KEGG   ORTHOLOGY: K12407Help
Entry
K12407                      KO                                     

Name
GCK
Definition
glucokinase [EC:2.7.1.2]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko00052  Galactose metabolism
ko00500  Starch and sucrose metabolism
ko00520  Amino sugar and nucleotide sugar metabolism
ko00521  Streptomycin biosynthesis
ko00524  Neomycin, kanamycin and gentamicin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01200  Carbon metabolism
ko04910  Insulin signaling pathway
ko04911  Insulin secretion
ko04917  Prolactin signaling pathway
ko04922  Glucagon signaling pathway
ko04930  Type II diabetes mellitus
ko04950  Maturity onset diabetes of the young
ko05230  Central carbon metabolism in cancer
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
Disease
H00410  Maturity onset diabetes of the young (MODY)
H00512  Permanent neonatal diabetes mellitus
H01267  Familial hyperinsulinemic hypoglycemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K12407  GCK; glucokinase
   00052 Galactose metabolism
    K12407  GCK; glucokinase
   00500 Starch and sucrose metabolism
    K12407  GCK; glucokinase
   00520 Amino sugar and nucleotide sugar metabolism
    K12407  GCK; glucokinase
  09110 Biosynthesis of other secondary metabolites
   00521 Streptomycin biosynthesis
    K12407  GCK; glucokinase
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K12407  GCK; glucokinase
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K12407  GCK; glucokinase
   04910 Insulin signaling pathway
    K12407  GCK; glucokinase
   04922 Glucagon signaling pathway
    K12407  GCK; glucokinase
   04917 Prolactin signaling pathway
    K12407  GCK; glucokinase
 09160 Human Diseases
  09161 Cancers: Overview
   05230 Central carbon metabolism in cancer
    K12407  GCK; glucokinase
  09167 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K12407  GCK; glucokinase
   04950 Maturity onset diabetes of the young
    K12407  GCK; glucokinase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
     K12407  GCK; glucokinase
   Other carbohydrate metabolism
    M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
     K12407  GCK; glucokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.2  glucokinase
     K12407  GCK; glucokinase
BRITE hierarchy
Other DBs
RN: R00299 R01600 R01786
GO: 0004340
Genes
HSA: 2645(GCK)
PTR: 737923(GCK)
PPS: 100979621(GCK)
GGO: 101138839(GCK)
PON: 100459152(GCK)
NLE: 100591653(GCK)
MCC: 699728(GCK)
MCF: 102127599(GCK)
CSAB: 103226145(GCK)
RRO: 104671144(GCK)
RBB: 108544024(GCK)
CJC: 100409392(GCK)
SBQ: 101027980(GCK)
MMU: 103988(Gck)
RNO: 24385(Gck)
CGE: 100763110(Gck)
NGI: 103734982(Gck)
HGL: 101721664(Gck)
CCAN: 109685901(Gck)
OCU: 100341946(GCK)
TUP: 102492140(GCK)
CFA: 606490(GCK)
AML: 100475738(GCK)
UMR: 103674684(GCK)
ORO: 101383256(GCK)
FCA: 100037406(GCK)
PTG: 102965436(GCK)
AJU: 106968236(GCK)
BTA: 616576(GCK)
BOM: 102277785(GCK)
BIU: 109557544(GCK)
PHD: 102337670(GCK)
CHX: 102185429(GCK)
OAS: 101117412(GCK)
SSC: 100514142(GCK)
CFR: 102506850(GCK)
CDK: 105092330(GCK)
BACU: 103004735(GCK)
LVE: 103074175(GCK)
OOR: 101286839(GCK)
ECB: 100051836
EPZ: 103554943(GCK)
EAI: 106822865(GCK)
MYB: 102261259(GCK)
MYD: 102757162(GCK)
HAI: 109373004(GCK)
RSS: 109447351(GCK)
PALE: 102884319(GCK)
LAV: 100658238(GCK)
TMU: 101346854
MDO: 100030125(GCK)
SHR: 100918168(GCK)
OAA: 100091176(GCK)
GGA: 430370(GCK)
MGP: 100546168(GCK)
CJO: 107323664(GCK)
TGU: 100222236(GCK)
GFR: 102040748(GCK)
FAB: 101821944(GCK)
PHI: 102105464(GCK)
PMAJ: 107213875(GCK)
CCW: 104683184(GCK)
FPG: 101920472(GCK)
FCH: 102058018(GCK)
CLV: 102084067(GCK)
EGZ: 104122939(GCK) 104129373
AAM: 106494575(GCK)
ASN: 102373336(GCK)
AMJ: 102558588(GCK)
PSS: 102457711(GCK)
CMY: 102932759(GCK)
CPIC: 101935155(GCK)
ACS: 100554306(gck)
PVT: 110084342(GCK)
PBI: 103062255(GCK)
GJA: 107117392(GCK)
XLA: 108712732 378602(gck.L)
XTR: 100124905(gck)
NPR: 108796074(GCK)
DRE: 751668(gck)
IPU: 108265751(gck)
AMEX: 103039737(gck)
TRU: 101063910(gck)
LCO: 104922970(gck)
NCC: 104956790(gck)
MZE: 101465626(gck)
OLA: 101168372(gck)
XMA: 102229323(gck)
PRET: 103470005(gck)
NFU: 107394278(gck)
CSEM: 103397747(gck)
LCF: 108881204(gck)
HCQ: 109526325(gck)
BPEC: 110153979(gck)
SASA: 106580581(gk) 106585167
ELS: 105014407(gck)
SFM: 108932222 108940338(gck)
LCM: 102364718(GCK)
CMK: 103187782(gck)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Iynedjian PB
  Title
Molecular physiology of mammalian glucokinase.
  Journal
Cell Mol Life Sci 66:27-42 (2009)
DOI:10.1007/s00018-008-8322-9
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