KEGG   ORTHOLOGY: K12330Help
Entry
K12330                      KO                                     

Name
ARHGEF1
Definition
Rho guanine nucleotide exchange factor 1
Pathway
ko04270  Vascular smooth muscle contraction
ko04611  Platelet activation
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05130  Pathogenic Escherichia coli infection
ko05135  Yersinia infection
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
   05205 Proteoglycans in cancer
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
   05135 Yersinia infection
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
Membrane trafficking [BR:ko04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    K12330  ARHGEF1; Rho guanine nucleotide exchange factor 1
BRITE hierarchy
Other DBs
GO: 0005089
Genes
HSA: 9138(ARHGEF1)
PTR: 456067(ARHGEF1)
PPS: 100972918(ARHGEF1)
GGO: 101131951(ARHGEF1)
PON: 100438951(ARHGEF1)
NLE: 100581841(ARHGEF1)
MCC: 722198(ARHGEF1)
MCF: 102143411(ARHGEF1)
CSAB: 103234745(ARHGEF1)
RRO: 104676067(ARHGEF1)
RBB: 108513891(ARHGEF1)
CJC: 100409602(ARHGEF1)
SBQ: 101043419(ARHGEF1)
MMU: 16801(Arhgef1)
MCAL: 110297443(Arhgef1)
MPAH: 110336315(Arhgef1)
RNO: 60323(Arhgef1)
MUN: 110566357(Arhgef1)
CGE: 100758784(Arhgef1)
NGI: 103744614(Arhgef1)
HGL: 101721865(Arhgef1)
CCAN: 109688529(Arhgef1)
OCU: 103347573(ARHGEF1)
TUP: 102484536(ARHGEF1)
CFA: 100856005 100856354(ARHGEF1)
VVP: 112931193(ARHGEF1)
AML: 100477081(ARHGEF1)
UMR: 103680187(ARHGEF1)
UAH: 113243505(ARHGEF1)
ORO: 101377895(ARHGEF1)
ELK: 111139489
FCA: 101083892(ARHGEF1)
PTG: 102956204(ARHGEF1)
PPAD: 109257994(ARHGEF1)
AJU: 106987699(ARHGEF1)
BTA: 513377(ARHGEF1)
BOM: 102271873(ARHGEF1)
BIU: 109572733(ARHGEF1)
BBUB: 102401949(ARHGEF1)
CHX: 102180150(ARHGEF1)
OAS: 101104265(ARHGEF1)
SSC: 100518073(ARHGEF1)
CFR: 102504201(ARHGEF1)
CDK: 105090229(ARHGEF1)
BACU: 103011772(ARHGEF1)
LVE: 103091388(ARHGEF1)
OOR: 101279717(ARHGEF1)
DLE: 111180799(ARHGEF1)
PCAD: 102984815(ARHGEF1)
ECB: 102150569(ARHGEF1)
EPZ: 103563986(ARHGEF1)
EAI: 106847953(ARHGEF1)
MYB: 102242342(ARHGEF1)
MYD: 102767102(ARHGEF1)
MNA: 107534237(ARHGEF1)
HAI: 109374465(ARHGEF1)
DRO: 112320150(ARHGEF1)
PALE: 102894194(ARHGEF1)
RAY: 107502587(ARHGEF1)
MJV: 108393666(ARHGEF1)
LAV: 100674589(ARHGEF1)
TMU: 101360283
SHR: 105750075(ARHGEF1)
PCW: 110219909(ARHGEF1)
OAA: 100078658(ARHGEF1)
NMEL: 110391747(ARHGEF1)
TGU: 115492918
PHI: 102104245(ARHGEF1)
ASN: 102387901(ARHGEF1)
AMJ: 106737254(ARHGEF1)
CPIC: 101943841(ARHGEF1) 101945099
ACS: 103282674(arhgef1)
PVT: 110086745(ARHGEF1)
PBI: 103053216(ARHGEF1)
PMUR: 107289707(ARHGEF1)
TSR: 106542680 106553273(ARHGEF1)
PMUA: 114603358(ARHGEF1)
GJA: 107123495
XLA: 108696695(arhgef1.L) 108697757(arhgef1.S)
XTR: 100037905(arhgef1)
NPR: 108785651(ARHGEF1)
DRE: 557983(arhgef1b)
SGH: 107593668(arhgef1) 107595767
IPU: 108256375(arhgef1)
PHYP: 113532549(arhgef1)
AMEX: 103031326(arhgef1)
EEE: 113571897(arhgef1)
TRU: 101072427(arhgef1)
LCO: 104927335(arhgef1)
NCC: 104958954
MZE: 101483769(arhgef1)
ONL: 102081168(arhgef1)
OLA: 101157484(arhgef1)
XMA: 102216423(arhgef1)
XCO: 114140709(arhgef1)
PRET: 103477916(arhgef1)
CVG: 107083568(arhgef1)
NFU: 107379672(arhgef1)
KMR: 108235505(arhgef1)
ALIM: 106523737(arhgef1)
AOCE: 111564210(arhgef1)
CSEM: 103388802(arhgef1)
POV: 109633391(arhgef1)
LCF: 108880744(arhgef1)
SDU: 111236046(arhgef1)
SLAL: 111657270(arhgef1)
HCQ: 109531672(arhgef1)
BPEC: 110174263(arhgef1)
MALB: 109954623(arhgef1)
SASA: 106593652 106595078 106605705(arhgef1)
SALP: 111964599(arhgef1)
ELS: 105024273(arhgef1)
SFM: 108922228(arhgef1)
PKI: 111854845(arhgef1)
LCM: 102347979(ARHGEF1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Guilluy C, Bregeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E, Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G
  Title
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.
  Journal
Nat Med 16:183-90 (2010)
DOI:10.1038/nm.2079
  Sequence
[hsa:9138] [mmu:16801]
Reference
PMID:8810315
  Authors
Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G
  Title
Identification of a novel guanine nucleotide exchange factor for the Rho GTPase.
  Journal
J Biol Chem 271:25452-8 (1996)
DOI:10.1074/jbc.271.41.25452
  Sequence
[hsa:9138]
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