KEGG   ORTHOLOGY: K14959
Entry
K14959                      KO                                     

Name
MLL4
Definition
[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
Pathway
ko00310  Lysine degradation
ko01100  Metabolic pathways
Disease
H00831  Primary dystonia
H01613  Follicular lymphoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   03036 Chromosome and associated proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   HMT complexes
    MLL3/MLL4 complex
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Other DBs
RN: R03875 R04866 R04867
GO: 0042800
Genes
HSA: 9757(KMT2B)
PTR: 455959(KMT2B)
PPS: 100979249(KMT2B)
GGO: 101139923(KMT2B)
PON: 100442005(KMT2B)
NLE: 100594433(KMT2B)
MCC: 718835(KMT2B)
MCF: 102115861(KMT2B)
CSAB: 103234531(KMT2B)
RRO: 104667085(KMT2B)
RBB: 108512323(KMT2B)
CJC: 100407541(KMT2B)
SBQ: 101034359(KMT2B)
MMU: 75410(Kmt2b)
MCAL: 110297666(Kmt2b)
MPAH: 110338314(Kmt2b)
RNO: 102550344(Kmt2b)
MUN: 110550986(Kmt2b)
CGE: 100750575(Kmt2b)
NGI: 103729965(Kmt2b)
HGL: 101699273(Kmt2b)
CCAN: 109689598(Kmt2b)
OCU: 100353483(KMT2B)
TUP: 102477772(KMT2B)
CFA: 100688666(KMT2B)
VVP: 112928324(KMT2B)
AML: 100469094(KMT2B)
UMR: 103682560(KMT2B)
UAH: 113244759(KMT2B)
ORO: 101370290(KMT2B)
ELK: 111161417
FCA: 101098760(KMT2B)
PTG: 102964982(KMT2B)
PPAD: 109251503(KMT2B)
AJU: 106974745(KMT2B)
BTA: 785776(KMT2B)
BOM: 102269320(KMT2B)
BIU: 109572325(KMT2B)
BBUB: 102400596(KMT2B)
CHX: 102172292(KMT2B)
OAS: 101104086(KMT2B)
SSC: 100520742(KMT2B)
CFR: 102520520(KMT2B)
CDK: 105088051
BACU: 103015601(KMT2B)
LVE: 103073652(KMT2B)
OOR: 101276223(KMT2B)
DLE: 111181136(KMT2B)
PCAD: 102987727(KMT2B)
ECB: 100059802(KMT2B)
EPZ: 103566091(KMT2B)
EAI: 106829152(KMT2B)
MYB: 102259087(KMT2B)
MYD: 102771251(KMT2B)
MNA: 107543372(KMT2B)
HAI: 109372008(KMT2B)
DRO: 112320053(KMT2B)
PALE: 102881431(KMT2B)
RAY: 107497624(KMT2B)
MJV: 108401519(KMT2B)
LAV: 100669611(KMT2B)
TMU: 101345928
MDO: 100617561(KMT2B)
SHR: 100927672(KMT2B)
PCW: 110201341(KMT2B)
OAA: 103165316(KMT2B)
ASN: 102382195(KMT2B)
CMY: 102931937(KMT2B)
CPIC: 101950574(KMT2B)
ACS: 100556600(kmt2b)
PVT: 110089900(KMT2B)
PBI: 103058696(KMT2B)
PMUR: 107287999(KMT2B)
TSR: 106550780(KMT2B)
PMUA: 114603572(KMT2B)
GJA: 107108169(KMT2B)
XTR: 100144721(kmt2b)
NPR: 108799776(KMT2B)
DRE: 560856(kmt2ba) 566825(kmt2bb)
IPU: 108272954 108277672(kmt2b)
PHYP: 113535181 113539221(kmt2b)
AMEX: 103022217(kmt2b) 103024771
EEE: 113572597 113586392(kmt2b)
LCO: 104927558 104932361(kmt2b)
NCC: 104960690 104961389(kmt2b)
MZE: 101467874 101481309(kmt2b)
ONL: 100689867 100700132(kmt2b)
OLA: 101157226 101174945(kmt2b)
XMA: 102222844 102229737(kmt2b)
XCO: 114142152(kmt2b) 114156616
PRET: 103472504 103478519(kmt2b)
CVG: 107086122(kmt2b) 107101115
NFU: 107372442(kmt2b) 107394636
KMR: 108240680 108241999(kmt2b)
ALIM: 106517704(kmt2b) 106537143
AOCE: 111571387 111577070(kmt2b)
CSEM: 103388508(kmt2b) 103394161
POV: 109633105(kmt2b) 109638782
LCF: 108888836 108890658(kmt2b)
SDU: 111223127 111234049(kmt2b)
SLAL: 111657578 111664979(kmt2b)
HCQ: 109514546 109525616(kmt2b)
BPEC: 110161138 110171497(kmt2b)
MALB: 109971699(kmt2b) 109973928
ELS: 105007527 105019114(kmt2b)
SFM: 108930328(kmt2b)
PKI: 111833696(kmt2b) 111839650
RTP: 109924675
FCD: 110859435
EGL: EGR_00862
EPA: 110242030
AMIL: 114953840
PDAM: 113686108
SPIS: 111338657
DGT: 114524461
HMG: 100210554
AQU: 100636799
 » show all
Reference
  Authors
Demers C, Chaturvedi CP, Ranish JA, Juban G, Lai P, Morle F, Aebersold R, Dilworth FJ, Groudine M, Brand M
  Title
Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.
  Journal
Mol Cell 27:573-84 (2007)
DOI:10.1016/j.molcel.2007.06.022
  Sequence
[hsa:9757]
Reference
  Authors
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K
  Title
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
  Journal
J Biol Chem 282:20395-406 (2007)
DOI:10.1074/jbc.M701574200
  Sequence
[hsa:9757]
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