
EAI: 106834715(PDK1)
MYB: 102262215(PDK1)
MYD: 102767099(PDK1)
MNA: 107531030(PDK1)
HAI: 109390399(PDK1)
DRO: 112305775(PDK1)
PALE: 102883688(PDK1)
RAY: 107505192(PDK1)
MJV: 108391482(PDK1)
LAV: 100655808(PDK1)
TMU: 101341826
MDO: 100617164(PDK1)
SHR: 100932777(PDK1)
PCW: 110211577(PDK1)
OAA: 100084173(PDK1)
GGA: 425972(PDK1)
MGP: 100551417(PDK1)
CJO: 107316706(PDK1)
NMEL: 110400361(PDK1)
APLA: 101790921(PDK1)
ACYG: 106029999(PDK1)
TGU: 100218846(PDK1)
LSR: 110482900(PDK1)
SCAN: 103814437(PDK1)
GFR: 102032982(PDK1)
FAB: 101812709(PDK1)
PHI: 102101703(PDK1)
PMAJ: 107207402(PDK1)
CCAE: 111932081(PDK1)
CCW: 104693871(PDK1)
ETL: 114054918(PDK1)
FPG: 101925003(PDK1)
FCH: 102050815(PDK1)
CLV: 102098636(PDK1)
EGZ: 104128057(PDK1)
NNI: 104010002(PDK1)
ACUN: 113482065(PDK1)
PADL: 103924235(PDK1)
AAM: 106499285(PDK1)
ASN: 102384931(PDK1)
AMJ: 102565725(PDK1)
PSS: 102462980(PDK1)
CMY: 102942305(PDK1)
CPIC: 101939432(PDK1)
ACS: 100555492(pdk1)
PVT: 110086017(PDK1)
PBI: 103052758(PDK1)
PMUR: 107291526(PDK1)
TSR: 106542459
PMUA: 114606930(PDK1)
GJA: 107107054(PDK1)
XLA: 432080(pdk1.L) 494745
XTR: 100497838(pdk1)
NPR: 108800388(PDK1)
DRE: 555840(pdk1)
SANH: 107657352(pdk1) 107671276
SGH: 107588235
CCAR: 109091412
IPU: 108266331(pdk1)
PHYP: 113526171(pdk1)
AMEX: 103033744(pdk1)
EEE: 113588394(pdk1)
TRU: 101066998(pdk1)
LCO: 104927781(pdk1)
NCC: 104948256(pdk1)
MZE: 101482626(pdk1)
ONL: 100700648(pdk1)
OLA: 101161766(pdk1)
XMA: 102235390(pdk1)
XCO: 114148095(pdk1)
PRET: 103458449(pdk1)
CVG: 107102278(pdk1)
NFU: 107390016(pdk1)
KMR: 108240758
ALIM: 106512868(pdk1)
AOCE: 111582187(pdk1)
CSEM: 103391842(pdk1)
POV: 109631285(pdk1)
LCF: 108888700(pdk1)
SDU: 111218429(pdk1)
HCQ: 109507862(pdk1)
BPEC: 110166617(pdk1)
MALB: 109958057(pdk1)
SASA: 106586231(pdk1)
OTW: 112236653
SALP: 111975134
ELS: 105016204(pdk1)
SFM: 108920673(pdk1)
TSP: Tsp_01211
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR
  Title
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
  Journal
Curr Biol 9:393-404 (1999)
DOI:10.1016/S0960-9822(99)80186-9
Reference
  Authors
Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL, Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S, Chen J
  Title
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
  Journal
Mol Cell 44:864-77 (2011)
DOI:10.1016/j.molcel.2011.10.015
  Sequence
[hsa:5163]
LinkDB All DBs

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